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  1. Book ; Online: Wechselkurssicherungsstrategien exportorientierter Unternehmen

    Geier, Christian

    2012  

    Abstract: Diese Arbeit entwickelt eine Entscheidungshilfe für die Auswahl von regelgebundenen, selektiven Wechselkurssicherungsstrategien auf Unternehmensebene. Neben einer Auseinandersetzung mit den Grundlagen der betrieblichen Sicherungsgeschäfte, des Corporate ... ...

    Abstract Diese Arbeit entwickelt eine Entscheidungshilfe für die Auswahl von regelgebundenen, selektiven Wechselkurssicherungsstrategien auf Unternehmensebene. Neben einer Auseinandersetzung mit den Grundlagen der betrieblichen Sicherungsgeschäfte, des Corporate Hedgings, folgt die allgemeine Analyse der Relevanz der Wechselkursproblematik im Lichte der Betriebswirtschaftslehre des Außenhandels. Ein weiterer Teilbereich wird der modernen Internationalen Portfoliotheorie entlehnt und widmet sich der Systematik regelgebundener selektiver Absicherungsstrategien. Anschließend werden die vorgestellten regelgebundenen, selektiven Wechselkurssicherungsstrategien anhand eines Backtests hinsichtlich ihrer Effizienz und Auswirkungen auf ein exportorientiertes Unternehmen untersucht und mit unterschiedlichen Maßzahlen in Bezug zu einander gesetzt
    Keywords Management. Industrial management
    Size 1 electronic resource (342 p.)
    Publisher Peter Lang International Academic Publishing Group
    Document type Book ; Online
    Note German ; Open Access
    HBZ-ID HT020100999
    ISBN 9783631634110 ; 3631634110
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Thesis: Analyse von CSRP3 als Kandidatengen der dilatativen und hypertrophen Kardiomyopathie beim Menschen

    Geier, Christian

    Mutanten des Muscle-LIM-Proteins verursachen eine hypertrophe Kardiomyopathie

    2005  

    Author's details von Christian Geier
    Language German
    Size V, 88, XXXV Bl., Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Charité, Univ.-Med., Diss., 2005
    HBZ-ID HT014634951
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 MB 1585 order for loan Magazin

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  3. Article ; Online: Therapeutic mTOR blockade in systemic autoimmunity: Implications for antiviral immunity and extension of lifespan.

    Geier, Christian / Perl, Andras

    Autoimmunity reviews

    2021  Volume 20, Issue 12, Page(s) 102984

    Abstract: The mechanistic target of rapamycin (mTOR) pathway integrates metabolic cues into cell fate decisions. A particularly fateful event during the adaptive immune response is the engagement of a T cell receptor by its cognate antigen presented by an antigen- ... ...

    Abstract The mechanistic target of rapamycin (mTOR) pathway integrates metabolic cues into cell fate decisions. A particularly fateful event during the adaptive immune response is the engagement of a T cell receptor by its cognate antigen presented by an antigen-presenting cell (APC). Here, the induction of adequate T cell activation and lineage specification is critical to mount protective immunity; at the same time, inadequate activation, which could lead to autoimmunity, must be avoided. mTOR forms highly conserved protein complexes 1 and 2 that shape lineage specification by integrating signals originating from TCR engagement, co-stimulatory or co-inhibitory receptors and cytokines and availability of nutrients. If one considers autoimmunity as the result of aberrant lineage specification in response to such signals, the importance of this pathway becomes evident; this provides the conceptual basis for mTOR inhibition in the treatment of systemic autoimmunity, such as systemic lupus erythematosus (SLE). Clinical trials in SLE patients have provided preliminary evidence that mTOR blockade by sirolimus (rapamycin) can reverse pro-inflammatory lineage skewing, including the expansion of Th17 and double-negative T cells and plasma cells and the contraction of regulatory T cells. Moreover, sirolimus has shown promising efficacy in the treatment of refractory idiopathic multicentric Castleman disease, newly characterized by systemic autoimmunity due to mTOR overactivation. Alternatively, mTOR blockade enhances responsiveness to vaccination and reduces infections by influenza virus in healthy elderly subjects. Such seemingly contradictory findings highlight the importance to further evaluate the clinical effects of mTOR manipulation, including its potential role in treatment of COVID-19 infection. mTOR blockade may extend healthy lifespan by abrogating inflammation induced by viral infections and autoimmunity. This review provides a mechanistic assessment of mTOR pathway activation in lineage specification within the adaptive and innate immune systems and its role in health and autoimmunity. We then discuss some of the recent experimental and clinical discoveries implicating mTOR in viral pathogensis and aging.
    MeSH term(s) Aged ; Antiviral Agents/therapeutic use ; Autoimmunity ; COVID-19 ; Humans ; Longevity ; Lupus Erythematosus, Systemic/drug therapy ; SARS-CoV-2 ; TOR Serine-Threonine Kinases/therapeutic use
    Chemical Substances Antiviral Agents ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2021-10-27
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2021.102984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5913: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book ; Online ; Thesis: Knotenwichtigkeiten in räumlich ausgedehnten dynamischen Systemen

    Geier, Christian [Verfasser]

    2018  

    Author's details Christian Geier
    Keywords Philosophie ; Philosophy
    Subject code sg100
    Language German
    Publisher Universitäts- und Landesbibliothek Bonn
    Publishing place Bonn
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  5. Article ; Online: The relative area score for sublingual varices reliability measurement: a diagnostic study.

    Klein, Christian R / Stoppenbrink, David / Geier, Jannik / Mayr, Andreas / Stark, Helmut

    BMC oral health

    2023  Volume 23, Issue 1, Page(s) 366

    Abstract: Background: Sublingual varices (SV) and their predictive potential for other clinical parameters is a much studied topic in oral medicine. SVs have been well studied as predictive markers for many common diseases such as arterial hypertension, ... ...

    Abstract Background: Sublingual varices (SV) and their predictive potential for other clinical parameters is a much studied topic in oral medicine. SVs have been well studied as predictive markers for many common diseases such as arterial hypertension, cardiovascular disease, smoking, type 2 diabetes mellitus and age. Despite many prevalence studies, it is still unclear how the reliability of SV inspection affects its predictive power. The aim of this study was to quantify the inspection reliability of SV.
    Methods: In a diagnostic study, the clinical inspection of 78 patients by 23 clinicians was examined for the diagnosis of SV. Digital images of the underside of the tongue were taken from each patient. The physicians were then asked to rate them for the presence of sublingual varices (0/1) in an online inspection experiment. Statistical analysis for inter-item and inter-rater reliability was performed in a τ-equivalent measurement model with Cronbach's [Formula: see text] and Fleiss κ.
    Results: The interrater reliability for sublingual varices was relatively low with κ = 0.397. The internal consistency of image findings for SV was relatively high with α≈ 0.937. This shows that although SV inspection is possible in principle, it has a low reliability R. This means that the inspection finding (0/1) of individual images often cannot be reproduced stably. Therefore, SV inspection is a difficult task of clinical investigation. The reliability R of SV inspection also limits the maximum linear correlation [Formula: see text] of SV with an arbitrary other parameter Y. The reliability of SV inspection R = 0.847 limits the maximum correlation to [Formula: see text] (SV, Y) = 0,920-a 100% correlation was a priori not achievable in our sample. To overcome the problem of low reliability in SV inspection, we propose the RA (relative area) score as a continuous classification system for SV, which normalises the area of visible sublingual veins to the square of the length of the tongue, providing a dimensionless measure of SV.
    Conclusions: The reliability of the SV inspection is relatively low. This limits the maximum possible correlation of SV with other (clinical) parameters. SV inspection reliability is an important indicator for the quality of SV as a predictive marker. This should be taken into account when interpreting previous studies on SV and has implications for future studies. The RA score could help to objectify the SV examination and thus increase its reliability.
    MeSH term(s) Humans ; Reproducibility of Results ; Diabetes Mellitus, Type 2 ; Varicose Veins/diagnosis ; Tongue/blood supply ; Hypertension
    Language English
    Publishing date 2023-06-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2091511-1
    ISSN 1472-6831 ; 1472-6831
    ISSN (online) 1472-6831
    ISSN 1472-6831
    DOI 10.1186/s12903-023-03068-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: 'Carpal tunnel syndrome' and 'tennis elbow' as prodromes for granulomatosis with polyangiitis (formerly Wegener's granulomatosis).

    Geier, Christian / Steed, Kelly

    BMJ case reports

    2019  Volume 12, Issue 2

    Abstract: A 62-year-old man presented with excruciating joint pains, back stiffness and numbness of his hands and feet. Over the past 18 months, he had experienced similar episodes for which the diagnoses of bilateral carpal tunnel syndrome and lateral ... ...

    Abstract A 62-year-old man presented with excruciating joint pains, back stiffness and numbness of his hands and feet. Over the past 18 months, he had experienced similar episodes for which the diagnoses of bilateral carpal tunnel syndrome and lateral epicondylitis had been made. Physical examination revealed polyarticular arthritis affecting the shoulders, wrists and right knee. Palpable purpura overlying the calves and ankles was present. Laboratory tests showed markedly elevated erythrocyte sedimentation rate and C-reactive protein in the setting of negative blood and urine cultures. Rheumatoid factor and antinuclear antibodies were negative. Chest CT demonstrated bilateral pulmonary infiltrates. A punch biopsy of the rash showed leukocytoclastic vasculitis. Anti-proteinase-3 titers returned strongly positive. A diagnosis of granulomatosis with polyangiitis was made. Treatment with high-dose steroids, followed by rituximab resulted in normalisation of inflammatory markers with subsequent resolution of joint pains, rash and pulmonary infiltrates and improvement of neuropathic symptoms.
    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; Arthralgia/etiology ; Biopsy ; Carpal Tunnel Syndrome ; Diagnosis, Differential ; Granulomatosis with Polyangiitis/diagnosis ; Granulomatosis with Polyangiitis/drug therapy ; Granulomatosis with Polyangiitis/pathology ; Humans ; Immunologic Factors/therapeutic use ; Lung/diagnostic imaging ; Male ; Methylprednisolone/therapeutic use ; Middle Aged ; Rituximab/therapeutic use ; Tennis Elbow ; Tomography, X-Ray Computed
    Chemical Substances Anti-Inflammatory Agents ; Immunologic Factors ; Rituximab (4F4X42SYQ6) ; Methylprednisolone (X4W7ZR7023)
    Language English
    Publishing date 2019-02-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2018-227348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Origin and Early Evolution of Hydrocharitaceae and the Ancestral Role of

    Ulrich, Silvia / Vieira, Manuel / Coiro, Mario / Bouchal, Johannes M / Geier, Christian / Jacobs, Bonnie F / Currano, Ellen D / Lenz, Olaf K / Wilde, Volker / Zetter, Reinhard / Grímsson, Friðgeir

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 7

    Abstract: The combined morphological features ... ...

    Abstract The combined morphological features of
    Language English
    Publishing date 2024-03-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13071008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Multiplexed neuropeptide mapping in ant brains integrating microtomography and three-dimensional mass spectrometry imaging.

    Geier, Benedikt / Gil-Mansilla, Esther / Liutkevičiūtė, Zita / Hellinger, Roland / Vanden Broeck, Jozef / Oetjen, Janina / Liebeke, Manuel / Gruber, Christian W

    PNAS nexus

    2023  Volume 2, Issue 5, Page(s) pgad144

    Abstract: Neuropeptides are important regulators of animal physiology and behavior. Hitherto the gold standard for the localization of neuropeptides have been immunohistochemical methods that require the synthesis of antibody panels, while another limiting factor ... ...

    Abstract Neuropeptides are important regulators of animal physiology and behavior. Hitherto the gold standard for the localization of neuropeptides have been immunohistochemical methods that require the synthesis of antibody panels, while another limiting factor has been the brain's opacity for subsequent in situ light or fluorescence microscopy. To address these limitations, we explored the integration of high-resolution mass spectrometry imaging (MSI) with microtomography for a multiplexed mapping of neuropeptides in two evolutionary distant ant species,
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article
    ISSN 2752-6542
    ISSN (online) 2752-6542
    DOI 10.1093/pnasnexus/pgad144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The relative area score for sublingual varices reliability measurement

    Christian R. Klein / David Stoppenbrink / Jannik Geier / Andreas Mayr / Helmut Stark

    BMC Oral Health, Vol 23, Iss 1, Pp 1-

    a diagnostic study

    2023  Volume 8

    Abstract: Abstract Background Sublingual varices (SV) and their predictive potential for other clinical parameters is a much studied topic in oral medicine. SVs have been well studied as predictive markers for many common diseases such as arterial hypertension, ... ...

    Abstract Abstract Background Sublingual varices (SV) and their predictive potential for other clinical parameters is a much studied topic in oral medicine. SVs have been well studied as predictive markers for many common diseases such as arterial hypertension, cardiovascular disease, smoking, type 2 diabetes mellitus and age. Despite many prevalence studies, it is still unclear how the reliability of SV inspection affects its predictive power. The aim of this study was to quantify the inspection reliability of SV. Methods In a diagnostic study, the clinical inspection of 78 patients by 23 clinicians was examined for the diagnosis of SV. Digital images of the underside of the tongue were taken from each patient. The physicians were then asked to rate them for the presence of sublingual varices (0/1) in an online inspection experiment. Statistical analysis for inter-item and inter-rater reliability was performed in a τ-equivalent measurement model with Cronbach's $$\alpha$$ α and Fleiss κ. Results The interrater reliability for sublingual varices was relatively low with κ = 0.397. The internal consistency of image findings for SV was relatively high with α≈ 0.937. This shows that although SV inspection is possible in principle, it has a low reliability R. This means that the inspection finding (0/1) of individual images often cannot be reproduced stably. Therefore, SV inspection is a difficult task of clinical investigation. The reliability R of SV inspection also limits the maximum linear correlation $${r}_{max}$$ r max of SV with an arbitrary other parameter Y. The reliability of SV inspection R = 0.847 limits the maximum correlation to $${r}_{max}$$ r max (SV, Y) = 0,920—a 100% correlation was a priori not achievable in our sample. To overcome the problem of low reliability in SV inspection, we propose the RA (relative area) score as a continuous classification system for SV, which normalises the area of visible sublingual veins to the square of the length of the tongue, providing a dimensionless measure of SV. ...
    Keywords Sublingual varices ; Reliability ; Clinical inspection ; Aging ; Oral science ; Maximum correlation ; Dentistry ; RK1-715
    Subject code 600
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article ; Online: Earliest fossil pollen records of endemic African Sclerosperma palms and the palaeoecological aspects of the genus

    Vieira, Manuel / Bouchal, Johannes M. / Geier, Christian / Ulrich, Silvia / Zetter, Reinhard / Grímsson, Friðgeir

    Review of Palaeobotany and Palynology. 2023 Oct., v. 317 p.104954-

    2023  

    Abstract: Palm diversity in present-day Africa is much less than in other tropical regions such as the Americas and Southeast Asia but comprises several endemic genera, including Sclerosperma. The origin and evolution of this small Arecaceae genus are still ... ...

    Abstract Palm diversity in present-day Africa is much less than in other tropical regions such as the Americas and Southeast Asia but comprises several endemic genera, including Sclerosperma. The origin and evolution of this small Arecaceae genus are still enigmatic, and every new fossil discovered helps fill the void in its palaeophytogeographic history. In this article, we report five different pollen morphologies assigned to Sclerosperma from the earliest Late Eocene (early Priabonian) of southeast Kenya, Africa. These pollen grains represent the earliest fossil records of Sclerosperma so far and add a new geographic region and time slot to the palaeophytogeographic history of this genus. The morphological variability observed in the fossil pollen suggests that the diversification within Sclerosperma was already underway by the onset of the Priabonian, c. 37 Ma. Detailed analysis of the distribution of the three extant Sclerosperma species shows that this genus occurs only under Equatorial/Tropical climates with MTCM ≥18 °C, such as fully humid Rainforest (Af), Monsoonal (Am), and winter dry Savannah (Aw) climates. Sclerosperma is also conservative when it comes to vegetation biomes and only occurs in three different but closely related biomes, the Tropical & Subtropical Moist Forests Biome, the Tropical & Subtropical Grasslands, Savannahs & Shrublands Biome, and the Mangroves Biome. No current outliners pinpoint to a wider ecological tolerance of this genus in the geological past. This suggests Sclerosperma to be an exceptionally reliable taxon for palaeoclimate estimations and when assigning palaeofloras to major vegetation biomes.
    Keywords Arecaceae ; Eocene epoch ; ecosystems ; evolution ; fossils ; paleobotany ; paleoclimatology ; paleoecology ; palynology ; pollen ; rain forests ; shrublands ; Kenya ; South East Asia ; Pollen morphology ; Rainforest ; Swamp elements ; Tropical climates ; Vegetation biomes
    Language English
    Dates of publication 2023-10
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ISSN 0034-6667
    DOI 10.1016/j.revpalbo.2023.104954
    Database NAL-Catalogue (AGRICOLA)

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