LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 396

Search options

  1. Article ; Online: Immune-Related Adverse Events of Immune Checkpoint Inhibitors.

    Ramos-Casals, Manuel / Sisó-Almirall, Antoni

    Annals of internal medicine

    2024  Volume 177, Issue 2, Page(s) ITC17–ITC32

    Abstract: Immune-related adverse events (irAEs) are toxicities that arise after the administration of monoclonal antibodies targeting immune checkpoints (immune checkpoint inhibitors [ICIs]) in patients with cancer. They can occur at any time after initiation of ... ...

    Abstract Immune-related adverse events (irAEs) are toxicities that arise after the administration of monoclonal antibodies targeting immune checkpoints (immune checkpoint inhibitors [ICIs]) in patients with cancer. They can occur at any time after initiation of ICI treatment, with a broad clinical phenotype that can be organ-specific or systemic. Although most irAEs manifest as mild to moderate signs and symptoms, severe forms of irAEs can lead to irreversible organ failure and have acute life-threatening presentations. Treatment should be tailored to the specific organ involved and the severity. Glucocorticoids are the first-line treatment for most irAEs, with immunosuppressants and biologics mainly used as second-line treatments.
    MeSH term(s) Humans ; Immune Checkpoint Inhibitors/adverse effects ; Antibodies, Monoclonal/adverse effects ; Neoplasms/etiology ; Immunosuppressive Agents/adverse effects ; Immunotherapy
    Chemical Substances Immune Checkpoint Inhibitors ; Antibodies, Monoclonal ; Immunosuppressive Agents
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/AITC202402200
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.178/2: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Hematological involvement in sarcoidosis: from cytopenias to lymphoma.

    Brito-Zerón, Pilar / Lower, Elyse E / Ramos-Casals, Manuel / Baughman, Robert P

    Expert review of clinical immunology

    2024  Volume 20, Issue 1, Page(s) 59–70

    Abstract: Introduction: We present an updated overview of the hematological involvementassociated with sarcoidosis, including a management approach forcytopenias and revisiting the association with hematologicalmalignancies.: Areas covered: Theetiology of ... ...

    Abstract Introduction: We present an updated overview of the hematological involvementassociated with sarcoidosis, including a management approach forcytopenias and revisiting the association with hematologicalmalignancies.
    Areas covered: Theetiology of cytopenias in sarcoidosis can be attributed to two majoretiopathogenic mechanisms: infiltration of hematopoietic organs suchas the spleen and bone marrow, and autoimmune-mediated cytopenias.With respect to the association with hematological malignancies, itrequires careful evaluation of patients from a chronologicalperspective. Patients must be classified into one of three pathogenicscenarios, including preexisting hematological malignancies,synchronous development of malignancy and sarcoidosis due to commonpredisposing factors, or sarcoidosis as a predisposing factor formalignancies.
    Expert opinion: The association between sarcoidosis and hematologic involvement isbest understood as a pathogenic continuum, with cytopenias andhematologic neoplasms intertwined due to various etiopathogenicmechanisms. These mechanisms include sarcoid infiltration ofhematopoietic organs, common predisposing immunogenetics for thedevelopment of autoimmune cytopenias and malignancies, and anincreased risk of neoplasm development in patients with autoimmunecytopenias. Collaboration among the main specialties involved in theclinical management of these patients is crucial for an earlymonitoring and management.
    MeSH term(s) Humans ; Cytopenia ; Sarcoidosis ; Lymphoma ; Hematologic Neoplasms/complications ; Thrombocytopenia/complications ; Neoplasms
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2023.2274363
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6661: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book: The digestive involvement in systemic autoimmune diseases

    Ramos-Casals, Manuel / Khamashta, Munther A. / Brito-Zerón, Pilar / Atzeni, Fabiola / Rodes, Joan

    (Handbook of systemic autoimmune diseases ; 13)

    2017  

    Author's details edited by Manuel Ramos-Casals, Munther Khamashta, Pilar Brito-Zeron, Fabiola Atzeni, Joan Rodés
    Series title Handbook of systemic autoimmune diseases ; 13
    Collection
    Keywords Digestive organs/Diseases ; Autoimmune diseases/Complications
    Subject code 616.3
    Language English
    Size xxiii, 470 Seiten, Illustrationen, 23 cm
    Edition Second edition
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT019244849
    ISBN 978-0-444-63707-9 ; 9780444637178 ; 0-444-63707-9 ; 0444637176
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 A 290 available for loan (reading room) Lesesaal EG

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Reply.

    Brito-Zerón, Pilar / Pérez-Álvarez, Roberto / Ramos-Casals, Manuel

    Medicina clinica

    2023  Volume 160, Issue 6, Page(s) 278

    Title translation Respuesta.
    Language Spanish
    Publishing date 2023-01-25
    Publishing country Spain
    Document type Letter ; Comment
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2022.11.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.279: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Síndrome de Sjögren.

    Brito-Zerón, Pilar / Retamozo, Soledad / Ramos-Casals, Manuel

    Medicina clinica

    2022  Volume 160, Issue 4, Page(s) 163–171

    Abstract: In 1933, the Swedish ophthalmologist Hendrik Sjögren was the first to suggest that behind the dryness that several of his patients presented, there could be a systemic disease related to an abnormal immune response. Since then, the term Sjögren's ... ...

    Title translation Sjögren syndrome.
    Abstract In 1933, the Swedish ophthalmologist Hendrik Sjögren was the first to suggest that behind the dryness that several of his patients presented, there could be a systemic disease related to an abnormal immune response. Since then, the term Sjögren's syndrome (SjS) has been used and it has been considered a minor and infrequent disorder compared to other systemic autoimmune diseases (SAD) and, consequently, with little progress both in clinical and therapeutic research. The emergence of new technologies at the end of the 20th century rapidly promoted the development of international projects of great impact and diffusion, which have completely changed this scenario, and in the last 20 years significant progress has been made in understanding the main epidemiological determinants and pathogenic mechanisms to increase the diagnostic accuracy and to design specific and individualized therapeutic strategies. Currently, SjS should be considered one of the most frequent SADs with an undoubtedly systemic phenotype beyond dryness, in which the identification of prognostic factors can allow personalized follow-up and, therefore, early therapeutic interventions that avoid severe, irreversible outcomes.
    MeSH term(s) Humans ; Sjogren's Syndrome/complications ; Sjogren's Syndrome/diagnosis ; Sjogren's Syndrome/therapy ; Phenotype
    Language Spanish
    Publishing date 2022-12-15
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2022.10.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.279: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Crioglobulinemia.

    Retamozo, Soledad / Quartuccio, Luca / Ramos-Casals, Manuel

    Medicina clinica

    2022  Volume 158, Issue 10, Page(s) 478–487

    Abstract: Cryoglobulins are immunoglobulins that precipitate in vitro at temperatures below 37 ̊C. Cryoglobulin-associated disease is heterogeneous, as not all patients present with it, includes various syndromic presentations (vasculitis is the most common, ... ...

    Title translation Cryoglobulinemia.
    Abstract Cryoglobulins are immunoglobulins that precipitate in vitro at temperatures below 37 ̊C. Cryoglobulin-associated disease is heterogeneous, as not all patients present with it, includes various syndromic presentations (vasculitis is the most common, hyperviscosity syndrome is more exceptional), and can be associated with acute clinical pictures with high mortality. Until the appearance of specific antiviral treatments, the main aetiology has been chronic HCV infection, and currently it is mainly associated with systemic autoimmune diseases, malignant neoplasms and cases with no identified aetiology (essential cryoglobulinemia). Treatment should be modulated according to the predominant etiopathogenesis (vasculitis or hyperviscosity), the severity of internal organ involvement and, especially, the associated underlying disease. Due to the complex aetiological, clinical and pathological scenario of cryoglobulinaemia, early recognition of the most common clinical presentations, a comprehensive clinical assessment of the different organs that may be affected, and multidisciplinary work led by a unit specialised in systemic autoimmune diseases is essential.
    MeSH term(s) Antiviral Agents/therapeutic use ; Autoimmune Diseases/complications ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/drug therapy ; Cryoglobulinemia/diagnosis ; Cryoglobulinemia/etiology ; Cryoglobulinemia/therapy ; Humans ; Immunoglobulins ; Vasculitis/diagnosis ; Vasculitis/etiology ; Vasculitis/therapy
    Chemical Substances Antiviral Agents ; Immunoglobulins
    Language Spanish
    Publishing date 2022-02-22
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2021.11.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.279: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Book: Drugs targeting B-Cells in autoimmune diseases

    Bosch, Xavier / Ramos-Casals, Manuel / Khamashta, Munther A.

    (Milestones in drug therapy)

    2014  

    Author's details Xavier Bosch ; Manuel Ramos-Casals ; Munther A. Khamashta ed
    Series title Milestones in drug therapy
    Keywords Autoimmune diseases/Chemotherapy ; B cells
    Subject code 616.978061
    Language English
    Size XI, 292 S. : Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018124707
    ISBN 978-3-0348-0705-0 ; 9783034807067 ; 3-0348-0705-8 ; 3034807066
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 77 available for loan (reading room) Lesesaal EG

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Sarcoidosis.

    Brito-Zerón, Pilar / Pérez-Álvarez, Roberto / Ramos-Casals, Manuel

    Medicina clinica

    2022  Volume 159, Issue 4, Page(s) 195–204

    Abstract: Sarcoidosis is a systemic autoimmune disease that is associated with the development of non-caseating granulomas. The disease especially affects the lymph nodes, lungs, skin and eyes. It is an infrequent but not rare disease, especially in northern ... ...

    Title translation Sarcoidosis.
    Abstract Sarcoidosis is a systemic autoimmune disease that is associated with the development of non-caseating granulomas. The disease especially affects the lymph nodes, lungs, skin and eyes. It is an infrequent but not rare disease, especially in northern Europe, the United States and India. Sarcoidosis affects more women and is diagnosed between the ages of 30 and 50. Etiopathogenically, it is closely linked to environmental factors, especially occupational exposures. Clinically, it stands out for a wide variety of presentation phenotypes (casual diagnosis, involvement of a single organ or systemic presentation). The diagnosis of sarcoidosis is complex and requires the integration of clinical, analytical, radiological, and histolopathogical data carried out by multidisciplinary clinical units. The evolution of the disease is variable, as is the indication for systemic treatment, based on the use of corticosteroids as first-line option, the use of immunosuppressants as second-line therapy, and anti-TNF agents in severe and/or refractory cases.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Sarcoidosis/diagnosis ; Sarcoidosis/epidemiology ; Sarcoidosis/therapy ; Skin/pathology ; Tumor Necrosis Factor Inhibitors
    Chemical Substances Adrenal Cortex Hormones ; Immunosuppressive Agents ; Tumor Necrosis Factor Inhibitors
    Language Spanish
    Publishing date 2022-06-06
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2022.03.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.279: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Pathophysiology of Sjögren's-like syndrome induced by cancer immunotherapies: similarities and differences with classical Sjögren's syndrome.

    Goules, Andreas V / Pringle, Sarah / Ramos-Casals, Manuel / Tzioufas, Athanasios G

    Clinical and experimental rheumatology

    2022  Volume 40, Issue 12, Page(s) 2237–2239

    MeSH term(s) Humans ; Sjogren's Syndrome/therapy ; Neoplasms ; Immunotherapy/adverse effects
    Language English
    Publishing date 2022-10-04
    Publishing country Italy
    Document type Editorial
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/v9zras
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2002: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Systemic and organ-specific immune-related manifestations of COVID-19.

    Ramos-Casals, Manuel / Brito-Zerón, Pilar / Mariette, Xavier

    Nature reviews. Rheumatology

    2021  Volume 17, Issue 6, Page(s) 315–332

    Abstract: Immune-related manifestations are increasingly recognized conditions in patients with COVID-19, with around 3,000 cases reported worldwide comprising more than 70 different systemic and organ-specific disorders. Although the inflammation caused by SARS- ... ...

    Abstract Immune-related manifestations are increasingly recognized conditions in patients with COVID-19, with around 3,000 cases reported worldwide comprising more than 70 different systemic and organ-specific disorders. Although the inflammation caused by SARS-CoV-2 infection is predominantly centred on the respiratory system, some patients can develop an abnormal inflammatory reaction involving extrapulmonary tissues. The signs and symptoms associated with this excessive immune response are very diverse and can resemble some autoimmune or inflammatory diseases, with the clinical phenotype that is seemingly influenced by epidemiological factors such as age, sex or ethnicity. The severity of the manifestations is also very varied, ranging from benign and self-limiting features to life-threatening systemic syndromes. Little is known about the pathogenesis of these manifestations, and some tend to emerge within the first 2 weeks of SARS-CoV-2 infection, whereas others tend to appear in a late post-infectious stage or even in asymptomatic patients. As the body of evidence comprises predominantly case series and uncontrolled studies, diagnostic and therapeutic decision-making is unsurprisingly often based on the scarcely reported experience and expert opinion. Additional studies are required to learn about the mechanisms involved in the development of these manifestations and apply that knowledge to achieve early diagnosis and the most suitable therapy.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/immunology ; Humans ; Immunity, Innate ; Inflammation/immunology ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-04-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-021-00608-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6338: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top