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Article ; Online: Respiratory-like movements during an apnea test.

Kida, Shinichi / Nagata, Isao / Takei, Tetsuhiro / Yoshizawa, Kazuhiro / Suzuki, Taketo / Yamada, Hiroyuki / Nakayama, Yusuke

Acute medicine & surgery

2024 Volume 11, Issue 1, Page(s) e959

Abstract: Background: Despite the possible occurrence of spontaneous movements during an apnea test, respiratory-like movements are rare.: Case presentation: A 51-year-old man was transferred to our hospital when a sudden disturbance of consciousness developed ...

Abstract	Background: Despite the possible occurrence of spontaneous movements during an apnea test, respiratory-like movements are rare. Case presentation: A 51-year-old man was transferred to our hospital when a sudden disturbance of consciousness developed into cardiac arrest. After spontaneous circulation returned, we diagnosed bilateral cerebellar hemorrhage. He remained comatose with dilated pupils, absent brainstem reflexes, spontaneous breathing, and electrocerebral activity. After being considered brain dead, his family opted for organ donation. The first legal brain death examination on day 5 was aborted because of respiratory-like movements mimicking repetitive abdominal respiration during the apnea test. However, an enhanced magnetic resonance image of the head indicated no blood flow and somatosensory evoked potential testing revealed no brain-derived potentials. Conclusion: Respiratory-like movements can occur during the apnea test in patients considered brain dead. Further research is required to understand this phenomenon.
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Case Reports
ZDB-ID	2751184-4
ISSN	2052-8817 ; 2052-8817
ISSN (online)	2052-8817
ISSN	2052-8817
DOI	10.1002/ams2.959
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Article ; Online: A case of testicular cancer in a long-term hydranencephaly survivor with undescended testes.

Hirata, Wataru / Shinojima, Toshiaki / Yokota, Kotaro / Kin, Rei / Yamada, Taketo / Asakura, Hirotaka

IJU case reports

2024 Volume 7, Issue 3, Page(s) 266–269

Abstract: Introduction: The development of malignant tumors in patients with hydranencephaly is extremely rare. We describe the first case of testicular cancer that developed in the undescended testes of a long-term survivor of hydranencephaly.: Case ... ...

Abstract	Introduction: The development of malignant tumors in patients with hydranencephaly is extremely rare. We describe the first case of testicular cancer that developed in the undescended testes of a long-term survivor of hydranencephaly. Case presentation: A 32-year-old man with severe cerebral palsy due to hydranencephaly was referred to our department for the evaluation of a subcutaneous lump in the lower right abdomen. He was a long-term survivor of hydranencephaly. After confirming the diagnosis of right testicular cancer originating in his undescended testes, surgical resection was performed. Pathological examination revealed a mixed-type germ cell tumor. Conclusion: The decision-making process for treating malignant tumors, like testicular cancer, in adults with severe cerebral palsy can be challenging. Clinical ethics consultation could be helpful in avoiding treatment delays.
Language	English
Publishing date	2024-04-01
Publishing country	Australia
Document type	Case Reports
ISSN	2577-171X
ISSN (online)	2577-171X
DOI	10.1002/iju5.12720
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Article ; Online: Ruptured aneurysms at the distal superior cerebellar artery successfully treated by combining occipital artery-superior cerebellar artery anastomosis and endovascular therapy: illustrative case.

Ogura, Takenori / Hatano, Taketo / Koyanagi, Masaomi / Kitamura, Taisuke / Yamada, Daisuke

Journal of neurosurgery. Case lessons

2023 Volume 5, Issue 7

Abstract: Background: Distal superior cerebellar artery (SCA) aneurysms are rare and are treated using various treatment strategies. Treatment often requires parent artery occlusion, which raises concerns regarding the potential risk of ischemia in the distal ... ...

Abstract	Background: Distal superior cerebellar artery (SCA) aneurysms are rare and are treated using various treatment strategies. Treatment often requires parent artery occlusion, which raises concerns regarding the potential risk of ischemia in the distal territory. Observations: An 81-year-old woman presented with subarachnoid hemorrhage. Diagnostic cerebral angiography revealed two tiny distal SCA aneurysms. Because significant ischemic damage following parent artery occlusion was concerned, two bypasses between the occipital artery and SCA branches were first performed with the patient in the prone position in a hybrid operating room. Each aneurysm was successively treated in the same position with endovascular internal trapping and intra-aneurysmal embolization. After adequate hemostasis was confirmed, the wound was closed. Both aneurysms were successfully occluded without symptomatic ischemic complications. Lessons: This combined surgical and endovascular approach would be helpful in cases with notable concerns regarding ischemia after sacrificing the parent artery.
Language	English
Publishing date	2023-02-13
Publishing country	United States
Document type	Journal Article
ISSN	2694-1902
ISSN (online)	2694-1902
DOI	10.3171/CASE22246
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Article ; Online: HDAC Inhibition Induces CD26 Expression on Multiple Myeloma Cells via the c-Myc/Sp1-mediated Promoter Activation.

Nishida, Hiroko / Suzuki, Reiko / Nakajima, Kiyora / Hayashi, Mutsumi / Morimoto, Chikao / Yamada, Taketo

Cancer research communications

2024 Volume 4, Issue 2, Page(s) 349–364

Abstract: CD26 is ubiquitously and intensely expressed in osteoclasts in patients with multiple myeloma, whereas its expression in plasma cells of patients with multiple myeloma is heterogeneous because of its cellular diversity, immune escape, and disease ... ...

Abstract	CD26 is ubiquitously and intensely expressed in osteoclasts in patients with multiple myeloma, whereas its expression in plasma cells of patients with multiple myeloma is heterogeneous because of its cellular diversity, immune escape, and disease progression. Decreased expression levels of CD26 in myeloma cells constitute one of the mechanisms underlying resistance to humanized anti-CD26 mAb therapy in multiple myeloma. In the current study, we show that histone deacetylase inhibition (HDACi) with broad or class-specific inhibitors involves the induction of CD26 expression on CD26neg myeloma cells both transcriptionally and translationally. Furthermore, dipeptidyl peptidase Ⅳ (DPPⅣ) enzymatic activity was concomitantly enhanced in myeloma cells. Combined treatment with HDACi plus CD26mAb synergistically facilitated lysis of CD26neg myeloma cells not only by antibody-dependent cellular cytotoxicity but also by the direct effects of mAb. Of note, its combination readily augmented lysis of CD26neg cell populations, refractory to CD26mAb or HDACi alone. Chromatin immunoprecipitation assay revealed that HDACi increased acetylation of histone 3 lysine 27 at the CD26 promoter of myeloma cells. Moreover, in the absence of HDACi, c-Myc was attached to the CD26 promoter via Sp1 on the proximal G-C box of myeloma cells, whereas, in the presence of HDACi, c-Myc was detached from Sp1 with increased acetylation of c-Myc on the promoter, leading to activation of the CD26 promoter and initiation of transcription in myeloma cells. Collectively, these results confirm that HDACi plays crucial roles not only through its anti-myeloma activity but by sensitizing CD26neg myeloma cells to CD26mAb via c-Myc/Sp1-mediated CD26 induction, thereby augmenting its cytotoxicity. Significance: There is a desire to induce and sustain CD26 expression on multiple myeloma cells to elicit superior anti-myeloma response by humanized anti-CD26 mAb therapy. HDACi upregulates the expression levels of CD26 on myeloma cells via the increased acetylation of c-MycK323 on the CD26 promoter, leading to initiation of CD26 transcription, thereby synergistically augments the efficacy of CD26mAb against CD26neg myeloma cells.
MeSH term(s)	Humans ; Multiple Myeloma/drug therapy ; Histone Deacetylase Inhibitors/pharmacology ; Dipeptidyl Peptidase 4/genetics ; Hydroxamic Acids/pharmacology ; Histones/metabolism ; Histone Deacetylases/genetics
Chemical Substances	Histone Deacetylase Inhibitors ; Dipeptidyl Peptidase 4 (EC 3.4.14.5) ; Hydroxamic Acids ; Histones ; Histone Deacetylases (EC 3.5.1.98)
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2767-9764
ISSN (online)	2767-9764
DOI	10.1158/2767-9764.CRC-23-0215
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Article ; Online: A convenient method for assessing steady-state carrier density and lifetime in solar cell materials using pulse excitation measurements.

Handa, Taketo / Yamada, Takumi / Kanemitsu, Yoshihiko

The Journal of chemical physics

2022 Volume 157, Issue 8, Page(s) 84201

Abstract: We describe the relation of the carrier lifetime of a light-absorber material determined with pulse-excitation time-resolved techniques to the steady-state carrier density and lifetime in a solar cell under continuous-wave excitation. Our approach ... ...

Abstract	We describe the relation of the carrier lifetime of a light-absorber material determined with pulse-excitation time-resolved techniques to the steady-state carrier density and lifetime in a solar cell under continuous-wave excitation. Our approach constitutes a simple experimental examination of the excitation-fluence-dependent carrier lifetime of absorber materials. It provides the steady-state carrier density and lifetime under 1-sun solar illumination for metal halide perovskite solar cells. The determination of the steady-state carrier responses allows the clarification of optical and photovoltaic properties under 1-sun illumination and thus the identification of loss mechanisms in device performance. Model calculations are also provided to show how the carrier lifetime governs the luminescence quantum yields and open-circuit voltages. The calculations quantify a scaling law between a monomolecular recombination lifetime and an open-circuit voltage as a result of a combination of two density-dependent effects.
Language	English
Publishing date	2022-08-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0101926
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Article ; Online: Diagnostic utility of cytology in a patient with Epstein-Barr virus-positive mucocutaneous ulcer in palatine tonsils: A case report.

Doi, Mieko / Hamada, Mei / Ishizawa, Keisuke / Fushimi, Naoki / Kase, Yasuhiro / Ikezono, Tetsuo / Tamaru, Jun-Ichi / Yamada, Taketo

Diagnostic cytopathology

2024

Abstract: Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is a newly established immunodeficiency-related disease. Herein, we report a case of EBVMCU and focus on its cytological usefulness for diagnosis. An 82-year-old man manifested pharyngalgia, ... ...

Abstract	Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is a newly established immunodeficiency-related disease. Herein, we report a case of EBVMCU and focus on its cytological usefulness for diagnosis. An 82-year-old man manifested pharyngalgia, dysphagia, and oral pain. His medical history included rheumatoid arthritis that had been treated with methotrexate. Clinically, peritonsillar abscess was suspected, but since neoplastic lesions, including malignant lymphoma (ML), could not be excluded, a series of cytohistological examination was attempted. Despite some alarming findings (e.g., frequent mitoses), fine-needle aspiration and touch imprint cytology consistently revealed a heterogeneous population of lymphoid and plasmacytoid cells with mild nuclear atypia. The final diagnosis of EBVMCU was established based on the permanent histologic specimen; however, retrospectively, cytology was more representative of the benign nature of the lesion than histology, helping a great deal to differentiate it from ML. Cytology can be a useful tool for the correct diagnosis of EBVMCU.
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	632710-2
ISSN	1097-0339 ; 8755-1039
ISSN (online)	1097-0339
ISSN	8755-1039
DOI	10.1002/dc.25309
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Zs.A 2117: Show issues

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Article: [Axillary Lymph Node Recurrence after Curative Surgery for Transverse Colon Cancer-A Case Report].

Nakayama, Fumitaka / Asada, Yusuke / Kameyama, Kaori / Yamada, Taketo / Takenoya, Takashi / Oto, Ippei / Nakamura, Tetsuya / Osumi, Koji / Kameyama, Noriaki

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 50, Issue 13, Page(s) 1479–1481

Abstract: We report the rare case of an 89-year-old female with axillary lymph node recurrence after curative surgery for transverse colon cancer who had undergone right hemicolectomy with D3 lymphadenectomy with an uneventful postoperative course. Pathological ... ...

Abstract	We report the rare case of an 89-year-old female with axillary lymph node recurrence after curative surgery for transverse colon cancer who had undergone right hemicolectomy with D3 lymphadenectomy with an uneventful postoperative course. Pathological examination confirmed the tumor's status as tub2>sig, T4aN3M0, and pStage Ⅲc, and signet-ring cell carcinoma was remarkably found in the metastatic lymph node. Genetic testing revealed wild-type RAS, a BRAF mutation, and a high MSI. After 9 months of follow-up without adjuvant chemotherapy, CEA increased sharply to 41.3 ng/mL by 9 months postoperatively, and CT showed nodules in the right axilla, adrenal gland, and retroperitoneum. PET-CT showed abnormal fluorodeoxyglucose uptake in the same regions. A core needle biopsy of the axillary lymph node revealed signet-ring cell carcinoma, which was diagnosed as a recurrence of transverse colon cancer. Although we suggested chemotherapy due to the unresectable recurrence of colorectal cancer, she preferred to receive supportive care instead. Three months after the recurrence was diagnosed, CEA increased to 248.4 ng/mL, and CT showed enlargement of the axillary lesion and a new lesion in the hilum of the lung.
MeSH term(s)	Female ; Humans ; Aged, 80 and over ; Colon, Transverse/surgery ; Colon, Transverse/pathology ; Axilla/pathology ; Positron Emission Tomography Computed Tomography ; Lymphatic Metastasis/pathology ; Lymph Nodes/pathology ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/surgery ; Colonic Neoplasms/pathology ; Lymph Node Excision ; Carcinoma, Signet Ring Cell/drug therapy ; Carcinoma, Signet Ring Cell/surgery
Language	Japanese
Publishing date	2024-02-01
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Combination of anti-CD25 antibody and poly I:C treatment in pregnant NOD mice may be used as 'pregnancy-related' type 1 diabetes model.

Shimada, Akira / Toda, Kyoko / Inoue, Ikuo / Yamada, Taketo / Oikawa, Yoichi

Journal of diabetes investigation

2022 Volume 13, Issue 9, Page(s) 1489–1495

Abstract: Aims/introduction: Some women develop type 1 diabetes during pregnancy or immediately after delivery. However, the underlying pathophysiology remains largely unknown, probably because of the lack of a suitable animal model. In this study, we ... ...

Abstract	Aims/introduction: Some women develop type 1 diabetes during pregnancy or immediately after delivery. However, the underlying pathophysiology remains largely unknown, probably because of the lack of a suitable animal model. In this study, we administered pregnant NOD mice with an anti-CD25 antibody to reduce regulatory T cells along with poly I:C and examined the onset of diabetes. Materials and methods: Anti-CD25 antibody and poly I:C were intraperitoneally administered to mated female NOD mice. Mice delivered within 3 weeks after the treatment, and the onset of diabetes during pregnancy or within 6 weeks after delivery was examined. Some mice were killed 1 week after treatment, and their spleen and pancreas were excised to examine the expression levels of cytokines and for histological examination. Results: Half of the mice treated with anti-CD25 antibody plus poly I:C developed diabetes, as compared with none of the poly I:C-injected mice (P < 0.05). The ratios of interleukin-18/forkhead box P3 and granzyme B/forkhead box P3 were higher in the pancreas of anti-CD25 antibody plus poly I:C-treated mice than in the pancreas of control mice. The insulitis score decreased in the pancreas of anti-CD25 antibody plus poly I:C-injected pregnant NOD mice. Conclusions: We describe the use of anti-CD25 antibody to reduce regulatory T cells and poly I:C as a Toll-like receptor 3 stimulator to mimic viral infection in a pregnant NOD mouse, which can be used as a model of 'pregnancy-related' type 1 diabetes.
MeSH term(s)	Animals ; Diabetes Mellitus, Type 1 ; Female ; Humans ; Mice ; Mice, Inbred NOD ; Pancreas/metabolism ; Poly I ; Pregnancy ; T-Lymphocytes, Regulatory
Chemical Substances	Poly I (25249-22-3)
Language	English
Publishing date	2022-05-26
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2625840-7
ISSN	2040-1124 ; 2040-1116
ISSN (online)	2040-1124
ISSN	2040-1116
DOI	10.1111/jdi.13829
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Article ; Online: Predictive Factors of Lower Urinary Tract Injuries and Spontaneous Voiding Failure After Pelvic Fractures.

Kaneko, Tomoyuki / Yanagida, Kazuki / Matsui, Kentaro / Kawai, Taketo / Yamada, Yukio / Ishii, Keisuke / Kurozumi, Taketo / Suzuki, Takashi / Watanabe, Yoshinobu / Kawano, Hirotaka / Sakamoto, Tetsuya / Nakagawa, Tohru

In vivo (Athens, Greece)

2023 Volume 37, Issue 3, Page(s) 1323–1327

Abstract: Background/aim: This study aimed to describe the voiding patterns of patients after surgical treatment of pelvic fractures and determine the predictive factors of lower urinary tract injuries (LUTIs) and spontaneous voiding failure among patients with ... ...

Abstract	Background/aim: This study aimed to describe the voiding patterns of patients after surgical treatment of pelvic fractures and determine the predictive factors of lower urinary tract injuries (LUTIs) and spontaneous voiding failure among patients with surgically treated pelvic fractures at a tertiary trauma center in Japan. Patients and methods: We retrospectively assessed patients with surgically treated pelvic fractures in our tertiary trauma center during May 2009-April 2021. We excluded patients who died during hospitalization and who had indwelling catheter prior to the injury. Patients' LUTIs and spontaneous voiding failure at discharge were recorded. Multivariate analysis was performed to assess the predictive factors of LUTIs and spontaneous voiding failure at discharge. Results: In total, 334 eligible patients were identified. Among them, 301 patients (90%) voided spontaneously with or without diapers at discharge. Thirty-three patients required some form of catheterization for bladder drainage. LUTIs were found to be associated with chronological age [odds ratio (OR)=0.96; 95% confidence interval (CI)=0.92-0.99; p=0.024] and pelvic ring fracture (OR=12.0; 95%CI=1.39-255.2; p=0.024). Spontaneous voiding failure was associated with intensive care unit admission (OR=7.17; 95%CI=1.49-34.4; p=0.004). Conclusion: Overall, 10% of patients with surgically treated pelvic fractures were not able to void spontaneously at discharge. Spontaneous voiding failure after pelvic fractures was related to injury severity.
MeSH term(s)	Humans ; Urinary Bladder/surgery ; Retrospective Studies ; Fractures, Bone/complications ; Fractures, Bone/surgery ; Catheters, Indwelling ; Hospitalization
Language	English
Publishing date	2023-04-27
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.13212
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Article: Monoclonal Antibody Therapies in Multiple Myeloma: A Challenge to Develop Novel Targets.

Nishida, Hiroko / Yamada, Taketo

Journal of oncology

2019 Volume 2019, Page(s) 6084012

Abstract: The treatment options in multiple myeloma (MM) has changed dramatically over the past decade with the development of novel agents such as proteasome inhibitors (PIs); bortezomib and immunomodulatory drugs (IMiDs); thalidomide, and lenalidomide which ... ...

Abstract	The treatment options in multiple myeloma (MM) has changed dramatically over the past decade with the development of novel agents such as proteasome inhibitors (PIs); bortezomib and immunomodulatory drugs (IMiDs); thalidomide, and lenalidomide which revealed high efficacy and improvement of overall survival (OS) in MM patients. However, despite these progresses, most patients relapse and become eventually refractory to these therapies. Thus, the development of novel, targeted immunotherapies has been pursued aggressively. Recently, next-generation PIs; carfilzomib and ixazomib, IMiD; pomalidomide, histone deacetylase inhibitor (HDADi); panobinostat and monoclonal antibodies (MoAbs); and elotuzumab and daratumumab have emerged, and especially, combination of mAbs plus novel agents has led to dramatic improvements in the outcome of MM patients. The field of immune therapies has been accelerating in the treatment of hematological malignancies and has also taken center stage in MM. This review focuses on an overview of current status of novel MoAb therapy including bispecific T-cell engager (BiTE) antibody (BsAb), antibody-drug conjugate (ADC), and chimeric antigen receptor (CAR) T cells, in relapsed or refractory MM (RRMM). Lastly, investigational novel MoAb-based therapy to overcome immunotherapy resistance in MM is shown.
Language	English
Publishing date	2019-11-03
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	2461349-6
ISSN	1687-8469 ; 1687-8450
ISSN (online)	1687-8469
ISSN	1687-8450
DOI	10.1155/2019/6084012
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