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Article: Surgical Delay-Associated Mortality Risk Varies by Subtype in Loco-Regional Breast Cancer Patients in SEER-Medicare.

Leslie, Macall / Pathak, Rashmi / Dooley, William C / Squires, Ronald A / Rui, Hallgeir / Chervoneva, Inna / Tanaka, Takemi

Research square

2024

Abstract: Substantial evidence supports that delay of surgery after breast cancer diagnosis is associated with increased mortality risk, leading to the introduction of a new Commission on Cancer quality measure for receipt of surgery within 60 days of diagnosis ... ...

Abstract	Substantial evidence supports that delay of surgery after breast cancer diagnosis is associated with increased mortality risk, leading to the introduction of a new Commission on Cancer quality measure for receipt of surgery within 60 days of diagnosis for non-neoadjuvant patients. Breast cancer subtype is a critical prognostic factor and determines treatment options; however, it remains unknown whether surgical delay-associated breast cancer-specific mortality (BCSM) risk differs by subtype. This retrospective cohort study aimed to assess whether the impact of delayed surgery on survival varies by subtype (hormone [HR]+/HER2-, HR-/HER2-, and HER2+) in patients with loco-regional breast cancer who received surgery as their first treatment between 2010-2017 using the SEER-Medicare. Continuous time to surgery from diagnostic biopsy (TTS; days) in reference to TTS = 30 days. BCSM were evaluated as flexibly dependent on continuous time (days) to surgery from diagnosis (TTS) using Cox proportional hazards and Fine and Gray competing-risk regression models, respectively, by HR status. Inverse propensity score-weighting was used to adjust for demographic, clinical, and treatment variables impacting TTS. Adjusted BCSM risk grew with increasing TTS across all subtypes, however, the pattern and extent of the association varied. HR+/HER2- patients exhibited the most pronounced increase in BCSM risk associated with TTS, with approximately exponential growth after 42 days, with adjusted subdistribution hazard ratios (sHR) of 1.21 (95% CI: 1.06-1.37) at TTS = 60 days, 1.79 (95% CI: 1.40-2.29) at TTS = 90 days, and 2.83 (95% CI: 1.76-4.55) at TTS = 120 days. In contrast, both HER2 + and HR-/HER2- patients showed slower, approximately linear growth in sHR, although non-significant in HR-HER2-.
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-4171651/v1
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Article ; Online: Increased breast cancer mortality due to treatment delay and needle biopsy type: a retrospective analysis of SEER-medicare.

Pathak, Rashmi / Leslie, Macall / Dondapati, Priya / Davis, Rachel / Tanaka, Kenichi / Jett, Elizabeth / Chervoneva, Inna / Tanaka, Takemi

Breast cancer (Tokyo, Japan)

2023 Volume 30, Issue 4, Page(s) 627–636

Abstract: Background: Substantial evidence indicates that delay of first treatment after diagnosis is associated with poorer survival outcomes in breast cancer. Accordingly, the Commission on Cancer introduced a quality measure for receipt of therapeutic surgery ... ...

Abstract	Background: Substantial evidence indicates that delay of first treatment after diagnosis is associated with poorer survival outcomes in breast cancer. Accordingly, the Commission on Cancer introduced a quality measure for receipt of therapeutic surgery within 60 days of diagnostic biopsy for stage I-III breast cancer patients in the non-neoadjuvant setting. It is unknown, however, what may contribute to mortality associated with treatment delay. Therefore, we investigated whether biopsy type moderates the effect of the mortality risk posed by treatment delay. Methods: Retrospective analysis of 31,306 women with stage I-III breast cancer diagnosed between 2003 and 2013 selected from the SEER-Medicare database was performed to determine whether needle biopsy type [core needle biopsy (CNB) or vacuum-assisted biopsy (VAB)] impacts time to treatment (TTT)-associated survival outcomes. Multivariable Fine-Gray competing risk survival models, adjusted for inverse propensity score weights, were used to determine the association between biopsy type, TTT, and breast cancer-specific mortality (BCSM). Results: TTT ≥ 60 days was associated with 45% higher risk of BCSM (sHR = 1.45, 95% CI 1.24-1.69) compared to those with TTT < 60 days in stage I-III cases. Independent of TTT, CNB was associated with 28% higher risk of BCSM compared to VAB in stage II-III cases (sHR = 1.28, 95% CI 1.11-1.36), translating to a 2.7% and 4.0% absolute difference in BCSM at 5 and 10 years, respectively. However, in stage I cases, the BCSM risk was not associated with type of biopsy. Conclusions: Our results suggest that treatment delay ≥ 60 days is independently associated with poorer survival outcomes in breast cancer patients. In stage II-III, CNB is associated with higher BCSM than VAB. However, type of biopsy does not underlie TTT-associated breast cancer mortality risk.
MeSH term(s)	United States/epidemiology ; Female ; Humans ; Aged ; Breast Neoplasms/therapy ; Breast Neoplasms/pathology ; Time-to-Treatment ; Retrospective Studies ; Medicare ; Breast/pathology ; Biopsy, Large-Core Needle/methods
Language	English
Publishing date	2023-05-03
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2052429-8
ISSN	1880-4233 ; 1340-6868
ISSN (online)	1880-4233
ISSN	1340-6868
DOI	10.1007/s12282-023-01456-3
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Article ; Online: Tofogliflozin Delays Portal Hypertension and Hepatic Fibrosis by Inhibiting Sinusoidal Capillarization in Cirrhotic Rats.

Asada, Shohei / Kaji, Kosuke / Nishimura, Norihisa / Koizumi, Aritoshi / Matsuda, Takuya / Tanaka, Misako / Yorioka, Nobuyuki / Sato, Shinya / Kitagawa, Koh / Namisaki, Tadashi / Akahane, Takemi / Yoshiji, Hitoshi

Cells

2024 Volume 13, Issue 6

Abstract: Background: Liver cirrhosis leads to portal hypertension (PH) with capillarization of liver sinusoidal endothelial cells (LSECs), although drug treatment options for PH are currently limited. Sodium glucose transporter 2 inhibitors, which are ... ...

Abstract	Background: Liver cirrhosis leads to portal hypertension (PH) with capillarization of liver sinusoidal endothelial cells (LSECs), although drug treatment options for PH are currently limited. Sodium glucose transporter 2 inhibitors, which are antidiabetic agents, have been shown to improve endothelial dysfunction. We aimed to elucidate the effect of tofogliflozin on PH and liver fibrosis in a rat cirrhosis model. Methods: Male-F344/NSlc rats repeatedly received carbon tetrachloride (CCl Results: Tofogliflozin prevented PH with attenuated intrahepatic vasoconstriction, sinusoidal capillarization, and remodeling independent of glycemic status in CCl Conclusions: Our study provides strong support for tofogliflozin in the prevention of liver cirrhosis-related PH.
MeSH term(s)	Rats ; Male ; Animals ; Endothelial Cells/pathology ; Rats, Inbred F344 ; Liver Cirrhosis/pathology ; Hypertension, Portal/drug therapy ; Benzhydryl Compounds ; Glucosides
Chemical Substances	6-((4-ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro(isobenzofuran-1(3H),2'-(2H)pyran)-3',4',5'-triol (P8DD8KX4O4) ; Benzhydryl Compounds ; Glucosides
Language	English
Publishing date	2024-03-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells13060538
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Article ; Online: Modelling of salt intake reduction by incorporation of umami substances into Japanese foods: a cross-sectional study.

Tanaka, Shiori / Yoneoka, Daisuke / Ishizuka, Aya / Adachi, Megumi / Hayabuchi, Hitomi / Nishimura, Toshihide / Takemi, Yukari / Uneyama, Hisayuki / Nakamura, Haruyo / Lwin, Kaung Suu / Shibuya, Kenji / Nomura, Shuhei

BMC public health

2023 Volume 23, Issue 1, Page(s) 516

Abstract: Background: Evidence has demonstrated that excess sodium intake is associated with development of several non-communicable diseases. The main source of sodium is salt. Therefore, reducing salt intake in foods is an important global public health effort ... ...

Abstract	Background: Evidence has demonstrated that excess sodium intake is associated with development of several non-communicable diseases. The main source of sodium is salt. Therefore, reducing salt intake in foods is an important global public health effort to achieve sodium reduction and improve health. This study aimed to model salt intake reduction with 'umami' substances among Japanese adults. The umami substances considered in this study include glutamate or monosodium glutamates (MSG), calcium diglutamate (CDG), inosinate, and guanylate. Methods: A total of 21,805 participants aged 57.8 years on average from the National Health and Nutrition Survey was used in the analysis. First, we employed a multivariable linear regression approach with overall salt intake (g/day) as a dependent variable, adjusting for food items and other covariates to estimate the contribution of salt intake from each food item that was selected through an extensive literature review. Assuming the participants already consume low-sodium products, we considered three scenarios in which salt intake could be reduced with the additional umami substances up to 30%, 60% and 100%. We estimated the total amount of population-level salt reduction for each scenario by age and gender. Under the 100% scenario, the Japan's achievement rates against the national and global salt intake reduction goals were also calculated. Results: Without compromising the taste, the 100% or universal incorporation of umami substances into food items reduced the salt intake of Japanese adults by 12.8-22.3% at the population-level average, which is equivalent to 1.27-2.22 g of salt reduction. The universal incorporation of umami substances into food items changed daily mean salt intake of the total population from 9.95 g to 7.73 g: 10.83 g to 8.40 g for men and 9.21 g to 7.17 g for women, respectively. This study suggested that approximately 60% of Japanese adults could achieve the national dietary goal of 8 g/day, while only 7.6% would meet the global recommendation of 5.0 g/day. Conclusions: Our study provides essential information on the potential salt reduction with umami substances. The universal incorporation of umami substances into food items would enable the Japanese to achieve the national dietary goal. However, the reduced salt intake level still falls short of the global dietary recommendation.
MeSH term(s)	Adult ; Male ; Humans ; Female ; Sodium Chloride, Dietary ; Cross-Sectional Studies ; East Asian People ; Food ; Sodium ; Taste
Chemical Substances	Sodium Chloride, Dietary ; Sodium (9NEZ333N27)
Language	English
Publishing date	2023-03-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-023-15322-6
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Book ; Online: Long-Term Ash Dispersal Dataset of the Sakurajima Taisho Eruption for Ashfall Disaster Countermeasure

Rahadianto, Haris / Tatano, Hirokazu / Iguchi, Masato / Tanaka, Hiroshi L. / Takemi, Tetsuya / Roy, Sudip

eISSN: 1866-3516

2022

Abstract: We present the ashfall deposit and airborne ash concentration dataset from ash dispersal simulation of a large-scale explosive volcanic eruption as a reference for ashfall disaster countermeasure. We select the Taisho (1914) eruption in Sakurajima ... ...

Abstract	We present the ashfall deposit and airborne ash concentration dataset from ash dispersal simulation of a large-scale explosive volcanic eruption as a reference for ashfall disaster countermeasure. We select the Taisho (1914) eruption in Sakurajima volcano, regarded as the strongest eruption in Japan in the last century, as our case study to provide a baseline for the worst-case scenario. We employ one eruption scenario approach by replicating the actual eruption under various extended weather conditions to show how it would affect contemporary Japan. Accumulated ashfall has devastating impacts on both surrounding areas of the volcano and other regions, affecting airline transportation, socio-economics activities, and human health. Therefore, it is crucial to discover places with a high probability of exposure to ashfall deposition. This knowledge can help assess the additional risk in the infrastructures, human lives, and economic impacts to make a better volcanic eruption response plan. We generate the ash dispersal dataset by simulating the ash transport of the Taisho eruption scenario with a volcanic ash dispersal model and meteorological reanalysis data for 64 years (1958–2021). We explain the dataset production process and provide the dataset in multiple formats for broader audiences. We also clarify the validity of the dataset with its limitations and uncertainties. The dataset is available at the DesignSafe-CI Data Depot: https://www.designsafe-ci.org/data/browser/public/designsafe.storage.published/PRJ-2848v2 or through the DOI: https://www.doi.org/10.17603/ds2-vw5f-t920 by selecting Version 2 (Rahadianto and Tatano, 2020).
Subject code	910
Language	English
Publishing date	2022-06-07
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Long-term ash dispersal dataset of the Sakurajima Taisho eruption for ashfall disaster countermeasure

Rahadianto, Haris / Tatano, Hirokazu / Iguchi, Masato / Tanaka, Hiroshi L. / Takemi, Tetsuya / Roy, Sudip

eISSN: 1866-3516

2022

Abstract: A large volcanic eruption can generate large amounts of ash which affect the socio-economic activities of surrounding areas, affecting airline transportation, socio-economics activities, and human health. Accumulated ashfall has devastating impacts on ... ...

Abstract	A large volcanic eruption can generate large amounts of ash which affect the socio-economic activities of surrounding areas, affecting airline transportation, socio-economics activities, and human health. Accumulated ashfall has devastating impacts on areas surrounding the volcano and in other regions, and eruption scale and weather conditions may escalate ashfall hazards to wider areas. It is crucial to discover places with a high probability of exposure to ashfall deposition. Here, as a reference for ashfall disaster countermeasures, we present a dataset containing the estimated distributions of the ashfall deposit and airborne ash concentration, obtained from a simulation of ash dispersal following a large-scale explosive volcanic eruption. We selected the Taisho (1914) eruption of the Sakurajima volcano, as our case study. This was the strongest eruption in Japan in the last century, and our study provides a baseline for a worst-case scenario. We employed one eruption scenario (OES) approach by replicating the actual event under various extended weather conditions to show how it would affect contemporary Japan. We generated an ash dispersal dataset by simulating the ash transport of the Taisho eruption scenario using a volcanic ash dispersal model and meteorological reanalysis data for 64 years (1958–2021). We explain the dataset production and provide the dataset in multiple formats for broader audiences. We examine the validity of the dataset, its limitations, and its uncertainties. Countermeasure strategies can be derived from this dataset to reduce ashfall risk. The dataset is available at the DesignSafe-CI Data Depot: https://www.designsafe-ci.org/data/browser/public/designsafe.storage.published/PRJ-2848v2 or through the following DOI: https://doi.org/10.17603/ds2-vw5f-t920 by selecting Version 2 (Rahadianto and Tatano, 2020).
Subject code	333
Language	English
Publishing date	2022-12-02
Publishing country	de
Document type	Book ; Online
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Article ; Online: Long-term ash dispersal dataset of the Sakurajima Taisho eruption for ashfall disaster countermeasure

H. Rahadianto / H. Tatano / M. Iguchi / H. L. Tanaka / T. Takemi / S. Roy

Earth System Science Data, Vol 14, Pp 5309-

2022 Volume 5332

Abstract	A large volcanic eruption can generate large amounts of ash which affect the socio-economic activities of surrounding areas, affecting airline transportation, socio-economics activities, and human health. Accumulated ashfall has devastating impacts on areas surrounding the volcano and in other regions, and eruption scale and weather conditions may escalate ashfall hazards to wider areas. It is crucial to discover places with a high probability of exposure to ashfall deposition. Here, as a reference for ashfall disaster countermeasures, we present a dataset containing the estimated distributions of the ashfall deposit and airborne ash concentration, obtained from a simulation of ash dispersal following a large-scale explosive volcanic eruption. We selected the Taisho (1914) eruption of the Sakurajima volcano, as our case study. This was the strongest eruption in Japan in the last century, and our study provides a baseline for a worst-case scenario. We employed one eruption scenario (OES) approach by replicating the actual event under various extended weather conditions to show how it would affect contemporary Japan. We generated an ash dispersal dataset by simulating the ash transport of the Taisho eruption scenario using a volcanic ash dispersal model and meteorological reanalysis data for 64 years (1958–2021). We explain the dataset production and provide the dataset in multiple formats for broader audiences. We examine the validity of the dataset, its limitations, and its uncertainties. Countermeasure strategies can be derived from this dataset to reduce ashfall risk. The dataset is available at the DesignSafe-CI Data Depot: https://www.designsafe-ci.org/data/browser/public/designsafe.storage.published/PRJ-2848v2 or through the following DOI: https://doi.org/10.17603/ds2-vw5f-t920 by selecting Version 2 (Rahadianto and Tatano, 2020).
Keywords	Environmental sciences ; GE1-350 ; Geology ; QE1-996.5
Subject code	333
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification and characterization of an antimicrobial peptide, lysozyme, from Suncus murinus.

Takemi, Shota / Ojima, Shiomi / Tanaka, Toru / Sakai, Takafumi / Sakata, Ichiro

Cell and tissue research

2019 Volume 376, Issue 3, Page(s) 401–412

Abstract: Lysozyme is one of the most prominent antimicrobial peptides and has been identified from many mammalian species. However, this enzyme has not been studied in the order Insectivora, which includes the most primitive placental mammals. Here, we done the ... ...

Abstract	Lysozyme is one of the most prominent antimicrobial peptides and has been identified from many mammalian species. However, this enzyme has not been studied in the order Insectivora, which includes the most primitive placental mammals. Here, we done the lysozyme cDNA from Suncus murinus (referred to as suncus, its laboratory name) and compare the predicted amino acid sequence to those from other mammalian species. Quantitative PCR analysis revealed a relatively higher expression of this gene in the spleen and gastrointestinal tract of suncus. The lysozyme-immunopositive (ip) cells were found mainly in the red pulp of the spleen and in the mucosa of the whole small intestine, including the follicle-associated epithelium and subepithelial dome of Peyer's patches. The lysozyme-ip cells in the small intestine were mostly distributed in the intestinal crypt, although lysozyme-expressing cells were found not only in the crypt but also in the villi. On the other hand, only a few lysozyme-ip cells were found in the villi and some granules showing intense fluorescence were located toward the lumen. As reported for other mammals, Ki67-ip cells were localized in the crypt and did not co-localize with the lysozyme-ip cells. Moreover, fasting induced a decrease in the mRNA levels of lysozyme in the intestine of suncus. In conclusion, we firstly identified the lysozyme mRNA sequence, clarified expression profile of lysozyme transcripts in suncus and found a unique distribution of lysozyme-producing cells in the suncus intestine.
MeSH term(s)	Animals ; Antimicrobial Cationic Peptides/chemistry ; Antimicrobial Cationic Peptides/genetics ; Antimicrobial Cationic Peptides/isolation & purification ; Antimicrobial Cationic Peptides/metabolism ; Intestinal Mucosa/enzymology ; Muramidase/chemistry ; Muramidase/genetics ; Muramidase/isolation & purification ; Muramidase/metabolism ; Peyer's Patches/enzymology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Shrews/metabolism ; Spleen/metabolism ; Tissue Distribution ; Transcriptome
Chemical Substances	Antimicrobial Cationic Peptides ; RNA, Messenger ; Muramidase (EC 3.2.1.17)
Language	English
Publishing date	2019-01-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	125067-x
ISSN	1432-0878 ; 0302-766X
ISSN (online)	1432-0878
ISSN	0302-766X
DOI	10.1007/s00441-019-02991-2
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Article ; Online: ASO Author Reflections: Does Prompt Breast-Conserving Surgery Matter?

Hills, Natalie / Leslie, Macall / Davis, Rachel / Crowell, Marielle / Kamemyama, Hiroyasu / Rui, Hallgeir / Chervoneva, Inna / Dooley, William / Tanaka, Takemi

Annals of surgical oncology

2021 Volume 28, Issue 11, Page(s) 5906

MeSH term(s)	Breast ; Breast Neoplasms/surgery ; Female ; Humans ; Mastectomy, Segmental
Language	English
Publishing date	2021-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-021-09753-x
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Article ; Online: Needle biopsy accelerates pro-metastatic changes and systemic dissemination in breast cancer: Implications for mortality by surgery delay.

Kameyama, Hiroyasu / Dondapati, Priya / Simmons, Reese / Leslie, Macall / Langenheim, John F / Sun, Yunguang / Yi, Misung / Rottschaefer, Aubrey / Pathak, Rashmi / Nuguri, Shreya / Fung, Kar-Ming / Tsaih, Shirng-Wern / Chervoneva, Inna / Rui, Hallgeir / Tanaka, Takemi

Cell reports. Medicine

2023 Volume 4, Issue 12, Page(s) 101330

Abstract: Increased breast cancer (BC) mortality risk posed by delayed surgical resection of tumor after diagnosis is a growing concern, yet the underlying mechanisms remain unknown. Our cohort analyses of early-stage BC patients reveal the emergence of a ... ...

Abstract	Increased breast cancer (BC) mortality risk posed by delayed surgical resection of tumor after diagnosis is a growing concern, yet the underlying mechanisms remain unknown. Our cohort analyses of early-stage BC patients reveal the emergence of a significantly rising mortality risk when the biopsy-to-surgery interval was extended beyond 53 days. Additionally, histology of post-biopsy tumors shows prolonged retention of a metastasis-permissive wound stroma dominated by M2-like macrophages capable of promoting cancer cell epithelial-to-mesenchymal transition and angiogenesis. We show that needle biopsy promotes systemic dissemination of cancer cells through a mechanism of sustained activation of the COX-2/PGE
MeSH term(s)	Humans ; Animals ; Mice ; Female ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cyclooxygenase 2 ; Biopsy, Needle
Chemical Substances	Cyclooxygenase 2 (EC 1.14.99.1)
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ISSN	2666-3791
ISSN (online)	2666-3791
DOI	10.1016/j.xcrm.2023.101330
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