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  1. Article ; Online: DMH

    Tokizane, Kyohei / Brace, Cynthia S / Imai, Shin-Ichiro

    Cell metabolism

    2024  Volume 36, Issue 2, Page(s) 377–392.e11

    Abstract: Recent studies have shown that the hypothalamus functions as a control center of aging in mammals that counteracts age-associated physiological decline through inter-tissue communications. We have identified a key neuronal subpopulation in the ... ...

    Abstract Recent studies have shown that the hypothalamus functions as a control center of aging in mammals that counteracts age-associated physiological decline through inter-tissue communications. We have identified a key neuronal subpopulation in the dorsomedial hypothalamus (DMH), marked by Ppp1r17 expression (DMH
    MeSH term(s) Mice ; Animals ; Longevity ; Aging ; Neurons/metabolism ; Synaptic Transmission ; Adipose Tissue/metabolism ; Hypothalamus/metabolism ; Dorsomedial Hypothalamic Nucleus/metabolism ; Mammals/metabolism ; Cyclic GMP-Dependent Protein Kinase Type I/metabolism
    Chemical Substances Prkg1 protein, mouse (EC 2.7.11.12) ; Cyclic GMP-Dependent Protein Kinase Type I (EC 2.7.11.12)
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2023.12.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6169: Show issues Location:
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  2. Article ; Online: NAD

    Tokizane, Kyohei / Imai, Shin-Ichiro

    Faculty reviews

    2021  Volume 10, Page(s) 42

    Abstract: A substantial body of evidence shows the importance of nicotinamide adenine dinucleotide ( ... ...

    Abstract A substantial body of evidence shows the importance of nicotinamide adenine dinucleotide (NAD
    Language English
    Publishing date 2021-04-27
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2732-432X
    ISSN (online) 2732-432X
    DOI 10.12703/r/10-42
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Absolute quantification of nicotinamide mononucleotide in biological samples by double isotope-mediated liquid chromatography-tandem mass spectrometry (dimeLC-MS/MS).

    Unno, Junya / Mills, Kathryn F / Ogura, Tairo / Nishimura, Masayuki / Imai, Shin-Ichiro

    npj aging

    2024  Volume 10, Issue 1, Page(s) 2

    Abstract: Nicotinamide adenine dinucleotide ( ... ...

    Abstract Nicotinamide adenine dinucleotide (NAD
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ISSN 2731-6068
    ISSN (online) 2731-6068
    DOI 10.1038/s41514-023-00133-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Quantification of localized NAD

    Johnson, Sean / Yoshioka, Kiyoshi / Brace, Cynthia S / Imai, Shin-Ichiro

    npj aging

    2023  Volume 9, Issue 1, Page(s) 1

    Abstract: Recently, it has become a consensus that systemic decreases in ... ...

    Abstract Recently, it has become a consensus that systemic decreases in NAD
    Language English
    Publishing date 2023-01-25
    Publishing country England
    Document type Journal Article
    ISSN 2731-6068
    ISSN (online) 2731-6068
    DOI 10.1038/s41514-023-00098-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Message from the new Co-Editor-in-Chief.

    Imai, Shin-Ichiro

    NPJ aging and mechanisms of disease

    2017  Volume 3, Page(s) 3

    Language English
    Publishing date 2017-02-15
    Publishing country England
    Document type Editorial
    ZDB-ID 2836493-4
    ISSN 2056-3973
    ISSN 2056-3973
    DOI 10.1038/s41514-017-0003-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Friends and foes: Extracellular vesicles in aging and rejuvenation.

    Lananna, Brian V / Imai, Shin-Ichiro

    FASEB bioAdvances

    2021  Volume 3, Issue 10, Page(s) 787–801

    Abstract: Extracellular vesicles (EVs) are released by many different cell types throughout the body and play a role in a diverse range of biological processes. EVs circulating in blood as well as in other body fluids undergo dramatic alterations over an organism' ... ...

    Abstract Extracellular vesicles (EVs) are released by many different cell types throughout the body and play a role in a diverse range of biological processes. EVs circulating in blood as well as in other body fluids undergo dramatic alterations over an organism's lifespan that are only beginning to be elucidated. The exact nature of these changes is an area of active and intense investigation, but lacks clear consensus due to the substantial heterogeneity in EV subpopulations and insufficiencies in current technologies. Nonetheless, emerging evidence suggests that EVs regulate systemic aging as well as the pathophysiology of age-related diseases. Here, we review the current literature investigating EVs and aging with an emphasis on consequences for the maintenance of human healthspan. Intriguingly, the biological utility of EVs both in vitro and in vivo and across contexts depends on the states of the source cells or tissues. As such, EVs secreted by cells in an aged or pathological state may impose detrimental consequences on recipient cells, while EVs secreted by youthful or healthy cells may promote functional improvement. Thus, it is critical to understand both functions of EVs and tip the balance toward their beneficial effects as an antiaging intervention.
    Language English
    Publishing date 2021-07-26
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2573-9832
    ISSN (online) 2573-9832
    DOI 10.1096/fba.2021-00077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Aging reduces motivation through decreased

    Lei, Hanyue Cecilia / Parker, Kyle E / Yuede, Carla M / McCall, Jordan G / Imai, Shin-Ichiro

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Age-associated reduced motivation is a hallmark of neuropsychiatric disorders in the elderly. In our rapidly aging societies, it is critical to keep motivation levels high enough to promote healthspan and lifespan. However, how motivation is reduced ... ...

    Abstract Age-associated reduced motivation is a hallmark of neuropsychiatric disorders in the elderly. In our rapidly aging societies, it is critical to keep motivation levels high enough to promote healthspan and lifespan. However, how motivation is reduced during aging remains unknown. Here, we used multiple mouse models to evaluate motivation and related affective states in young and old mice. We also compared the effect of social isolation, a common stressor, to those of aging. We found that both social isolation and aging decreased motivation in mice, but that
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.19.524624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: NAD

    Johnson, Sean / Imai, Shin-Ichiro

    F1000Research

    2018  Volume 7, Page(s) 132

    Abstract: Nicotinamide adenine dinucleotide ( ... ...

    Abstract Nicotinamide adenine dinucleotide (NAD
    Language English
    Publishing date 2018-02-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.12120.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD

    Imai, Shin-Ichiro

    NPJ systems biology and applications

    2016  Volume 2, Page(s) 16018

    Abstract: The original concept of the NAD World was proposed in 2009, providing a comprehensive framework to investigate critical issues of biological robustness and trade-offs in mammalian aging and longevity control. Significant progress has been made over the ... ...

    Abstract The original concept of the NAD World was proposed in 2009, providing a comprehensive framework to investigate critical issues of biological robustness and trade-offs in mammalian aging and longevity control. Significant progress has been made over the past 7 years, advancing our understanding of the mechanisms by which biological robustness is maintained, and providing extensive support to the concept of the NAD World. Three key organs and tissues have been identified as basic elements in this control system for mammalian aging and longevity: the hypothalamus as the control center of aging, skeletal muscle as an effector, and adipose tissue as a modulator. While the hypothalamus sends a signal to skeletal muscle through the sympathetic nervous system, adipose tissue remotely regulates hypothalamic function by coordinating NAD
    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2056-7189
    ISSN 2056-7189
    DOI 10.1038/npjsba.2016.18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Estimation of Microvascular Dysfunction by Using

    Imai, Shogo / Kiriyama, Tomonari / Kanaya, Koji / Aoyama, Satoe / Takano, Hitoshi / Kumita, Shin-Ichiro

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi

    2023  Volume 90, Issue 2, Page(s) 228–236

    Abstract: Background: Although coronary artery disease (CAD) is characterized by epicardial atherosclerosis and microvascular disease, the importance of evaluating microvascular dysfunction has not been sufficiently recognized in clinical practice. We estimated ... ...

    Abstract Background: Although coronary artery disease (CAD) is characterized by epicardial atherosclerosis and microvascular disease, the importance of evaluating microvascular dysfunction has not been sufficiently recognized in clinical practice. We estimated microvascular disease severity by assessing hyperemic microvascular resistance (MVR), as determined by absolute quantification of myocardial blood flow (MBF) with
    Methods: We retrospectively collected data for 23 CAD patients who underwent both stress/rest PET-MPI and invasive coronary angiography (CAG) with fractional flow reserve (FFR) measurement. Among 30 vessels for which FFR measurement was performed, 13 had a low FFR (FFR ≤0.75). For each patient, myocardial segments of a standard 17-segment model were assigned to the stenotic myocardial area perfused by the FFR-measured vessel and a reference normal-perfusion area based on PET-MPI and the coronary distribution on CAG. Hyperemic MVR was calculated by using the formula, hyperemic MVR = hyperemic mean blood pressure × FFR/hyperemic MBF of the stenotic vessel.
    Results: A strong negative correlation was observed between hyperemic MVR and hyperemic MBF in the reference normal-perfusion area (R = -0.758, P<0.001).
    Conclusion: Microvascular disease severity in chronic CAD can be estimated by hyperemic MBF of the normal-perfusion area with
    MeSH term(s) Humans ; Ammonia ; Fractional Flow Reserve, Myocardial/physiology ; Retrospective Studies ; Coronary Artery Disease/diagnostic imaging ; Positron-Emission Tomography ; Coronary Angiography ; Myocardial Perfusion Imaging/methods ; Predictive Value of Tests
    Chemical Substances Ammonia (7664-41-7)
    Language English
    Publishing date 2023-02-21
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2091563-9
    ISSN 1347-3409 ; 1345-4676
    ISSN (online) 1347-3409
    ISSN 1345-4676
    DOI 10.1272/jnms.JNMS.2023_90-213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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