LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 8 of total 8

Search options

  1. Article ; Online: SWEDISH CRIME FICTION AS SOCIALLY INVOLVED LITERATURE

    Monika Samsel-Chojnacka

    Studia Humanistyczne AGH, Vol 10, Iss 1, Pp 103-

    2011  Volume 118

    Abstract: Swedish crime novel has been transforming for many years to become more socially involved. The ambition of many writers is not only to entertain the readers but also to participating in the social debate, criticizing the political and economical system, ... ...

    Abstract Swedish crime novel has been transforming for many years to become more socially involved. The ambition of many writers is not only to entertain the readers but also to participating in the social debate, criticizing the political and economical system, focusing on important issues such as violence against women, exploitation of working class by the privileged ruling class, the problems of a modern family and the situation of immigrants. Since the moment when in the mid 60’s two journalists Maj Sjöwall and Per Wahlöö decided to use popular literature to spread social matters many other Swedish writers have decided to follow their way. Some of them are journalists – like Liza Marklund, Börge Hellström and Anders Roslund or Stieg Larsson. Their novels as well as the ones written by Henning Mannkel on Kurt Wallander have become crucial evidence of changes of Swedish society in the past twenty years. Modern Swedish crime fiction illustrates the population in the model fashion that is the reason why it can become one of the interests of the sociology of literature.
    Keywords crime fiction ; sociology of literature ; Sweden ; Social sciences (General) ; H1-99 ; Social Sciences ; H ; DOAJ:Social Sciences
    Subject code 300
    Language Polish
    Publishing date 2011-01-01T00:00:00Z
    Publisher Wydawnictwa AGH
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article: Therapeutic potential of adenosine analogues and conjugates.

    Samsel, Monika / Dzierzbicka, Krystyna

    Pharmacological reports : PR

    2011  Volume 63, Issue 3, Page(s) 601–617

    Abstract: This review summarizes current knowledge of adenosine analogues and conjugates with promising therapeutic properties. Adenosine is a signaling molecule that triggers numerous physiological responses. It acts through the adenosine receptors (ARs), ... ...

    Abstract This review summarizes current knowledge of adenosine analogues and conjugates with promising therapeutic properties. Adenosine is a signaling molecule that triggers numerous physiological responses. It acts through the adenosine receptors (ARs), belonging to the family of G-protein-coupled receptors and widely distributed throughout the body. Moreover, adenosine is involved in key biochemical processes as a part of ATP, the universal energy currency. Thus, compounds that are analogues of adenosine and its conjugates have been extensively studied as potential therapeutics. Many inhibitors of ARs are in clinical trials as promising agents in treatment of inflammation, type 2 diabetes, arrhythmia and as vasodilators used in the myocardial perfusion imaging (MPI) stress test. Furthermore, adenosine analogues revealed high efficacy as enzyme inhibitors, tested for antitrypanosomal action and as bivalent ligands and adenosine-oligoarginine conjugates as inhibitors of protein kinases.
    MeSH term(s) Adenosine/analogs & derivatives ; Adenosine/metabolism ; Animals ; Arginine/chemistry ; Enzyme Inhibitors/pharmacology ; Humans ; Oligopeptides/chemistry ; Protein Kinase Inhibitors/pharmacology ; Receptors, Purinergic P1/drug effects ; Receptors, Purinergic P1/metabolism
    Chemical Substances Enzyme Inhibitors ; Oligopeptides ; Protein Kinase Inhibitors ; Receptors, Purinergic P1 ; Arginine (94ZLA3W45F) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2011-08-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2186248-5
    ISSN 1734-1140
    ISSN 1734-1140
    DOI 10.1016/s1734-1140(11)70573-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 861: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Synthesis and antiproliferative activity of conjugates of adenosine with muramyl dipeptide and nor-muramyl dipeptide derivatives.

    Samsel, Monika / Dzierzbicka, Krystyna / Trzonkowski, Piotr

    Bioorganic & medicinal chemistry letters

    2014  Volume 24, Issue 15, Page(s) 3587–3591

    Abstract: We synthesized a series of MDP(D,D) and nor-MDP(D,D) derivatives conjugated with adenosine through a spacer as potential immunosuppressants. New conjugates 8a-k were evaluated on two leukemia cell lines (Jurkat and L1210) and PBMC from healthy donors. ... ...

    Abstract We synthesized a series of MDP(D,D) and nor-MDP(D,D) derivatives conjugated with adenosine through a spacer as potential immunosuppressants. New conjugates 8a-k were evaluated on two leukemia cell lines (Jurkat and L1210) and PBMC from healthy donors. The conjugates 8a-k and MDP(D,D)/nor-MDP(D,D) derivatives 7e, f, i, j were active against L1210 cell line. Unconjugated nor-MDP(D,D) had better antiproliferative properties, but the conjugates 8b, f, g had the highest values of selectivity index. Both cell lines as well as PBMC were resistant to analogs 11a, b with the 6-aminohexanoic linker.
    MeSH term(s) Acetylmuramyl-Alanyl-Isoglutamine/chemical synthesis ; Acetylmuramyl-Alanyl-Isoglutamine/chemistry ; Acetylmuramyl-Alanyl-Isoglutamine/pharmacology ; Adenosine/chemistry ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Jurkat Cells ; Mice ; Molecular Conformation ; Structure-Activity Relationship
    Chemical Substances Antineoplastic Agents ; Acetylmuramyl-Alanyl-Isoglutamine (53678-77-6) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2014-08-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2014.05.043
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3203: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Adenozyna, jej analogi i koniugaty.

    Samsel, Monika / Dzierzbicka, Krystyna / Trzonkowski, Piotr

    Postepy higieny i medycyny doswiadczalnej (Online)

    2013  Volume 67, Page(s) 1189–1203

    Abstract: Adenosine is an endogenous purine nucleoside that plays an important role in many biochemical processes. It acts through the four types of adenosine receptors: A1, A2A, A2B, A3 which are located i.a. in the immune, nervous, circulatory, respiratory or ... ...

    Title translation Adenosine, its analogues and conjugates.
    Abstract Adenosine is an endogenous purine nucleoside that plays an important role in many biochemical processes. It acts through the four types of adenosine receptors: A1, A2A, A2B, A3 which are located i.a. in the immune, nervous, circulatory, respiratory or urinary system. Adenosine is used as an antiarrhythmic agent in the treatment of paroxysmal supraventricular tachycardia. However, due to a very short blood half-time other clinical applications are limited. In order to overcome this obstacle many analogues and conjugates of adenosine with better pharmacokinetic properties have been synthesized. Some of them have been successfully registered as drugs, but there is still a big number of adenosine analogues in clinical trials or preclinical studies. Synthesized compounds demonstrate not only antiarrhytmic, antinociceptive, antidibetic, antiphlogistic or antiviral actions but also influence the course of immune diseases, such as rheumatoid arthritis, nephritis, uveitis or endotoxin shock. This article is focused on novel adenosine analogues and conjugates with potential biological properties.
    MeSH term(s) Adenosine/analogs & derivatives ; Adenosine/chemical synthesis ; Adenosine/pharmacokinetics ; Adenosine/therapeutic use ; Anti-Arrhythmia Agents/pharmacokinetics ; Anti-Arrhythmia Agents/pharmacology ; Arthritis, Rheumatoid/drug therapy ; Half-Life ; Humans ; Nephritis/drug therapy ; Shock, Septic/drug therapy ; Tachycardia, Supraventricular/drug therapy ; Uveitis/drug therapy
    Chemical Substances Anti-Arrhythmia Agents ; Adenosine (K72T3FS567)
    Language Polish
    Publishing date 2013-12-03
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 418865-2
    ISSN 1732-2693 ; 0032-5449
    ISSN (online) 1732-2693
    ISSN 0032-5449
    DOI 10.5604/17322693.1078588
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 634: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Observation and Clinical Pattern in Patients with White Dot Syndromes: The Role of Color Photography in Monitoring Ocular Changes in Long-Term Observation.

    Brydak-Godowska, Joanna / Gołębiewska, Joanna / Turczyńska, Monika / Moneta-Wielgoś, Joanna / Samsel, Agnieszka / Borkowski, Piotr K / Ciszek, Michał / Płonecka-Rodzoch, Agnieszka / Kużnik-Borkowska, Aleksandra / Ciszewska, Joanna / Makomaska-Szaroszyk, Elżbieta / Brydak, Lidia B / Kęcik, Dariusz

    Medical science monitor : international medical journal of experimental and clinical research

    2017  Volume 23, Page(s) 1106–1115

    Abstract: BACKGROUND The aim of this study was to assess the clinical course and distinctive features of different white dot syndromes (WDS) in patients attending the Ophthalmology Department, Medical University of Warsaw in the years 1995-2015. MATERIAL AND ... ...

    Abstract BACKGROUND The aim of this study was to assess the clinical course and distinctive features of different white dot syndromes (WDS) in patients attending the Ophthalmology Department, Medical University of Warsaw in the years 1995-2015. MATERIAL AND METHODS Sixty-two (62) patients (43 females and 19 males), aged 18 to 77 years, referred with a WDS were included in this prospective study, with observation period ranging from 5 months to 16 years. All patients underwent a complete ophthalmological examination and multimodal imaging studies. RESULTS In this cohort of 62 patients, the following WDS entities were identified: multifocal choroiditis with panuveitis (MFCPU), multifocal choroiditis (MFC), punctate inner choroidopathy (PIC), birdshot, acute posterior multifocal placoid pigment epitheliopathy (APMPPE), subretinal fibrosis and uveitis, multiple evanescent white dot syndrome (MEWDS), serpiginous choroiditis, and single cases of acute annular outer retinopathy (AAOR). CONCLUSIONS The study was performed at a Polish referral center and may to some extent reflect the varied geographical distribution of white dot syndromes, as none of the subjects was found to suffer from acute zonal occult outer retinopathy (AZOOR), acute macular neuroretinopathy (AMN), or diffuse unilateral subacute neuroretinitis (DUSN). Long-term follow-up is warranted by the evolution of lesions in the eye fundus, while management depends on correct diagnosis of WDS. When the posterior pole is involved in some cases of the WDS an immunosuppressive treatment, the use of the PDT or anti-VEGF injections were necessary.
    MeSH term(s) Adolescent ; Adult ; Aged ; Choroiditis/diagnosis ; Choroiditis/pathology ; Eye Diseases/diagnosis ; Female ; Fundus Oculi ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Panuveitis/pathology ; Photography/methods ; Prospective Studies ; Retinal Diseases/diagnosis ; Visual Acuity/physiology
    Language English
    Publishing date 2017-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1439041-3
    ISSN 1643-3750 ; 1234-1010
    ISSN (online) 1643-3750
    ISSN 1234-1010
    DOI 10.12659/msm.901744
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4924: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Synthesis of novel aryl(heteroaryl)sulfonyl ureas of possible biological interest.

    Saczewski, Franciszek / Kuchnio, Anna / Samsel, Monika / Łobocka, Marta / Kiedrowska, Agnieszka / Lisewska, Karolina / Saczewski, Jarosław / Gdaniec, Maria / Bednarski, Patrick J

    Molecules (Basel, Switzerland)

    2010  Volume 15, Issue 3, Page(s) 1113–1126

    Abstract: The course of reaction of aryl and heteroaryl sulfonamides with diphenylcarbonate (DPC) and 4-dimethylaminopyridine (DMAP) was found to depend on the pKa of the sulfonamide used. Aryl sulfonamides with pKa approximately 10 gave 4-dimethylamino-pyridinium ...

    Abstract The course of reaction of aryl and heteroaryl sulfonamides with diphenylcarbonate (DPC) and 4-dimethylaminopyridine (DMAP) was found to depend on the pKa of the sulfonamide used. Aryl sulfonamides with pKa approximately 10 gave 4-dimethylamino-pyridinium arylsulfonyl-carbamoylides, while the more acidic heteroaryl sulfonamides (pKa approximately 8) furnished 4-dimethylaminopyridinium heteroarylsulfonyl carbamates. Both the carbamoylides and carbamate salts reacted with aliphatic and aromatic amines with the formation of appropriate aryl(heteroaryl)sulfonyl ureas, and therefore, can be regarded as safe and stable substitutes of the hazardous and difficult to handle aryl(heteroaryl)sulfonyl isocyanates.
    MeSH term(s) Cell Line, Tumor ; Crystallography, X-Ray ; Drug Screening Assays, Antitumor ; Humans ; Magnetic Resonance Spectroscopy ; Models, Molecular ; Spectrophotometry, Infrared ; Sulfonylurea Compounds/chemical synthesis ; Sulfonylurea Compounds/chemistry ; Sulfonylurea Compounds/pharmacology
    Chemical Substances Sulfonylurea Compounds
    Language English
    Publishing date 2010-02-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules15031113
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Synthesis of Novel Aryl(heteroaryl)sulfonyl Ureas of Possible Biological Interest

    Maria Gdaniec / Jarosław Sączewski / Karolina Lisewska / Agnieszka Kiedrowska / Marta Łobocka / Monika Samsel / Anna Kuchnio / Franciszek Sączewski / Patrick J. Bednarski

    Molecules, Vol 15, Iss 3, Pp 1113-

    2010  Volume 1126

    Abstract: The course of reaction of aryl and heteroaryl sulfonamides with diphenylcarbonate (DPC) and 4-dimethylaminopyridine (DMAP) was found to depend on the pKa of the sulfonamide used. Aryl sulfonamides with pKa ~ 10 gave 4-dimethylamino-pyridinium ... ...

    Abstract The course of reaction of aryl and heteroaryl sulfonamides with diphenylcarbonate (DPC) and 4-dimethylaminopyridine (DMAP) was found to depend on the pKa of the sulfonamide used. Aryl sulfonamides with pKa ~ 10 gave 4-dimethylamino-pyridinium arylsulfonyl-carbamoylides, while the more acidic heteroaryl sulfonamides (pKa ~ 8) furnished 4-dimethylaminopyridinium heteroarylsulfonyl carbamates. Both the carbamoylides and carbamate salts reacted with aliphatic and aromatic amines with the formation of appropriate aryl(heteroaryl)sulfonyl ureas, and therefore, can be regarded as safe and stable substitutes of the hazardous and difficult to handle aryl(heteroaryl)sulfonyl isocyanates.
    Keywords 4-dimethylaminopyridinium arylsulfonylcarbamoylides ; 4-dimethylamino-pyridinium arylsulfonyl carbamates ; arylsulfonyl ureas ; heteroarylsulfonyl ureas ; arylsulfonyl isocyanate substitutes ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2010-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: Białaczka włochatokomórkowa u kobiety w ciazy.

    Kopeć, Izabella / Debski, Romuald / Samsel, Marzena / Winter, Waldemar / Maryniak, Renata / Prochorec, Monika / Podstawka, Urszula / Maj, Stanisław / Banaczek, Zbigniew / Warzocha, Krzysztof

    Ginekologia polska

    2005  Volume 76, Issue 11, Page(s) 898–901

    Abstract: Pregnancy complicated by HCL is an extremlely rare event: only 5 report of HCL in pregnancy have been previously described. A 36-year-old women was diagnosed of HCL presented in 14 week of her 5th pregnancy. Therapy was initiated in 18 wk of gestation ... ...

    Title translation Hairy cell leukemia in pregnancy.
    Abstract Pregnancy complicated by HCL is an extremlely rare event: only 5 report of HCL in pregnancy have been previously described. A 36-year-old women was diagnosed of HCL presented in 14 week of her 5th pregnancy. Therapy was initiated in 18 wk of gestation with IFN-alpha at dose 6 x 106 U subcutaneous 3 times per week and prednisone 20 mg/d. IFN-alpha administration was well tolerated. After IFN-alpha therapy partial remission was achieved. The course of the pregnancy was normal. At week 39 of gestation a cesarean cection was performed and the patient delivered a healthy male infant weighing 3460 g with Apgar score of 10. The placenta was of normal size, no infiltration of hairy cell was founded. Post-partum course was uncomplicated. The patient elected to not breast feed her infant. 3 weeks after delivery patient had a 5-days course of 2CDA
    MeSH term(s) Adult ; Antineoplastic Agents/therapeutic use ; Female ; Humans ; Interferon-alpha/administration & dosage ; Leukemia, Hairy Cell/diagnosis ; Leukemia, Hairy Cell/drug therapy ; Prednisone/administration & dosage ; Pregnancy ; Pregnancy Complications, Neoplastic/diagnosis ; Pregnancy Complications, Neoplastic/drug therapy ; Pregnancy Outcome
    Chemical Substances Antineoplastic Agents ; Interferon-alpha ; Prednisone (VB0R961HZT)
    Language Polish
    Publishing date 2005-11
    Publishing country Poland
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 130894-4
    ISSN 0017-0011
    ISSN 0017-0011
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 118: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top