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Article ; Online: Myxoid Liposarcoma of the Breast Mimicking Phyllodes Tumor: A Case Report.

Lee, Se Jin / Ryu, Jung Kyu / Won, Kyu Yeoun / Han, Sang-Ah

Journal of the Korean Society of Radiology

2023 Volume 84, Issue 4, Page(s) 952–957

Abstract: Myxoid liposarcoma is an extremely rare malignant breast tumor. We report the case of a 44-year-old woman who had myxoid liposarcoma of the breast with a history of phyllodes tumor and describe the imaging findings on US, mammography, and MRI. Before ... ...

Abstract	Myxoid liposarcoma is an extremely rare malignant breast tumor. We report the case of a 44-year-old woman who had myxoid liposarcoma of the breast with a history of phyllodes tumor and describe the imaging findings on US, mammography, and MRI. Before surgery, the mass was considered to be a recurrent phyllodes tumor. However, using US, we retrospectively identified some differences between myxoid liposarcomas and phyllodes tumors.
Language	English
Publishing date	2023-07-14
Publishing country	Korea (South)
Document type	Case Reports
ISSN	2951-0805
ISSN (online)	2951-0805
DOI	10.3348/jksr.2022.0146
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Article ; Online: Diabetes duration, cholesterol levels, and risk of cardiovascular diseases in individuals with type 2 diabetes.

Kim, Mee Kyoung / Lee, Kyu Na / Han, Kyungdo / Lee, Seung-Hwan

The Journal of clinical endocrinology and metabolism

2024

Abstract: Objective: To investigate the association of diabetes duration with cardiovascular disease (CVD) risk and to examine the relationship between lipid levels and CVD risk over the duration.: Methods: Using the Korean National Health Insurance Service ... ...

Abstract	Objective: To investigate the association of diabetes duration with cardiovascular disease (CVD) risk and to examine the relationship between lipid levels and CVD risk over the duration. Methods: Using the Korean National Health Insurance Service Cohort database, we identified 2,359,243 subjects with type 2 DM aged ≥20 years in 2015-2016. Baseline lipid levels and diabetes duration were evaluated, and followed up until December 2020 (mean follow-up, 3.9 years). Subjects were categorized according to diabetes duration (new-onset, <5 years, 5-9 years, or ≥10 years). We analyzed the new-onset diabetes group with low-density lipoprotein cholesterol (LDL-C), <70 mg/dL, as the reference group. The hazard ratios (HRs) and 95% confidence intervals (CIs) of myocardial infarction (MI), and ischemic stroke (IS) were estimated using a Cox proportional hazards model adjusted for potential confounders. Results: During follow-up, 45,883 cases of MI and 53,538 cases of IS were identified. The risk of MI or IS began to increase at LDL-C ≥160 mg/dL in the new-onset diabetes group, and at LDL-C ≥130 mg/dL in the diabetes duration <5 years group. Among subjects with a diabetes duration of 5-9 years, LDL-C 100-129 mg/dL, LDL-C 130-159 mg/dL, and ≥160 mg/dL were significantly associated with the risk of MI, with HRs (95% CI) of 1.13 (1.04-1.22), 1.28 (1.17-1.39), and 1.58 (1.42-1.76), respectively. The risk of MI in the diabetes duration ≥10 years group was increased by 16%, even in the LDL-C 70-99 mg/dL population (HR [95% CI] 1.16 [1.08-1.25]). Conclusions: This population-based longitudinal study revealed that the LDL-C cutoff level for increasing the risk of cardiovascular disease varied with diabetes duration, and that the target LDL-C level should depend on the duration.
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgae092
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Article ; Online: Beneficial Effect of Curved Dilator System for Femoral Tunnel Creation in Preventing Femoral Tunnel Widening after Anterior Cruciate Ligament Reconstruction.

Lee, O-Sung / Kim, Joong Il / Han, Seok Hyeon / Lee, Joon Kyu

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 8

Abstract: Backgrounds and objectives: ...

Abstract	Backgrounds and objectives:
MeSH term(s)	Humans ; Retrospective Studies ; Femur/surgery ; Tibia ; Anterior Cruciate Ligament Reconstruction ; Cluster Analysis
Language	English
Publishing date	2023-08-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59081437
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Article ; Online: Erratum of the "A booster administration of the OKA/SK strain causes fatal disseminated VZV infection in an immunocompetent child".

Kang, Hyun Mi / Kang, Kyu Ri / Kim, Ye Ji / Kang, Jin Han / Lee, Soo-Young

Journal of medical virology

2024 Volume 96, Issue 1, Page(s) e29410

Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Published Erratum
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29410
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Article ; Online: Successful robotic kidney transplantation for surgeons with no experience in minimally invasive surgery: a single institution experience.

Kim, Hyun Jeong / Jeong, Wooju / Lee, Juhan / Yang, Seok Jeong / Lee, Jong Soo / Na, Joon Chae / Han, Woong Kyu / Huh, Kyu Ha

International journal of surgery (London, England)

2024 Volume 110, Issue 3, Page(s) 1586–1594

Abstract: Background: Robotic kidney transplantation (RKT) is a novel and welcomed innovation yielding good surgical outcomes. However, data on the feasibility and safety of performing RKT by surgeons with a lack of prior minimally invasive surgery (MIS) ... ...

Abstract	Background: Robotic kidney transplantation (RKT) is a novel and welcomed innovation yielding good surgical outcomes. However, data on the feasibility and safety of performing RKT by surgeons with a lack of prior minimally invasive surgery (MIS) experience are limited. The authors aimed to evaluate the surgical and functional results of RKT and present the learning curves (LC) of RKT by a single surgeon with no prior experience in MIS. Materials and methods: This was a retrospective study of all RKT performed between November 2019 and April 2023 at Severance Hospital in Seoul, South Korea. The authors analyzed surgical and functional outcomes, as well as complication rates of RKT in comparison to open kidney transplantation (OKT). The authors evaluated LCs using the cumulative summation method to describe the number of cases associated with the competency of a single surgeon. Results: A total of 50 patients who underwent RKT and 104 patients who underwent OKT were included in this study. In RKT group, the median surgical console time was 193 min (interquartile range, 172-222) and the median vascular anastomoses time was 38 min (35-44). Total operation time was 323 min (290-371) and rewarming time was 62.5 min (56.0-70.0) in RKT group compared to 210 min (190-239) and 25 min (21-30), respectively, in OKT group. Despite extended surgical durations with a robotic technique, both groups had comparable intraoperative and postoperative outcomes, as well as renal function. Estimated blood loss and post-transplant hospital stays were significantly lower in RKT group than in OKT group. LC analysis of RKT by the single surgeon revealed that surgical competence was achieved after 15 cases. Conclusion: Even if surgeons do not have prior experience with MIS, they can rapidly overcome the LC and safely perform RKT with adequate preparation and acquisition of basic robotic surgical techniques.
MeSH term(s)	Humans ; Kidney Transplantation/methods ; Robotic Surgical Procedures/adverse effects ; Retrospective Studies ; Minimally Invasive Surgical Procedures/adverse effects ; Surgeons
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1097/JS9.0000000000000977
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Article ; Online: Fluorescence-Based Peptidolytic Assay for High-Throughput Screening of MMP14 Inhibitors.

Lee, Hyun / Ibrahimi, Lucas / Han, Kyu-Yeon

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2747, Page(s) 229–242

Abstract: The membrane-bound matrix metalloproteinase 14 (MMP14, also known as MT1-MMP) plays important roles in the remodeling of the extracellular matrix during various cellular processes such as cancer metastasis, angiogenesis, and wound healing through its ... ...

Abstract	The membrane-bound matrix metalloproteinase 14 (MMP14, also known as MT1-MMP) plays important roles in the remodeling of the extracellular matrix during various cellular processes such as cancer metastasis, angiogenesis, and wound healing through its proteolytic activity. There are no known MMP14-specific inhibitors to date, and hence identification of MMP14-specific inhibitors will be beneficial for finding potential therapeutics for various diseases, including cancer and inflammation. High-throughput screening (HTS) assays have become a common way to search for new small compounds, peptides, and natural products. Enzymatic assays are highly amenable to HTS because most enzyme activities are quantifiable with the effect of many small molecules of interest on a specific target enzyme. Here, we describe a fluorescence-based enzymatic assay that can be applied as a large-scale HTS and a follow-up enzyme kinetics assay to find MMP14-specific inhibitors.
MeSH term(s)	Humans ; Matrix Metalloproteinase 14/chemistry ; High-Throughput Screening Assays ; Peptides ; Neoplasms ; Wound Healing
Chemical Substances	Matrix Metalloproteinase 14 (EC 3.4.24.80) ; Peptides ; MMP14 protein, human (EC 3.4.24.80)
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3589-6_18
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Article ; Online: OASIS portable: User-friendly offline suite for secure survival analysis.

Han, Seong Kyu / Kwon, Hyunwoo C / Yang, Jae-Seong / Kim, Sanguk / Lee, Seung-Jae V

Molecules and cells

2024 Volume 47, Issue 2, Page(s) 100011

Abstract: Online application for survival analysis (OASIS) and its update, OASIS 2, have been widely used for survival analysis in biological and medical sciences. Here, we provide a portable version of OASIS, an all-in-one offline suite, to facilitate secure ... ...

Abstract	Online application for survival analysis (OASIS) and its update, OASIS 2, have been widely used for survival analysis in biological and medical sciences. Here, we provide a portable version of OASIS, an all-in-one offline suite, to facilitate secure survival analysis without uploading the data to online servers. OASIS portable provides a virtualized and isolated instance of the OASIS 2 webserver, operating on the users' personal computers, and enables user-friendly survival analysis without internet connection and security issues.
MeSH term(s)	Survival Analysis ; Internet
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Letter
ZDB-ID	1148964-9
ISSN	0219-1032 ; 1016-8478
ISSN (online)	0219-1032
ISSN	1016-8478
DOI	10.1016/j.mocell.2024.100011
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Article ; Online: The Relation Between Cigarette Smoking and Development of Sepsis: A 10-Year Follow-Up Study of Four Million Adults from the National Health Screening Program.

Lee, Eun Hwa / Lee, Kyoung Hwa / Lee, Kyu-Na / Park, Yebin / Do Han, Kyung / Han, Sang Hoon

Journal of epidemiology and global health

2024

Abstract: Background: Sepsis remains a growing global health concern with soaring mortality and no direct anti-sepsis drug. Although smoking has distinct deleterious effects on chronic inflammatory illnesses and can impair immune function, a comprehensive ... ...

Abstract	Background: Sepsis remains a growing global health concern with soaring mortality and no direct anti-sepsis drug. Although smoking has distinct deleterious effects on chronic inflammatory illnesses and can impair immune function, a comprehensive analysis of the connection between sepsis and smoking is lacking. Methods: This large-scale longitudinal cohort study retrospectively assessed adults aged ≥ 20 years who underwent national health checkups under the Korean National Health Insurance Service between January and December 2009 (N = 4,234,415) and were followed up for 10 years. Sepsis was identified based on the International Classification of Diseases, 10th Revision codes, and smoking status, including accumulated amount, was collected through a self-administered questionnaire. The Cox proportional hazard regression model was used, adjusting for age, sex, household income, body mass index, drinking, exercise, diabetes, hypertension, dyslipidemia, and chronic renal disease. Results: After excluding cases with sepsis occurring before follow-up or after ≤ 1 year of follow-up, 3,881,958 participants, including non-smokers (N = 2,342,841), former smokers (N = 539,850), and active smokers (N = 999,267), were included. Compared to non-smokers, all active smokers (adjust hazard ratio: 1.41, 95% confidence interval 1.38-1.44) and former smokers (1.10, 1.07-1.14) with ≥ 20 pack-years exhibited a significantly higher risk of sepsis (p < 0.001). Smoking of ≥ 30 pack-years in former and active smokers groups significantly increased sepsis incidence (adjust hazard ratio [95% confidence interval] 1.34 [1.31-1.38], p < 0.001). Conclusions: Smoking is closely associated with the incidence of sepsis. Smoking cessation may help in the primary prevention of sepsis.
Language	English
Publishing date	2024-02-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2645324-1
ISSN	2210-6014 ; 2210-6014
ISSN (online)	2210-6014
ISSN	2210-6014
DOI	10.1007/s44197-024-00197-6
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Article ; Online: Comparing Physicochemical Properties, Fatty Acid Profiles, Amino Acid Composition, and Volatile Compounds in Dry-Cured Loin: The Impact of Different Levels of Proteolysis and Lipid Oxidation.

Seo, Jin-Kyu / Lee, Youn Su / Eom, Jeong-Uk / Yang, Han-Sul

Food science of animal resources

2024 Volume 44, Issue 1, Page(s) 103–118

Abstract: The aim of this study is to compare the quality characteristics of dry-cured loins with different levels of proteolysis and lipid oxidation and to investigate the relationship between these factors on quality characteristics. The dry-cured loins were ... ...

Abstract	The aim of this study is to compare the quality characteristics of dry-cured loins with different levels of proteolysis and lipid oxidation and to investigate the relationship between these factors on quality characteristics. The dry-cured loins were divided into four groups [proteolytic index (PI) and 2-thiobarbituric acid reactive substances (TBARS) of high levels (HH), PI of high level and TBARS of low level (HL), PI of low level and TBARS of high level (LH), and PI and TBARS of low levels (LL)] based on the proteolysis index and TBARS. Moisture, protein, and fat content were all significantly influenced by proteolysis and lipid oxidation (p<0.05). The total fatty acid content in the high proteolysis groups (HH and HL) was significantly lower than that in the low proteolysis groups (LH and LL; p<0.05). For total free amino acid content, HH was the highest, and LL was the lowest (p<0.05). On the other hand, there was no significant difference between HL and LH (p>0.05). In the amount of total volatile compounds, there was no significant difference between HH and HL (p>0.05), but LH and LL significantly differed (p<0.05). In conclusion, proteolysis and lipid oxidation can influence the quality characteristics of dry-cured loin. Additionally, proteolysis might be as influential in generating volatile compounds as lipid oxidation.
Language	English
Publishing date	2024-01-01
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3016289-0
ISSN	2636-0780 ; 2636-0772
ISSN (online)	2636-0780
ISSN	2636-0772
DOI	10.5851/kosfa.2023.e60
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Article ; Online: Self-Mixed Biphasic Liquid Metal Composite with Ultra-High Stretchability and Strain-Insensitivity for Neuromorphic Circuits.

Lee, Do Hoon / Lim, Taesu / Pyeon, Jeongsu / Park, Hyunmin / Lee, Sang-Won / Lee, Seungkyu / Kim, Wonsik / Kim, Min / Lee, Jeong-Chan / Kim, Do-Wan / Han, Seungmin / Kim, Hyoungsoo / Park, Steve / Choi, Yang-Kyu

Advanced materials (Deerfield Beach, Fla.)

2024 Volume 36, Issue 16, Page(s) e2310956

Abstract: Neuromorphic circuits that can function under extreme deformations are important for various data-driven wearable and robotic applications. Herein, biphasic liquid metal particle (BMP) with unprecedented stretchability and strain-insensitivity (ΔR/ ... ...

Abstract	Neuromorphic circuits that can function under extreme deformations are important for various data-driven wearable and robotic applications. Herein, biphasic liquid metal particle (BMP) with unprecedented stretchability and strain-insensitivity (ΔR/R
Language	English
Publishing date	2024-01-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202310956
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