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  1. Article: Variations in obsessive compulsive disorder symptomatology across cultural dimensions.

    Hassan, Wassim / El Hayek, Samer / de Filippis, Renato / Eid, Mario / Hassan, Sarah / Shalbafan, Mohammadreza

    Frontiers in psychiatry

    2024  Volume 15, Page(s) 1329748

    Language English
    Publishing date 2024-01-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2024.1329748
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Therapeutic targeting of TRP channels--the TR(i)P to pain relief.

    Eid, Samer R

    Current topics in medicinal chemistry

    2011  Volume 11, Issue 17, Page(s) 2118–2130

    Abstract: Following the cloning and characterization of the transient receptor potential vanilloid 1 (TRPV1), a growing body of research has identified the important role of TRPV1 and related channels in diverse physiological functions including temperature ... ...

    Abstract Following the cloning and characterization of the transient receptor potential vanilloid 1 (TRPV1), a growing body of research has identified the important role of TRPV1 and related channels in diverse physiological functions including temperature transduction and pain signalling. As a result, there has been a great deal of interest by the pharmaceutical industry to develop small molecule modulators of the activity of these channels for potential therapeutic use. While most of the efforts have focused on examining the role of TRPV1 in nociception, more recent work has begun to assess the therapeutic utility of targeting other TRP channels. This manuscript is aimed at introducing the reader of this special issue to the promising new developments and findings as well as emerging challenges in the targeting of the thermoTRP family of receptors for clinical therapeutic use. This chapter will focus on current efforts from the pharmaceutical industry to develop highly potent and efficacious compounds that modulate TRP channel function. In particular, this chapter will highlight recent drug discovery activities around the transient receptor potential vanilloid family members TRPV1, TRPV3, and TRPV4, the transient receptor potential ankyrin family member TRPA1, and the transient receptor potential melastatin family member TRPM8. The majority of the work included in this chapter will focus on recent findings in the development of TRP modulators for pain indications; however, for certain targets where data exist, other indications will be discussed. The increasing number of small biotech and pharmaceutical companies pursuing targets in these families of ion channels highlights the perceived importance of these targets in the treatment of a variety of disease states including inflammatory and neuropathic pain, urinary incontinence, painful bladder syndrome, and even types of prostate cancer.
    MeSH term(s) Animals ; Drug Discovery ; Humans ; Pain/complications ; Pain/drug therapy ; Pain/metabolism ; Transient Receptor Potential Channels/antagonists & inhibitors
    Chemical Substances Transient Receptor Potential Channels
    Language English
    Publishing date 2011-06-13
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2064823-6
    ISSN 1873-4294 ; 1568-0266
    ISSN (online) 1873-4294
    ISSN 1568-0266
    DOI 10.2174/156802611796904898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exploration of the nutrition knowledge among general population: multi-national study in Arab countries.

    Bany-Yasin, Hammam / Elmor, Abdellatif A / Ebrahim, Basant Khaled / Ahmed, Asaad Ayoub Mohamed / Alarachi, Mohammad Roujan / Abedalqader, Lina / Amer, Rawan / Alyousef, Ahmad Mohammad Samer / Alhajeh, Yasmine Fawaz / Alyoussef, Abdullah / Eid, Hadeer Ahmed Mohamed Ahmed / Elsayed, Maab Mohamed / Desouky, Eman D El / Salem, Hosni Khairy / Salem, Marwa Rashad

    BMC public health

    2023  Volume 23, Issue 1, Page(s) 1178

    Abstract: Background: Knowing what to eat and realizing the significance of healthful eating habits are among the important steps to promoting eating behavior. The current study aims to assess the nutrition knowledge (NK) among a convenient sample in four ... ...

    Abstract Background: Knowing what to eat and realizing the significance of healthful eating habits are among the important steps to promoting eating behavior. The current study aims to assess the nutrition knowledge (NK) among a convenient sample in four different countries, determine the association between different demographic factors and NK, and investigate the need for future interventions on nutrition in the four selected countries.
    Methods: A cross-sectional multi-national survey study among a convenient sample of 8,191 subjects from Egypt, Syria, Saudi Arabia, and Jordan who undertook surveys between January 2019 and January 2020. A pre-tested interview questionnaire was utilized for data collection from study participants. It included three sections: i) Sociodemographic characteristics:. ii). Section two included twenty-one questions related to NK.. iii). Section three included one question about NK sources.
    Results: About three-quarters showed inadequate nutrition knowledge (73.1%). Youth (15-24 yrs.) were more dependent on social media, with 87% using it as a primary source of NK, while adults (≥ 25 yrs.) demonstrated that 43% of them used social media. In contrast, TV was more prominent among them, with participants' characteristics such as living with parents, body mass index, and country of residence showing no association with NK. However, female sex, education, and reading nutrition articles are significantly correlated with adequate knowledge (p < 0.001). Significant predictors of satisfactory knowledge were age, sex, education, living with parents, and reading nutrition articles.
    Conclusion: The study revealed low levels of NK indicating an urgent need to implement educational programs to promote nutrition knowledge. As NK is a modifiable determinant of diet intake and can positively impact the need for developing strategies in counselling and raising awareness among the general population to improve their health status.
    MeSH term(s) Adult ; Adolescent ; Humans ; Female ; Cross-Sectional Studies ; Arabs ; Middle East ; Nutritional Status ; Egypt ; Surveys and Questionnaires ; Health Knowledge, Attitudes, Practice
    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-023-15791-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Laparoscopic sleeve gastrectomy for super obese patients: forty-eight percent excess weight loss after 6 to 8 years with 93% follow-up.

    Eid, George M / Brethauer, Stacy / Mattar, Samer G / Titchner, Rebecca L / Gourash, William / Schauer, Philip R

    Annals of surgery

    2012  Volume 256, Issue 2, Page(s) 262–265

    Abstract: Objectives: In this study, we report long-term outcomes of high-risk, high-BMI (body mass index) patients who underwent laparoscopic sleeve gastrectomy (LSG).: Background: Short- and medium-term data appear to support the effectiveness of LSG, but ... ...

    Abstract Objectives: In this study, we report long-term outcomes of high-risk, high-BMI (body mass index) patients who underwent laparoscopic sleeve gastrectomy (LSG).
    Background: Short- and medium-term data appear to support the effectiveness of LSG, but long-term data to support its durability are sparse.
    Methods: A prospective database was reviewed on all high-risk patients who underwent LSG as part of a staged approach for surgical treatment of severe obesity between January 2002 and February 2004. We included only patients who did not proceed to second-stage surgery (gastric bypass). Analyzed data included demographics, BMI, comorbidities, and surgical outcomes. All partial gastrectomies were performed using a 50F bougie.
    Results: Seventy-four patients underwent LSG, and follow-up data were available on 69 of 74 patients (93%). The mean age was 50 years (25-78) and the mean number of co-morbidities was 9.6. Perioperative mortality (<30 days) was zero, and the incidence of short- and long-term postoperative complications was 15%. The mean overall follow-up time period was 73 months (38-95). Mean excess weight loss (EWL) at 72, 84, and 96 months after LSG was 52%, 43%, and 46%, respectively, with an overall EWL of 48%. The mean BMI decreased from 66 kg/m(2) (43-90) to 46 kg/m(2) (22-73). Seventy-seven percent of the diabetic patients showed improvement or remission of the disease.
    Conclusions: This study reports the longest follow-up of LSG patients thus far and supports the effectiveness, safety, and durability of laparoscopic sleeve gastrectomy as a definitive therapeutic option for severe obesity, even in high-risk, high-BMI patients.
    MeSH term(s) Adult ; Aged ; Body Mass Index ; Comorbidity ; Diabetes Mellitus/epidemiology ; Female ; Follow-Up Studies ; Gastrectomy/methods ; Humans ; Hypertension/epidemiology ; Laparoscopy ; Male ; Middle Aged ; Obesity, Morbid/epidemiology ; Obesity, Morbid/surgery ; Retrospective Studies ; Sleep Apnea Syndromes/epidemiology ; Treatment Outcome ; Weight Loss
    Keywords covid19
    Language English
    Publishing date 2012-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0b013e31825fe905
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept.

    Szallasi, Arpad / Cortright, Daniel N / Blum, Charles A / Eid, Samer R

    Nature reviews. Drug discovery

    2007  Volume 6, Issue 5, Page(s) 357–372

    Abstract: The clinical use of TRPV1 (transient receptor potential vanilloid subfamily, member 1; also known as VR1) antagonists is based on the concept that endogenous agonists acting on TRPV1 might provide a major contribution to certain pain conditions. Indeed, ... ...

    Abstract The clinical use of TRPV1 (transient receptor potential vanilloid subfamily, member 1; also known as VR1) antagonists is based on the concept that endogenous agonists acting on TRPV1 might provide a major contribution to certain pain conditions. Indeed, a number of small-molecule TRPV1 antagonists are already undergoing Phase I/II clinical trials for the indications of chronic inflammatory pain and migraine. Moreover, animal models suggest a therapeutic value for TRPV1 antagonists in the treatment of other types of pain, including pain from cancer. We argue that TRPV1 antagonists alone or in conjunction with other analgesics will improve the quality of life of people with migraine, chronic intractable pain secondary to cancer, AIDS or diabetes. Moreover, emerging data indicate that TRPV1 antagonists could also be useful in treating disorders other than pain, such as urinary urge incontinence, chronic cough and irritable bowel syndrome. The lack of effective drugs for treating many of these conditions highlights the need for further investigation into the therapeutic potential of TRPV1 antagonists.
    MeSH term(s) Analgesics/therapeutic use ; Animals ; Cloning, Molecular ; Glucose/metabolism ; Humans ; Migraine Disorders/drug therapy ; Muscular Diseases/drug therapy ; Pain/drug therapy ; Skin Diseases/drug therapy ; TRPV Cation Channels/agonists ; TRPV Cation Channels/antagonists & inhibitors ; TRPV Cation Channels/genetics ; TRPV Cation Channels/physiology ; Urologic Diseases/drug therapy
    Chemical Substances Analgesics ; TRPV Cation Channels ; TRPV1 protein, human ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2007-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/nrd2280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Embryonic expression of Xenopus SGLT-1L, a novel member of the solute carrier family 5 (SLC5), is confined to tubules of the pronephric kidney.

    Eid, Samer R / Terrettaz, Anne / Nagata, Katsumi / Brändli, André W

    The International journal of developmental biology

    2002  Volume 46, Issue 1, Page(s) 177–184

    Abstract: Plasma membrane proteins of the solute carrier family 5 (SLC5) are responsible for sodium-coupled uptake of ions, sugars and nutrients in the vertebrate body. Mutations in SLC5 genes are the cause of several inherited human disorders. We have recently ... ...

    Abstract Plasma membrane proteins of the solute carrier family 5 (SLC5) are responsible for sodium-coupled uptake of ions, sugars and nutrients in the vertebrate body. Mutations in SLC5 genes are the cause of several inherited human disorders. We have recently reported the cloning and transport properties of SGLT-1L, a Xenopus homologue of the sodium-dependent glucose cotransporter 1 (SGLT-1) [Nagata et al. (1999) Am. J. Physiol. 276: G1251 -G 1259]. Here, we describe the phylogenetic relationship of SGLT-1L with other members of the SLC5 family and characterize its expression during Xenopus embryogenesis and in organ cultures. Sequence comparisons and phylogenetic analyses of all known vertebrate SLC5 sequences indicated that Xenopus SGLT-1L encodes a novel SLC5 member, which shares highest amino acid identity with mammalian ST-1 proteins. Temporal and spatial expression of SGLT-1L during Xenopus embryogenesis was examined by whole mount in situ hybridization. Initiation of SGLT-1L expression occurred in the late tailbud embryo. Remarkably, expression was restricted to the developing pronephric kidney. SGLT-1L was highly expressed in tubular epithelia, but completely absent from the epithelia of the duct. Analysis of growth factor-treated animal caps indicated that expression of SGLT-1L could also be induced in organ cultures. Taken together, our findings indicate that the expression of sodium-dependent solute cotransporter genes in early segments of the excretory system appears to be conserved between pronephric and metanephric kidneys. Furthermore, we establish SGLT-1L as a novel, highly specific molecular marker for pronephric tubule epithelia undergoing maturation and terminal differentiation in Xenopus.
    MeSH term(s) Animals ; Cell Membrane/metabolism ; In Situ Hybridization ; Kidney/pathology ; Ligands ; Membrane Glycoproteins/biosynthesis ; Membrane Glycoproteins/chemistry ; Membrane Glycoproteins/genetics ; Molecular Sequence Data ; Monosaccharide Transport Proteins/biosynthesis ; Monosaccharide Transport Proteins/chemistry ; Monosaccharide Transport Proteins/genetics ; Organ Culture Techniques ; Phylogeny ; Reverse Transcriptase Polymerase Chain Reaction ; Sodium-Glucose Transporter 1 ; Time Factors ; Transcription, Genetic ; Xenopus ; Xenopus Proteins/biosynthesis ; Xenopus Proteins/genetics
    Chemical Substances Ligands ; Membrane Glycoproteins ; Monosaccharide Transport Proteins ; SLC5A11 protein, Xenopus ; Sodium-Glucose Transporter 1 ; Xenopus Proteins
    Language English
    Publishing date 2002-03-04
    Publishing country Spain
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1036070-0
    ISSN 1696-3547 ; 0214-6282
    ISSN (online) 1696-3547
    ISSN 0214-6282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Enhance the performance of photovoltaic solar panels by a self-cleaning and hydrophobic nanocoating

    Samir Ahmed Tayel / Ashour Eid Abu El-Maaty / Eman Mohamed Mostafa / Youssef Fayez Elsaadawi

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Volume 13

    Abstract: Abstract The photovoltaic (PV) solar panels are negatively impacted by dust accumulation. The variance in dust density from point to point raises the risk of forming hot spots. Therefore, a prepared PDMS/SiO2 nanocoating was used to reduce the ... ...

    Abstract Abstract The photovoltaic (PV) solar panels are negatively impacted by dust accumulation. The variance in dust density from point to point raises the risk of forming hot spots. Therefore, a prepared PDMS/SiO2 nanocoating was used to reduce the accumulated dust on the PV panels' surface. However, the effectiveness of these coatings is greatly influenced by geographical and climatic factors. Three identical PV modules were installed to run comparable experimental tests simultaneously. The first module is coated with the prepared PDMS/SiO2 nanocoating, the second is coated with commercial nanocoating, and the third module is uncoated and serves as a reference. The prepared nanocoating was hydrophobic and had a self-cleaning effect. The fill factors for the reference panel (RP), commercial-nanocoated panel (CNP), and prepared-nanocoated panel (PNP), were 0.68, 0.69, and 0.7, respectively. After 40 days of exposure to outdoor conditions, the dust densities on the RP and PNP panels' surfaces were 10 and 4.39 g/m2, respectively. Thus, the nanocoated panel's efficiency was found to be higher than that of the reference panel by 30.7%.
    Keywords Medicine ; R ; Science ; Q
    Subject code 600
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Laparoscopic gastric bypass surgery: current technique.

    Schauer, Philip R / Ikramuddin, Sayeed / Hamad, Giselle / Eid, George M / Mattar, Samer / Cottam, Dan / Ramanathan, Ramesh / Gourash, William

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2003  Volume 13, Issue 4, Page(s) 229–239

    MeSH term(s) Anastomosis, Roux-en-Y ; Gastric Bypass/instrumentation ; Gastric Bypass/methods ; Humans ; Laparoscopy/methods ; Minimally Invasive Surgical Procedures ; Outcome and Process Assessment (Health Care)
    Language English
    Publishing date 2003-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1381909-4
    ISSN 1092-6429
    ISSN 1092-6429
    DOI 10.1089/109264203322333557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Medium-term follow-up confirms the safety and durability of laparoscopic ventral hernia repair with PTFE.

    Eid, George M / Prince, Jose M / Mattar, Samer G / Hamad, Giselle / Ikrammudin, Sayeed / Schauer, Philip R

    Surgery

    2003  Volume 134, Issue 4, Page(s) 599–603; discussion 603–4

    Abstract: Background: Ventral abdominal wall hernias are common lesions and may be associated with life-threatening complications. The application of laparoscopic principles to the treatment of ventral hernias has reduced recurrence rates from a range of 25% to ... ...

    Abstract Background: Ventral abdominal wall hernias are common lesions and may be associated with life-threatening complications. The application of laparoscopic principles to the treatment of ventral hernias has reduced recurrence rates from a range of 25% to 52% to a range of 3.4% to 9%. In this study, we review our experience and assess the clinical outcome of patients who have undergone laparoscopic repair of ventral hernias.
    Methods: We reviewed the outcome of 79 patients with more than 1 year of follow-up who underwent laparoscopic ventral hernia repair between March 1996 and December 2001. Patient demographics, hernia characteristics, operative parameters, and clinical outcomes were evaluated.
    Results: Of the 79 patients, 37 were males. Mean age was 55.8 years (range 28-81). Sixty-eight patients had incisional hernias, including 17 with recurrent hernias. Eleven patients had primary ventral hernias. The mean defect size was 103 cm(2) (range 4-510); incarceration was present in 22 patients (27.8%), and multiple (Swiss-cheese) defects in 20 (25.3%). Laparoscopic expanded polytetrafluoroethylene mesh repair by the modified Rives-Stoppa technique was completed in 78 (98.7%). One conversion occurred because of bowel injury. The mean operating time was 110 minutes (range 45-210) and mean hospital stay was 1.7 days (range 0-20), with 46 patients (58.2%) being discharged within 24 hours of surgery. Complications included seroma formation (3), chronic pain (3), prolonged ileus (1), hematoma formation (1), and missed bowel injury (1) for a complication rate of (11.4%). There were no deaths. After a follow-up of up to 6 years (a mean of 34 months), there were 4 recurrences (5%).
    Conclusion: The laparoscopic repair of ventral hernias is safe, effective, and durable with minimal morbidity. It is particularly successful in patients with recurrent lesions. The laparoscopic approach to ventral hernia repair should be considered the standard of care.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Follow-Up Studies ; Hernia, Ventral/surgery ; Humans ; Intestines/injuries ; Intraoperative Complications ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Male ; Middle Aged ; Peritonitis/etiology ; Peritonitis/surgery ; Polytetrafluoroethylene ; Recurrence ; Reoperation ; Surgical Mesh ; Time Factors ; Treatment Outcome ; Wounds, Penetrating/complications
    Chemical Substances Polytetrafluoroethylene (9002-84-0)
    Language English
    Publishing date 2003-08-15
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/s0039-6060(03)00283-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Laparoscopic repair of umbilical hernias in conjunction with other laparoscopic procedures.

    Eid, George M / Thodiyil, Paul A / Collins, Joy / Bonanomi, Gianluca / Mattar, Samer G / Hughes, Steven J / Schauer, Philip R / Wilson, Mark

    JSLS : Journal of the Society of Laparoendoscopic Surgeons

    2006  Volume 10, Issue 1, Page(s) 63–65

    Abstract: Background: This study evaluates the feasibility of laparoscopic transfascial suture repair of umbilical hernias when combined with another laparoscopic procedure that potentially contaminates the peritoneal cavity.: Method: From August 1997 to ... ...

    Abstract Background: This study evaluates the feasibility of laparoscopic transfascial suture repair of umbilical hernias when combined with another laparoscopic procedure that potentially contaminates the peritoneal cavity.
    Method: From August 1997 to November 2001, 32 patients underwent laparoscopic umbilical suture repair in association with another laparoscopic procedure. The repair was performed with the Carter-Thomason suture passer.
    Results: Of the 32, 26 patients with more than 1-year follow-up were included in the study. The mean diameter of the umbilical hernia defect was 1.67 cm (range, 0.5 to 3). At a mean follow-up of 34 months (range, 12 to 60), there were only 2 recurrences (7.7%) both of which happened in patients with hernia defects larger than 2 cm in diameter. Apart from 2 wound infections, no other complications occurred.
    Conclusion: Laparoscopic suture repair of umbilical hernias with the suture passer method is effective and durable even when combined with other laparoscopic procedures that potentially contaminate the peritoneal cavity with bile or enteric contents.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Follow-Up Studies ; Hernia, Umbilical/surgery ; Humans ; Laparoscopy/methods ; Male ; Middle Aged ; Recurrence ; Suture Techniques
    Language English
    Publishing date 2006-05-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2011211-7
    ISSN 1938-3797 ; 1086-8089
    ISSN (online) 1938-3797
    ISSN 1086-8089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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