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  1. Article: Attraction of Sitophilus zeamais (Coleoptera: Curculionidae) to Four Host Plants

    Stuhl, Charles J. / Romero, Maritza

    Florida entomologist. 2021 Sept. 23, v. 104, no. 3

    2021  

    Abstract: The maize weevil Sitophilus zeamais (Motschulsky) (Coleoptera: Curculionidae) is an important pest of stored grains, predominantly maize (Zea mays L.), wheat (Triticum L. spp.), rice (Oryza L. spp.), and sorghum (Sorghum bicolor [L.] Moench) (all Poaceae) ...

    Abstract The maize weevil Sitophilus zeamais (Motschulsky) (Coleoptera: Curculionidae) is an important pest of stored grains, predominantly maize (Zea mays L.), wheat (Triticum L. spp.), rice (Oryza L. spp.), and sorghum (Sorghum bicolor [L.] Moench) (all Poaceae). Weevil infestations occur in the field and weevils are carried to the storage facility after harvest. Infestation also occurs in the grain storage facility. There is no effective field or storage trapping system for control. They are commonly parasitized by Pteromalidae Dalman (Hymenoptera: Chalcidoidea) spp. parasitoids in the Tropics; however, there is no biocontrol use of these Hymenoptera. Therefore, pesticide application and the development of resistant grain are the current control strategies; although, studies have indicated that odors associated with the grain upon which the weevils feed, mate, and oviposit are attractive to the weevil. Host plant produced volatiles and their associations with the maize weevil have not been investigated fully. To better understand the weevil's attraction to crop plants, a study was initiated to investigate the weevil's preference for immature host plants. Weevils that had been reared on 4 types of grain for several generations were presented immature plants of all 4 types of grains in choice tests to determine if they prefer grains of the host plant on which they had been reared. This research demonstrated that immature rice plants have the greatest attraction, and that previous feeding did not influence the weevil's host plant attraction. The isolation of key rice plant semiochemicals will be the focus in the development of an attractant for S. zeamais and may also prove effective for the control of Sitophilus oryzae (L.) (Coleoptera: Curculionidae).
    Keywords Pteromalidae ; Sitophilus oryzae ; Sitophilus zeamais ; Sorghum bicolor ; Triticum ; Zea mays ; biological control ; corn ; entomologists ; host plants ; oviposition ; parasitoids ; pesticide application ; rice ; semiochemicals ; storage pests ; wheat ; Florida
    Language English
    Dates of publication 2021-0923
    Size p. 158-161.
    Publishing place Florida Entomological Society
    Document type Article
    ZDB-ID 1439588-5
    ISSN 1938-5102
    ISSN 1938-5102
    DOI 10.1653/024.104.0302
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Home blood pressure variability: a new target to monitor in chronic kidney disease patients with low eGFR?

    Romero, Maritza J

    Hypertension research : official journal of the Japanese Society of Hypertension

    2013  Volume 36, Issue 8, Page(s) 673–675

    MeSH term(s) Albuminuria/physiopathology ; Antihypertensive Agents/therapeutic use ; Blood Pressure/physiology ; Diabetes Mellitus, Type 2/physiopathology ; Diabetic Nephropathies/physiopathology ; Female ; Glomerular Filtration Rate/physiology ; Humans ; Hypertension/physiopathology ; Male
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2013-08
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/hr.2013.53
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Efecto genotóxico y citotóxico del plomo en meristemos radiculares de dos variedades de Vicia faba L. y su relación con la domesticación

    S. J. Garnica Acuña / Maritza López Herrera / L. Romero Bautista / M. Meza Sánchez

    Revista Biológico Agropecuaria Tuxpan, Vol 8, Iss

    2020  Volume 2

    Abstract: Las problemáticas ambientales asociadas al incremento de metales pesados como el plomo han promovido la búsqueda de bioindicadores eficientes; Vicia faba es uno de los más utilizados, sin embargo, su aprovechamiento a nivel mundial ha provocado el uso ... ...

    Abstract Las problemáticas ambientales asociadas al incremento de metales pesados como el plomo han promovido la búsqueda de bioindicadores eficientes; Vicia faba es uno de los más utilizados, sin embargo, su aprovechamiento a nivel mundial ha provocado el uso indistinto de sus variedades silvestres y domesticadas, sin considerar las implicaciones del proceso de domesticación. Por tal motivo, la presente investigación tiene como objetivo evaluar el efecto genotóxico y citotóxico del plomo en células meristemáticas de raíz de semillas de V. faba silvestre y de la variedad Major (domesticada) a través de la presencia de micronúcleos y la determinación del índice mitótico, con la finalidad de conocer sus respuestas ante este metal y su relación con la domesticación, así como sugerir el uso de la variedad más sensible como bioindicador. Para ello, los meristemos radiculares se sometieron a tratamientos con 0, 0.005, 0.01 y 0.02 g L-1 de acetato de plomo y se realizaron tinciones con aceto-orceína; se obtuvo la frecuencia de micronúcleos y el índice mitótico por cada 1000 células observadas. Los resultados obtenidos indican que el acetato de plomo tiene un efecto genotóxico y citotóxico diferencial entre ambas variedades, siendo V. faba var. Major la que presenta una alta sensibilidad al metal pesado, debido a una pérdida en la resistencia al estrés, por lo que se sugiere su uso como bioindicador; mientras que en las semillas silvestres mostraron mayor tolerancia al tener un bajo grado de domesticación.
    Keywords metal pesado ; haba ; micronúcleos ; mitosis ; bioindicador ; Veterinary medicine ; SF600-1100 ; Agriculture ; S
    Language Spanish
    Publishing date 2020-12-01T00:00:00Z
    Publisher Editorial Agrícola Tuxpan
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Direct endothelial ENaC activation mitigates vasculopathy induced by SARS-CoV2 spike protein.

    Romero, Maritza J / Yue, Qian / Singla, Bhupesh / Hamacher, Jürg / Sridhar, Supriya / Moseley, Auriel S / Song, Chang / Mraheil, Mobarak A / Fischer, Bernhard / Zeitlinger, Markus / Chakraborty, Trinad / Fulton, David / Gan, Lin / Annex, Brian H / Csanyi, Gabor / Eaton, Douglas C / Lucas, Rudolf

    Frontiers in immunology

    2023  Volume 14, Page(s) 1241448

    Abstract: Introduction: Although both COVID-19 and non-COVID-19 ARDS can be accompanied by significantly increased levels of circulating cytokines, the former significantly differs from the latter by its higher vasculopathy, characterized by increased oxidative ... ...

    Abstract Introduction: Although both COVID-19 and non-COVID-19 ARDS can be accompanied by significantly increased levels of circulating cytokines, the former significantly differs from the latter by its higher vasculopathy, characterized by increased oxidative stress and coagulopathy in lung capillaries. This points towards the existence of SARS-CoV2-specific factors and mechanisms that can sensitize the endothelium towards becoming dysfunctional. Although the virus is rarely detected within endothelial cells or in the circulation, the S1 subunit of its spike protein, which contains the receptor binding domain (RBD) for human ACE2 (hACE2), can be detected in plasma from COVID-19 patients and its levels correlate with disease severity. It remains obscure how the SARS-CoV2 RBD exerts its deleterious actions in lung endothelium and whether there are mechanisms to mitigate this.
    Methods: In this study, we use a combination of
    Results: We show that SARS-CoV2 RBD impairs endothelial ENaC activity, reduces surface hACE2 expression and increases reactive oxygen species (ROS) and tissue factor (TF) generation in monolayers of HL-MVEC, as such promoting barrier dysfunction and coagulopathy. The TNF-derived TIP peptide (a.k.a. solnatide, AP301) -which directly activates ENaC upon binding to its a subunit- can override RBD-induced impairment of ENaC function and hACE2 expression, mitigates ROS and TF generation and restores barrier function in HL-MVEC monolayers. In correlation with the increased mortality observed in COVID-19 patients co-infected with S. pneumoniae, compared to subjects solely infected with SARS-CoV2, we observe that prior intraperitoneal RBD treatment in transgenic mice globally expressing hACE2 significantly increases fibrin deposition and capillary leak upon intratracheal instillation of S. pneumoniae and that this is mitigated by TIP peptide treatment.
    MeSH term(s) Animals ; Mice ; Humans ; Endothelial Cells ; Angiotensin-Converting Enzyme 2/genetics ; RNA, Viral ; Reactive Oxygen Species ; Spike Glycoprotein, Coronavirus ; COVID-19 ; SARS-CoV-2 ; Endothelium
    Chemical Substances Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; RNA, Viral ; spike protein, SARS-CoV-2 ; Reactive Oxygen Species ; Spike Glycoprotein, Coronavirus
    Language English
    Publishing date 2023-08-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1241448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Arginase in the vascular endothelium: friend or foe?

    Lucas, Rudolf / Fulton, David / Caldwell, Robert William / Romero, Maritza J

    Frontiers in immunology

    2014  Volume 5, Page(s) 589

    Language English
    Publishing date 2014
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2014.00589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Fungal and herbivore elicitation of the novel maize sesquiterpenoid, zealexin A4, is attenuated by elevated CO

    Christensen, Shawn A / Huffaker, Alisa / Sims, James / Hunter, Charles T / Block, Anna / Vaughan, Martha M / Willett, Denis / Romero, Maritza / Mylroie, J Erik / Williams, W Paul / Schmelz, Eric A

    Planta

    2017  Volume 247, Issue 4, Page(s) 863–873

    Abstract: Main conclusion: Chemical isolation and NMR-based structure elucidation revealed a novel keto-acidic sesquiterpenoid, termed zealexin A4 (ZA4). ZA4 is elicited by pathogens and herbivory, but attenuated by heightened levels of ... ...

    Abstract Main conclusion: Chemical isolation and NMR-based structure elucidation revealed a novel keto-acidic sesquiterpenoid, termed zealexin A4 (ZA4). ZA4 is elicited by pathogens and herbivory, but attenuated by heightened levels of CO
    MeSH term(s) Alkyl and Aryl Transferases/metabolism ; Anti-Infective Agents/metabolism ; Aspergillus flavus/metabolism ; Carbon Dioxide/pharmacology ; Gene Expression Regulation, Plant/drug effects ; Plant Immunity ; Rhizopus/metabolism ; Seedlings/metabolism ; Sesquiterpenes/metabolism ; Zea mays/drug effects ; Zea mays/metabolism ; Zea mays/microbiology
    Chemical Substances Anti-Infective Agents ; Sesquiterpenes ; zealexin A4 ; Carbon Dioxide (142M471B3J) ; Alkyl and Aryl Transferases (EC 2.5.-) ; terpene synthase (EC 2.5.1.-)
    Language English
    Publishing date 2017-12-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 208909-9
    ISSN 1432-2048 ; 0032-0935 ; 1866-2749
    ISSN (online) 1432-2048
    ISSN 0032-0935 ; 1866-2749
    DOI 10.1007/s00425-017-2830-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Impact of KRAS

    Caballé-Perez, Enrique / Hernández-Pedro, Norma / Ramos-Ramírez, Maritza / Barrios-Bernal, Pedro / Romero-Núñez, Eunice / Lucio-Lozada, José / Ávila-Ríos, Santiago / Reyes-Terán, Gustavo / Cardona, Andrés F / Arrieta, Oscar

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

    2023  Volume 26, Issue 4, Page(s) 836–850

    Abstract: Purpose: Mutations in the Kirsten rat sarcoma viral (KRAS) oncogene constitute a significant driver of lung adenocarcinoma, present in 10-40% of patients, which exhibit heterogeneous clinical outcomes, mainly driven by concurrent genetic alterations. ... ...

    Abstract Purpose: Mutations in the Kirsten rat sarcoma viral (KRAS) oncogene constitute a significant driver of lung adenocarcinoma, present in 10-40% of patients, which exhibit heterogeneous clinical outcomes, mainly driven by concurrent genetic alterations. However, characterization of KRAS mutational subtypes and their impact on clinical outcomes in Latin America is limited.
    Methods: A cohort study was conducted at the National Cancer Institute (INCan) of Mexico. Individuals with advance-staged of adenocarcinoma and KRAS mutations, detected by next-generation sequencing, having undergone at least one line of therapy were included for analysis. Clinical and pathological characteristics were retrieved from institutional database from June 2014 to March 2023.
    Results: KRAS was identified in fifty-four (15.6%) of 346 patients, among which 50 cases were included for analysis. KRAS
    Conclusions: To our knowledge, this study represents the first effort to comprehensively characterize the molecular heterogeneity of KRAS-mutant NSCLC in Latin American patients. Our data reinforce the current view that KRAS-mutated NSCLC is not a single oncogene-driven disease and emphasizes the prognostic impact of diverse molecular profiles in this genomically defined subset of NSCLC. Further validation is warranted in larger multicenter Latin American cohorts to confirm our findings.
    MeSH term(s) Female ; Humans ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Cohort Studies ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Mutation ; Proto-Oncogene Proteins p21(ras)/genetics
    Chemical Substances KRAS protein, human ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2023-07-25
    Publishing country Italy
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2397359-6
    ISSN 1699-3055 ; 1699-048X
    ISSN (online) 1699-3055
    ISSN 1699-048X
    DOI 10.1007/s12094-023-03279-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The role of RhoA/Rho kinase pathway in endothelial dysfunction.

    Yao, Lin / Romero, Maritza J / Toque, Haroldo A / Yang, Guang / Caldwell, Ruth B / Caldwell, R William

    Journal of cardiovascular disease research

    2011  Volume 1, Issue 4, Page(s) 165–170

    Abstract: Endothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK) pathway has been found to elevate vascular tone through unbalancing ... ...

    Abstract Endothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK) pathway has been found to elevate vascular tone through unbalancing the production of vasodilating and vasoconstricting substances. Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a variety of pathological conditions. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of the ROCK pathway and its roles in endothelial dysfunction.
    Language English
    Publishing date 2011-01-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 2571611-6
    ISSN 0976-2833 ; 0975-3583
    ISSN (online) 0976-2833
    ISSN 0975-3583
    DOI 10.4103/0975-3583.74258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Role of Adipose Tissue Endothelial ADAM17 in Age-Related Coronary Microvascular Dysfunction.

    Dou, Huijuan / Feher, Attila / Davila, Alec C / Romero, Maritza J / Patel, Vijay S / Kamath, Vinayak M / Gooz, Monika Beck / Rudic, R Daniel / Lucas, Rudolf / Fulton, David J / Weintraub, Neal L / Bagi, Zsolt

    Arteriosclerosis, thrombosis, and vascular biology

    2017  Volume 37, Issue 6, Page(s) 1180–1193

    Abstract: Objective: A disintegrin and metalloproteinase ADAM17 (tumor necrosis factor-α [TNF]-converting enzyme) regulates soluble TNF levels. We tested the hypothesis that aging-induced activation in adipose tissue (AT)-expressed ADAM17 contributes to the ... ...

    Abstract Objective: A disintegrin and metalloproteinase ADAM17 (tumor necrosis factor-α [TNF]-converting enzyme) regulates soluble TNF levels. We tested the hypothesis that aging-induced activation in adipose tissue (AT)-expressed ADAM17 contributes to the development of remote coronary microvascular dysfunction in obesity.
    Approach and results: Coronary arterioles (CAs, ≈90 µm) from right atrial appendages and mediastinal AT were examined in patients (aged: 69±11 years, BMI: 30.2±5.6 kg/m
    Conclusions: The present study indicates that aging and obesity cooperatively reduce caveolin-1 expression and increase vascular endothelial ADAM17 activity and soluble TNF release in AT, which may contribute to the development of remote coronary microvascular dysfunction in older obese patients.
    MeSH term(s) ADAM17 Protein/genetics ; ADAM17 Protein/metabolism ; Adipose Tissue/enzymology ; Adipose Tissue/transplantation ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Aging/genetics ; Aging/metabolism ; Animals ; Arterioles/enzymology ; Arterioles/physiopathology ; Caveolin 1/deficiency ; Caveolin 1/genetics ; Caveolin 1/metabolism ; Cells, Cultured ; Coronary Artery Disease/enzymology ; Coronary Artery Disease/genetics ; Coronary Artery Disease/physiopathology ; Coronary Vessels/enzymology ; Coronary Vessels/physiopathology ; Diet, High-Fat ; Disease Models, Animal ; Endothelial Cells/enzymology ; Female ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; Obesity/enzymology ; Obesity/genetics ; Obesity/physiopathology ; RNA Interference ; Risk Factors ; Signal Transduction ; Transfection ; Tumor Necrosis Factor-alpha/metabolism ; Vasodilation
    Chemical Substances CAV1 protein, human ; Cav1 protein, mouse ; Caveolin 1 ; Tumor Necrosis Factor-alpha ; ADAM17 Protein (EC 3.4.24.86) ; ADAM17 protein, human (EC 3.4.24.86) ; Adam17 protein, mouse (EC 3.4.24.86)
    Language English
    Publishing date 2017-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.117.309430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Streptococcus pneumoniae

    Gonzales, Joyce / Chakraborty, Trinad / Romero, Maritza / Mraheil, Mobarak Abu / Kutlar, Abdullah / Pace, Betty / Lucas, Rudolf

    Toxins

    2021  Volume 13, Issue 2

    Abstract: Sickle cell disease (SCD) is one of the most common autosomal recessive disorders in the world. Due to functional asplenia, a dysfunctional antibody response, antibiotic drug resistance and poor response to immunization, SCD patients have impaired ... ...

    Abstract Sickle cell disease (SCD) is one of the most common autosomal recessive disorders in the world. Due to functional asplenia, a dysfunctional antibody response, antibiotic drug resistance and poor response to immunization, SCD patients have impaired immunity. A leading cause of hospitalization and death in SCD patients is the acute chest syndrome (ACS). This complication is especially manifested upon infection of SCD patients with
    MeSH term(s) Acute Chest Syndrome/diagnosis ; Acute Chest Syndrome/drug therapy ; Acute Chest Syndrome/microbiology ; Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/diagnosis ; Animals ; Anti-Bacterial Agents/therapeutic use ; Bacterial Proteins/metabolism ; Host-Pathogen Interactions ; Humans ; Hydrogen Peroxide/metabolism ; Pneumonia, Pneumococcal/diagnosis ; Pneumonia, Pneumococcal/drug therapy ; Pneumonia, Pneumococcal/microbiology ; Prognosis ; Risk Factors ; Streptococcus pneumoniae/drug effects ; Streptococcus pneumoniae/metabolism ; Streptococcus pneumoniae/pathogenicity ; Streptolysins/metabolism ; Virulence ; Virulence Factors/metabolism
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; Streptolysins ; Virulence Factors ; plY protein, Streptococcus pneumoniae ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2021-02-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins13020157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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