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Article ; Online: ASO Author Reflections: Do Patients with Ipsilateral Breast Tumor Recurrence Prefer Repeat Breast-Conserving Surgery or Mastectomy?

Seto, Yukiko / Ishitobi, Makoto / Nakayama, Takahiro

2024

Language	English
Publishing date	2024-04-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-024-15363-0
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Zs.A 4042: Show issues

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Article ; Online: Corrigendum to 'Acquisition and processing of high-speed atomic force microscopy videos for single amyloid aggregate observation' [Methods (2022), 197, 4-12].

Watanabe-Nakayama, Takahiro / Ono, Kenjiro

Methods (San Diego, Calif.)

2022 Volume 199, Page(s) 80

Language	English
Publishing date	2022-02-04
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1066584-5
ISSN	1095-9130 ; 1046-2023
ISSN (online)	1095-9130
ISSN	1046-2023
DOI	10.1016/j.ymeth.2022.01.010
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Zs.A 3239: Show issues

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Article ; Online: Single-molecule observation of self-propagating amyloid fibrils.

Watanabe-Nakayama, Takahiro / Ono, Kenjiro

Microscopy (Oxford, England)

2022 Volume 71, Issue 3, Page(s) 133–141

Abstract: The assembly of misfolded proteins into amyloid fibrils is associated with amyloidosis, including neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases. The self-propagation of amyloid fibrils is widely observed in the ... ...

Abstract	The assembly of misfolded proteins into amyloid fibrils is associated with amyloidosis, including neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases. The self-propagation of amyloid fibrils is widely observed in the aggregation pathways of numerous amyloidogenic proteins. This propensity with plasticity in primary nucleation allows amyloid fibril polymorphism, which is correlated with the pathology/phenotypes of patients. Because the interference with the nucleation and replication processes of amyloid fibrils can alter the amyloid structure and the outcome of the disease, these processes can be a target for developing clinical drugs. Single-molecule observations of amyloid fibril replication can be an experimental system to provide the kinetic parameters for simulation studies and confirm the effect of clinical drugs. Here, we review the single-molecule observation of the amyloid fibril replication process using fluorescence microscopy and time-lapse atomic force microscopy, including high-speed atomic force microscopy. We discussed the amyloid fibril replication process and combined single-molecule observation results with molecular dynamics simulations.
MeSH term(s)	Amyloid/chemistry ; Humans ; Kinetics ; Microscopy, Atomic Force ; Microscopy, Fluorescence ; Molecular Dynamics Simulation
Chemical Substances	Amyloid
Language	English
Publishing date	2022-03-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2707496-1
ISSN	2050-5701 ; 2050-5698
ISSN (online)	2050-5701
ISSN	2050-5698
DOI	10.1093/jmicro/dfac011
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Article ; Online: Stage at diagnosis of colorectal cancer through diagnostic route: Who should be screened?

Agatsuma, Nobukazu / Utsumi, Takahiro / Nishikawa, Yoshitaka / Horimatsu, Takahiro / Seta, Takeshi / Yamashita, Yukitaka / Tanaka, Yukari / Inoue, Takahiro / Nakanishi, Yuki / Shimizu, Takahiro / Ohno, Mikako / Fukushima, Akane / Nakayama, Takeo / Seno, Hiroshi

World journal of gastroenterology

2024 Volume 30, Issue 10, Page(s) 1368–1376

Abstract: Background: Colorectal cancer (CRC) is a global health concern, with advanced-stage diagnoses contributing to poor prognoses. The efficacy of CRC screening has been well-established; nevertheless, a significant proportion of patients remain unscreened, ... ...

Abstract	Background: Colorectal cancer (CRC) is a global health concern, with advanced-stage diagnoses contributing to poor prognoses. The efficacy of CRC screening has been well-established; nevertheless, a significant proportion of patients remain unscreened, with > 70% of cases diagnosed outside screening. Although identifying specific subgroups for whom CRC screening should be particularly recommended is crucial owing to limited resources, the association between the diagnostic routes and identification of these subgroups has been less appreciated. In the Japanese cancer registry, the diagnostic routes for groups discovered outside of screening are primarily categorized into those with comorbidities found during hospital visits and those with CRC-related symptoms. Aim: To clarify the stage at CRC diagnosis based on diagnostic routes. Methods: We conducted a retrospective observational study using a cancer registry of patients with CRC between January 2016 and December 2019 at two hospitals. The diagnostic routes were primarily classified into three groups: Cancer screening, follow-up, and symptomatic. The early-stage was defined as Stages 0 or I. Multivariate and univariate logistic regressions were exploited to determine the odds of early-stage diagnosis in the symptomatic and cancer screening groups, referencing the follow-up group. The adjusted covariates were age, sex, and tumor location. Results: Of the 2083 patients, 715 (34.4%), 1064 (51.1%), and 304 (14.6%) belonged to the follow-up, symptomatic, and cancer screening groups, respectively. Among the 2083 patients, CRCs diagnosed at an early stage were 57.3% (410 of 715), 23.9% (254 of 1064), and 59.5% (181 of 304) in the follow-up, symptomatic, and cancer screening groups, respectively. The symptomatic group exhibited a lower likelihood of early-stage diagnosis than the follow-up group [ Conclusion: CRCs detected during hospital visits for comorbidities were diagnosed earlier, similar to cancer screening. CRC screening should be recommended, particularly for patients without periodical hospital visits for comorbidities.
MeSH term(s)	Humans ; Colonoscopy ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/pathology ; Early Detection of Cancer ; Logistic Models ; Retrospective Studies ; Male ; Female
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v30.i10.1368
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Article ; Online: Chromatin accessibility analysis suggested vascular induction of the biliary epithelium via the Notch signaling pathway in the human liver.

Yoshihara, Masaharu / Nakayama, Takahiro / Takahashi, Satoru

BMC research notes

2023 Volume 16, Issue 1, Page(s) 379

Abstract: The biliary epithelial cells (cholangiocytes) in the liver originate from undifferentiated liver parenchymal cells (hepatoblasts) that are located adjacent to the portal vein. This differentiation process is driven by Notch signaling, which is recognized ...

Abstract	The biliary epithelial cells (cholangiocytes) in the liver originate from undifferentiated liver parenchymal cells (hepatoblasts) that are located adjacent to the portal vein. This differentiation process is driven by Notch signaling, which is recognized for generating salt-and-pepper (fine-grained) patterns, in contrast to one- or two-cell layer (spatially confined) patterning in cholangiocyte differentiation. It is unclear how Notch signaling acts and localizes only in cholangiocytes. A computer simulation study suggested that low production rates of the ligands or receptors of Notch signaling are crucial for the spatially confined patterning, although biochemical examination is lacking. Here, we analyzed a publicly available single-cell ATAC-sequencing dataset from human fetal liver samples. We showed high chromatin accessibility for the ligands only in vascular cells, while that for the receptor is limited to a small population of hepatoblasts. This finding strengthens the previously proposed idea that low production rates of the ligands or receptors of Notch signaling enable vascular induction of cholangiocytes.
MeSH term(s)	Humans ; Chromatin/metabolism ; Computer Simulation ; Liver/metabolism ; Signal Transduction ; Epithelium ; Bile Ducts/metabolism
Chemical Substances	Chromatin
Language	English
Publishing date	2023-12-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2413336-X
ISSN	1756-0500 ; 1756-0500
ISSN (online)	1756-0500
ISSN	1756-0500
DOI	10.1186/s13104-023-06674-8
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Article ; Online: Linderapyrone analogue LPD-01 as a cancer treatment agent by targeting importin7.

Kitagawa, Takahiro / Matsumoto, Takahiro / Ohta, Tomoe / Yoshida, Tatsusada / Saito, Youhei / Nakayama, Yuji / Hadate, Yuki / Ashihara, Eishi / Watanabe, Tetsushi

Journal of natural medicines

2024 Volume 78, Issue 2, Page(s) 370–381

Abstract: The Wnt/β-catenin signaling pathway plays important roles in several cancer cells, including cell proliferation and development. We previously succeeded in synthesizing a small molecule compound inhibiting the Wnt/β-catenin signaling pathway, named LPD- ... ...

Abstract	The Wnt/β-catenin signaling pathway plays important roles in several cancer cells, including cell proliferation and development. We previously succeeded in synthesizing a small molecule compound inhibiting the Wnt/β-catenin signaling pathway, named LPD-01 (1), and 1 inhibited the growth of human colorectal cancer (HT-29) cells. In this study, we revealed that 1 inhibits the growth of HT-29 cells stronger than that of another human colorectal cancer (SW480) cells. Therefore, we have attempted to identify the target proteins of 1 in HT-29 cells. Firstly, we investigated the effect on the expression levels of the Wnt/β-catenin signaling pathway-related proteins. As a result, 1 inhibited the expression of target proteins of Wnt/β-catenin signaling pathway (c-Myc and Survivin) and their genes, whereas the amount of transcriptional co-activator (β-catenin) was not decreased, suggesting that 1 inhibited the Wnt/β-catenin signaling pathway without affecting β-catenin. Next, we investigated the target proteins of 1 using magnetic FG beads. Chemical pull-down assay combined with mass spectrometry suggested that 1 directly binds to importin7. As expected, 1 inhibited the nuclear translocation of importin7 cargoes such as Smad2 and Smad3 in TGF-β-stimulated HT-29 cells. In addition, the knockdown of importin7 by siRNA reduced the expression of target genes of Wnt/β-catenin signaling pathway. These results suggest that importin7 is one of the target proteins of 1 for inhibition of the Wnt/β-catenin signaling pathway.
MeSH term(s)	Humans ; beta Catenin/metabolism ; Wnt Signaling Pathway ; Cell Proliferation ; Colorectal Neoplasms/drug therapy ; Cell Line, Tumor
Chemical Substances	beta Catenin
Language	English
Publishing date	2024-01-24
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2227540-X
ISSN	1861-0293 ; 1340-3443
ISSN (online)	1861-0293
ISSN	1340-3443
DOI	10.1007/s11418-023-01774-y
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Article: Laugier-Hunziker Syndrome: A Rare Cause of Oral Mucosa Pigmentation.

Iijima, Yosuke / Nakayama, Nami / Yamada, Miki / Hino, Shunsuke / Horie, Norio / Kaneko, Takahiro

Gerontology & geriatric medicine

2023 Volume 9, Page(s) 23337214231191295

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-08-08
Publishing country	United States
Document type	Case Reports
ZDB-ID	2844974-5
ISSN	2333-7214 ; 2333-7214
ISSN (online)	2333-7214
ISSN	2333-7214
DOI	10.1177/23337214231191295
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Article ; Online: Evaluation of the effect of sagging correction calibration errors in radiotherapy software on image matching.

Yamazawa, Yumi / Osaka, Akitane / Fujii, Yasushi / Nakayama, Takahiro / Nishioka, Kunio / Tanabe, Yoshinori

Physical and engineering sciences in medicine

2024

Abstract: To investigate the impact of sagging correction calibration errors in radiotherapy software on image matching. Three software applications were used, with and without a polymethyl methacrylate rod supporting the ball bearings (BB). The calibration error ... ...

Abstract	To investigate the impact of sagging correction calibration errors in radiotherapy software on image matching. Three software applications were used, with and without a polymethyl methacrylate rod supporting the ball bearings (BB). The calibration error for sagging correction across nine flex maps (FMs) was determined by shifting the BB positions along the Left-Right (LR), Gun-Target (GT), and Up-Down (UD) directions from the reference point. Lucy and pelvic phantom cone-beam computed tomography (CBCT) images underwent auto-matching after modifying each FM. Image deformation was assessed in orthogonal CBCT planes, and the correlations among BB shift magnitude, deformation vector value, and differences in auto-matching were analyzed. The average difference in analysis results among the three softwares for the Winston-Lutz test was within 0.1 mm. The determination coefficients (R
Language	English
Publishing date	2024-02-19
Publishing country	Switzerland
Document type	Journal Article
ISSN	2662-4737
ISSN (online)	2662-4737
DOI	10.1007/s13246-024-01388-y
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Article: Do maxillary dentures protect the skull base from penetration injury?

Hino, Shunsuke / Iijima, Yosuke / Mochizuki, Shuto / Nakayama, Nami / Yamada, Miki / Horie, Norio / Kaneko, Takahiro

Clinical case reports

2024 Volume 12, Issue 3, Page(s) e8611

Abstract: Key clinical message: Foreign bodies penetrating from the oral cavity can damage surrounding tissues. This case is considered an extremely rare and fortunate instance in which a maxillary denture appeared to weaken the external force and change the ... ...

Abstract	Key clinical message: Foreign bodies penetrating from the oral cavity can damage surrounding tissues. This case is considered an extremely rare and fortunate instance in which a maxillary denture appeared to weaken the external force and change the direction of the scissors, preventing damage to vital organs. Abstract: The patient was a 73-year-old man. While on a ladder pruning a plant, he accidentally fell. The gardening scissors passed through the maxillary sinus from the maxillary alveolus and penetrated below the zygomatic arch. At the time of injury, the patient was wearing a metal-frame denture on the maxilla, and contact between the cutting edge and the denture was speculated to have weakened the piercing force of the blade and changed the direction of the cutting edge. This extremely rare case demonstrates how a maxillary denture could reduce the severity of a penetrating injury caused by scissors.
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.8611
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Article ; Online: Prognostic impact of clinical and radiological factors on leptomeningeal metastasis from solid cancers.

Nakagawa, Kanji / Takano, Koji / Nishino, Kazumi / Ohe, Shuichi / Nakayama, Takahiro / Arita, Hideyuki

Journal of neuro-oncology

2024

Abstract: Purpose: The number of leptomeningeal metastasis (LM) patients has increased in recent years, as the cancer survival rates increased. An optimal prediction of prognosis is essential for selecting an appropriate treatment. The European Association of ... ...

Abstract	Purpose: The number of leptomeningeal metastasis (LM) patients has increased in recent years, as the cancer survival rates increased. An optimal prediction of prognosis is essential for selecting an appropriate treatment. The European Association of Neuro-Oncology-European Society for Medical Oncology (EANO-ESMO) guidelines for LM proposed a classification based on the cerebrospinal fluid cytological findings and contrast-enhanced magnetic resonance imaging (MRI) pattern. However, few studies have validated the utility of this classification. This study aimed to investigate the prognostic factors of LM, including the radiological and cytological types. Methods: We retrospectively analyzed the data of 240 adult patients with suspected LM who had undergone lumbar puncture between April 2014 and September 2021. Results: The most common primary cancer types were non-small-cell lung cancer (NSCLC) (143 (60%)) and breast cancer (27 (11%)). Positive cytology results and the presence of leptomeningeal lesions on contrast-enhanced MRI correlated with decreased survival in all patients. Nodular lesions detected on contrast-enhanced magnetic resonance were a poor prognostic factor in cytology-negative patients, while contrast-enhanced patterns had no prognostic significance in cytology-positive patients. Systemic therapy using cytotoxic agents and molecular-targeted therapy after LM diagnosis correlated with prolonged survival, regardless of the cytology results. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor treatment and systemic chemotherapy after LM improved the survival of EGFR-mutated and wild-type NSCLC patients with positive cytology results. Conclusions: This study validated the efficacy of prognostication according to the EANO-ESMO guidelines for LM. Systemic therapy after LM diagnosis improves the survival of NSCLC patients.
Language	English
Publishing date	2024-03-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	604875-4
ISSN	1573-7373 ; 0167-594X
ISSN (online)	1573-7373
ISSN	0167-594X
DOI	10.1007/s11060-024-04616-3
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