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Article ; Online: Giuseppe Dagnini (1866-1928): Discoverer of the Trigemino-Cardiac Reflex and Practical Implications in Neurosurgery and Other Medical Specialties.

La Corte, Emanuele / Gelmi, Clarissa Ann Elisabeth / Bertolini, Giacomo / Ruggiero, Federica / Younus, Iyan / Sturiale, Carmelo / Mazzatenta, Diego / Conti, Alfredo / Aspide, Raffaele

World neurosurgery

2024 Volume 186, Page(s) 116–121

Abstract: The authors present the life and art of Giuseppe Dagnini, a renowned Italian physician who was born ...

Abstract	The authors present the life and art of Giuseppe Dagnini, a renowned Italian physician who was born in Bologna in 1866. He was the chief of the Maggiore Hospital in Bologna and authored valuable scientific works on the trigemino-cardiac reflex which is still applied in modern clinical practice. Dr. Dagnini firstly described the reflex in 1908 postulating that stimulation of one of the 3 branches of the trigeminal nerve triggers the afferent pathway in lowering heart rate. The authors also provide a modern outlook on the clinical implications of the TCR in neurosurgery, neuroanesthesia, and other medical specialties.
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2024.03.086
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Zs.A 1159: Show issues

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Article ; Online: Image-guided biopsy of intracranial lesions in children, with a small robotic device: a case series.

Spennato, Pietro / Di Costanzo, Marianna / Mirone, Giuseppe / Cicala, Domenico / De Martino, Lucia / Onorini, Nicola / Ruggiero, Claudio / Cinalli, Giuseppe

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

2024

Abstract: Background and objectives: Robot-assisted biopsies have gained popularity in the last years. Most robotic procedures are performed with a floor-based robotic arm. Recently, Medtronic Stealth Autoguide, a miniaturized robotic arm that work together with ... ...

Abstract	Background and objectives: Robot-assisted biopsies have gained popularity in the last years. Most robotic procedures are performed with a floor-based robotic arm. Recently, Medtronic Stealth Autoguide, a miniaturized robotic arm that work together with an optical neuronavigation system, was launched. Its application in pediatric cases is relatively unexplored. In this study, we retrospectively report our experience using the Stealth Autoguide, for frameless stereotactic biopsies in pediatric patients. Methods: Pediatric patients who underwent stereotactic biopsy using the Stealth Autoguide cranial robotic platform from July 2020 to May 2023 were included in this study. Clinical, neuroradiological, surgical, and histological data were collected and analyzed. Results: Nineteen patients underwent 20 procedures (mean age was 9-year-old, range 1-17). In four patients, biopsy was part of a more complex surgical procedure (laser interstitial thermal therapy - LITT). The most common indication was diffuse intrinsic brain stem tumor, followed by diffuse supratentorial tumor. Nine procedures were performed in prone position, eight in supine position, and three in lateral position. Facial surface registration was adopted in six procedures, skull-fixed fiducials in 14. The biopsy diagnostic tissue acquisition rate was 100% in the patients who underwent only biopsy, while in the biopsy/LITT group, one case was not diagnostic. No patients developed clinically relevant postoperative complications. Conclusion: The Stealth Autoguide system has proven to be safe, diagnostic, and highly accurate in performing stereotactic biopsies for both supratentorial and infratentorial lesions in the pediatric population.
Language	English
Publishing date	2024-03-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	605988-0
ISSN	1433-0350 ; 0302-2803 ; 0256-7040
ISSN (online)	1433-0350
ISSN	0302-2803 ; 0256-7040
DOI	10.1007/s00381-024-06349-0
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Zs.A 2036: Show issues

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Article ; Online: Parotid squamous cell carcinoma metastases: Application of human papillomavirus -DNA test on liquid-based cytology to recognize oropharyngeal origin of the neoplasm.

Montella, Marco / Ruggiero, Raffaella / Savarese, Giovanni / Colella, Giuseppe / Ronchi, Andrea / Franco, Renato / Cozzolino, Immacolata

Diagnostic cytopathology

2024

Abstract: Malignancies of the parotid gland are relatively uncommon and in most cases are primary neoplasms; intraparotid metastases are rare. Oral and oropharyngeal squamous cell carcinoma (O- and OP-SCC) can potentially metastasize to the parotid gland or ... ...

Abstract	Malignancies of the parotid gland are relatively uncommon and in most cases are primary neoplasms; intraparotid metastases are rare. Oral and oropharyngeal squamous cell carcinoma (O- and OP-SCC) can potentially metastasize to the parotid gland or intraparotid lymph nodes. Fine-needle aspiration cytology (FNAC) serves as the initial diagnostic approach for this purpose. HPV status in FNAC specimens is relevant and can guide the diagnostic workup, indicating a potential oropharyngeal origin of the primary tumor. A small series of occult SCC metastases is presented below, in which HPV-DNA testing of FNAC specimens helped identify primary neoplasms located in the oropharynx. US-guided FNAC of parotid nodules was conducted by an experienced interventional cytopathologist in three cases. Each patient underwent assessment of direct smears, cell blocks, and liquid-based samples for HPV testing. The morphological and immunocytochemical features of SCC were documented, and real-time PCR was employed for the detection and genotyping of HPV. The role of HPV testing on FNAC specimens in pinpointing the primary neoplasms in the oropharynx is highlighted. Consequently, FNAC samples emerge as valuable diagnostic and prognostic tools in this context, providing essential insights for patient management.
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	632710-2
ISSN	1097-0339 ; 8755-1039
ISSN (online)	1097-0339
ISSN	8755-1039
DOI	10.1002/dc.25334
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Zs.A 2117: Show issues

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Article ; Online: Transversus abdominis plane block versus thoracic epidural analgesia for laparoscopic surgery: advancing the definitive evolution of ERAS?

Ruggiero, Alessandro / Papa, Mario V / Costa, Fabio / Strumia, Alessandro / Pascarella, Giuseppe / Carassiti, Massimiliano

Minerva anestesiologica

2023 Volume 90, Issue 1-2, Page(s) 104–106

MeSH term(s)	Humans ; Analgesia, Epidural ; Laparoscopy ; Nerve Block ; Abdominal Muscles
Language	English
Publishing date	2023-09-28
Publishing country	Italy
Document type	Journal Article
ZDB-ID	123584-9
ISSN	1827-1596 ; 0026-4717 ; 0375-9393
ISSN (online)	1827-1596
ISSN	0026-4717 ; 0375-9393
DOI	10.23736/S0375-9393.23.17657-7
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Zs.A 516: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The potential etiopathogenetic role and diagnostic utility of CD3

Rubino, Valentina / Leone, Stefania / Carriero, Flavia / Pane, Fabrizio / Ruggiero, Giuseppina / Terrazzano, Giuseppe

European journal of haematology

2023 Volume 110, Issue 5, Page(s) 578–579

MeSH term(s)	Humans ; T-Lymphocytes, Regulatory ; Killer Cells, Natural ; Myelodysplastic Syndromes/diagnosis ; CD56 Antigen ; CD3 Complex
Chemical Substances	CD56 Antigen ; CD3 Complex
Language	English
Publishing date	2023-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	392482-8
ISSN	1600-0609 ; 0902-4441
ISSN (online)	1600-0609
ISSN	0902-4441
DOI	10.1111/ejh.13931
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Zs.A 323: Show issues

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Book ; Online: Entanglement R\'enyi Entropies from Ballistic Fluctuation Theory

Del Vecchio, Giuseppe Del Vecchio / Doyon, Benjamin / Ruggiero, Paola

the free fermionic case

2023

Abstract: The large-scale behaviour of entanglement entropy in finite-density states, in and out of equilibrium, can be understood using the physical picture of particle pairs. However, the full theoretical origin of this picture is not fully established yet. In ... ...

Abstract	The large-scale behaviour of entanglement entropy in finite-density states, in and out of equilibrium, can be understood using the physical picture of particle pairs. However, the full theoretical origin of this picture is not fully established yet. In this work, we clarify this picture by investigating entanglement entropy using its connection with the large-deviation theory for thermodynamic and hydrodynamic fluctuations. We apply the universal framework of Ballistic Fluctuation Theory (BFT), based the Euler hydrodynamics of the model, to correlation functions of \emph{branch-point twist fields}, the starting point for computing R\'enyi entanglement entropies within the replica approach. Focusing on free fermionic systems in order to illustrate the ideas, we show that both the equilibrium behavior and the dynamics of R\'enyi entanglement entropies can be fully derived from the BFT. In particular, we emphasise that long-range correlations develop after quantum quenches, and accounting for these explain the structure of the entanglement growth. We further show that this growth is related to fluctuations of charge transport, generalising to quantum quenches the relation between charge fluctuations and entanglement observed earlier. The general ideas we introduce suggest that the large-scale behaviour of entanglement has its origin within hydrodynamic fluctuations. Comment: 53 pages, 2 figures
Keywords	Quantum Physics ; Condensed Matter - Statistical Mechanics
Subject code	612
Publishing date	2023-01-05
Publishing country	us
Document type	Book ; Online
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Article ; Online: Regulatory T

Carriero, Flavia / Rubino, Valentina / Leone, Stefania / Montanaro, Rosangela / Brancaleone, Vincenzo / Ruggiero, Giuseppina / Terrazzano, Giuseppe

Cells

2023 Volume 12, Issue 24

Abstract: The interplay between immune activation and immune regulation is a fundamental aspect of the functional harmony of the immune system. This delicate balance is essential to triggering correct and effective immune responses against pathogens while ... ...

Abstract	The interplay between immune activation and immune regulation is a fundamental aspect of the functional harmony of the immune system. This delicate balance is essential to triggering correct and effective immune responses against pathogens while preventing excessive inflammation and the immunopathogenic mechanisms of autoimmunity. The knowledge of all the mechanisms involved in immune regulation is not yet definitive, and, probably, the overall picture is much broader than what has been described in the scientific literature so far. Given the plasticity of the immune system and the diversity of organisms, it is highly probable that numerous other cells and molecules are still to be ascribed to the immune regulation process. Here, we report a general overview of how immune activation and regulation interact, based on the involvement of molecules and cells specifically dedicated to these processes. In addition, we discuss the role of T
MeSH term(s)	Humans ; Immunity ; Autoimmunity ; T-Lymphocytes, Regulatory ; Inflammation
Language	English
Publishing date	2023-12-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12242841
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Article ; Online: The fecal bacterial microbiota is not useful for discriminating between lymphoplasmacytic enteritis and low-grade intestinal T-cell lymphoma in cats nor for predicting therapeutic response.

Benvenuti, Elena / Ferriani, Riccardo / Gianella, Paola / Ruggiero, Pietro / Cagnasso, Federica / Borrelli, Antonio / Benvenuto, Giuseppe / Bertoldi, Loris / Bottero, Enrico

American journal of veterinary research

2024 Volume 85, Issue 4

Abstract: Objective: To evaluate the fecal bacterial microbiota at the time of diagnosis (T0) and after 1 month of therapy (T1) in cats diagnosed with lymphoplasmacytic enteritis (LPE) or cats with low-grade intestinal T-cell lymphoma (LGITL) and to compare these ...

Abstract	Objective: To evaluate the fecal bacterial microbiota at the time of diagnosis (T0) and after 1 month of therapy (T1) in cats diagnosed with lymphoplasmacytic enteritis (LPE) or cats with low-grade intestinal T-cell lymphoma (LGITL) and to compare these findings with those of healthy cats. Animals: 5 healthy cats, 13 cats with LPE, and 7 cats with LGITL were prospectively enrolled between June 2020 and June 2021. Methods: Fecal samples were collected at T0 and T1, and DNA was extracted for 16S ribosomal amplicon sequencing. Alpha diversity and beta diversity were computed. The taxonomic assignment was performed using sequences from the Silva v138 formatted reference database. Differential abundant taxa were selected in each taxonomic level, with the P value adjusted < .05, as the cut-off. Results: No significant differences in alpha and beta diversity were found either at T0 or T1 between healthy and diseased cats or between cats with LPE and LGITL. Beta-diversity analysis showed an increase in the Fusobacteriaceae family in cats with LGITL at T0, compared to cats with LPE. Regardless of histological diagnosis, several microbiota differences were found at T0 based on serum cobalamin levels. Clinical relevance: Fecal samples were successfully used to characterize the bacteriome of the intestinal tract in cats by 16S rRNA gene sequencing. However, results highlighted that the metagenomic evaluation was not useful to discriminate between LPE and LGITL nor to predict the therapeutic response in this study population.
MeSH term(s)	Humans ; Cats ; Animals ; RNA, Ribosomal, 16S/genetics ; Enteritis/diagnosis ; Enteritis/veterinary ; Feces/microbiology ; Bacteria ; Microbiota ; Lymphoma, T-Cell/veterinary ; Cat Diseases/diagnosis
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	390796-x
ISSN	1943-5681 ; 0002-9645
ISSN (online)	1943-5681
ISSN	0002-9645
DOI	10.2460/ajvr.23.11.0251
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Zs.A 422: Show issues

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Article ; Online: Efficacy and safety of deucravacitinib for the management of psoriasis: a drug safety evaluation.

Potestio, Luca / Tommasino, Nello / Lauletta, Giuseppe / Feo, Federica / Ruggiero, Angelo / Martora, Fabrizio / Portarapillo, Antonio / Guerriero, Luigi / Megna, Matteo

Expert opinion on drug safety

2024

Abstract: Introduction: Nowadays, despite the wide availability of biological drugs and apremilast for psoriasis management, there is always a need for new therapies to customize the therapeutic approach on the basis of the patient's clinical features and ... ...

Abstract	Introduction: Nowadays, despite the wide availability of biological drugs and apremilast for psoriasis management, there is always a need for new therapies to customize the therapeutic approach on the basis of the patient's clinical features and comorbidities, especially in order to achieve a prolonged therapeutic response. Thus, new treatment strategies are required to offer patients a personalized approach. In this scenario, major knowledge on psoriasis pathogenesis led to the development of deucravacitinib, an orally administered selective TYK2 inhibitor. Areas covered: The aim of this manuscript is to review current literature on the effectiveness and safety of deucravacitinib in psoriasis to offer readers a wide perspective. The current English literature was analyzed using the PubMed, Google Scholar, Embase, Cochrane Skin, and clinicaltrials.gov databases, selecting the most relevant manuscripts. Expert opinion: Deucravacitinib appears to be an innovative weapon for the management of moderate to severe psoriasis. Despite its efficacy and safety profiles have been revealed by RCTs, real-life data are still scant. Certainly, deucravacitinib broadens the range of therapeutic alternatives for psoriasis patients, thus enhancing the holistic and personalized approach required for the treatment of this disease.
Language	English
Publishing date	2024-05-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2088728-0
ISSN	1744-764X ; 1474-0338
ISSN (online)	1744-764X
ISSN	1474-0338
DOI	10.1080/14740338.2024.2351462
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Zs.A 6096: Show issues

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Article ; Online: The effect of image-guided ventricular catheter placement on shunt failure: a systematic review and meta-analysis.

Spennato, Pietro / Vitulli, Francesca / Onorini, Nicola / Imperato, Alessia / Mirone, Giuseppe / Ruggiero, Claudio / Cinalli, Giuseppe

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

2022 Volume 38, Issue 6, Page(s) 1069–1076

Abstract: Introduction: Cerebrospinal fluid (CSF) diversion for the treatment of hydrocephalus is one of the most common neurosurgical procedures. Over the years, the development of the neuronavigation system has allowed the surgeon to be guided in real time ... ...

Abstract	Introduction: Cerebrospinal fluid (CSF) diversion for the treatment of hydrocephalus is one of the most common neurosurgical procedures. Over the years, the development of the neuronavigation system has allowed the surgeon to be guided in real time during the procedures. Nevertheless, to date, the revision rate remains as high as 30-40%. The aim of this study was to investigate the role of intraoperative image guidance in the prevention of shunt failure. We herein report the first literature meta-analysis of image guidance and shunt revision rate in the pediatric population. Methods: Principal online databases were searched for English-language articles published between January, 1980, and December, 2021. Analysis was limited to articles that included patients younger than 18 years of age at the time of primary V-P shunt. Articles reporting combined results of free-hand and image-guided placement of ventricular catheter (VC) were included. The main outcome measure of the study was the revision rate in relation to the intraoperative tools. Secondary variables collected were the age of the patient and ventricle size. Statistical analyses and meta-analysis plots were done via R and RStudio. Heterogeneity was formally assessed using Q, I Result: A total of 9 studies involving 2017 pediatric patients were included in the meta-analysis. 55.9% of procedures were carried out with the aid of intraoperative tools, while 44.1% procedures were conducted free hand. The intraoperative tools used were ultrasound (9.1%), electromagnetic neuronavigation (21.07%), endoscope (67.32%), and combined images (2.4%).The image-guided placement of VC was not statistically associated with a lower revision rate. The pooled OR was 0.97 [CI 95% 0.88-1.07] with an I Conclusion: Our analysis suggest images guidance during VC shunt placement does not statistically affect shunt survival. Nevertheless, intraoperative tools can support the surgeon especially in patients with difficult anatomy, slit ventricles or complex loculated hydrocephalus.
MeSH term(s)	Catheters ; Cerebral Ventricles/diagnostic imaging ; Cerebral Ventricles/surgery ; Cerebrospinal Fluid Shunts/methods ; Child ; Humans ; Hydrocephalus/surgery ; Neuronavigation/methods ; Ventriculoperitoneal Shunt/methods
Language	English
Publishing date	2022-05-03
Publishing country	Germany
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	605988-0
ISSN	1433-0350 ; 0302-2803 ; 0256-7040
ISSN (online)	1433-0350
ISSN	0302-2803 ; 0256-7040
DOI	10.1007/s00381-022-05547-y
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