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Article: Ozone Exerts Cytoprotective and Anti-Inflammatory Effects in Cardiomyocytes and Skin Fibroblasts after Incubation with Doxorubicin.

Simonetti, V / Quagliariello, V / Franzini, M / Iaffaioli, R V / Maurea, N / Valdenassi, L

Evidence-based complementary and alternative medicine : eCAM

2019 Volume 2019, Page(s) 2169103

Abstract: Introduction: Skin reactions and cardiotoxicity are one of the most common side effects of doxorubicin in cancer patients. The main mechanisms based on the etiopathogenesis of these reactions are mediated by the overproduction of proinflammatory ... ...

Abstract	Introduction: Skin reactions and cardiotoxicity are one of the most common side effects of doxorubicin in cancer patients. The main mechanisms based on the etiopathogenesis of these reactions are mediated by the overproduction of proinflammatory cytokines, metalloproteases, and the disruption of mitochondrial homeostasis. Ozone therapy demonstrated anti-inflammatory effects in several preclinical and clinical studies. The aim of this research is based on the evaluation of cardioprotective and dermatoprotective effects of ozone during incubation with doxorubicin, giving preliminary evidences for further studies in the field of cardio-oncology. Methods: Human skin fibroblast cells and human fetal cardiomyocytes were exposed to doxorubicin at subclinical concentration (100 nM) alone or combined with ozone concentrated from 10 up to 50 Results: Ozone decreased significantly the cytotoxicity of doxorubicin in skin fibroblasts and cardiomyocytes after 24 h of incubation. The best cytoprotective effect of ozone was reached to 30 Conclusion: Ozone exerts cardioprotective and dermatoprotective effects during incubation with doxorubicin, and the involved mechanisms are mediated by its anti-inflammatory effects. The overall picture described herein is a pilot study for preclinical studies in oncology.
Language	English
Publishing date	2019-11-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2019/2169103
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Article ; Online: Ozone Exerts Cytoprotective and Anti-Inflammatory Effects in Cardiomyocytes and Skin Fibroblasts after Incubation with Doxorubicin

V. Simonetti / V. Quagliariello / M. Franzini / R. V. Iaffaioli / N. Maurea / L. Valdenassi

Evidence-Based Complementary and Alternative Medicine, Vol

2019 Volume 2019

Abstract: Introduction. Skin reactions and cardiotoxicity are one of the most common side effects of doxorubicin in cancer patients. The main mechanisms based on the etiopathogenesis of these reactions are mediated by the overproduction of proinflammatory ... ...

Abstract	Introduction. Skin reactions and cardiotoxicity are one of the most common side effects of doxorubicin in cancer patients. The main mechanisms based on the etiopathogenesis of these reactions are mediated by the overproduction of proinflammatory cytokines, metalloproteases, and the disruption of mitochondrial homeostasis. Ozone therapy demonstrated anti-inflammatory effects in several preclinical and clinical studies. The aim of this research is based on the evaluation of cardioprotective and dermatoprotective effects of ozone during incubation with doxorubicin, giving preliminary evidences for further studies in the field of cardio-oncology. Methods. Human skin fibroblast cells and human fetal cardiomyocytes were exposed to doxorubicin at subclinical concentration (100 nM) alone or combined with ozone concentrated from 10 up to 50 μg/mL. Cell viability and multiple anti-inflammatory studies were performed in both cell lines, with particular attention on the quantification of interleukins, leukotriene B4, NF-κB, and Nrf2 expressions during treatments. Results. Ozone decreased significantly the cytotoxicity of doxorubicin in skin fibroblasts and cardiomyocytes after 24 h of incubation. The best cytoprotective effect of ozone was reached to 30 μg/mL with a plateau phase at higher concentration. Ozone also demonstrated anti-inflammatory effects decreasing significantly the interleukins and proinflammatory mediators in both cells. Conclusion. Ozone exerts cardioprotective and dermatoprotective effects during incubation with doxorubicin, and the involved mechanisms are mediated by its anti-inflammatory effects. The overall picture described herein is a pilot study for preclinical studies in oncology.
Keywords	Other systems of medicine ; RZ201-999
Subject code	571
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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Article ; Online: Reasons why COVID-19 survivors should follow dietary World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations: from hyper-inflammation to cardiac dysfunctions.

Quagliariello, V / D'Aiuto, G / Iaffaioli, R V / Berretta, M / Buccolo, S / Iovine, M / Paccone, A / Cerrone, F / Bonanno, S / Nunnari, G / Laganà, N / Botti, G / Maurea, N

European review for medical and pharmacological sciences

2021 Volume 25, Issue 10, Page(s) 3898–3907

Abstract: The World Cancer Research Fund and American Institute for Cancer Research (WCRF/AICR) advise cancer survivors to follow their lifestyle recommendations for cancer prevention. Recent research indicates that a proper diet could exerts beneficial metabolic ...

Abstract	The World Cancer Research Fund and American Institute for Cancer Research (WCRF/AICR) advise cancer survivors to follow their lifestyle recommendations for cancer prevention. Recent research indicates that a proper diet could exerts beneficial metabolic and immune effects in humans through the involvement of several, not yet properly known, metabolic pathways. Here, we argue that following WCRF/AICR recommendations could be a strategy to prevent cardiovascular outcomes [fulminant myocarditis, heart failure, venous thromboembolism (VTE)] and acute respiratory distress syndrome (ARDS) in patients during follow-up post COVID-19 infection. We discuss the metabolic effects of a WCRF/AICR based diet, highlighting on the involved cardio-metabolic pathways related on NLRP3 inflammasome-cytokines axis aimed to improve prognosis of COVID-19, especially in patients with cancer.
MeSH term(s)	Alcohol Drinking ; Body Weight ; COVID-19/complications ; COVID-19/pathology ; COVID-19/virology ; Carbonated Beverages ; Cytokines/metabolism ; Diet ; Guidelines as Topic ; Humans ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Neoplasms/complications ; Neoplasms/pathology ; Prognosis ; Red Meat ; Risk Factors ; SARS-CoV-2/isolation & purification ; Survivors
Chemical Substances	Cytokines ; NLR Family, Pyrin Domain-Containing 3 Protein
Language	English
Publishing date	2021-06-10
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202105_25957
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Article ; Online: Low doses of Bisphenol A have pro-inflammatory and pro-oxidant effects, stimulate lipid peroxidation and increase the cardiotoxicity of Doxorubicin in cardiomyoblasts.

Quagliariello, V / Coppola, C / Mita, D G / Piscopo, G / Iaffaioli, R V / Botti, G / Maurea, N

Environmental toxicology and pharmacology

2019 Volume 69, Page(s) 1–8

Abstract: Endocrine disrupters are strictly associated to cancer and several cardiovascular risk factors. Bisphenol A (BPA) is an endocrine disrupter commonly used in the manufacturing of plastics based on polycarbonate, polyvinyl chloride and resins. Our study ... ...

Abstract	Endocrine disrupters are strictly associated to cancer and several cardiovascular risk factors. Bisphenol A (BPA) is an endocrine disrupter commonly used in the manufacturing of plastics based on polycarbonate, polyvinyl chloride and resins. Our study aims to investigate whether BPA may cause pro-oxidative and pro-inflammatory effects on cardiomyoblasts, thus exacerbating the Doxorubicin (DOXO)-induced cardiotoxicity phenomena. We tested the metabolic effects of BPA at low doses analyzing its affections on the intracellular calcium uptake, oxidative stress, lipid peroxidation and production of nitric oxide and interleukins. Co-incubation of BPA and DOXO significantly reduced the cardiomyoblast viability, compared to only DOXO exposure cells. The mechanisms underlying these effects are based on the stimulation of the intracellular calcium accumulation and lipid peroxidation. Notably, BPA increase the production of pro-inflammatory interleukins involved in cardiovascular diseases as well as in DOXO-Induced cardiotoxicity phenomena. This study provides a rationale for translational studies in the field of cardio-oncology.
MeSH term(s)	Animals ; Antibiotics, Antineoplastic/toxicity ; Benzhydryl Compounds/toxicity ; Calcium/metabolism ; Cardiotoxicity/etiology ; Cardiotoxicity/metabolism ; Cell Line, Tumor ; Cytokines/metabolism ; Doxorubicin/toxicity ; Drug Synergism ; Endocrine Disruptors/toxicity ; Inflammation/chemically induced ; Inflammation/immunology ; Inflammation/metabolism ; Lipid Peroxidation/drug effects ; Myoblasts, Cardiac/drug effects ; Myoblasts, Cardiac/metabolism ; Nitric Oxide/metabolism ; Oxidative Stress/drug effects ; Phenols/toxicity ; Rats ; Reactive Oxygen Species/metabolism
Chemical Substances	Antibiotics, Antineoplastic ; Benzhydryl Compounds ; Cytokines ; Endocrine Disruptors ; Phenols ; Reactive Oxygen Species ; Nitric Oxide (31C4KY9ESH) ; Doxorubicin (80168379AG) ; bisphenol A (MLT3645I99) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2019-03-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1318302-3
ISSN	1872-7077 ; 1382-6689
ISSN (online)	1872-7077
ISSN	1382-6689
DOI	10.1016/j.etap.2019.03.006
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Article ; Online: Nano-Encapsulation of Coenzyme Q10 in Secondary and Tertiary Nano-Emulsions for Enhanced Cardioprotection and Hepatoprotection in Human Cardiomyocytes and Hepatocytes During Exposure to Anthracyclines and Trastuzumab.

Quagliariello, Vincenzo / Vecchione, Raffaele / De Capua, Alberta / Lagreca, Elena / Iaffaioli, Rosario Vincenzo / Botti, Gerardo / Netti, Paolo A / Maurea, Nicola

International journal of nanomedicine

2020 Volume 15, Page(s) 4859–4876

Abstract: Introduction: CoenzymeQ: Methods: We tested cardioprotective and hepatoprotective effects of CoQ: Results: Nano-carriers showed high stability and loading ability and increased cell viability both in hepatocytes and cardiomyocytes during ... ...

Abstract	Introduction: CoenzymeQ Methods: We tested cardioprotective and hepatoprotective effects of CoQ Results: Nano-carriers showed high stability and loading ability and increased cell viability both in hepatocytes and cardiomyocytes during anticancer treatments. We observed that these effects are mediated by the inhibition of lipid peroxidation and reduction of the inflammation. CoQ Discussion: Anthracyclines and Human epidermal growth factor receptor (HER2) inhibitors have shown significant anticancer effects in clinical practice but their use is characterized by cardiotoxicity and hepatotoxicity. Nano-carriers loaded with CoQ
MeSH term(s)	Animals ; Anthracyclines/adverse effects ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Capsules ; Cardiotonic Agents/chemistry ; Cardiotonic Agents/pharmacology ; Cell Survival/drug effects ; Cytoprotection/drug effects ; Female ; Hepatocytes/metabolism ; Humans ; Lipid Peroxidation/drug effects ; Liver/cytology ; Liver/drug effects ; Liver/metabolism ; Mice ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Nanostructures/chemistry ; Trastuzumab/adverse effects ; Ubiquinone/analogs & derivatives ; Ubiquinone/chemistry ; Ubiquinone/pharmacology
Chemical Substances	Anthracyclines ; Anti-Inflammatory Agents ; Capsules ; Cardiotonic Agents ; Ubiquinone (1339-63-5) ; coenzyme Q10 (EJ27X76M46) ; Trastuzumab (P188ANX8CK)
Keywords	covid19
Language	English
Publishing date	2020-07-09
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S245170
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Zs.A 6606: Show issues

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Article ; Online: Resveratrol in Cancer Patients: From Bench to Bedside.

Berretta, Massimiliano / Bignucolo, Alessia / Di Francia, Raffaele / Comello, Francesco / Facchini, Gaetano / Ceccarelli, Manuela / Iaffaioli, Rosario Vincenzo / Quagliariello, Vincenzo / Maurea, Nicola

International journal of molecular sciences

2020 Volume 21, Issue 8

Abstract: Resveratrol (3,5,4'-trihydroxystilbene) is a natural phytoalexin that accumulates in several vegetables and fruits like nuts, grapes, apples, red fruits, black olives, capers, red rice as well as red wines. Being both an extremely reactive molecule and ... ...

Abstract	Resveratrol (3,5,4'-trihydroxystilbene) is a natural phytoalexin that accumulates in several vegetables and fruits like nuts, grapes, apples, red fruits, black olives, capers, red rice as well as red wines. Being both an extremely reactive molecule and capable to interact with cytoplasmic and nuclear proteins in human cells, resveratrol has been studied over the years as complementary and alternative medicine (CAM) for the therapy of cancer, metabolic and cardiovascular diseases like myocardial ischemia, myocarditis, cardiac hypertrophy and heart failure. This review will describe the main biological targets, cardiovascular outcomes, physico-chemical and pharmacokinetic properties of resveratrol in preclinical and clinical models implementing its potential use in cancer patients.
MeSH term(s)	Animals ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/therapeutic use ; Cardiovascular Diseases/drug therapy ; Chemical Phenomena ; Clinical Studies as Topic ; Drug Evaluation, Preclinical ; Drug Interactions ; Humans ; Neoplasms/drug therapy ; Resveratrol/pharmacology ; Resveratrol/therapeutic use ; Structure-Activity Relationship ; Translational Research, Biomedical ; Treatment Outcome
Chemical Substances	Antineoplastic Agents, Phytogenic ; Resveratrol (Q369O8926L)
Language	English
Publishing date	2020-04-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21082945
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Article ; Online: SARS-CoV-2 infection: NLRP3 inflammasome as plausible target to prevent cardiopulmonary complications?

Quagliariello, V / Bonelli, A / Caronna, A / Lombari, M C / Conforti, G / Libutti, M / Iaffaioli, R V / Berretta, M / Botti, G / Maurea, N

European review for medical and pharmacological sciences

2020 Volume 24, Issue 17, Page(s) 9169–9171

Abstract: NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome has recently become an intriguing target of several chronic and viral diseases. Here, we argue that targeting NLRP3 inflammasome could be a strategy to prevent cardiovascular outcomes [ ...

Abstract	NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome has recently become an intriguing target of several chronic and viral diseases. Here, we argue that targeting NLRP3 inflammasome could be a strategy to prevent cardiovascular outcomes [fulminant myocarditis, heart failure, venous thromboembolism (VTE)] and acute respiratory distress syndrome (ARDS) in patients with SARS-CoV-2 infection. We discuss the rationale for NLRP3 targeting in clinical trials as an effective therapeutic strategy aimed to improve prognosis of COVID-19, analyzing the potential of two therapeutic options (tranilast and OLT1177) currently available in clinical practice.
MeSH term(s)	Betacoronavirus/isolation & purification ; COVID-19 ; Cardiovascular Diseases/prevention & control ; Clinical Trials as Topic ; Coronavirus Infections/diagnosis ; Coronavirus Infections/virology ; Cytokines/metabolism ; Humans ; Inflammasomes/metabolism ; Myocarditis/prevention & control ; NLR Family, Pyrin Domain-Containing 3 Protein/antagonists & inhibitors ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Nitriles/therapeutic use ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/virology ; Prognosis ; SARS-CoV-2 ; Venous Thromboembolism/prevention & control ; ortho-Aminobenzoates/therapeutic use
Chemical Substances	Cytokines ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nitriles ; ortho-Aminobenzoates ; dapansutrile (2Z03364G96) ; tranilast (HVF50SMY6E)
Keywords	covid19
Language	English
Publishing date	2020-09-23
Publishing country	Italy
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202009_22867
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Article ; Online: Intermittent chemotherapy in advanced colorectal cancer: is it the future?

Ottaiano, A / Di Lazzaro, A / Iaffaioli, V R

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2012 Volume 14, Issue 2, Page(s) 256–257

MeSH term(s)	Antineoplastic Agents/administration & dosage ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; Humans ; Neoplasm Metastasis ; Quality of Life
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2012-02
Publishing country	England
Document type	Letter
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/j.1463-1318.2011.02851.x
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Article ; Online: Nano-Encapsulation of Coenzyme Q10 in Secondary and Tertiary Nano-Emulsions for Enhanced Cardioprotection and Hepatoprotection in Human Cardiomyocytes and Hepatocytes During Exposure to Anthracyclines and Trastuzumab

Quagliariello V / Vecchione R / De Capua A / Lagreca E / Iaffaioli RV / Botti G / Netti PA / Maurea N

International Journal of Nanomedicine, Vol Volume 15, Pp 4859-

2020 Volume 4876

Abstract: ... Vincenzo Iaffaioli,3 Gerardo Botti,4 Paolo A Netti,2 Nicola Maurea1 1Division of Cardiology, Istituto ...

Abstract	Vincenzo Quagliariello,1,* Raffaele Vecchione,2,* Alberta De Capua,2 Elena Lagreca,2 Rosario Vincenzo Iaffaioli,3 Gerardo Botti,4 Paolo A Netti,2 Nicola Maurea1 1Division of Cardiology, Istituto Nazionale Tumori- IRCCS- Fondazione G. Pascale, Napoli, Italia; 2Center for Advanced Biomaterial for Health Care (CABHC), Istituto Italiano di Tecnologia, Largo Barsanti e Matteucci 53, Naples, Italy; 3Multidisciplinary Studies in Oncology and Mediterranean Diet, Piazza Nicola Amore, Naples, Italy; 4Scientific Direction, Istituto Nazionale Tumori- IRCCS- Fondazione G. Pascale, Napoli, Italia*These authors contributed equally to this workCorrespondence: Vincenzo QuagliarielloDivision of Cardiology, Istituto Nazionale Tumori- IRCCS- Fondazione G. Pascale, Napoli, ItaliaTel +390815903349Email quagliariello.enzo@gmail.comIntroduction: CoenzymeQ10 (CoQ10) is a well-known antioxidant and anti-inflammatory agent with cardioprotective properties. However, clinical trials based on its oral administration have failed to provide significant effect on cardiac functionality. The main limitation of CoQ10 is based on its very low oral bioavailability and instability that limit dramatically its effects as a cardioprotective agent. Herein, we loaded CoQ10 in high bioavailable nano-emulsions (NEs) coated with chitosan or chitosan and hyaluronic acid in order to improve its performance.Methods: We tested cardioprotective and hepatoprotective effects of CoQ10-loaded nano-carriers against Doxorubicin and Trastuzumab toxicities in cardiomyocytes and liver cells through analysis of cell viability, lipid peroxidation, expression of leukotrienes, p65/NF-kB and pro-inflammatory cytokines involved in anticancer-induced cardio and hepatotoxicity.Results: Nano-carriers showed high stability and loading ability and increased cell viability both in hepatocytes and cardiomyocytes during anticancer treatments. We observed that these effects are mediated by the inhibition of lipid peroxidation and reduction of the inflammation. CoQ10-loaded ...
Keywords	cardio-oncology ; nano-medicine ; coenzyme q10 ; doxorubicin ; trastuzumab ; inflammation ; Medicine (General) ; R5-920
Subject code	540
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
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Article ; Online: Association of Ozone with 5-Fluorouracil and Cisplatin in Regulation of Human Colon Cancer Cell Viability

V. Simonetti / V. Quagliariello / P. Giustetto / M. Franzini / R. V. Iaffaioli

Evidence-Based Complementary and Alternative Medicine, Vol

In Vitro Anti-Inflammatory Properties of Ozone in Colon Cancer Cells Exposed to Lipopolysaccharides

2017 Volume 2017

Abstract: Introduction. Ozone therapy is an effective medical treatment for different diseases like mucositis, psoriasis, acute pain, neurovascular diseases, and cancer. The aim of this study is based on the association of different ozone concentration with 5- ... ...

Abstract	Introduction. Ozone therapy is an effective medical treatment for different diseases like mucositis, psoriasis, acute pain, neurovascular diseases, and cancer. The aim of this study is based on the association of different ozone concentration with 5-fluorouracil and cisplatin in human colon cancer cell (HT29 cell line) in order to investigate possible anticancer synergistic effects. Methods. HT29 cells were incubated with ozone at different concentration ranging from 10 up to 50 μg/ml at different incubation time alone or in combination with cisplatin and 5-fluorouracil. Cell viability was performed by using a modified MTT method. Anti-inflammatory studies were conducted incubating HT29 with or without 20, 30, or 50 μg/ml of ozone before exposure to lipopolysaccharides. Results. Ozone alone has a time and concentration dependent cytotoxicity against HT29 cells (IC50 at 24 h: 30 μg/ml). Association of ozone with drugs increases cytotoxicity by 15–20%. Preincubation of ozone at 50 μg/ml decreases IL-8, IL-6, and IL-1β production by 50, 56, and 70%, respectively, compared to untreated cells. Conclusion. These results indicated that ozone could be useful in colon cancer management in combination with 5-fluorouracil and cisplatin with significant inhibition of cytokines having a central role in colon cancer cell survival and chemoresistance.
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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