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Article ; Online: Open-Label Phase II Prospective, Randomized, Controlled Study of Romyelocel-L Myeloid Progenitor Cells to Reduce Infection During Induction Chemotherapy for Acute Myeloid Leukemia.

Desai, Pinkal M / Brown, Janice / Gill, Saar / Solh, Melham M / Akard, Luke P / Hsu, Jack W / Ustun, Celalettin / Andreadis, Charalambos / Frankfurt, Olga / Foran, James M / Lister, John / Schiller, Gary J / Wieduwilt, Matthew J / Pagel, John M / Stiff, Patrick J / Liu, Delong / Khan, Irum / Stock, Wendy / Kambhampati, Suman /

Tallman, Martin S / Morris, Lawrence / Edwards, John / Pusic, Iskra / Kantarjian, Hagop M / Mamelok, Richard / Wong, Alicia / Van Syoc, Rodney / Kellerman, Lois / Panuganti, Swapna / Mandalam, Ramkumar / Abboud, Camille N / Ravandi, Farhad

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2021 Volume 39, Issue 29, Page(s) 3261–3272

Abstract: ... in prolonged neutropenia and risk of infection. Romyelocel-L is a universal, allogeneic myeloid progenitor cell ... randomly assigned on day 0 (d0), of whom 120 were evaluable. Subjects received either romyelocel-L infusion ... 2.36 : Conclusion: Subjects receiving romyelocel-L showed a decreased incidence of infections ...

Abstract	Purpose: Standard cytotoxic induction chemotherapy for acute myeloid leukemia (AML) results in prolonged neutropenia and risk of infection. Romyelocel-L is a universal, allogeneic myeloid progenitor cell product being studied to reduce infection during induction chemotherapy. Patients and methods: One hundred sixty-three patients with de novo AML (age ≥ 55 years) receiving induction chemotherapy were randomly assigned on day 0 (d0), of whom 120 were evaluable. Subjects received either romyelocel-L infusion on d9 with granulocyte colony-stimulating factor (G-CSF) starting daily d14 (treatment group) or G-CSF daily alone on d14 (control) until absolute neutrophil count recovery to 500/µL. End points included days in febrile episode, microbiologically defined infections, clinically diagnosed infection, and days in hospital. Results: Mean days in febrile episode was shorter in the treatment arm from d15 through d28 (2.36 Conclusion: Subjects receiving romyelocel-L showed a decreased incidence of infections, antimicrobial use, and hospitalization, suggesting that romyelocel-L may provide a new option to reduce infections in patients with AML undergoing induction therapy.
MeSH term(s)	Adult ; Aged ; Antifungal Agents/therapeutic use ; Female ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Humans ; Induction Chemotherapy ; Leukemia, Myeloid, Acute/drug therapy ; Male ; Middle Aged ; Myeloid Progenitor Cells/transplantation ; Neutrophils/physiology ; Prospective Studies
Chemical Substances	Antifungal Agents ; Granulocyte Colony-Stimulating Factor (143011-72-7)
Language	English
Publishing date	2021-06-22
Publishing country	United States
Document type	Clinical Trial, Phase II ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.20.01739
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Article ; Online: Halide Effects on the Sublimation Temperature of X-Au-L Complexes: Implications for Their Use as Precursors in Vapor Phase Deposition Methods.

Carden, Will G / Pedziwiatr, Jakub / Abboud, Khalil A / McElwee-White, Lisa

ACS applied materials & interfaces

2017 Volume 9, Issue 46, Page(s) 40998–41005

Abstract: ... of the type X-Au-L [X = Cl, Br, I; L = CN ...

Abstract	Trends in volatility with changes in the halide ligand were established for gold(I) complexes of the type X-Au-L [X = Cl, Br, I; L = CN
Language	English
Publishing date	2017-11-22
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.7b12465
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Article ; Online: Foliar potassium nitrate spray induces changes in potassium- sodium balance and biochemical mechanisms in olive (Olea europaea L. cv Chemlali) plants submitted to salt stress

Soumaya Dbara / Samia Abboud / Amani Bchir

Journal of Horticulture and Postharvest Research, Vol 5, Iss Issue 4, Pp 309-

2022 Volume 322

Abstract: ... plants. One-year-old olive plants (cv Chemlali) irrigated with a saline water (10g/L) were subjected ...

Abstract	Purpose: Nowadays with the precipitation scarcity induced by climate change, the use of non-conventional water resources in irrigation is needed such as saline water. The irrigation of salt tolerance species like olive could be adopted with potassium foliar spray. In this work we present how olive plants modulate sodium potassium balance and metabolism to mitigate salt stress. Research method: A pot experiment was conducted to assess how potassium nitrate modify Na/K ratio and biochemical compounds in olive plants. One-year-old olive plants (cv Chemlali) irrigated with a saline water (10g/L) were subjected to three treatments: K0, K1 and K2 (0, 1 and 2% of potassium nitrate foliar spray, respectively). Findings: Results showed differences between treatments. The mineral composition particularly the sodium and potassium content of leaves and roots revealed that the K1 and K2 treatments slightly increased K/Na in leaves and decreased in roots. Moreover, the salt stress was moderate through the osmotic adjustment. The accumulation of osmolytes (proline and soluble sugars) decreased by k1 and K2 treatments. Secondry metabolites (phenols) showed an increase by K1 and K2. Lipid peroxydation was also reduced by treatments especially in young leaves and then increased. In conclusion, potassium can be recommended in order to mitigate the harmful effects of salinity. Research limitations: No limitations were founded. Originality/Value: In the condition of current water scarcity the saline water could be used with potassium application.
Keywords	mitigation ; saline ; tolerance ; Agriculture ; S
Subject code	580
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	University of Birjand
Document type	Article ; Online
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Article: Water status, biochemical and hormonal changes involved in the response of Olea europaea L. to water deficit induced by partial root-zone drying irrigation (PRD)

Abboud, Samia / Vives-Peris, Vicente / Dbara, Soumaya / Gómez-Cadenas, Aurelio / Pérez-Clemente, Rosa María / Abidi, Walid / Braham, Mohamed

Scientia horticulturae. 2021 Jan. 27, v. 276

2021

Abstract: Changes in the plant water status, biochemical and hormonal responses, were investigated in three olive cultivars (Arbequina, Arbosana and Chetoui) grown in a super-high-density orchard under partial root-zone drying (PRD) irrigation. Four irrigation ... ...

Abstract	Changes in the plant water status, biochemical and hormonal responses, were investigated in three olive cultivars (Arbequina, Arbosana and Chetoui) grown in a super-high-density orchard under partial root-zone drying (PRD) irrigation. Four irrigation treatments were applied during two growing seasons (2015 and 2016); control treatment (100 % ETc) irrigated at 100 % of crop evapotranspiration on both parts of the root-zone and three PRD irrigation treatments (100 % PRD, 75 % PRD and 50 % PRD) irrigated at 100 %, 75 %, and 50 % of crop evapotranspiration only on one alternated part of the root-zone. The results indicated that the three studied olive cultivars showed a clear difference in their response to PRD irrigation. Arbequina cultivar has shown a conservative strategy for using water since relative water content (RWC) and stem water potential (Ψₛₜₑₘ) were reduced more in Arbosana and Chetoui under PRD irrigation. In fact, PRD irrigation has led to a strong activation of secondary metabolites with antioxidant properties such as pigments, phenols and flavonoids. Other metabolic changes, including the accumulation of soluble sugars and proline have been also triggered by PRD irrigation. Among the studied cultivars, Arbequina displayed the highest levels of proline, total soluble sugars, phenols and flavonoids, and the lowest ones for Malondialdehyde (MDA) and hydrogen peroxide (H₂O₂).The increase in Superoxide dismutase (SOD), catalase (CAT) and guaiacol peroxidase (POD) activity and the reduction in polyphenoloxidase (PPO) activity under PRD irrigation were more pronounced in 2016 season with highest activities obtained from cultivar Arbequina.For all the three cultivars, PRD irrigation increased phytohormones concentration in both, roots and leaves and the highest levels were recorded in 2016. In leaves, Arbequina showed the lowest levels of abscisic acid (ABA), and the highest levels of jasmonic acid (JA), salicylic acid (SA) and indole-3-acetic acid (IAA). PRD irrigation also induces a higher accumulation of ABA, JA and IAA in dried roots than in wetted ones.Taken together, physiological and biochemical mechanisms induced by PRD irrigation were more effective in Arbequina suggesting better protection of their foliar functions compared to other cultivars and its higher adaptability to PRD.
Keywords	Olea europaea ; abscisic acid ; catalase ; catechol oxidase ; cultivars ; evapotranspiration ; flavonoids ; hydrogen peroxide ; indole acetic acid ; jasmonic acid ; malondialdehyde ; olives ; orchards ; peroxidase ; proline ; rhizosphere ; salicylic acid ; secondary metabolites ; superoxide dismutase ; water content ; water potential
Language	English
Dates of publication	2021-0127
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	185557-8
ISSN	0304-4238
ISSN	0304-4238
DOI	10.1016/j.scienta.2020.109737
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: L-asparaginase-induced pancreatitis in children with acute lymphoblastic leukemia: is allopurinol protective?

Muwakkit, Samar / Saab, Raya / Yazbeck, Nadine / Samia, Loma / Abboud, Miguel R

Pediatric hematology and oncology

2010 Volume 27, Issue 6, Page(s) 496–501

MeSH term(s)	Allopurinol/therapeutic use ; Asparaginase/adverse effects ; Child ; Humans ; Pancreatitis/chemically induced ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications ; Retrospective Studies ; Xanthine Oxidase/antagonists & inhibitors
Chemical Substances	Allopurinol (63CZ7GJN5I) ; Xanthine Oxidase (EC 1.17.3.2) ; Asparaginase (EC 3.5.1.1)
Language	English
Publishing date	2010-09
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	632914-7
ISSN	1521-0669 ; 0888-0018
ISSN (online)	1521-0669
ISSN	0888-0018
DOI	10.3109/08880018.2010.489935
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Article ; Online: Oral supplementation with L-glutamine alters gut microbiota of obese and overweight adults: A pilot study.

de Souza, Alessandra Zanin Zambom / Zambom, Adriano Zanin / Abboud, Kahlile Youssef / Reis, Sabrina Karen / Tannihão, Fabiana / Guadagnini, Dioze / Saad, Mario J A / Prada, Patricia Oliveira

Nutrition (Burbank, Los Angeles County, Calif.)

2015 Volume 31, Issue 6, Page(s) 884–889

Abstract: Objective: The aim of this study was to determine whether oral supplementation with L-glutamine ... were randomly assigned to receive either oral supplementation with 30 g of L-alanine (ALA group control ...

Abstract	Objective: The aim of this study was to determine whether oral supplementation with L-glutamine (GLN) modifies the gut microbiota composition in overweight and obese adults. Methods: Thirty-three overweight and obese adults, ages between 23 and 59 y and body mass index between 25.03 and 47.12 kg/m(2), were randomly assigned to receive either oral supplementation with 30 g of L-alanine (ALA group control) or 30 g of GLN (GLN group) daily for 14 d. We analyzed the gut microbiota composition with new-generation sequencing techniques and bioinformatics analysis. Results: After 14 d of supplementation, adults in the GLN group exhibited statistically significant differences in the Firmicutes and Actinobacteria phyla compared with those in the ALA group. The ratio of Firmicutes to Bacteroidetes, a good biomarker for obesity, decreased in the GLN group from 0.85 to 0.57, whereas it increased from 0.91 to 1.12 in the ALA group. At the genus level, Dialister, Dorea, Pseudobutyrivibrio, and Veillonella, belonging to the Firmicutes phylum, had statistically significant reduction. Conclusion: Oral supplementation with GLN, for a short time, altered the composition of the gut microbiota in overweight and obese humans reducing the Firmicutes to Bacteroidetes ratio, which resembled weight loss programs already seen in the literature.
MeSH term(s)	Administration, Oral ; Adult ; Bacteria/drug effects ; Bacteria/growth & development ; Bacteroidetes/drug effects ; Bacteroidetes/growth & development ; Body Mass Index ; Dietary Supplements ; Female ; Firmicutes/drug effects ; Firmicutes/growth & development ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Tract/microbiology ; Glutamine/pharmacology ; Humans ; Male ; Middle Aged ; Obesity/microbiology ; Overweight ; Pilot Projects ; Young Adult
Chemical Substances	Glutamine (0RH81L854J)
Language	English
Publishing date	2015-06
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2015.01.004
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Article: Halide Effects on the Sublimation Temperature of XâAuâL Complexes: Implications for Their Use as Precursors in Vapor Phase Deposition Methods

Carden, Will G / Pedziwiatr Jakub / Abboud Khalil A / McElwee-White Lisa

ACS applied materials & interfaces. 2017 Nov. 22, v. 9, no. 46

2017

Abstract: ... of the type XâAuâL [X = Cl, Br, I; L = CNáµBu, CNMe, PMeâ, P(NMeâ)â, P(OCHâCFâ)â ...

Abstract	Trends in volatility with changes in the halide ligand were established for gold(I) complexes of the type XâAuâL [X = Cl, Br, I; L = CNáµBu, CNMe, PMeâ, P(NMeâ)â, P(OCHâCFâ)â] by determining the temperatures for the onset of sublimation (Tâáµ¤b) at a fixed pressure. Within each series of isocyanide complexes, Tâáµ¤b decreases with increasing atomic radius of the halide, making the iodide complex the most volatile. For the phosphine and phosphoramidate complexes, the chloride and bromide have similar Tâáµ¤b values with the bromide slightly higher, but the iodide complex is again the most volatile of the three. The trends in volatility can be correlated to variation in AuâAu bond distances and aggregation patterns in the solid state structures. For the P(OCHâCFâ)â complexes, melting occurred before sublimation, but the iodide complex was still more volatile than the bromide. These trends have implications for the use of these complexes in electron beam induced deposition and chemical vapor deposition, for which precursor volatility is important.
Keywords	bromides ; bromine ; chemical bonding ; chlorides ; chlorine ; gold ; iodides ; ligands ; materials science ; melting ; phosphine ; sublimation ; temperature ; vapors
Language	English
Dates of publication	2017-1122
Size	p. 40998-41005.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021%2Facsami.7b12465
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Meiotic behavior and pollen viability in Jatropha curcas L.

Isabela Pereira Diegues / Pedro Corrêa Damasceno Junior / Nathália Virgínia da Silva Ribeiro / Marcus Vinicius Magro Reis / Antônio Carlos de Souza Abboud

Semina: Ciências Agrárias, Vol 36, Iss 1, Pp 141-

2015 Volume 150

Abstract: The Jatropha curcas, known as physic nut, belonging to the Euphorbiaceae family, figure today as one of the greatest potential of oilseeds for biodiesel production in Brazil. The present study aimed to evaluate meiosis and pollen viability in J. curcas ... ...

Abstract	The Jatropha curcas, known as physic nut, belonging to the Euphorbiaceae family, figure today as one of the greatest potential of oilseeds for biodiesel production in Brazil. The present study aimed to evaluate meiosis and pollen viability in J. curcas accesses from UFRRJ germplasm collection. To do that, flower buds were collected from 20 plants, these were fixed in acetic acid 3:1 solution and alcohol 70%. The staining of the cells was done by acetic carmine 2% solution and Alexander’s triple solution, for the analysis of meiotic and pollen viability, respectively. All observations were carried out under an optical microscope. It was observed that the species has 2n = 2x = 22 chromosomes. It was observed many irregularities during the meiotic division as the presence of sticky chromosomes and irregular meiotic products, such as monads, dyads, triads and polyads, and the occurrence of cytomixis and micronucleus, these latter two anomalies had a higher frequency among the accessions. The meiotic index was estimated in 84.21% and the average pollen viability in 89.85%. The lowest pollen viability was 78% (UFRRJ885), while the maximum observed was 96% (UFRRJ861). Based on the results obtained, although Jatropha curcas presents certain anomalies during meiosis, the accessions analyzed here showed satisfactory pollen viability.
Keywords	Cytomixis ; Meiotic index ; Meiotic irregularities ; Meiosis ; Agriculture (General) ; S1-972
Subject code	580
Language	English
Publishing date	2015-02-01T00:00:00Z
Publisher	Universidade Estadual de Londrina
Document type	Article ; Online
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Article: Maize (Zea Mays L.) Growth and Metabolic Dynamics with Plant Growth-Promoting Rhizobacteria under Salt Stress

YS, Masrahi , / A, Mohamed , / Abboud, Al , / MM, Alawlaqi , / I Elhussieny, Nadeem ,

Plant Pathology & Microbiology

2015. September. , Issue (9)

Abstract: Maize (Zea mays L.) biomass and its allied attributes were assessed under salinity stress and three ...

Abstract	Maize (Zea mays L.) biomass and its allied attributes were assessed under salinity stress and three plant growthpromoting rhizobacteria (Pseudomonas fluorescens, Pseudomonas putida and Azotobacter vinelandii) treatments. The three PGPRs inocula exhibited a different pattern of shoot growth under both normal and saline stress conditions. Plant biomass, carbohydrates, protein and chlorophyll content were reduced by saline stress, however application of PGPRs treatments improved them either in comparison to control samples or to untreated samples under saline stress. Lipids and antioxidant enzymes (catalase and peroxidase) increased as a response for saline stress as an indication of oxidative stress. Plant growth-promoting rhizobacteria treatment restored them to semi-normal levels. Sodium/ potassium balance was observed to be disturbed by saline stress through higher levels of Na+ and lower levels of K+, but treating samples balance was clearly restored close to normal conditions especially in the root system.
Language	English
Document type	Article
ISSN	2157-7471
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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Article: Oral supplementation with l-glutamine alters gut microbiota of obese and overweight adults: A pilot study

Zambom de Souza, Alessandra Zanin / Adriano Zanin Zambom / Dioze Guadagnini / Fabiana Tannihão / Kahlile Youssef Abboud / Mario J.A. Saad / Patricia Oliveira Prada / Sabrina Karen Reis

Nutrition. 2015 June, v. 31, no. 6

2015

Abstract: The aim of this study was to determine whether oral supplementation with l-glutamine (GLN) modifies ... to receive either oral supplementation with 30 g of l-alanine (ALA group control) or 30 g of GLN (GLN group ...

Abstract	The aim of this study was to determine whether oral supplementation with l-glutamine (GLN) modifies the gut microbiota composition in overweight and obese adults.Thirty-three overweight and obese adults, ages between 23 and 59 y and body mass index between 25.03 and 47.12 kg/m2, were randomly assigned to receive either oral supplementation with 30 g of l-alanine (ALA group control) or 30 g of GLN (GLN group) daily for 14 d. We analyzed the gut microbiota composition with new-generation sequencing techniques and bioinformatics analysis.After 14 d of supplementation, adults in the GLN group exhibited statistically significant differences in the Firmicutes and Actinobacteria phyla compared with those in the ALA group. The ratio of Firmicutes to Bacteroidetes, a good biomarker for obesity, decreased in the GLN group from 0.85 to 0.57, whereas it increased from 0.91 to 1.12 in the ALA group. At the genus level, Dialister, Dorea, Pseudobutyrivibrio, and Veillonella, belonging to the Firmicutes phylum, had statistically significant reduction.Oral supplementation with GLN, for a short time, altered the composition of the gut microbiota in overweight and obese humans reducing the Firmicutes to Bacteroidetes ratio, which resembled weight loss programs already seen in the literature.
Keywords	Actinobacteria ; adults ; alanine ; Bacteroidetes ; bioinformatics ; biomarkers ; body mass index ; Dialister ; glutamine ; intestinal microorganisms ; obesity ; Pseudobutyrivibrio ; Veillonella ; weight loss
Language	English
Dates of publication	2015-06
Size	p. 884-889.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2015.01.004
Database	NAL-Catalogue (AGRICOLA)

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