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  1. Book: Advances in pain research: Mechanisms and modulation of chronic pain

    Shyu, Bai-Chuang / Tominaga, Makoto

    (Advances in experimental medicine and biology ; 1099)

    2018  

    Author's details Bai-Chuang Shyu, Makoto Tominaga editors
    Series title Advances in experimental medicine and biology ; 1099
    Collection
    Keywords Chronic pain ; Neuropathic pain ; Nociceptive mechanisms ; Pain comorbid ; Pain managements
    Subject code 610
    Language English
    Size x, 265 Seiten, Illustrationen, 23.5 cm x 15.5 cm
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book
    HBZ-ID HT019863393
    ISBN 978-981-13-1755-2 ; 981-13-1755-0 ; 9789811317569 ; 9811317569
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -1099- not available for loan Zeitschriften-Lesesaal

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  2. Article: [ITCH IN NEUROPHYSIOLOGY].

    Tominaga, Makoto

    Arerugi = [Allergy

    2020  Volume 69, Issue 1, Page(s) 1–6

    MeSH term(s) Humans ; Neurophysiology ; Pruritus/physiopathology ; Sensory Receptor Cells/physiology ; Skin
    Language Japanese
    Publishing date 2020-02-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 974201-3
    ISSN 0021-4884
    ISSN 0021-4884
    DOI 10.15036/arerugi.69.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 245: Show issues Location:
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  3. Article ; Online: Role of novel de novo gain-of-function TRPM3 mutations in a spectrum of neurodevelopmental disorders.

    Kashio, Makiko / Tominaga, Makoto

    Cell calcium

    2023  Volume 110, Page(s) 102704

    MeSH term(s) Humans ; Gain of Function Mutation ; Neurodevelopmental Disorders/genetics ; Mutation ; TRPM Cation Channels/genetics
    Chemical Substances TRPM3 protein, human ; TRPM Cation Channels
    Language English
    Publishing date 2023-02-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2023.102704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Endoscopic ultrasound sclerotherapy for refractory hepatic encephalopathy associated with rectal varices.

    Tominaga, Shintaro / Kobayashi, Makoto / Kato, Hiroki

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

    2024  Volume 36, Issue 3, Page(s) 382–383

    MeSH term(s) Humans ; Sclerotherapy ; Hepatic Encephalopathy/diagnostic imaging ; Hepatic Encephalopathy/etiology ; Hepatic Encephalopathy/therapy ; Varicose Veins/complications ; Varicose Veins/diagnostic imaging ; Varicose Veins/therapy ; Rectum ; Esophageal and Gastric Varices/complications ; Esophageal and Gastric Varices/diagnostic imaging ; Gastrointestinal Hemorrhage/diagnostic imaging ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/therapy ; Recurrence
    Language English
    Publishing date 2024-01-30
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1171589-3
    ISSN 1443-1661 ; 0915-5635
    ISSN (online) 1443-1661
    ISSN 0915-5635
    DOI 10.1111/den.14747
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    Zs.A 3854: Show issues Location:
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  5. Article ; Online: Thermal gradient ring for analysis of temperature-dependent behaviors involving TRP channels in mice.

    Ujisawa, Tomoyo / Lei, Jing / Kashio, Makiko / Tominaga, Makoto

    The journal of physiological sciences : JPS

    2024  Volume 74, Issue 1, Page(s) 9

    Abstract: There are a lot of temperature-sensitive proteins including transient receptor potential (TRP) channels. Some TRP channels are temperature receptors having specific activation temperatures in vitro that are within the physiological temperature range. ... ...

    Abstract There are a lot of temperature-sensitive proteins including transient receptor potential (TRP) channels. Some TRP channels are temperature receptors having specific activation temperatures in vitro that are within the physiological temperature range. Mice deficient in specific TRP channels show abnormal thermal behaviors, but the role of TRP channels in these behaviors is not fully understood. The Thermal Gradient Ring is a new apparatus that allows mice to freely move around the ring floor and not stay in a corner. The system can analyze various factors (e.g., 'Spent time', 'Travel distance', 'Moving speed', 'Acceleration') associated with temperature-dependent behaviors of TRP-deficient mice. For example, the Ring system clearly discriminated differences in temperature-dependent phenotypes between mice with diabetic peripheral neuropathy and TRPV1
    MeSH term(s) Humans ; Mice ; Animals ; Transient Receptor Potential Channels ; Temperature ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism ; Skin/metabolism ; Diabetic Neuropathies
    Chemical Substances Transient Receptor Potential Channels ; TRPV Cation Channels
    Language English
    Publishing date 2024-02-08
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2234472-X
    ISSN 1880-6562 ; 1880-6546
    ISSN (online) 1880-6562
    ISSN 1880-6546
    DOI 10.1186/s12576-024-00903-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Mechanisms Underlying Thermosensation].

    Tominaga, Makoto / Kashio, Makiko

    Brain and nerve = Shinkei kenkyu no shinpo

    2022  Volume 74, Issue 2, Page(s) 127–132

    Abstract: The ability to sense ambient temperatures is essential for human survival. Sensory nerve endings contain ion channels that are activated by temperature stimuli, which lead to cation influx and depolarization with consequent action potential generation ... ...

    Abstract The ability to sense ambient temperatures is essential for human survival. Sensory nerve endings contain ion channels that are activated by temperature stimuli, which lead to cation influx and depolarization with consequent action potential generation via activation of voltage-gated Na
    MeSH term(s) Action Potentials ; Humans ; Neurons ; Thermosensing ; Transient Receptor Potential Channels
    Chemical Substances Transient Receptor Potential Channels
    Language Japanese
    Publishing date 2022-01-19
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416201997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 398: Show issues Location:
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  7. Article ; Online: Physiological and Pathological Significance of Esophageal TRP Channels: Special Focus on TRPV4 in Esophageal Epithelial Cells.

    Boudaka, Ammar / Tominaga, Makoto

    International journal of molecular sciences

    2022  Volume 23, Issue 9

    Abstract: Transient receptor potential vanilloid 4 (TRPV4) is a non-selective cation channel that is broadly expressed in different human tissues, including the digestive system, where it acts as a molecular sensor and a transducer that regulates a variety of ... ...

    Abstract Transient receptor potential vanilloid 4 (TRPV4) is a non-selective cation channel that is broadly expressed in different human tissues, including the digestive system, where it acts as a molecular sensor and a transducer that regulates a variety of functional activities. Despite the extensive research to determine the role of this channel in the physiology and pathophysiology of different organs, the unique morphological and functional features of TRPV4 in the esophagus remain largely unknown. Ten years ago, TRPV4 was shown to be highly expressed in esophageal epithelial cells where its activation induces Ca
    MeSH term(s) Epithelial Cells/metabolism ; Esophageal Mucosa/metabolism ; Esophagus/metabolism ; Humans ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism
    Chemical Substances TRPV Cation Channels ; TRPV4 protein, human
    Language English
    Publishing date 2022-04-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23094550
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  8. Article ; Online: TRP channels in thermosensation.

    Kashio, Makiko / Tominaga, Makoto

    Current opinion in neurobiology

    2022  Volume 75, Page(s) 102591

    Abstract: The ability to sense external temperature is assumed by somatosensory neurons, in which temperature information is converted to neural activity by afferent input to the central nervous system. Somatosensory neurons consist of various populations with ... ...

    Abstract The ability to sense external temperature is assumed by somatosensory neurons, in which temperature information is converted to neural activity by afferent input to the central nervous system. Somatosensory neurons consist of various populations with specialized gene expression, including thermosensitive transient receptor potential ion channels (thermo-TRPs). Thermo-TRPs are responsible for thermal transduction at the peripheral ends of somatosensory neurons and over a wide range of temperatures. In this review, we focus on several thermo-TRPs expressed in sensory neurons: TRPV1, TRPV4, TRPM2, TRPM3, TRPM8, TRPC5, and TRPA1. TRPV3, TRPV4, and TRPC5 expressed in non-neuronal cells that are also involved in somatosensation are also discussed, whereas TRPM2 and TRPM8 are involved in thermosensation in the brain.
    MeSH term(s) Sensory Receptor Cells ; TRPC Cation Channels/genetics ; TRPM Cation Channels/genetics ; TRPM Cation Channels/metabolism ; TRPV Cation Channels ; Transient Receptor Potential Channels/genetics
    Chemical Substances TRPC Cation Channels ; TRPM Cation Channels ; TRPV Cation Channels ; Transient Receptor Potential Channels
    Language English
    Publishing date 2022-06-18
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1078046-4
    ISSN 1873-6882 ; 0959-4388
    ISSN (online) 1873-6882
    ISSN 0959-4388
    DOI 10.1016/j.conb.2022.102591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3260: Show issues Location:
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  9. Article ; Online: Physiological and Pathological Significance of Esophageal TRP Channels

    Ammar Boudaka / Makoto Tominaga

    International Journal of Molecular Sciences, Vol 23, Iss 4550, p

    Special Focus on TRPV4 in Esophageal Epithelial Cells

    2022  Volume 4550

    Abstract: Transient receptor potential vanilloid 4 (TRPV4) is a non-selective cation channel that is broadly expressed in different human tissues, including the digestive system, where it acts as a molecular sensor and a transducer that regulates a variety of ... ...

    Abstract Transient receptor potential vanilloid 4 (TRPV4) is a non-selective cation channel that is broadly expressed in different human tissues, including the digestive system, where it acts as a molecular sensor and a transducer that regulates a variety of functional activities. Despite the extensive research to determine the role of this channel in the physiology and pathophysiology of different organs, the unique morphological and functional features of TRPV4 in the esophagus remain largely unknown. Ten years ago, TRPV4 was shown to be highly expressed in esophageal epithelial cells where its activation induces Ca 2+ -dependent ATP release, which, in turn, mediates several functions, ranging from mechanosensation to wound healing. This review summarizes the research progress on TRPV4, and focuses on the functional expression of TRPV4 in esophageal epithelium and its possible role in different esophageal diseases that would support TRPV4 as a candidate target for future therapeutic approaches to treat patients with these conditions.
    Keywords ATP ; Ca 2+ homeostasis ; esophageal cancer ; esophageal epithelial cells ; esophagus ; GERD ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: G protein-coupled receptor-based thermosensation determines temperature acclimatization of Caenorhabditis elegans.

    Ohnishi, Kohei / Sokabe, Takaaki / Miura, Toru / Tominaga, Makoto / Ohta, Akane / Kuhara, Atsushi

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1660

    Abstract: Animals must sense and acclimatize to environmental temperatures for survival, yet their thermosensing mechanisms other than transient receptor potential (TRP) channels remain poorly understood. We identify a trimeric G protein-coupled receptor (GPCR), ... ...

    Abstract Animals must sense and acclimatize to environmental temperatures for survival, yet their thermosensing mechanisms other than transient receptor potential (TRP) channels remain poorly understood. We identify a trimeric G protein-coupled receptor (GPCR), SRH-40, which confers thermosensitivity in sensory neurons regulating temperature acclimatization in Caenorhabditis elegans. Systematic knockdown of 1000 GPCRs by RNAi reveals GPCRs involved in temperature acclimatization, among which srh-40 is highly expressed in the ADL sensory neuron, a temperature-responsive chemosensory neuron, where TRP channels act as accessorial thermoreceptors. In vivo Ca
    MeSH term(s) Animals ; Caenorhabditis elegans/genetics ; Temperature ; Sensory Receptor Cells/physiology ; Caenorhabditis elegans Proteins/genetics ; Acclimatization/genetics ; Receptors, G-Protein-Coupled/genetics
    Chemical Substances Caenorhabditis elegans Proteins ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46042-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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