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  1. Article: Thermotropic effects of PEGylated lipids on the stability of HPPH-encapsulated lipid nanoparticles (LNP).

    Kalyanram, Poornima / Puri, Anu / Gupta, Anju

    Journal of thermal analysis and calorimetry

    2021  Volume 147, Issue 11, Page(s) 6337–6348

    Abstract: In this work, we demonstrate the enhanced thermal and steric stability of lipid-based formulations in the presence of encapsulated HPPH that have demonstrated potential cancer applications in previously presented in vivo studies. Differential scanning ... ...

    Abstract In this work, we demonstrate the enhanced thermal and steric stability of lipid-based formulations in the presence of encapsulated HPPH that have demonstrated potential cancer applications in previously presented in vivo studies. Differential scanning calorimeter (DSC) was used to study the phase transitions, and domain formations, and to qualify the thermodynamic properties associated with change in lipid bilayer behavior due to the presence of PEGylated at varying concentrations and sizes, and the encapsulated HPPH molecules. Thermal instability was quantified by dramatic changes in calculated enthalpy, and the shape of the melting peak or calculated half width of melting peak. This systematic study focused on understanding the effects of varying molecular mass and concentrations of PEG polymers in the photopolymerizable lipid DC
    Language English
    Publishing date 2021-06-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2017304-0
    ISSN 1572-8943 ; 1588-2926 ; 1388-6150 ; 1418-2874
    ISSN (online) 1572-8943 ; 1588-2926
    ISSN 1388-6150 ; 1418-2874
    DOI 10.1007/s10973-021-10929-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Interaction of Cyanine-D112 with Binary Lipid Mixtures: Molecular Dynamics Simulation and Differential Scanning Calorimetry Study.

    Li, Jinhui / Kalyanram, Poornima / Rozati, Seyedalireza / Monje-Galvan, Viviana / Gupta, Anju

    ACS omega

    2022  Volume 7, Issue 11, Page(s) 9765–9774

    Abstract: This comprehensive molecular dynamics (MD) simulation and experimental study investigates the lipid bilayer interactions of dye D112 for potential photodynamic therapy (PDT) applications. PDT involves formation of a reactive oxidant species in the ... ...

    Abstract This comprehensive molecular dynamics (MD) simulation and experimental study investigates the lipid bilayer interactions of dye D112 for potential photodynamic therapy (PDT) applications. PDT involves formation of a reactive oxidant species in the presence of a light sensitive molecule and light, interrupting cellular functions. D112 was developed as a photographic emulsifier, and we hypothesized that its combined cationic and lipophilic nature can render a superior photosensitizing property-crucial in various light therapies. The focus of this study is to elucidate the binding and insertion mechanisms of D112 with mixed lipid bilayers of anionic dipalmitoyl-phosphatidylserine (DPPS) and zwitterionic dipalmitoyl-phosphatidylcholine (DPPC) lipids to resemble cancer cell membranes. Our studies confirm initial electrostatic binding between the positively charged moieties of D112 and negatively charged lipid headgroups. Additionally, MD simulations combined with differential scanning calorimetry (DSC) studies confirm that D112-lipid interactions are governed by enthalpy-driven nonclassical hydrophobic effects in the membrane interior. It was further noted that despite the electrostatic preference of D112 toward the anionic lipids, D112 molecules colocalized on DPPC-rich domains after insertion. Atomistic level MD studies point toward two possible insertion mechanisms for D112: harpoon and flip. Further insights from the simulation showcase the interactions of low and high aggregates of D112 with the bilayer as the concentration of D112 increases in solution. The size of aggregates modulates the orientation and degree of insertion, providing important information for future studies on membrane permeation mechanisms.
    Language English
    Publishing date 2022-03-11
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.1c07378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Interaction of amphiphilic coumarin with DPPC/DPPS lipid bilayer: effects of concentration and alkyl tail length.

    Kalyanram, Poornima / Ma, Huilin / Marshall, Shena / Goudreau, Christina / Cartaya, Ana / Zimmermann, Tyler / Stadler, Istvan / Nangia, Shikha / Gupta, Anju

    Physical chemistry chemical physics : PCCP

    2020  Volume 22, Issue 27, Page(s) 15197–15207

    Abstract: In this work, interactions between amphiphilic amino methyl coumarin and dipalmitoyl-sn-glycero-3-phosphocholine/dipalmitoyl-sn-glycero-3-phosphoserine (DPPC/DPPS) lipid bilayer were investigated. A combination of experimental techniques (zeta potential, ...

    Abstract In this work, interactions between amphiphilic amino methyl coumarin and dipalmitoyl-sn-glycero-3-phosphocholine/dipalmitoyl-sn-glycero-3-phosphoserine (DPPC/DPPS) lipid bilayer were investigated. A combination of experimental techniques (zeta potential, fluorescence spectroscopy, and differential scanning calorimetry) along with molecular dynamics simulations was employed to examine the influence of alkyl tail length and concentration of the amphiphilic coumarin on the lipid bilayer. Alkyl tails comprising 5(C
    MeSH term(s) 1,2-Dipalmitoylphosphatidylcholine/chemistry ; Coumarins/chemical synthesis ; Coumarins/chemistry ; Hydrophobic and Hydrophilic Interactions ; Lipid Bilayers/chemistry ; Molecular Dynamics Simulation ; Molecular Structure ; Phosphatidylserines/chemistry ; Surface-Active Agents/chemical synthesis ; Surface-Active Agents/chemistry
    Chemical Substances Coumarins ; Lipid Bilayers ; Phosphatidylserines ; Surface-Active Agents ; 1,2-Dipalmitoylphosphatidylcholine (2644-64-6) ; dipalmitoylphosphatidylserine (3036-82-6) ; coumarin (A4VZ22K1WT)
    Language English
    Publishing date 2020-05-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d0cp00696c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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