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Article: Simulation-Based Outreach Program Improves Rural Hospitals' Team Confidence in Neonatal Resuscitation.

Zanno, Allison / Melendi, Misty / Cutler, Anya / Stone, Benjamin / Chipman, Micheline / Holmes, Jeffrey / Craig, Alexa

2022 Volume 14, Issue 9, Page(s) e28670

Abstract: Introduction: Neonatal resuscitation is a high acuity, low occurrence event (HALO), and in rural community hospitals, low birth rates prevent providers from regular opportunities to maintain essential resuscitation skills. Simulation is an effective ... ...

Abstract	Introduction: Neonatal resuscitation is a high acuity, low occurrence event (HALO), and in rural community hospitals, low birth rates prevent providers from regular opportunities to maintain essential resuscitation skills. Simulation is an effective training modality for medical education, although resources for simulation are often limited in rural hospitals. Our primary objective was to test the hypothesis that in situ neonatal resuscitation simulation training improves rural hospitals' delivery room team confidence in performing key Neonatal Resuscitation Program Methods: We conducted a quasi-experimental pre-training survey and post-training survey of delivery room team confidence in NRP Results: Our data demonstrate a significant improvement in self-assessed confidence levels pre- and post-simulation training in key areas of neonatal resuscitation. Participants reported higher confidence in airway management (4 vs. 3, p=0.003), emergency intravenous access (3 vs. 2, p=0.007), and the ability to manage a code in the delivery room (4 vs. 3, p=0.013) and the operating room (4 vs. 3, p=0.028). Improvements were also noted in their team member's knowledge and skills to perform neonatal resuscitation. While improvements were appreciated in confidence, the performance of skills (NRP Conclusions: An in situ-based neonatal resuscitation outreach simulation program improves self-confidence among rural delivery room teams. Additional research is needed to understand how to translate improved confidence into actual improved performance.
Language	English
Publishing date	2022-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.28670
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Conference proceedings: The National Heart, Lung, and Blood Institute Workshop on Salt and Blood Pressure

Cutler, Jeffrey A.

[Bethesda, Maryland, November 1 - 2, 1989]

(Hypertension ; 17,1, Suppl. 1)

1991

Institution	National Heart, Lung, and Blood Institute
Event/congress	Workshop on Salt and Blood Pressure (1989, BethesdaMd.)
Author's details	guest ed.: Jeffrey A. Cutler
Series title	Hypertension ; 17,1, Suppl. 1
Collection
Keywords	Hypertension / congresses ; Sodium, Dietary / congresses ; Blutdruck ; Kochsalz
Subject	Speisesalz ; Tafelsalz
Language	English
Size	221 S. : graph. Darst.
Publisher	American Heart Association
Publishing place	Dallas, TX
Publishing country	United States
Document type	Book ; Conference proceedings
HBZ-ID	HT003824874
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

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Zs A 1488 -17,1,Suppl.1-	verfügbar in Königswinter	Königswinter

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Book ; Conference proceedings: The National Heart, Lung, and Blood Institute Workshop on Antihypertensive Drug Treatment

Cutler, Jeffrey A.

the benefits, costs, and choices ; [Bethesda, Md. on June 11 - 12, 1987]

(Hypertension ; 13,5, Suppl. 1)

1989

Institution	National Heart, Lung, and Blood Institute
Event/congress	Workshop on Antihypertensive Drug Treatment (1987, BethesdaMd.)
Author's details	guest ed. Jeffrey A. Cutler
Series title	Hypertension ; 13,5, Suppl. 1
Collection
Keywords	Hypertension / drug therapy / congresses ; Cost-Benefit Analysis / congresses
Language	English
Size	I-172 S. : graph. Darst.
Publisher	American Heart Assoc
Publishing place	Dallas, TX
Publishing country	United States
Document type	Book ; Conference proceedings
HBZ-ID	HT003347372
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
Zs A 1488 -13,5,Suppl.1-	verfügbar in Königswinter	Königswinter

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Article ; Online: Pharmacologic Treatment of Hypertension in Adults Aged 60 Years or Older.

Cushman, William C / Johnson, Karen C / Applegate, William B / Cutler, Jeffrey A

Annals of internal medicine

2017 Volume 167, Issue 4, Page(s) 290–291

Language	English
Publishing date	2017-08-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/L17-0284
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Ua VI Zs.178/2: Show issues

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Article ; Online: Longitudinal DNA methylation profiling of the rectal mucosa identifies cell-specific signatures of disease status, severity and clinical outcomes in ulcerative colitis cell-specific DNA methylation signatures of UC.

Venkateswaran, Suresh / Somineni, Hari K / Matthews, Jason D / Kilaru, Varun / Hyams, Jeffrey S / Denson, Lee A / Kellamayer, Richard / Gibson, Greg / Cutler, David J / Conneely, Karen N / Smith, Alicia K / Kugathasan, Subra

Clinical epigenetics

2023 Volume 15, Issue 1, Page(s) 50

Abstract: Background: In peripheral blood, DNA methylation (DNAm) patterns in inflammatory bowel disease patients reflect inflammatory status rather than disease status. Here, we examined DNAm in diseased rectal mucosa from ulcerative colitis (UC) patients, ... ...

Abstract	Background: In peripheral blood, DNA methylation (DNAm) patterns in inflammatory bowel disease patients reflect inflammatory status rather than disease status. Here, we examined DNAm in diseased rectal mucosa from ulcerative colitis (UC) patients, focusing on constituent cell types with the goal of identifying therapeutic targets for UC other than the immune system. We profiled DNAm of rectal mucosal biopsies of pediatric UC at diagnosis (n = 211) and non-IBD control (n = 85) patients and performed epigenome-wide association studies (EWAS) of specific cell types to understand DNAm changes in epithelial, immune and fibroblast cells across disease states, course, and clinical outcomes. We also examined longitudinal analysis on follow-up samples (n = 73), and comparisons were made among patients with clinical outcomes including those undergoing colectomy versus those who did not. Additionally, we included RNA-seq from the same subjects to assess the impact of CpG sites on the transcription of nearby genes during the disease course. Results: At diagnosis, UC rectal mucosa exhibited a lower proportion of epithelial cells and fibroblasts, and higher proportion of immune cells, in conjunction with variation in the DNAm pattern. While treatment had significant effects on the methylation signature of immune cells, its effects on fibroblasts and epithelial cells were attenuated. Individuals who required colectomy exhibited cell composition and DNAm patterns at follow-up more similar to disease onset than patients who did not require colectomy. Combining these results with gene expression profiles, we identify CpG sites whose methylation patterns are most consistent with a contribution to poor disease outcomes and could thus be potential therapeutic targets. Conclusions: Cell-specific epigenetic changes in the rectal mucosa in UC are associated with disease severity and outcome. Current therapeutics may more effectively target the immune than the epithelial and fibroblast compartments.
MeSH term(s)	Child ; Humans ; Colitis, Ulcerative/genetics ; DNA Methylation ; Crohn Disease/genetics ; Rectum/surgery ; Mucous Membrane/metabolism
Language	English
Publishing date	2023-03-24
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553921-8
ISSN	1868-7083 ; 1868-7075
ISSN (online)	1868-7083
ISSN	1868-7075
DOI	10.1186/s13148-023-01462-4
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Article: Genetic manipulation of candidate phyla radiation bacteria provides functional insights into microbial dark matter.

Wang, Yaxi / Gallagher, Larry A / Andrade, Pia A / Liu, Andi / Humphreys, Ian R / Turkarslan, Serdar / Cutler, Kevin J / Arrieta-Ortiz, Mario L / Li, Yaqiao / Radey, Matthew C / McLean, Jeffrey S / Cong, Qian / Baker, David / Baliga, Nitin S / Peterson, S Brook / Mougous, Joseph D

bioRxiv : the preprint server for biology

2023

Abstract: The study of bacteria has yielded fundamental insights into cellular biology and physiology, biotechnological advances and many therapeutics. Yet due to a lack of suitable tools, the significant portion of bacterial diversity held within the candidate ... ...

Abstract	The study of bacteria has yielded fundamental insights into cellular biology and physiology, biotechnological advances and many therapeutics. Yet due to a lack of suitable tools, the significant portion of bacterial diversity held within the candidate phyla radiation (CPR) remains inaccessible to such pursuits. Here we show that CPR bacteria belonging to the phylum Saccharibacteria exhibit natural competence. We exploit this property to develop methods for their genetic manipulation, including the insertion of heterologous sequences and the construction of targeted gene deletions. Imaging of fluorescent protein-labeled Saccharibacteria provides high spatiotemporal resolution of phenomena accompanying epibiotic growth and a transposon insertion sequencing genome-wide screen reveals the contribution of enigmatic Saccharibacterial genes to growth on their Actinobacteria hosts. Finally, we leverage metagenomic data to provide cutting-edge protein structure-based bioinformatic resources that support the strain
Language	English
Publishing date	2023-05-11
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.05.02.539146
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Case Series and Systematic Review of Electronic Scooter Crashes and Severe Traumatic Brain Injury.

Azab, Mohammad / Gamboa, Nicholas / Nadel, Jeffrey / Cutler, Christopher / Henson, Jeffrey Curran / Lucke-Wold, Brandon / Panther, Eric / Brandel, Michael G / Khalessi, Alexander A / Rennert, Robert C / Menacho, Sarah T / Mazur, Marcus D / Karsy, Michael

World neurosurgery

2022 Volume 167, Page(s) e184–e195

Abstract: Objective: Electric scooters (e-scooters) are an increasingly popular form of transportation, but their use has also resulted in increased incidence of traumatic brain injury (TBI). Previous reports have predominantly described mild TBI with limited ... ...

Abstract	Objective: Electric scooters (e-scooters) are an increasingly popular form of transportation, but their use has also resulted in increased incidence of traumatic brain injury (TBI). Previous reports have predominantly described mild TBI with limited attention to other injury patterns. Our objective was to evaluate the impact of e-scooter use on rates of severe TBI. Methods: We performed a multicenter retrospective case review of patients who presented with severe TBI (Glasgow Coma Scale score 3-8) related to e-scooter use and undertook a systematic literature review to identify other reports of severe TBI related to e-scooter use. Results: Of the 19 patients (mean age, 38 ± 16 years; 73.7% male) included in the case series, 13 (68.4%) experienced a fall and 6 (31.6%) were involved in a collision. Various cerebral injury patterns, associated craniofacial fractures, and cervical spine injuries were also seen. Twelve patients (63.2%) underwent intracranial pressure monitor placement and 6 (31.6%) underwent a decompressive hemicraniectomy. Most patients (n = 12; 63.2%) were discharged to acute rehabilitation, with a median modified Rankin Scale score of 2 at 4.9 ± 7.7 months follow-up (52.6% had a good outcome of modified Rankin Scale score ≤2), but 4 patients died of primary injuries. The systematic review identified 18 studies with 77,069 patients between 2019 and 2021, with 37 patients who required intensive care and 6 patients who had neurosurgical intervention. Conclusions: Severe TBI after e-scooter use is associated with high morbidity and is likely underdiagnosed in the literature. Awareness and public policies may be helpful to reduce the impact of injury.
MeSH term(s)	Humans ; Male ; Young Adult ; Adult ; Middle Aged ; Female ; Accidents, Traffic ; Retrospective Studies ; Brain Injuries, Traumatic/epidemiology ; Brain Injuries, Traumatic/surgery ; Brain Injuries ; Fractures, Bone/epidemiology ; Multicenter Studies as Topic
Language	English
Publishing date	2022-08-06
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2022.07.126
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Zs.A 1159: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle.

Cell

2023 Volume 186, Issue 22, Page(s) 4803–4817.e13

Abstract: Patescibacteria, also known as the candidate phyla radiation (CPR), are a diverse group of bacteria that constitute a disproportionately large fraction of microbial dark matter. Its few cultivated members, belonging mostly to Saccharibacteria, grow as ... ...

Abstract	Patescibacteria, also known as the candidate phyla radiation (CPR), are a diverse group of bacteria that constitute a disproportionately large fraction of microbial dark matter. Its few cultivated members, belonging mostly to Saccharibacteria, grow as epibionts on host Actinobacteria. Due to a lack of suitable tools, the genetic basis of this lifestyle and other unique features of Patescibacteira remain unexplored. Here, we show that Saccharibacteria exhibit natural competence, and we exploit this property for their genetic manipulation. Imaging of fluorescent protein-labeled Saccharibacteria provides high spatiotemporal resolution of phenomena accompanying epibiotic growth, and a transposon-insertion sequencing (Tn-seq) genome-wide screen reveals the contribution of enigmatic Saccharibacterial genes to growth on their hosts. Finally, we leverage metagenomic data to provide cutting-edge protein structure-based bioinformatic resources that support the strain Southlakia epibionticum and its corresponding host, Actinomyces israelii, as a model system for unlocking the molecular underpinnings of the epibiotic lifestyle.
MeSH term(s)	Bacteria/classification ; Bacteria/genetics ; Bacteria/growth & development ; Metagenome ; Metagenomics ; Phylogeny ; Actinobacteria/physiology
Language	English
Publishing date	2023-09-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2023.08.017
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Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 58: Show issues

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Article ; Online: Positive Psychological Well-Being in Hematopoietic Stem Cell Transplantation Survivors.

Amonoo, Hermioni L / Lam, Jeffrey A / Daskalakis, Elizabeth / Deary, Emma C / Celano, Christopher / Onyeaka, Henry K / Newcomb, Richard / Barata, Anna / Horick, Nora / Cutler, Corey / Pirl, William F / Lee, Stephanie J / Huffman, Jeff C / El-Jawahri, Areej

Transplantation and cellular therapy

2023 Volume 29, Issue 9, Page(s) 583.e1–583.e9

Abstract: Positive thoughts and emotions contribute to overall psychological health in diverse medical populations, including patients undergoing HSCT. However, few studies have described positive psychological well-being (eg, optimism, gratitude, flourishing) in ... ...

Abstract	Positive thoughts and emotions contribute to overall psychological health in diverse medical populations, including patients undergoing HSCT. However, few studies have described positive psychological well-being (eg, optimism, gratitude, flourishing) in patients undergoing HSCT using well-established, validated patient-reported outcome measures. We conducted cross-sectional secondary analyses of baseline data in 156 patients at 100 days post-HSCT enrolled in a randomized controlled trial of a psychological intervention (ClinicalTrials.gov identifier NCT05147311) and a prospective study assessing medication adherence at a tertiary care academic cancer center from September 2021 to December 2022. We used descriptive statistics to outline participant reports of positive psychological well-being (PPWB) using validated measures for optimism, gratitude, positive affect, life satisfaction, and flourishing. The participants had a mean age of 57.4 ± 13.1 years, and 51% were male (n = 79). Many, but not all, participants reported high levels of PPWB (ie, optimism, gratitude, positive affect, life satisfaction, and flourishing), defined as agreement with items on a given PPWB measure. For example, for optimism, 29% of participants did not agree that "overall, I expect more good things to happen to me than bad." Aside from life satisfaction, mean PPWB scores were higher in the HSCT population than in other illness populations. Although many patients with hematologic malignancies undergoing HSCT report high levels of PPWB, a substantial minority of patients reported low PPWB (i.e., no agreement with items on a given PPWB measure). Because PPWB is associated with important clinical outcomes in medical populations, further research should determine whether an intervention to promote PPWB can improve quality of life in HSCT recipients.
MeSH term(s)	Humans ; Male ; Adult ; Middle Aged ; Aged ; Female ; Psychological Well-Being ; Quality of Life ; Cross-Sectional Studies ; Prospective Studies ; Hematopoietic Stem Cell Transplantation ; Survivors
Language	English
Publishing date	2023-07-11
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3062231-1
ISSN	2666-6367
ISSN (online)	2666-6367
DOI	10.1016/j.jtct.2023.07.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5082: Show issues

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Article ; Online: Profiling non-coding RNA levels with clinical classifiers in pediatric Crohn's disease.

Pelia, Ranjit / Venkateswaran, Suresh / Matthews, Jason D / Haberman, Yael / Cutler, David J / Hyams, Jeffrey S / Denson, Lee A / Kugathasan, Subra

BMC medical genomics

2021 Volume 14, Issue 1, Page(s) 194

Abstract: Background: Crohn's disease (CD) is a heritable chronic inflammatory disorder. Non-coding RNAs (ncRNAs) play an important role in epigenetic regulation by affecting gene expression, but can also directly affect protein function, thus having a ... ...

Abstract	Background: Crohn's disease (CD) is a heritable chronic inflammatory disorder. Non-coding RNAs (ncRNAs) play an important role in epigenetic regulation by affecting gene expression, but can also directly affect protein function, thus having a substantial impact on biological processes. We investigated whether non-coding RNAs (ncRNA) at diagnosis are dysregulated during CD at different CD locations and future disease behaviors to determine if ncRNA signatures can serve as an index to outcomes. Methods: Using subjects belonging to the RISK cohort, we analyzed ncRNA from the ileal biopsies of 345 CD and 71 non-IBD controls, and ncRNA from rectal biopsies of 329 CD and 61 non-IBD controls. Sequence alignment was done (STAR package) using Human Genome version 38 (hg38) as reference panel. The differential expression (DE) analysis was performed with EdgeR package and DE ncRNAs were identified with a threshold of fold change (FC) > 2 and FDR < 0.05 after multiple test corrections. Results: In total, we identified 130 CD specific DE ncRNAs (89 in ileum and 41 in rectum) when compared to non-IBD controls. Similarly, 35 DE ncRNAs were identified between B1 and B2 in ileum, whereas no differences among CD disease behaviors were noticed in rectum. We also found inflammation specific ncRNAs between inflamed and non-inflamed groups in ileal biopsies. Overall, we observed that expression of mir1244-2, mir1244-3, mir1244-4, and RN7SL2 were increased during CD, regardless of disease behavior, location, or inflammatory status. Lastly, we tested ncRNA expression at baseline as potential tool to predict the disease status, disease behaviors and disease inflammation at 3-year follow up. Conclusions: We have identified ncRNAs that are specific to disease location, disease behavior, and disease inflammation in CD. Both ileal and rectal specific ncRNA are changing over the course of CD, specifically during the disease progression in the intestinal mucosa. Collectively, our findings show changes in ncRNA during CD and may have a clinical utility in early identification and characterization of disease progression.
MeSH term(s)	Crohn Disease
Language	English
Publishing date	2021-07-29
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1755-8794
ISSN (online)	1755-8794
DOI	10.1186/s12920-021-01041-7
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