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  1. Article ; Online: Prevention of Cardiovascular Disease in Type 1 Diabetes.

    Manrique-Acevedo, Camila / Hirsch, Irl B / Eckel, Robert H

    The New England journal of medicine

    2024  Volume 390, Issue 13, Page(s) 1207–1217

    MeSH term(s) Humans ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 2 ; Primary Prevention ; Risk Factors
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra2311526
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  2. Article ; Online: Volume Removal in Heart Failure: Current Concepts and a Look into the Future.

    Whaley-Connell, Adam / Ronco, Claudio / Manrique-Acevedo, Camila

    Cardiorenal medicine

    2023  Volume 13, Issue 1, Page(s) 342–343

    MeSH term(s) Humans ; Heart Failure/therapy ; Stroke Volume
    Language English
    Publishing date 2023-09-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2595659-0
    ISSN 1664-5502 ; 1664-3828
    ISSN (online) 1664-5502
    ISSN 1664-3828
    DOI 10.1159/000534094
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  3. Article ; Online: New insights into mechanisms of endothelial insulin resistance in type 2 diabetes.

    Padilla, Jaume / Manrique-Acevedo, Camila / Martinez-Lemus, Luis A

    American journal of physiology. Heart and circulatory physiology

    2022  Volume 323, Issue 6, Page(s) H1231–H1238

    Abstract: Insulin resistance in the vasculature is a hallmark of type 2 diabetes (T2D), and blunting of insulin-induced vasodilation is its primary consequence. Individuals with T2D exhibit a marked impairment in insulin-induced dilation in resistance arteries ... ...

    Abstract Insulin resistance in the vasculature is a hallmark of type 2 diabetes (T2D), and blunting of insulin-induced vasodilation is its primary consequence. Individuals with T2D exhibit a marked impairment in insulin-induced dilation in resistance arteries across vascular beds. Importantly, reduced insulin-stimulated vasodilation and blood flow to skeletal muscle limits glucose uptake and contributes to impaired glucose control in T2D. The study of mechanisms responsible for the suppressed vasodilatory effects of insulin has been a growing topic of interest for not only its association with glucose control and extension to T2D but also its relationship with cardiovascular disease development and progression. In this mini-review, we integrate findings from recent studies by our group with the existing literature focused on the mechanisms underlying endothelial insulin resistance in T2D.
    MeSH term(s) Humans ; Insulin Resistance/physiology ; Diabetes Mellitus, Type 2 ; Blood Glucose ; Insulin/pharmacology ; Vasodilation ; Muscle, Skeletal
    Chemical Substances Blood Glucose ; Insulin
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00537.2022
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  4. Article: CISD3 is required for Complex I function, mitochondrial integrity, and skeletal muscle maintenance.

    Marjault, Henri-Baptiste / Karmi, Ola / Rowland, Linda / Nguyen, Thi Thao / Grant, DeAna / Manrique-Acevedo, Camila / Nechushtai, Rachel / Mittler, Ron

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Mitochondria play a central role in muscle metabolism and function. In skeletal muscles, a unique family of iron-sulfur proteins, termed CISD proteins, support mitochondrial function. The abundance of these proteins declines with aging leading to muscle ... ...

    Abstract Mitochondria play a central role in muscle metabolism and function. In skeletal muscles, a unique family of iron-sulfur proteins, termed CISD proteins, support mitochondrial function. The abundance of these proteins declines with aging leading to muscle degeneration. Although the function of the outer mitochondrial proteins CISD1 and CISD2 has been defined, the role of the inner mitochondrial protein CISD3, is currently unknown. Here we show that CISD3 deficiency in mice results in muscle atrophy that shares proteomic features with Duchenne Muscular Dystrophy. We further reveal that CISD3 deficiency impairs the function and structure of skeletal muscle mitochondria, and that CISD3 interacts with, and donates its clusters to, Complex I respiratory chain subunit NDUFV2. These findings reveal that CISD3 is important for supporting the biogenesis and function of Complex I, essential for muscle maintenance and function. Interventions that target CISD3 could therefore impact muscle degeneration syndromes, aging, and related conditions.
    Language English
    Publishing date 2023-06-04
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.03.543558
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  5. Article: Socioepidemiological macro-determinants associated with the cumulative incidence of bacterial meningitis: A focus on the African Meningitis Belt.

    Pinilla-Monsalve, Gabriel D / Llanos-Leyton, Natalia / González, Maria Camila / Manrique-Hernández, Edgar Fabian / Rey-Serrano, Juan José / Quiñones-Bautista, Jairo Alonso

    Frontiers in neurology

    2023  Volume 14, Page(s) 1088182

    Abstract: Background: Bacterial meningitis (BM) is a public health challenge as it is associated with high lethality and neurological sequelae. Worldwide, most cases are registered in the African Meningitis Belt (AMB). The role of particular socioepidemiological ... ...

    Abstract Background: Bacterial meningitis (BM) is a public health challenge as it is associated with high lethality and neurological sequelae. Worldwide, most cases are registered in the African Meningitis Belt (AMB). The role of particular socioepidemiological features is essential for understanding disease dynamics and optimizing policy-making.
    Objective: To identify socioepidemiological macro-determinants that contribute to explaining the differences in BM incidence between AMB and the rest of Africa.
    Methods: Country-level ecologic study based on the cumulative incidence estimates of the Global Burden of Disease study and reports of the MenAfriNet Consortium. Data about relevant socioepidemiological features were extracted from international sources. Multivariate regression models were implemented to define variables associated with the classification of African countries within the AMB and the incidence of BM worldwide.
    Results: Cumulative incidences at the AMB sub-regions were 111.93 (west), 87.23 (central), 65.10 (east), and 42.47 (north) per 100,000 population. A pattern of common origin with continuous exposition and seasonality of cases was observed. Socio-epidemiological determinants contributing to differentiating the AMB from the rest of Africa were household occupancy (OR 3.17 CI 95% 1.09-9.22,
    Conclusion: Socioeconomic and climate conditions are macro-determinants associated with BM cumulative incidence. Multilevel designs are required to confirm these findings.
    Language English
    Publishing date 2023-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1088182
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  6. Article ; Online: The [2Fe-2S] protein CISD2 plays a key role in preventing iron accumulation in cardiomyocytes.

    Karmi, Ola / Rowland, Linda / King, Skylar D / Manrique-Acevedo, Camila / Cabantchik, Ioav Z / Nechushtai, Rachel / Mittler, Ron

    FEBS letters

    2022  Volume 596, Issue 6, Page(s) 747–761

    Abstract: Considered a key aging gene, CISD2, encoding CDGSH iron-sulfur domain-containing protein 2, plays a central role in regulating calcium homeostasis, preventing mitochondrial dysfunction, and the activation of autophagy and apoptosis in different cells. ... ...

    Abstract Considered a key aging gene, CISD2, encoding CDGSH iron-sulfur domain-containing protein 2, plays a central role in regulating calcium homeostasis, preventing mitochondrial dysfunction, and the activation of autophagy and apoptosis in different cells. Here, we show that cardiomyocytes from CISD2-null mice accumulate high levels of iron and contain high levels of transferrin receptor and ferritin. Using proteomics and transmission electron microscopy, we further show that the lack of CISD2 induces several features of the aging process in young mice, but other features are not induced. Taken together, our findings suggest that CISD2 protects cardiomyocytes from overaccumulation of iron, which is common in aging hearts and can contribute to the pathogenesis of heart failure.
    MeSH term(s) Aging ; Animals ; Autophagy-Related Proteins ; Carrier Proteins ; Iron/metabolism ; Mice ; Mice, Knockout ; Myocytes, Cardiac/metabolism ; Nerve Tissue Proteins
    Chemical Substances Autophagy-Related Proteins ; Carrier Proteins ; Nerve Tissue Proteins ; Noxp70 protein, mouse ; Iron (E1UOL152H7)
    Language English
    Publishing date 2022-01-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14277
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  7. Article ; Online: Human intestinal lipid storage through sequential meals reveals faster dinner appearance is associated with hyperlipidemia.

    Jacome-Sosa, Miriam / Hu, Qiong / Manrique-Acevedo, Camila M / Phair, Robert D / Parks, Elizabeth J

    JCI insight

    2021  Volume 6, Issue 15

    Abstract: BackgroundIt is increasingly recognized that intestinal cells can store lipids after a meal, yet the effect of this phenomenon on lipid absorption patterns in insulin resistance remains unknown.MethodsThe kinetics of meal fat appearance were measured in ... ...

    Abstract BackgroundIt is increasingly recognized that intestinal cells can store lipids after a meal, yet the effect of this phenomenon on lipid absorption patterns in insulin resistance remains unknown.MethodsThe kinetics of meal fat appearance were measured in insulin-sensitive (IS, n = 8) and insulin-resistant (IR, n = 8) subjects after sequential, isotopically labeled lunch and dinner meals. Plasma dynamics on triacylglycerol-rich (TAG-rich) lipoproteins and plasma hormones were analyzed using a nonlinear, non-steady state kinetic model.ResultsAt the onset of dinner, IS subjects showed an abrupt plasma appearance of lunch lipid consistent with the "second-meal effect," followed by slower appearance of dinner fat in plasma, resulting in reduced accumulation of dinner TAG of 48% compared with lunch. By contrast, IR subjects exhibited faster meal TAG appearance rates after both lunch and dinner. This effect of lower enterocyte storage between meals was associated with greater nocturnal and next-morning hyperlipidemia. The biochemical data and the kinetic analysis of second-meal effect dynamics are consistent with rapid secretion of stored TAG bypassing lipolysis and resynthesis. In addition, the data are consistent with a role for the diurnal pattern of plasma leptin in regulating the processing of dietary lipid.ConclusionThese data support the concept that intestinal lipid storage may be physiologically beneficial in IS subjects.Trial registrationClinicalTrials.gov NCT02020343.FundingThis study was supported by a grant from the American Diabetes Association (grant 1-13-TS-12).
    MeSH term(s) Adult ; Body Fat Distribution ; Dietary Fats/metabolism ; Feeding Behavior/physiology ; Female ; Humans ; Insulin Resistance ; Insulin Secretion ; Intestinal Absorption/physiology ; Intestines/physiology ; Leptin/blood ; Leptin/metabolism ; Lipid Metabolism/physiology ; Lipoproteins/metabolism ; Male ; Triglycerides/metabolism
    Chemical Substances Dietary Fats ; Leptin ; Lipoproteins ; Triglycerides
    Language English
    Publishing date 2021-08-09
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.148378
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  8. Article ; Online: Young Women Are Protected Against Vascular Insulin Resistance Induced by Adoption of an Obesogenic Lifestyle.

    Smith, James A / Soares, Rogerio N / McMillan, Neil J / Jurrissen, Thomas J / Martinez-Lemus, Luis A / Padilla, Jaume / Manrique-Acevedo, Camila

    Endocrinology

    2022  Volume 163, Issue 11

    Abstract: Vascular insulin resistance is a feature of obesity and type 2 diabetes that contributes to the genesis of vascular disease and glycemic dysregulation. Data from preclinical models indicate that vascular insulin resistance is an early event in the ... ...

    Abstract Vascular insulin resistance is a feature of obesity and type 2 diabetes that contributes to the genesis of vascular disease and glycemic dysregulation. Data from preclinical models indicate that vascular insulin resistance is an early event in the disease course, preceding the development of insulin resistance in metabolically active tissues. Whether this is translatable to humans requires further investigation. To this end, we examined if vascular insulin resistance develops when young healthy individuals (n = 18 men, n = 18 women) transition to an obesogenic lifestyle that would ultimately cause whole-body insulin resistance. Specifically, we hypothesized that short-term (10 days) exposure to reduced ambulatory activity (from >10 000 to <5000 steps/day) and increased consumption of sugar-sweetened beverages (6 cans/day) would be sufficient to prompt vascular insulin resistance. Furthermore, given that incidence of insulin resistance and cardiovascular disease is lower in premenopausal women than in men, we postulated that young females would be protected against vascular insulin resistance. Consistent with this hypothesis, we report that after reduced ambulation and increased ingestion of carbonated beverages high in sugar, young healthy men, but not women, exhibited a blunted leg blood flow response to insulin and suppressed skeletal muscle microvascular perfusion. These findings were associated with a decrease in plasma adropin and nitrite concentrations. This is the first evidence in humans that vascular insulin resistance can be provoked by short-term adverse lifestyle changes. It is also the first documentation of a sexual dimorphism in the development of vascular insulin resistance in association with changes in adropin levels.
    MeSH term(s) Blood Glucose ; Diabetes Mellitus, Type 2/etiology ; Diabetes Mellitus, Type 2/prevention & control ; Female ; Humans ; Insulin ; Insulin Resistance ; Life Style ; Male ; Nitrites
    Chemical Substances Blood Glucose ; Insulin ; Nitrites
    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqac137
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  9. Article ; Online: Endothelin-1 receptor blockade does not alter the sympathetic and hemodynamic response to acute intermittent hypoxia in men.

    Limberg, Jacqueline K / Baker, Sarah E / Ott, Elizabeth P / Jacob, Dain W / Scruggs, Zachariah M / Harper, Jennifer L / Manrique-Acevedo, Camila M

    Journal of applied physiology (Bethesda, Md. : 1985)

    2022  Volume 133, Issue 4, Page(s) 867–875

    Abstract: Repeat exposures to low oxygen (intermittent hypoxia, IH), like that observed in sleep apnea, elicit increases in muscle sympathetic nerve activity (MSNA) and blood pressure (BP) in men. Endothelin (ET) receptor antagonists can attenuate the sympathetic ... ...

    Abstract Repeat exposures to low oxygen (intermittent hypoxia, IH), like that observed in sleep apnea, elicit increases in muscle sympathetic nerve activity (MSNA) and blood pressure (BP) in men. Endothelin (ET) receptor antagonists can attenuate the sympathetic and BP response to IH in rodents; whether these data translate to humans are unclear. We hypothesized that ET-receptor antagonism would ameliorate any rise in MSNA and BP following acute IH in humans. Twelve healthy men (31 ± 1 yr) completed two visits (control, bosentan) separated by at least 1 wk. MSNA, BP, and baroreflex sensitivity (modified Oxford) were assessed during normoxic rest before and following 30 min of IH. The midpoint (T50) for each individual's baroreflex curve was calculated. Acute IH increased plasma ET-1 (
    MeSH term(s) Baroreflex/physiology ; Blood Pressure/physiology ; Bosentan ; Endothelin-1 ; Endothelins ; Heart Rate/physiology ; Hemodynamics ; Humans ; Hypoxia ; Male ; Muscle, Skeletal ; Oxygen ; Receptor, Endothelin A ; Sympathetic Nervous System/physiology
    Chemical Substances Endothelin-1 ; Endothelins ; Receptor, Endothelin A ; Bosentan (Q326023R30) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-08-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00837.2021
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  10. Book ; Online: Locating Zika

    Quintero, Juliana / Pimentel, Camila / Pavía-Ruz, Norma / Oliveira Nogueira, Carolina de / Nascimento / Silva, Lenir da / Lopes de Melo, Ana Paula / Corrêa Matta, Gustavo / Manrique-Saide, Pablo / Maciel Lyra, Tereza / Heydari, Naveed / Henderson, Rebecca Rose / Guevara, Milady / González-Uribe, Catalina / Gómez-Dantés, Héctor / García-Betancourt, Tatiana / Fujii, Yui / Fuentes-Vallejo, Mauricio / Briceño-León, Roberto /
    Borbor-Cordova, Mercy J. / Bennett, Priscilla / Bardosh, Kevin / Valongueiro Alves, Sandra / Velho Barreto de Araújo, Thália / Socorro Veloso de Albuquerque, Maria do

    2019  

    Abstract: The emergence of Zika virus challenged conventional ideas of mosquito-borne diseases, tested the resilience of health systems and embedded itself within local sociocultural worlds, with major implications for environmental, sexual, reproductive and ... ...

    Abstract The emergence of Zika virus challenged conventional ideas of mosquito-borne diseases, tested the resilience of health systems and embedded itself within local sociocultural worlds, with major implications for environmental, sexual, reproductive and paediatric health. This book explores this complex viral epidemic and situates it within its broader social, epidemiological and historical context in Latin America and the Caribbean. The chapters include a diverse set of case studies from scholars and health practitioners working across the region, from Brazil, Venezuela, Ecuador, Mexico, Colombia, the United States and Haiti. The book explores how mosquito-borne disease epidemics (not only Zika but also chikungunya, dengue and malaria) intersect with social change and health governance. By doing so, the authors reflect on the ways in which situated knowledge and social science approaches can contribute to more effective health
    Keywords Anthropology
    Size 1 electronic resource (238 pages)
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020394862
    ISBN 9781138315112 ; 9780429456558 ; 1138315117 ; 0429456557
    DOI 10.4324/9780429456558
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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