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  1. Article: Synthesis of melicodenines C, D and E

    Holla, Harish / Jenkins, Ian D / Neve, Juliette E / Pouwer, Rebecca H / Pham, Ngoc / Teague, Simon J / Quinn, Ronald J

    Tetrahedron letters. 2012 Dec. 26, v. 53, no. 52

    2012  

    Abstract: A synthesis of the unusual cyclobutane-quinolinone alkaloids melicodenines C, D and E ...

    Abstract A synthesis of the unusual cyclobutane-quinolinone alkaloids melicodenines C, D and E by intermolecular [2+2] cycloaddition is described.
    Keywords alkaloids ; chemical reactions ; chemical structure
    Language English
    Dates of publication 2012-1226
    Size p. 7101-7103.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2012.10.087
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 2837: Show issues Location:
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  2. Article ; Online: Clavatadines C-E, guanidine alkaloids from the Australian sponge Suberea clavata.

    Buchanan, Malcolm S / Carroll, Anthony R / Wessling, Deborah / Jobling, Michael / Avery, Vicky M / Davis, Rohan A / Feng, Yunjiang / Hooper, John N A / Quinn, Ronald J

    Journal of natural products

    2009  Volume 72, Issue 5, Page(s) 973–975

    Abstract: Three new marine alkaloids, clavatadines C-E (1-3), together with the three known compounds ...

    Abstract Three new marine alkaloids, clavatadines C-E (1-3), together with the three known compounds aerophobin 1 (4), purealdin L (5), and aplysinamisine II (6) were isolated from extracts of the sponge Suberea clavata by bioassay-guided fractionation using a serine protease factor XIa assay. Their structures were determined by 1D and 2D NMR spectroscopy. Compounds 1-6 exhibited weak inhibition of factor XIa.
    MeSH term(s) Alkaloids/chemistry ; Alkaloids/isolation & purification ; Alkaloids/pharmacology ; Animals ; Australia ; Factor XIa/antagonists & inhibitors ; Guanidines/chemistry ; Guanidines/isolation & purification ; Guanidines/pharmacology ; Marine Biology ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Porifera/chemistry
    Chemical Substances Alkaloids ; Guanidines ; clavatadine C ; clavatadine D ; clavatadine E ; Factor XIa (EC 3.4.21.27)
    Language English
    Publishing date 2009-05-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/np8008013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Longithorols C-E. Three new macrocyclic sesquiterpene hydroquinone metabolites from the australian ascidian, aplidium longithorax

    Davis / Carroll / Quinn

    Journal of natural products

    1999  Volume 62, Issue 10, Page(s) 1405–1409

    Abstract: ... and a novel macrocyclic chromenol, longithorol E (3). Longithorol C (1) had its absolute ... in the isolation of two new para-substituted cyclofarnesylated hydroquinone compounds, longithorols C (1) and D (2 ...

    Abstract Chemical investigation of a Great Barrier Reef ascidian, Aplidium longithorax has resulted in the isolation of two new para-substituted cyclofarnesylated hydroquinone compounds, longithorols C (1) and D (2), and a novel macrocyclic chromenol, longithorol E (3). Longithorol C (1) had its absolute stereochemistry determined by the advanced Mosher method and all compounds had their structures determined by interpretation of spectroscopic data.
    Language English
    Publishing date 1999-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/np990217a
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  4. Article ; Online: Comments on: "Hertzian contact response of dentin with loading rate and orientation" by N.R. da Silva, F. Lalani, P.G. Coelho, E.A. Clark, C.A. de Oliveira Fernandes, V.P. Thompson [Arch. Oral Biol. 53 (2008) 729-735].

    Arola, Dwayne D / Bajaj, Devendra / Romberg, Elaine / Quinn, George D

    Archives of oral biology

    2009  Volume 54, Issue 12, Page(s) 1125–1127

    MeSH term(s) Animals ; Cattle ; Dental Stress Analysis ; Dentin/physiology ; Dentin/ultrastructure ; Elastic Modulus ; Humans ; Stress, Mechanical
    Language English
    Publishing date 2009-12
    Publishing country England
    Document type Comment ; Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 80227-x
    ISSN 1879-1506 ; 0003-9969
    ISSN (online) 1879-1506
    ISSN 0003-9969
    DOI 10.1016/j.archoralbio.2009.10.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Diimidazo[1,2-c:4',5'-e]pyrimidines: N6-N1 conformationally restricted adenosines.

    Camp, D / Li, Y / McCluskey, A / Moni, R W / Quinn, R J

    Bioorganic & medicinal chemistry letters

    1998  Volume 8, Issue 6, Page(s) 695–698

    Abstract: ... of conformationally restricted adenosine analogues. The resultant diimidazo[1,2-c:4',5'-e]pyrimidines were shown to be ...

    Abstract Tethering the N6-substituents of N6-substituted adenosines to N1 has resulted in a series of conformationally restricted adenosine analogues. The resultant diimidazo[1,2-c:4',5'-e]pyrimidines were shown to be adenosine A1 selective.
    MeSH term(s) Animals ; Brain/metabolism ; Cells, Cultured ; Corpus Striatum/metabolism ; Humans ; Models, Chemical ; Phenylisopropyladenosine/analogs & derivatives ; Phenylisopropyladenosine/metabolism ; Purinergic P1 Receptor Agonists ; Pyrimidines/chemical synthesis ; Pyrimidines/metabolism ; Rats ; Receptors, Purinergic P1/metabolism
    Chemical Substances Purinergic P1 Receptor Agonists ; Pyrimidines ; Receptors, Purinergic P1 ; Phenylisopropyladenosine (29193-86-0)
    Language English
    Publishing date 1998-03-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/s0960-894x(98)00101-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Diimidazo[1,2-c:4',5'-e]pyrimidines: adenosine agonist activity demonstrated by microphysiometry.

    Camp, D / Green, J M / Kaiser, S M / Moni, R W / Townsend-Nicholson, A / Schofield, P R / Quinn, R J

    Bioorganic & medicinal chemistry letters

    1998  Volume 8, Issue 6, Page(s) 691–694

    Abstract: ... demonstrated that a series of diimidazo[1,2-c:4',5'-e]pyrimidines were agonists at the human adenosine A1 ... receptor. 5-amino-7,8-dihydro-3-ribofuranose-8-(R)-(phenyl)-3H-diimidazo [1,2-c:4',5'-e]pyrimidine (2a) had ...

    Abstract Silicon-based microphysiometry, measuring extracellular acidification rate of cells in culture, demonstrated that a series of diimidazo[1,2-c:4',5'-e]pyrimidines were agonists at the human adenosine A1 receptor. 5-amino-7,8-dihydro-3-ribofuranose-8-(R)-(phenyl)-3H-diimidazo [1,2-c:4',5'-e]pyrimidine (2a) had an EC50 of 100 microM and reached 90% of the Emax produced by R-PIA.
    MeSH term(s) Animals ; Brain/metabolism ; Cells, Cultured ; Corpus Striatum/metabolism ; Humans ; Microchemistry/methods ; Models, Chemical ; Phenylisopropyladenosine/analogs & derivatives ; Phenylisopropyladenosine/metabolism ; Purinergic P1 Receptor Agonists ; Pyrimidines/chemical synthesis ; Pyrimidines/pharmacology ; Rats ; Receptors, Purinergic P1/metabolism ; Silicon
    Chemical Substances Purinergic P1 Receptor Agonists ; Pyrimidines ; Receptors, Purinergic P1 ; Phenylisopropyladenosine (29193-86-0) ; Silicon (Z4152N8IUI)
    Language English
    Publishing date 1998-03-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/s0960-894x(98)00102-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: On the role of dysferlin in striated muscle: membrane repair, t-tubules and Ca

    Quinn, C J / Cartwright, E J / Trafford, A W / Dibb, K M

    The Journal of physiology

    2024  

    Abstract: Dysferlin is a 237 kDa membrane-associated protein characterised by multiple C2 domains with a diverse role in skeletal and cardiac muscle physiology. Mutations in DYSF are known to cause various types of human muscular dystrophies, known collectively as ...

    Abstract Dysferlin is a 237 kDa membrane-associated protein characterised by multiple C2 domains with a diverse role in skeletal and cardiac muscle physiology. Mutations in DYSF are known to cause various types of human muscular dystrophies, known collectively as dysferlinopathies, with some patients developing cardiomyopathy. A myriad of in vitro membrane repair studies suggest that dysferlin plays an integral role in the membrane repair complex in skeletal muscle. In comparison, less is known about dysferlin in the heart, but mounting evidence suggests that dysferlin's role is similar in both muscle types. Recent findings have shown that dysferlin regulates Ca
    Language English
    Publishing date 2024-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP285103
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  8. Article ; Online: A participatory approach to understand what might be most meaningful to people living with dementia in a positive psychology intervention.

    Jackman, Victoria / Wolverson, Emma / Clarke, Chris / Quinn, Catherine

    Aging & mental health

    2024  , Page(s) 1–10

    Abstract: Objectives: This study aimed to understand which character strengths are most important for people living with dementia and therefore which strengths-based psychological interventions could be most meaningful and acceptable.: Methods: A participatory ...

    Abstract Objectives: This study aimed to understand which character strengths are most important for people living with dementia and therefore which strengths-based psychological interventions could be most meaningful and acceptable.
    Methods: A participatory design, utilising Delphi methodology, was incorporated into an iterative three stage framework: (1) literature reviewed for Positive Psychology (PP) interventions and patient public involvement to define the character strengths; (2) modified Delphi (
    Results: Love, kindness and humour were deemed the most important character strengths for living with dementia. Qualitative data from the focus groups was captured in three superordinate themes: (1) lack of opportunity not capacity; (2) key considerations of PP interventions for people living with dementia; and (3) potential benefits of PP interventions.
    Conclusions: Love, kindness and humour come naturally to people with dementia, but people may lack social opportunities to use these strengths. Therefore, a PP intervention promoting positive emotion, social relationships and connection to one's values appears most meaningful and acceptable as this may provide a social context to use and maintain these strengths.
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1474804-6
    ISSN 1364-6915 ; 1360-7863
    ISSN (online) 1364-6915
    ISSN 1360-7863
    DOI 10.1080/13607863.2023.2299967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5081: Show issues Location:
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  9. Article: Longithorols C-E. Three new macrocyclic sesquiterpene hydroquinone metabolites from the Australian ascidian, Aplidium longithorax

    Davis, R.A / Carroll, A.R / Quinn, R.J

    Journal of natural products. Oct 1999. v. 62 (10)

    1999  

    Keywords chemical composition ; hydroquinone ; metabolites ; spectral analysis ; chemical structure ; aquatic invertebrates ; drugs ; sesquiterpenoids ; Australia
    Language English
    Dates of publication 1999-10
    Size p. 1405-1409.
    Document type Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Prevalence and Correlates of Exposure (Direct and Indirect) to Perceived Racism-Based Police Violence among Black Emerging Adult College Students.

    Motley, Robert / Williamson, Eric / Quinn, Camille

    Social work in public health

    2024  , Page(s) 1–12

    Abstract: A growing body of evidence makes plain that exposure to perceived racism-based events, particularly for Black emerging adults aged 18-29, represents a major public health concern in the United States given its widespread prevalence and documented ... ...

    Abstract A growing body of evidence makes plain that exposure to perceived racism-based events, particularly for Black emerging adults aged 18-29, represents a major public health concern in the United States given its widespread prevalence and documented association with adverse health outcomes. However, research on the prevalence and correlates of exposure to perceived racism-based police violence (RPV) for Black emerging adults is scant. The current study examines the prevalence and correlates of RPV exposure among a sample of 300 Black emerging adult college students, utilizing computer-assisted surveys. Univariate, bivariate, and multiple linear regression analyzes were conducted. We found moderately low rates for direct RPV exposure (
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2414992-5
    ISSN 1937-190X ; 1937-1918
    ISSN (online) 1937-190X
    ISSN 1937-1918
    DOI 10.1080/19371918.2024.2341838
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