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  1. Article ; Online: Imaging of Community-acquired Pneumonia.

    Franquet, Tomás

    Journal of thoracic imaging

    2018  Volume 33, Issue 5, Page(s) 282–294

    Abstract: Community-acquired pneumonia refers to an acute infection of the lung in patients who did not meet any of the criteria for health care-acquired pneumonia, and is associated with at least some symptoms of acute infection, accompanied by the presence of an ...

    Abstract Community-acquired pneumonia refers to an acute infection of the lung in patients who did not meet any of the criteria for health care-acquired pneumonia, and is associated with at least some symptoms of acute infection, accompanied by the presence of an acute infiltrate on a chest radiograph. Chest radiography remains an important component of the evaluation of a patient with a suspicion of pneumonia, and is usually the first examination to be obtained. The diagnosis of community-acquired pneumonia is based on the presence of select clinical features and is supported by imaging of the lung, usually by chest radiography. Infection of the lower respiratory tract typically presents radiologically as one of 3 patterns: (a) focal nonsegmental or lobar pneumonia, (b) multifocal bronchopneumonia or lobular pneumonia, and (c) focal or diffuse "interstitial" pneumonia. High-resolution computed tomography allows a better depiction of the pattern and distribution of pneumonia than the radiograph but is seldom required in the evaluation of patients with suspected or proven bacterial pneumonia. However, high-resolution computed tomography is a useful adjunct to conventional radiography in selected cases.
    MeSH term(s) Community-Acquired Infections/diagnostic imaging ; Humans ; Lung/diagnostic imaging ; Pneumonia/diagnostic imaging ; Radiography/methods ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2018-07-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632900-7
    ISSN 1536-0237 ; 0883-5993
    ISSN (online) 1536-0237
    ISSN 0883-5993
    DOI 10.1097/RTI.0000000000000347
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  2. Article ; Online: Pulmonary Infections in People Living with HIV.

    Franquet, Tomás / Domingo, Pere

    Radiologic clinics of North America

    2022  Volume 60, Issue 3, Page(s) 507–520

    Abstract: Despite the development of combination antiretroviral therapy (cART) infections continue to cause significant morbidity and mortality among people living with HIV (PLWH). Pulmonary infections with Streptococcus pneumoniae, Haemophilus influenza, and ... ...

    Abstract Despite the development of combination antiretroviral therapy (cART) infections continue to cause significant morbidity and mortality among people living with HIV (PLWH). Pulmonary infections with Streptococcus pneumoniae, Haemophilus influenza, and Staphylococcus aureus remain common. One-third of PLWH worldwide are infected with tuberculosis and the infection manifests at any stage of HIV infection. Fungal infection is usually confined to PLWH unaware of their HIV infection until immunosuppression is advanced or those choosing to discontinue cART. The importance of viral infections has diminished since wide availability of cART; however, mortality from COVID-19 in PLWH may remain greater than in the non-HIV population.
    MeSH term(s) COVID-19 ; HIV Infections/complications ; HIV Infections/epidemiology ; Humans
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215712-3
    ISSN 1557-8275 ; 0033-8389
    ISSN (online) 1557-8275
    ISSN 0033-8389
    DOI 10.1016/j.rcl.2022.01.008
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  3. Article ; Online: Different forms of pulmonary aspergillosis: A pictorial essay.

    Tamkeviciute, Laima / Tumenas, Augustinas / Zaveckiene, Jurgita / Irion, Klaus / Franquet, Tomas / Radike, Monika

    European journal of radiology

    2024  Volume 171, Page(s) 111290

    Abstract: Pulmonary aspergillosis is a group of mycotic diseases affecting the lungs. The form of the disease mainly depends on the immune status of the patient and underlying conditions. Invasive pulmonary aspergillosis usually affects immunocompromised patients - ...

    Abstract Pulmonary aspergillosis is a group of mycotic diseases affecting the lungs. The form of the disease mainly depends on the immune status of the patient and underlying conditions. Invasive pulmonary aspergillosis usually affects immunocompromised patients - angio-invasive and airway-invasive forms are possible. Chronic aspergillosis usually appears in mildly immunosuppressed or immunocompetent patients with underlying structural lung changes and may have diverse forms: simple aspergilloma, chronic cavitary pulmonary aspergillosis, chronic fibrosing pulmonary aspergillosis, subacute invasive pulmonary aspergillosis, aspergillus nodules and endobronchial aspergilloma. Allergic bronchopulmonary aspergillosis is a hyper-reactivity reaction to Aspergillus species, and usually develops in asthma and cystic fibrosis patients. The aim of this article is to comprehensively overview different forms of aspergillosis, their symptoms and underlying conditions and to present imaging findings.
    MeSH term(s) Humans ; Invasive Pulmonary Aspergillosis ; Pulmonary Aspergillosis/diagnostic imaging ; Aspergillosis, Allergic Bronchopulmonary ; Aspergillosis ; Lung/diagnostic imaging
    Language English
    Publishing date 2024-01-08
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 138815-0
    ISSN 1872-7727 ; 0720-048X
    ISSN (online) 1872-7727
    ISSN 0720-048X
    DOI 10.1016/j.ejrad.2024.111290
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  4. Article ; Online: Diagnostic Value of Krebs von den Lungen (KL-6) for Interstitial Lung Disease: A European Prospective Cohort.

    Millan-Billi, Paloma / Castellví, Iván / Martinez-Martinez, Laura / Mariscal, Anais / Barril, Silvia / D'Alessandro, Miriana / Franquet, Tomás / Castillo, Diego

    Archivos de bronconeumologia

    2024  

    Abstract: Introduction: Krebs von den Lungen 6 (KL-6) is a mucin-1 glycoprotein produced by type II pneumocytes. High levels of KL-6 in blood may be found in patients with lung fibrosis. In Asia this biomarker is used for diagnosis and prognosis in interstitial ... ...

    Abstract Introduction: Krebs von den Lungen 6 (KL-6) is a mucin-1 glycoprotein produced by type II pneumocytes. High levels of KL-6 in blood may be found in patients with lung fibrosis. In Asia this biomarker is used for diagnosis and prognosis in interstitial lung diseases (ILD). There is a lack of information regarding KL-6 cut-off point for diagnosis and prognosis in European population. The aim of this study was to establish the cut-off point for serum KL-6 associated with the presence of ILD in the Spanish population.
    Methods: Prospective study including subjects who underwent chest HRCT, PFTs and autoimmune blood analysis. Two groups were created: non-ILD subjects and ILD patients. Serum KL-6 concentrations were measured using a Lumipulse KL-6 reagent assay and the optimal cut-off value was evaluated by a ROC analysis. Data on demographics and smoking history was also collected.
    Results: One hundred seventy-nine patients were included, 102 with ILD. Median serum KL-6 values overall were 762U/mL, 1080 (±787)U/mL for the ILD group vs 340 (±152)U/mL for the non-ILD group (p<0.0001). The main radiological pattern was NSIP (43%). ROC analysis showed greater specificity (86%) and sensitivity (82%) for KL-6 465U/mL for detecting ILD patients. The multivariate logistic regression model pointed to the male sex, higher KL-6 values, lower FVC and low DLCO values as independent factors associated with ILD.
    Conclusion: Serum KL-6 values greater than 465U/mL have excellent sensitivity and specificity for detecting ILD in our Spanish cohort. Multicentre studies are needed to validate our results.
    Language Spanish
    Publishing date 2024-04-06
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2024.03.028
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  5. Article ; Online: Imaging Thoracic Infections: New Answers for Old Questions.

    Ketai, Loren / Franquet, Tomás

    Journal of thoracic imaging

    2018  Volume 33, Issue 5, Page(s) 271–272

    MeSH term(s) Diagnostic Imaging ; Humans ; Infection/diagnostic imaging ; Lung/diagnostic imaging ; Lung/microbiology ; Thoracic Diseases/diagnostic imaging ; Thoracic Diseases/microbiology
    Language English
    Publishing date 2018-08-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 632900-7
    ISSN 1536-0237 ; 0883-5993
    ISSN (online) 1536-0237
    ISSN 0883-5993
    DOI 10.1097/RTI.0000000000000352
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  6. Article ; Online: Imaging of pulmonary viral pneumonia.

    Franquet, Tomás

    Radiology

    2011  Volume 260, Issue 1, Page(s) 18–39

    Abstract: Imaging and clinical manifestations of viral pneumonia are protean and not reliably predictive of its origin. All patients with neutropenic fever and normal findings at chest radiography should undergo thin-section computed tomography to determine ... ...

    Abstract Imaging and clinical manifestations of viral pneumonia are protean and not reliably predictive of its origin. All patients with neutropenic fever and normal findings at chest radiography should undergo thin-section computed tomography to determine whether parenchyma abnormalities are present. Although the radiologic manifestations of viral pneumonia are nonspecific and difficult to differentiate from those of other infections, it is important to consider viral infection when confronted with a rapidly progressive pneumonia in patients with risk factors for infection. Although definitive diagnosis cannot be made on the basis of imaging features alone, the use of a combination of clinical and radiographic findings can substantially improve the accuracy of diagnosis in this disease.
    MeSH term(s) Humans ; Lung/diagnostic imaging ; Pneumonia, Viral/diagnostic imaging ; Radiographic Image Enhancement/methods ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2011-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.11092149
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  7. Article ; Online: Técnicas de imagen en la exploración de la vía aérea pequeña: asma y EPOC.

    Franquet, Tomás

    Archivos de bronconeumologia

    2011  Volume 47 Suppl 2, Page(s) 20–26

    Abstract: Imaging techniques are highly useful diagnostic tools to study small airway diseases. Despite their differences, from a clinical pathological perspective, these diseases show similar radiological manifestations. High-resolution computed tomography (CT) ... ...

    Title translation Imaging techniques in the examination of the distal airways: asthma and COPD.
    Abstract Imaging techniques are highly useful diagnostic tools to study small airway diseases. Despite their differences, from a clinical pathological perspective, these diseases show similar radiological manifestations. High-resolution computed tomography (CT) is the technique of choice to study diffuse diseases and those of the small airways; the slices obtained in expiratory high-resolution CT scan should form part of the study protocol of small airway diseases. Based on the findings of high-resolution CT, small airway diseases can be divided into two large groups: (a) those presenting direct morphological signs of bronchiolar involvement, and (b) those showing indirect signs of bronchiolar involvement (air trapping/mosaic pattern). High-resolution CT is highly useful to study the complications of asthma (allergic bronchopulmonary aspergillosis) and to evaluate clinically similar processes, such as hypersensitivity pneumonitis. In asthmatic patients, multi-detector CT (MDTC) allows clinical symptoms, thickening of the airway wall and the degree of airflow obstruction to be directly correlated. MDTC is also useful for quantitative evaluation of the degree of air trapping in patients with emphysema. Magnetic resonance imaging after inhalation of distinct gases, such as (3)He and xenon-129 and dual-energy CT are also useful imaging techniques in the direct or indirect evaluation of the degree of airflow obstruction (air trapping).
    MeSH term(s) Airway Obstruction/diagnostic imaging ; Airway Obstruction/etiology ; Airway Obstruction/pathology ; Alveolitis, Extrinsic Allergic/diagnostic imaging ; Aspergillosis, Allergic Bronchopulmonary/diagnostic imaging ; Asthma/diagnostic imaging ; Asthma/pathology ; Asthma/physiopathology ; Bronchi/pathology ; Bronchioles/pathology ; Bronchiolitis Obliterans/diagnostic imaging ; Bronchography/methods ; Diagnosis, Differential ; Diagnostic Imaging/methods ; Helium ; Humans ; Isotopes ; Magnetic Resonance Imaging ; Perfusion Imaging/methods ; Pulmonary Alveoli/blood supply ; Pulmonary Alveoli/diagnostic imaging ; Pulmonary Alveoli/pathology ; Pulmonary Disease, Chronic Obstructive/diagnostic imaging ; Pulmonary Disease, Chronic Obstructive/pathology ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Pulmonary Emphysema/diagnostic imaging ; Tomography, Spiral Computed ; Tomography, X-Ray Computed/methods ; Xenon Isotopes
    Chemical Substances Isotopes ; Xenon Isotopes ; Helium (206GF3GB41)
    Language Spanish
    Publishing date 2011-04
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/S0300-2896(11)70017-5
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  8. Article ; Online: Air trapping in COVID-19 patients following hospital discharge: retrospective evaluation with paired inspiratory/expiratory thin-section CT.

    Franquet, Tomás / Giménez, Ana / Ketai, Loren / Mazzini, Sandra / Rial, Andrea / Pomar, Virginia / Domingo, Pere

    European radiology

    2022  Volume 32, Issue 7, Page(s) 4427–4436

    Abstract: Objectives: The study reports our experience with paired inspiration/expiration thin-section computed tomographic (CT) scans in the follow-up of COVID-19 patients with persistent respiratory symptoms.: Methods: From August 13, 2020, to May 31, 2021, ... ...

    Abstract Objectives: The study reports our experience with paired inspiration/expiration thin-section computed tomographic (CT) scans in the follow-up of COVID-19 patients with persistent respiratory symptoms.
    Methods: From August 13, 2020, to May 31, 2021, 48 long-COVID patients with respiratory symptoms (27 men and 21 women; median age, 62.0 years; interquartile range: 54.0-69.0 years) underwent follow-up paired inspiration-expiration thin-section CT scans. Patient demographics, length of hospital stay, intensive care unit admission rate, and clinical and laboratory features of acute infection were also included. The scans were obtained on a median of 72.5 days after onset of symptoms (interquartile range: 58.5-86.5) and at least 30 days after hospital discharge. Thin-section CT findings included ground-glass opacity, mosaic attenuation pattern, consolidation, traction bronchiectasis, reticulation, parenchymal bands, bronchial wall thickening, and air trapping. We used a quantitative score to determine the degree of air trapping in the expiratory scans.
    Results: Parenchymal abnormality was found in 50% (24/48) of patients and included air trapping (37/48, 77%), ground-glass opacities (19/48, 40%), reticulation (18/48, 38%), parenchymal bands (15/48, 31%), traction bronchiectasis (9/48, 19%), mosaic attenuation pattern (9/48, 19%), bronchial wall thickening (6/48, 13%), and consolidation (2/48, 4%). The absence of air trapping was observed in 11/48 (23%), mild air trapping in 20/48 (42%), moderate in 13/48 (27%), and severe in 4/48 (8%). Independent predictors of air trapping were, in decreasing order of importance, gender (p = 0.0085), and age (p = 0.0182).
    Conclusions: Our results, in a limited number of patients, suggest that follow-up with paired inspiratory/expiratory CT in long-COVID patients with persistent respiratory symptoms commonly displays air trapping.
    Key points: • Our experience indicates that paired inspiratory/expiratory CT in long-COVID patients with persistent respiratory symptoms commonly displays air trapping. • Iterative reconstruction and dose-reduction options are recommended for demonstrating air trapping in long-COVID patients.
    MeSH term(s) Bronchiectasis ; COVID-19/complications ; Female ; Hospitals ; Humans ; Lung/diagnostic imaging ; Male ; Middle Aged ; Patient Discharge ; Retrospective Studies ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2022-02-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-022-08580-2
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  9. Article ; Online: Imaging of Pulmonary Infection

    Franquet, Tomás / Chung, Johnathan H.

    Diseases of the Chest, Breast, Heart and Vessels 2019-2022

    Abstract: The spectrum of organisms known to cause respiratory infections is broad and constantly increasing as new pathogens are identified, and an increasing number of patients have impaired immunity due to disease or medications. The radiographic manifestations ...

    Abstract The spectrum of organisms known to cause respiratory infections is broad and constantly increasing as new pathogens are identified, and an increasing number of patients have impaired immunity due to disease or medications. The radiographic manifestations of a given organism may be variable depending on the immunologic status of the patient and the presence of pre- or coexisting lung disease. Moreover, the clinical data and radiographic findings often fail to lead to a definitive diagnosis of pneumonia because there are an extensive number of noninfectious processes associated with febrile pneumonitis. This chapter describes and illustrates the characteristic imaging manifestations of the most common community- acquired pneumonias, nosocomial pneumonias, and the various infections seen in both immunocompetent and immunocompromised patients.
    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.1007/978-3-030-11149-6_7
    Database COVID19

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  10. Article ; Online: Atypical Pneumonia: Definition, Causes, and Imaging Features.

    Dueck, Nicholas P / Epstein, Samantha / Franquet, Tomás / Moore, Christopher C / Bueno, Juliana

    Radiographics : a review publication of the Radiological Society of North America, Inc

    2021  Volume 41, Issue 3, Page(s) 720–741

    Abstract: Pneumonia is among the most common causes of death worldwide. The epidemiologic and clinical heterogeneity of pneumonia results in challenges in diagnosis and treatment. There is inconsistency in the definition of the group of microorganisms that cause " ... ...

    Abstract Pneumonia is among the most common causes of death worldwide. The epidemiologic and clinical heterogeneity of pneumonia results in challenges in diagnosis and treatment. There is inconsistency in the definition of the group of microorganisms that cause "atypical pneumonia." Nevertheless, the use of this term in the medical and radiologic literature is common. Among the causes of community-acquired pneumonia, atypical bacteria are responsible for approximately 15% of cases. Zoonotic and nonzoonotic bacteria, as well as viruses, have been considered among the causes of atypical pneumonia in a patient who is immunocompetent and have been associated with major community outbreaks of respiratory infection, with relevant implications in public health policies. Considering the difficulty of isolating atypical microorganisms and the significant overlap in clinical manifestations, a targeted empirical therapy is not possible. Imaging plays an important role in the diagnosis and management of atypical pneumonia, as in many cases its findings may first suggest the possibility of an atypical infection. Clarifying and unifying the definition of atypical pneumonia among the medical community, including radiologists, are of extreme importance. The prompt diagnosis and prevention of community spread of some atypical microorganisms can have a relevant impact on local, regional, and global health policies.
    MeSH term(s) Community-Acquired Infections/diagnostic imaging ; Humans ; Lung Diseases, Interstitial ; Mycoses ; Pneumonia/diagnostic imaging ; Pneumonia, Bacterial
    Language English
    Publishing date 2021-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603172-9
    ISSN 1527-1323 ; 0271-5333
    ISSN (online) 1527-1323
    ISSN 0271-5333
    DOI 10.1148/rg.2021200131
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