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  1. Book ; Online ; Thesis: Study on the therapeutic mechanism of Tumor Treating Fields (TTFields) and Trihexyphenidyl （THP） and identification of clinical predictive expression signature for glioblastoma

    Du, Renfei [Verfasser] / Kahlert, Ulf Dietrich [Gutachter] / Berndt, Carsten [Gutachter]

    2023  

    Author's details Renfei Du ; Gutachter: Ulf Dietrich Kahlert, Carsten Berndt
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: Systemic and strict regulation of the glutathione redox state in mitochondria and cytosol is needed for zebrafish ontogeny.

    Hamre, Kristin / Zhang, Wuxiao / Austgulen, Maren Hoff / Mykkeltvedt, Eva / Yin, Peng / Berntssen, Marc / Espe, Marit / Berndt, Carsten

    Biochimica et biophysica acta. General subjects

    2024  Volume 1868, Issue 6, Page(s) 130603

    Abstract: Background: Redox control seems to be indispensable for proper embryonic development. The ratio between glutathione (GSH) and its oxidized disulfide (GSSG) is the most abundant cellular redox circuit.: Methods: We used zebrafish harboring the ... ...

    Abstract Background: Redox control seems to be indispensable for proper embryonic development. The ratio between glutathione (GSH) and its oxidized disulfide (GSSG) is the most abundant cellular redox circuit.
    Methods: We used zebrafish harboring the glutaredoxin 1-redox sensitive green fluorescent protein (Grx1-roGFP) probe either in mitochondria or cytosol to test the hypothesis that the GSH:GSSG ratio is strictly regulated through zebrafish embryogenesis to sustain the different developmental processes of the embryo.
    Results: Following the GSSG:GSH ratio as a proxy for the GSH-dependent reduction potential (E
    Conclusions: Mitochondrial and cytosolic GSSG:GSH ratios are almost identical in different organs during zebrafish development indicating that the E
    General significance: Our data confirm that vertebrate embryogenesis depends on strictly regulated redox homeostasis. Disturbance of the GSSG:GSH circuit, e.g. induced by environmental pollution, leads to malformation and death.
    MeSH term(s) Animals ; Zebrafish/metabolism ; Zebrafish/embryology ; Oxidation-Reduction ; Glutathione/metabolism ; Mitochondria/metabolism ; Cytosol/metabolism ; Embryonic Development ; Glutathione Disulfide/metabolism ; Embryo, Nonmammalian/metabolism
    Chemical Substances Glutathione (GAN16C9B8O) ; Glutathione Disulfide (ULW86O013H)
    Language English
    Publishing date 2024-03-21
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbagen.2024.130603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online ; Thesis: Der Einfluss der FeS-Zentrum-Koordination in Glutaredoxinen auf Physiologie und Pathologie

    Engelke, Anna Dorothee [Verfasser] / Berndt, Carsten [Gutachter] / Reichert, Andreas [Gutachter]

    2021  

    Author's details Anna Dorothee Engelke ; Gutachter: Carsten Berndt, Andreas Reichert
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
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  4. Article: Glutaredoxins with iron-sulphur clusters in eukaryotes - Structure, function and impact on disease

    Berndt, Carsten / Christ, Loïck / Rouhier, Nicolas / Mühlenhoff, Ulrich

    Biochimica et biophysica acta. 2021 Jan. 01, v. 1862, no. 1

    2021  

    Abstract: Among the thioredoxin superfamily of proteins, the observation that numerous glutaredoxins bind iron-sulphur (Fe/S) clusters is one of the more recent and major developments concerning their functional properties. Glutaredoxins are present in most ... ...

    Abstract Among the thioredoxin superfamily of proteins, the observation that numerous glutaredoxins bind iron-sulphur (Fe/S) clusters is one of the more recent and major developments concerning their functional properties. Glutaredoxins are present in most organisms. All members of the class II subfamily (including most monothiol glutaredoxins), but also some members of the class I (mostly dithiol glutaredoxins) and class III (land plant-specific monothiol or dithiol glutaredoxins) are Fe/S proteins. In glutaredoxins characterised so far, the [2Fe2S] cluster is coordinated by two active-site cysteine residues and two molecules of non-covalently bound glutathione in homo-dimeric complexes bridged by the cluster. In contrast to dithiol glutaredoxins, monothiol glutaredoxins possess no or very little oxidoreductase activity, but have emerged as important players in cellular iron metabolism. In this review we summarise the recent developments of the most prominent Fe/S glutaredoxins in eukaryotes, the mitochondrial single domain monothiol glutaredoxin 5, the chloroplastic single domain monothiol glutaredoxin S14 and S16, the nuclear/cytosolic multi-domain monothiol glutaredoxin 3, and the mitochondrial/cytosolic dithiol glutaredoxin 2.
    Keywords active sites ; cysteine ; eukaryotic cells ; functional properties ; glutathione ; iron absorption ; land ; mitochondria ; organisms ; proteins ; thioredoxins
    Language English
    Dates of publication 2021-0101
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-light
    ZDB-ID 282711-6
    ISSN 0005-2728 ; 0304-4173
    ISSN 0005-2728 ; 0304-4173
    DOI 10.1016/j.bbabio.2020.148317
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Glutaredoxins with iron-sulphur clusters in eukaryotes - Structure, function and impact on disease.

    Berndt, Carsten / Christ, Loïck / Rouhier, Nicolas / Mühlenhoff, Ulrich

    Biochimica et biophysica acta. Bioenergetics

    2020  Volume 1862, Issue 1, Page(s) 148317

    Abstract: Among the thioredoxin superfamily of proteins, the observation that numerous glutaredoxins bind iron-sulphur (Fe/S) clusters is one of the more recent and major developments concerning their functional properties. Glutaredoxins are present in most ... ...

    Abstract Among the thioredoxin superfamily of proteins, the observation that numerous glutaredoxins bind iron-sulphur (Fe/S) clusters is one of the more recent and major developments concerning their functional properties. Glutaredoxins are present in most organisms. All members of the class II subfamily (including most monothiol glutaredoxins), but also some members of the class I (mostly dithiol glutaredoxins) and class III (land plant-specific monothiol or dithiol glutaredoxins) are Fe/S proteins. In glutaredoxins characterised so far, the [2Fe2S] cluster is coordinated by two active-site cysteine residues and two molecules of non-covalently bound glutathione in homo-dimeric complexes bridged by the cluster. In contrast to dithiol glutaredoxins, monothiol glutaredoxins possess no or very little oxidoreductase activity, but have emerged as important players in cellular iron metabolism. In this review we summarise the recent developments of the most prominent Fe/S glutaredoxins in eukaryotes, the mitochondrial single domain monothiol glutaredoxin 5, the chloroplastic single domain monothiol glutaredoxin S14 and S16, the nuclear/cytosolic multi-domain monothiol glutaredoxin 3, and the mitochondrial/cytosolic dithiol glutaredoxin 2.
    MeSH term(s) Glutaredoxins/chemistry ; Glutaredoxins/genetics ; Glutaredoxins/metabolism ; Humans ; Iron/chemistry ; Iron/metabolism ; Iron-Sulfur Proteins/chemistry ; Iron-Sulfur Proteins/genetics ; Iron-Sulfur Proteins/metabolism ; Plant Diseases ; Plant Proteins/chemistry ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plants/enzymology ; Structure-Activity Relationship ; Sulfur/chemistry ; Sulfur/metabolism
    Chemical Substances Glutaredoxins ; Iron-Sulfur Proteins ; Plant Proteins ; Sulfur (70FD1KFU70) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2020-09-24
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 60-7
    ISSN 1879-2650 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2650 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbabio.2020.148317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Thesis: Redox-dependent differentiation and dedifferentiation

    Wilms, Christina [Verfasser] / Berndt, Carsten [Gutachter] / von Gall, Charlotte [Gutachter]

    2021  

    Author's details Christina Wilms ; Gutachter: Carsten Berndt, Charlotte von Gall
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
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  7. Article ; Online: JNK Signalling Regulates Self-Renewal of Proliferative Urine-Derived Renal Progenitor Cells via Inhibition of Ferroptosis.

    Nguyen, Lisa / Thewes, Leonie / Westerhoff, Michelle / Wruck, Wasco / Reichert, Andreas S / Berndt, Carsten / Adjaye, James

    Cells

    2023  Volume 12, Issue 17

    Abstract: With a global increase in chronic kidney disease patients, alternatives to dialysis and organ transplantation are needed. Stem cell-based therapies could be one possibility to treat chronic kidney disease. Here, we used multipotent urine-derived renal ... ...

    Abstract With a global increase in chronic kidney disease patients, alternatives to dialysis and organ transplantation are needed. Stem cell-based therapies could be one possibility to treat chronic kidney disease. Here, we used multipotent urine-derived renal progenitor cells (UdRPCs) to study nephrogenesis. UdRPCs treated with the JNK inhibitor-AEG3482 displayed decreased proliferation and downregulated transcription of cell cycle-associated genes as well as the kidney progenitor markers-SIX2, SALL1 and VCAM1. In addition, levels of activated SMAD2/3, which is associated with the maintenance of self-renewal in UdRPCs, were decreased. JNK inhibition resulted in less efficient oxidative phosphorylation and more lipid peroxidation via ferroptosis, an iron-dependent non-apoptotic cell death pathway linked to various forms of kidney disease. Our study is the first to describe the importance of JNK signalling as a link between maintenance of self-renewal and protection against ferroptosis in SIX2-positive renal progenitor cells.
    MeSH term(s) Humans ; Ferroptosis ; Kidney ; Renal Dialysis ; Renal Insufficiency, Chronic ; Stem Cells ; MAP Kinase Signaling System
    Language English
    Publishing date 2023-09-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12172197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Melissantes

    Berndt, Carsten

    ein Thüringer Polyhistor und seine Berufsbeschreibungen im 18. Jahrhundert ; Leben und Wirken des Johann Gottfried Gregorii (1685 - 1770) als Beitrag zur Geschichte von Geographie, Kartographie, Genealogie, Psychologie, Pädagogik und Berufskunde in Deutschland

    2014  

    Title variant Melissantes : ein Thüringer Geograph und Universalgelehrter (1685 - 1770)
    Author's details Carsten Berndt
    Language German
    Size 390 S., Ill., Kt.
    Edition 2., erg. und erw. Aufl.
    Publisher Rockstuhl
    Publishing place Bad Langensalza
    Document type Book
    Note Literaturverz. S. 310 - 312
    ISBN 9783867771665 ; 3867771669
    Database Former special subject collection: coastal and deep sea fishing

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  9. Article ; Online: Glutathione, Glutaredoxins, and Iron.

    Berndt, Carsten / Lillig, Christopher Horst

    Antioxidants & redox signaling

    2017  Volume 27, Issue 15, Page(s) 1235–1251

    Abstract: Significance: Glutathione (GSH) is the most abundant cellular low-molecular-weight thiol in the majority of organisms in all kingdoms of life. Therefore, functions of GSH and disturbed regulation of its concentration are associated with numerous ... ...

    Abstract Significance: Glutathione (GSH) is the most abundant cellular low-molecular-weight thiol in the majority of organisms in all kingdoms of life. Therefore, functions of GSH and disturbed regulation of its concentration are associated with numerous physiological and pathological situations. Recent Advances: The function of GSH as redox buffer or antioxidant is increasingly being questioned. New functions, especially functions connected to the cellular iron homeostasis, were elucidated. Via the formation of iron complexes, GSH is an important player in all aspects of iron metabolism: sensing and regulation of iron levels, iron trafficking, and biosynthesis of iron cofactors. The variety of GSH coordinated iron complexes and their functions with a special focus on FeS-glutaredoxins are summarized in this review. Interestingly, GSH analogues that function as major low-molecular-weight thiols in organisms lacking GSH resemble the functions in iron homeostasis.
    Critical issues: Since these iron-related functions are most likely also connected to thiol redox chemistry, it is difficult to distinguish between mechanisms related to either redox or iron metabolisms.
    Future directions: The ability of GSH to coordinate iron in different complexes with or without proteins needs further investigation. The discovery of new Fe-GSH complexes and their physiological functions will significantly advance our understanding of cellular iron homeostasis. Antioxid. Redox Signal. 27, 1235-1251.
    Language English
    Publishing date 2017-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2017.7132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5488: Show issues Location:
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  10. Book: Melissantes

    Berndt, Carsten

    ein Thüringer Polyhistor und seine Berufsbeschreibungen im 18. Jahrhundert ; Leben und Wirken des Johann Gottfried Gregorii (1685 - 1770) als Beitrag zur Geschichte von Geographie, Kartographie, Genealogie, Psychologie, Pädagogik und Berufskunde in Deutschland

    2013  

    Title variant Melissantes : ein Thüringer Geograph und Universalgelehrter
    Author's details Carsten Berndt
    Keywords Cartographers ; Geographers
    Language German
    Size 318 S., Ill., Kt.
    Edition 1. Aufl.
    Publisher Rockstuhl
    Publishing place Bad Langensalza
    Document type Book
    Note Literaturverz. S. 310 - 312
    ISBN 9783867771665 ; 3867771669
    Database Former special subject collection: coastal and deep sea fishing

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