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Article: Jia-Wei-Si-Miao-Yong-An decoction modulates intestinal flora and metabolites in acute coronary syndrome model.

Zhao, Ning / Wang, Ying / Ma, Yan / Liang, Xiaoxue / Zhang, Xi / Gao, Yuan / Dong, Yingying / Bai, Dong / Hu, Jingqing

2023 Volume 9, Page(s) 1038273

Abstract: Aims: We assessed the efficacy of the traditional Chinese medicine formulation Jia-Wei-Si-Miao ...

Abstract	Aims: We assessed the efficacy of the traditional Chinese medicine formulation Jia-Wei-Si-Miao-Yong-An decoction (HJ11) in the treatment of acute coronary syndrome and evaluated its impact on the intestinal microbiota and their metabolites. Methods: An acute coronary syndrome model was established in rats, which were randomly assigned to the model, HJ11 treatment, and atorvastatin treatment groups. Rats were then administered saline solution (model and sham operation control groups) or drugs by oral gavage for 28 d. Echocardiography was performed and serum creatine kinase-MB and cardiac troponin I levels were monitored to examine the cardiac function. Inflammation was evaluated using hematoxylin and eosin staining of heart tissue, and serum interleukin-2, interleukin-6, tumor necrosis factor alpha, and high-sensitivity C-reactive protein measurements. Gut microbiota composition was analyzed Results: HJ11 improved cardiac function and attenuated inflammation in rats with acute coronary syndrome. Relative to the untreated model group, the HJ11-treated group presented normalized Firmicutes/Bacteroidetes ratio and reduced abundances of the bacterial genera Conclusion: This work demonstrated that HJ11 effectively treats acute coronary syndrome. HJ11 seems to increase the abundance of beneficial bacterial taxa (
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.1038273
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Jia-ga-song-tang protection against alcoholic liver and intestinal damage.

Fang, Jiamin / Wu, Yuhuan / Gan, Changlian / Ruan, Shufang / He, Xiaoliang / Wang, Bixia / Wang, Ying / Yu, Jingtao / Sang, Chuanlan / Zeren, Dawa / Xiong, Tianqin

Frontiers in pharmacology

2022 Volume 13, Page(s) 981706

Abstract: ... We investigated whether the beneficial effects and underlying mechanisms of Jia-ga-song Tang (JGST) against ALD ... the relationship between Jia-Ga-Song-Tang (JGST) and alcoholic liver disease (ALD) was designed by Network ...

Abstract	Gut-liver axis and cellular homeostasis play key roles in alcohol liver disease (ALD). Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a stress-sensitive guarantor of cellular homeostasis. We investigated whether the beneficial effects and underlying mechanisms of Jia-ga-song Tang (JGST) against ALD were associated with gut-liver axis and cellular homeostasis. A predictive network depicting the relationship between Jia-Ga-Song-Tang (JGST) and alcoholic liver disease (ALD) was designed by Network pharmacology. Next, 5% v/v Lieber-DeCarli alcohol liquid diet was used to establish the ALD. JGST protected the liver damage, repaired the intestines to alleviate the Two-hit on the liver, and balanced the cellular homeostasis. It was manifested in repairing the liver and intestinal pathological structure, reducing serum ALT, AST, and liver TG, TC, MDA, CAT, and increasing liver GSH, and intestine GSH-Px. JGST mainly inhibited the liver mRNA levels of HO-1, NQO1, GCLC, FASN, and PPARα and activated the intestinal mRNA levels of HO-1 and NQO1, while inhibiting the liver protein levels of HO-1, NQO1. Furthermore, LPS and LBP in the plasma and the expression of inflammatory factors such as IL-1β, TNF-α, IL-6, TGFβ1, CD14, and Myd88 were reduced after treatment to prove that JGST protects the liver from Two-hit. Ethanol was used to intervene in HepG2 and IEC-6 to establish an ALD cell model and treated by Germacrone, ML385, and TBHQ. repaired the intestinal barrier, and inhibited Nrf2 in IEC-6, but protect the HepG2 by activating Nrf2 to balance cellular homeostasis. Our results reinforce that JGST provides an effective protective method for alcoholic liver disease (ALD) by regulating Gut-liver axis and cellular homeostasis.
Language	English
Publishing date	2022-09-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.981706
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Bie-Jia-Ruan-Mai-Tang, a Chinese Medicine Formula, Inhibits Retinal Neovascularization in Diabetic Mice Through Inducing the Apoptosis of Retinal Vascular Endothelial Cells.

Liu, Qiu-Ping / Chen, Yu-Ying / Yu, Yuan-Yuan / An, Pei / Xing, Yi-Zhuo / Yang, Hong-Xuan / Zhang, Yin-Jian / Rahman, Khalid / Zhang, Lei / Luan, Xin / Zhang, Hong

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 959298

Abstract: ... Jia-Ruan-Mai-Tang (BJ), a Chinese medicine formula, has a good therapeutic effect on PDR clinically ...

Abstract	Proliferative diabetic retinopathy (PDR) is one of the main complications of diabetes, mainly caused by the aberrant proliferation of retinal vascular endothelial cells and the formation of new blood vessels. Traditional Chinese medicines possess great potential in the prevention and treatment of PDR. Bie-Jia-Ruan-Mai-Tang (BJ), a Chinese medicine formula, has a good therapeutic effect on PDR clinically; however, the mechanism of action involved remains unclear. Therefore, we investigated the effect of BJ on PDR through
Language	English
Publishing date	2022-07-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.959298
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Traditional Chinese medicine xin-mai-jia recouples endothelial nitric oxide synthase to prevent atherosclerosis in vivo.

Yin, Ya-Ling / Zhu, Mo-Li / Wan, Jia / Zhang, Chong / Pan, Guo-Pin / Lu, Jun-Xiu / Ping, Song / Chen, Yuan / Zhao, Fan-Rong / Yu, Hai-Ya / Guo, Tao / Jian, Xu / Liu, Li-Ying / Zhang, Jia-Ning / Wan, Guang-Rui / Wang, Shuang-Xi / Li, Peng

Scientific reports

2017 Volume 7, Page(s) 43508

Abstract: ... an initial step in atherosclerosis. This study was designed to explore whether Chinese medicine xin-mai-jia ...

Abstract	Endothelial dysfunction, which is caused by endothelial nitric oxide synthase (eNOS) uncoupling, is an initial step in atherosclerosis. This study was designed to explore whether Chinese medicine xin-mai-jia (XMJ) recouples eNOS to exert anti-atherosclerotic effects. Pretreatment of XMJ (25, 50, 100 μg/ml) for 30 minutes concentration-dependently activated eNOS, improved cell viabilities, increased NO generations, and reduced ROS productions in human umbilical vein endothelial cells incubated with H
MeSH term(s)	Animals ; Atherosclerosis/drug therapy ; Atherosclerosis/etiology ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Biomarkers ; Cell Survival/drug effects ; Cytokines/metabolism ; Diet, High-Fat ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/pathology ; Gene Expression Profiling ; Human Umbilical Vein Endothelial Cells ; Humans ; Hydrogen Peroxide/pharmacology ; Male ; Medicine, Chinese Traditional ; Nitric Oxide/biosynthesis ; Nitric Oxide Synthase Type III/metabolism ; Oxidative Stress/drug effects ; Phosphorylation ; Plaque, Atherosclerotic/metabolism ; Plaque, Atherosclerotic/pathology ; Rats ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; Transcriptome
Chemical Substances	Biomarkers ; Cytokines ; Drugs, Chinese Herbal ; Reactive Oxygen Species ; Nitric Oxide (31C4KY9ESH) ; Hydrogen Peroxide (BBX060AN9V) ; Nitric Oxide Synthase Type III (EC 1.14.13.39)
Language	English
Publishing date	2017-03-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep43508
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Proteomics analysis reveals suppression of IL-17 signaling pathways contributed to the therapeutic effects of Jia-Wei Bu-Shen-Yi-Qi formula in a murine asthma model.

Qin, Jingjing / Wuniqiemu, Tulake / Wei, Ying / Teng, Fangzhou / Cui, Jie / Sun, Jing / Yi, La / Tang, Weifeng / Zhu, Xueyi / Xu, Weifang / Dong, Jingcheng

Phytomedicine : international journal of phytotherapy and phytopharmacology

2021 Volume 95, Page(s) 153803

Abstract: Background: Jia-Wei Bu-Shen-Yi-Qi formula (JWBSYQF), a Chinese herbal formula, is a commonly used ...

Abstract	Background: Jia-Wei Bu-Shen-Yi-Qi formula (JWBSYQF), a Chinese herbal formula, is a commonly used prescription for treating asthma patients. However, the targeted proteins associated with JWBSYQF treatment remain unknown. Purpose: Present study aims to evaluate the therapeutic efficacy of JWBSYQF and identify the targeted proteins in addition to functional pathways. Study design: The ovalbumin (OVA)-induced murine asthma model was established to explore the therapeutic effect of JWBSYQF treatment. Proteomic profiling and quantifications were performed using data-independent acquisition (DIA) methods. Differentially expressed proteins (DEPs) were validated via western blot (WB) and immunohistochemistry (IHC). Methods: A murine asthma model was made by OVA sensitization and challenge, and JWBSYQF (2.25, 4.50, 9,00 g/kg body weight) or dexamethasone (1 mg/ kg body weight) were administered orally. Airway hyperresponsiveness (AHR) to methacholine (Mch), inflammatory cell counts and classification in bronchoalveolar lavage fluid (BALF), lung histopathology, and cytokine levels were measured. Furthermore, DIA proteomic analyses were performed to explore the DEPs targeted by JWBSYQF and were further validated by WB and IHC. Results: Our results exhibited that JWBSYQF attenuated AHR which was mirrored by decreased airway resistance and increased lung compliance. In addition, JWBSYQF-treated mice showed reduced inflammatory score, mucus hypersecretion, as well as reduced the number of BALF leukocytes along with decreased content of BALF Th2 inflammatory cytokines (IL-4, IL-5, IL-13) and serum IgE. Proteomics analysis identified 704 DEPs between the asthmatic mice and control group (MOD vs CON), and 120 DEPs between the JWBSYQF-treatment and the asthmatic mice (JWB-M vs MOD). A total of 33 overlapped DEPs were identified among the three groups. Pathway enrichment analysis showed that DEPs were significantly enriched in IL-17 signaling pathway, in which DEPs, Lcn2, TGF-β1, Gngt2, and Ppp2r5e were common DEPs between three experimental groups. WB and IHC results further validated expressional levels and tendency of these proteins. Our results also showed that JWBSYQF affects mitogen activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) signaling pathways, that are activated by IL-17 signaling. Conclusion: The present study suggested that JWBSYQF could attenuate AHR and airway inflammation in OVA-induced asthmatic mice. In addition, proteomics analysis revealed that suppression of IL-17 signaling pathways contributes to the therapeutic effects of JWBSYQF.
MeSH term(s)	Animals ; Asthma/drug therapy ; Bronchoalveolar Lavage Fluid ; Cytokines ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Interleukin-17 ; Lung ; Mice ; Mice, Inbred BALB C ; Ovalbumin ; Proteomics ; Signal Transduction
Chemical Substances	Cytokines ; Drugs, Chinese Herbal ; Interleukin-17 ; Ovalbumin (9006-59-1)
Language	English
Publishing date	2021-10-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2021.153803
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Efficacy and safety of Jia Wei Bushen Yiqi formulas as an adjunct therapy to systemic glucocorticoids on acute exacerbation of COPD

Qing Kong / Shuming Mo / Wenqian Wang / Zihui Tang / Ying Wei / Yijie Du / Baojun Liu / Lingwen Kong / Yubao Lv / Jingcheng Dong

Trials, Vol 21, Iss 1, Pp 1-

study protocol for a randomized, double-blinded, multi-center, placebo-controlled clinical trial

2020 Volume 16

Abstract: ... the efficacy and safety of Jia Wei Bushen Yiqi (JWBY) formulas in patients who suffer from COPD exacerbations ...

Abstract	Abstract Background Systemic glucocorticoids are effective for the management of chronic obstructive pulmonary disease (COPD) exacerbation but have serious adverse effects. Traditional Chinese medicine (TCM) can bring additional benefits to these patients but has few adverse effects. The present study aims to evaluate the efficacy and safety of Jia Wei Bushen Yiqi (JWBY) formulas in patients who suffer from COPD exacerbations and to investigate whether the short-term (5-days) systemic glucocorticoid therapy is non-inferior to the long-term (9-day) regime. Methods In this multi-center, randomized, double-blinded trial, eligible inpatients with COPD exacerbation are randomly assigned to four groups (A, B, C, and D). Group A will receive placebo plus 5-day prednisone, group B will receive placebo plus 9-day prednisone, group C will receive JWBY formulas plus 5-day prednisone, and group D will receive JWBY formulas plus 9-day prednisone. The primary outcomes are the time interval to the patient’s next exacerbation during a 180-day following up and the COPD assessment test (CAT) during treatment. Secondary outcomes include lung function, TCM syndrome assessment, laboratory tests, and safety. The changes of the hypothalamic pituitary adrenaline axis (HPA axis) and inflammatory cytokine will be measured as well. Discussion By demonstrating the advantages of utilizing TCM and an appropriate duration of systemic glucocorticoids, this effectiveness comparison trial will provide new references to physicians on how to improve the management of COPD exacerbation. The results of HPA axis and inflammation cytokine measurements will shed light on the molecular mechanisms and entail further mechanism studies. Trial registration www.chictr.org.cn ChiCTR1900023364. Registered on 24 May 2019.
Keywords	Randomized clinical trial ; Design and method ; Acute exacerbation of COPD ; Traditional Chinese medicine ; Systemic glucocorticoids duration ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Proteomics analysis reveals suppression of IL-17 signaling pathways contributed to the therapeutic effects of Jia-Wei Bu-Shen-Yi-Qi formula in a murine asthma model

Qin, Jingjing / Wuniqiemu, Tulake / Wei, Ying / Teng, Fangzhou / Cui, Jie / Sun, Jing / Yi, La / Tang, Weifeng / Zhu, Xueyi / Xu, Weifang / Dong, Jingcheng

Phytomedicine. 2022 Jan., v. 95

2022

Abstract: Jia-Wei Bu-Shen-Yi-Qi formula (JWBSYQF), a Chinese herbal formula, is a commonly used prescription ...

Abstract	Jia-Wei Bu-Shen-Yi-Qi formula (JWBSYQF), a Chinese herbal formula, is a commonly used prescription for treating asthma patients. However, the targeted proteins associated with JWBSYQF treatment remain unknown.Present study aims to evaluate the therapeutic efficacy of JWBSYQF and identify the targeted proteins in addition to functional pathways.The ovalbumin (OVA)-induced murine asthma model was established to explore the therapeutic effect of JWBSYQF treatment. Proteomic profiling and quantifications were performed using data-independent acquisition (DIA) methods. Differentially expressed proteins (DEPs) were validated via western blot (WB) and immunohistochemistry (IHC).A murine asthma model was made by OVA sensitization and challenge, and JWBSYQF (2.25, 4.50, 9,00 g/kg body weight) or dexamethasone (1 mg/ kg body weight) were administered orally. Airway hyperresponsiveness (AHR) to methacholine (Mch), inflammatory cell counts and classification in bronchoalveolar lavage fluid (BALF), lung histopathology, and cytokine levels were measured. Furthermore, DIA proteomic analyses were performed to explore the DEPs targeted by JWBSYQF and were further validated by WB and IHC.Our results exhibited that JWBSYQF attenuated AHR which was mirrored by decreased airway resistance and increased lung compliance. In addition, JWBSYQF-treated mice showed reduced inflammatory score, mucus hypersecretion, as well as reduced the number of BALF leukocytes along with decreased content of BALF Th2 inflammatory cytokines (IL-4, IL-5, IL-13) and serum IgE. Proteomics analysis identified 704 DEPs between the asthmatic mice and control group (MOD vs CON), and 120 DEPs between the JWBSYQF-treatment and the asthmatic mice (JWB-M vs MOD). A total of 33 overlapped DEPs were identified among the three groups. Pathway enrichment analysis showed that DEPs were significantly enriched in IL-17 signaling pathway, in which DEPs, Lcn2, TGF-β1, Gngt2, and Ppp2r5e were common DEPs between three experimental groups. WB and IHC results further validated expressional levels and tendency of these proteins. Our results also showed that JWBSYQF affects mitogen activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) signaling pathways, that are activated by IL-17 signaling.The present study suggested that JWBSYQF could attenuate AHR and airway inflammation in OVA-induced asthmatic mice. In addition, proteomics analysis revealed that suppression of IL-17 signaling pathways contributes to the therapeutic effects of JWBSYQF.
Keywords	Western blotting ; animal disease models ; asthma ; blood serum ; body weight ; dexamethasone ; gene expression regulation ; histopathology ; hypersecretion ; immunohistochemistry ; inflammation ; interleukin-13 ; interleukin-17 ; interleukin-4 ; interleukin-5 ; lung function ; lungs ; mitogen-activated protein kinase ; mucus ; ovalbumin ; proteomics ; therapeutics
Language	English
Dates of publication	2022-01
Publishing place	Elsevier GmbH
Document type	Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2021.153803
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 4115: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Efficacy and safety of Jia Wei Bushen Yiqi formulas as an adjunct therapy to systemic glucocorticoids on acute exacerbation of COPD: study protocol for a randomized, double-blinded, multi-center, placebo-controlled clinical trial.

Kong, Qing / Mo, Shuming / Wang, Wenqian / Tang, Zihui / Wei, Ying / Du, Yijie / Liu, Baojun / Kong, Lingwen / Lv, Yubao / Dong, Jingcheng

Trials

2020 Volume 21, Issue 1, Page(s) 760

Abstract: ... the efficacy and safety of Jia Wei Bushen Yiqi (JWBY) formulas in patients who suffer from COPD exacerbations ...

Abstract	Background: Systemic glucocorticoids are effective for the management of chronic obstructive pulmonary disease (COPD) exacerbation but have serious adverse effects. Traditional Chinese medicine (TCM) can bring additional benefits to these patients but has few adverse effects. The present study aims to evaluate the efficacy and safety of Jia Wei Bushen Yiqi (JWBY) formulas in patients who suffer from COPD exacerbations and to investigate whether the short-term (5-days) systemic glucocorticoid therapy is non-inferior to the long-term (9-day) regime. Methods: In this multi-center, randomized, double-blinded trial, eligible inpatients with COPD exacerbation are randomly assigned to four groups (A, B, C, and D). Group A will receive placebo plus 5-day prednisone, group B will receive placebo plus 9-day prednisone, group C will receive JWBY formulas plus 5-day prednisone, and group D will receive JWBY formulas plus 9-day prednisone. The primary outcomes are the time interval to the patient's next exacerbation during a 180-day following up and the COPD assessment test (CAT) during treatment. Secondary outcomes include lung function, TCM syndrome assessment, laboratory tests, and safety. The changes of the hypothalamic pituitary adrenaline axis (HPA axis) and inflammatory cytokine will be measured as well. Discussion: By demonstrating the advantages of utilizing TCM and an appropriate duration of systemic glucocorticoids, this effectiveness comparison trial will provide new references to physicians on how to improve the management of COPD exacerbation. The results of HPA axis and inflammation cytokine measurements will shed light on the molecular mechanisms and entail further mechanism studies. Trial registration: www.chictr.org.cn ChiCTR1900023364. Registered on 24 May 2019.
MeSH term(s)	Double-Blind Method ; Glucocorticoids/adverse effects ; Humans ; Hypothalamo-Hypophyseal System ; Medicine, Chinese Traditional ; Multicenter Studies as Topic ; Pituitary-Adrenal System ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Randomized Controlled Trials as Topic ; Treatment Outcome
Chemical Substances	Glucocorticoids
Keywords	covid19
Language	English
Publishing date	2020-09-03
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1468-6708
ISSN (online)	1745-6215 ; 1468-6694
ISSN	1468-6708
DOI	10.1186/s13063-020-04669-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: ["Chuan Jia Re" combined with abdominal needle for 23 cases of periarthritis of shoulder with wind cold dampness type].

Jin, Pengchao / Jiang, Ying / Fang, Xiaoli

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2016 Volume 36, Issue 5, Page(s) 527–528

MeSH term(s)	Acupuncture Points ; Acupuncture Therapy/instrumentation ; Acupuncture Therapy/methods ; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Periarthritis/therapy
Language	Chinese
Publishing date	2016-05
Publishing country	China
Document type	Journal Article
ISSN	0255-2930
ISSN	0255-2930
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Ming Qing yi jia lun wen yi

Su, Ying

2013

Author's details	Su Ying zhu bian
MeSH term(s)	Pandemics/prevention & control ; Communicable Disease Control ; Medicine, Chinese Traditional/methods
Language	Chinese
Size	2, 3, 5, 268 p.
Edition	Di 1 ban.
Publisher	Zhongguo zhong yi yao chu ban she
Publishing place	Beijing
Document type	Book
ISBN	9787513216289 ; 7513216282
Database	Catalogue of the US National Library of Medicine (NLM)

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