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Article ; Online: White spot lesions: diagnosis and treatment - a systematic review.

Lopes, Pedro C / Carvalho, Teresa / Gomes, Ana T P C / Veiga, Nelio / Blanco, Letícia / Correia, Maria José / Mello-Moura, Anna Carolina Volpi

BMC oral health

2024 Volume 24, Issue 1, Page(s) 58

Abstract: Background: White spot lesions represent the first stage of caries and their prevalence has been increasing in recent years, particularly in patients undergoing orthodontic treatment. DIferential diagnosis and lesion activity are essential to decide on ... ...

Abstract	Background: White spot lesions represent the first stage of caries and their prevalence has been increasing in recent years, particularly in patients undergoing orthodontic treatment. DIferential diagnosis and lesion activity are essential to decide on the clinical approaches to treatment. The aim of this study is to understand if the new diagnostic tools such as fluorescence, microradiography and computed microtomography have the potential to change the conventional treatment of white spots". Methods: A systematic search of available studies in the literature was carried out, using PRISMA guidelines, in Pubmed and Scopus electronic databases and manually to identify relevant articles to answer the PICO question: "Do the new diagnostic tools have the potential to change the conventional treatment of white spots?". This systematic review included randomized controlled trials (RCT), cross-sectional and longitudinal studies complying with the following inclusion criteria: (i) studies in humans, (ii) studies about white spot lesions, (iii) studies published between 2012 and 2023, (iv) studies having both diagnosis and treatment and (v) studies with full text available. In this review we excluded other systematic reviews of clinical trials and in vitro studies. The RoB tool was used to assess the risk of bias. Results: The systematic literature search identified 143 potentially relevant references, which after applying the exclusion criteria, resulted in 20 articles. Regarding diagnostic methods, most articles found were based on conventional methods of visual examination (n:10) or fluorescence (n:7). The least referenced diagnostic techniques were based on the use of clinical photographs (n:2), cross-sectional microradiography (n:1) and computed microtomography (n:1). The use of DIAGNOdent was reported by 3 in vitro studies. With regard to therapies, most studies reported the use of infiltrating resin (n:7) and fluoride-based products (n:5). Other studies have reported the use of self-assembling peptide P11-4 (n:1), home care (n:1), casein phosphopeptide-amorphous calcium phosphate (n:2) and hydrochloric acid (n:1). Combination therapies were also considered. Conclusion: Diagnostic tool does not have the potential to change the form of treatment, whether it is a conventional method or a more differentiated one.
MeSH term(s)	Humans ; Combined Modality Therapy ; Dental Care ; Caseins ; Databases, Factual ; Dental Caries ; Fluorides
Chemical Substances	Caseins ; Fluorides (Q80VPU408O)
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-023-03720-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Development of pH-Sensitive Magnetoliposomes Containing Shape Anisotropic Nanoparticles for Potential Application in Combined Cancer Therapy.

Pacheco, Ana Rita F / Cardoso, Beatriz D / Pires, Ana / Pereira, André M / Araújo, João P / Carvalho, Violeta M / Rodrigues, Raquel O / Coutinho, Paulo J G / Castelo-Grande, Teresa / Augusto, Paulo A / Barbosa, Domingos / Lima, Rui A / Teixeira, Senhorinha F C F / Rodrigues, Ana Rita O / Castanheira, Elisabete M S

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 6

Abstract: Late diagnosis and systemic toxicity associated with conventional treatments make oncological therapy significantly difficult. In this context, nanomedicine emerges as a new approach in the prevention, diagnosis and treatment of cancer. In this work, pH- ... ...

Abstract	Late diagnosis and systemic toxicity associated with conventional treatments make oncological therapy significantly difficult. In this context, nanomedicine emerges as a new approach in the prevention, diagnosis and treatment of cancer. In this work, pH-sensitive solid magnetoliposomes (SMLs) were developed for controlled release of the chemotherapeutic drug doxorubicin (DOX). Shape anisotropic magnetic nanoparticles of magnesium ferrite with partial substitution by calcium (Mg
Language	English
Publishing date	2023-03-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13061051
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Article ; Online: Brain-derived neurotrophic factor serum levels following ketamine and esketamine intervention for treatment-resistant depression: secondary analysis from a randomized trial.

Trends in psychiatry and psychotherapy

2023 Volume 45, Page(s) e20210298

Abstract: Objectives: Evidence suggests that ketamine's influence on brain-derived neurotrophic factor (BDNF) might be involved in its mechanism of rapid antidepressant action. We aimed to evaluate the differential impact of ketamine and esketamine on serum BDNF ... ...

Abstract	Objectives: Evidence suggests that ketamine's influence on brain-derived neurotrophic factor (BDNF) might be involved in its mechanism of rapid antidepressant action. We aimed to evaluate the differential impact of ketamine and esketamine on serum BDNF levels and its association with response patterns in treatment-resistant depression (TRD). Methods: Participants (n = 53) are from a randomized, double-blind clinical trial comparing the efficacy of single-dose ketamine (0.5mg/kg, n = 27) and esketamine (0.25mg/kg, n = 26) in TRD. Depression severity was assessed before and 24 hours, 72 hours, and 7 days after the intervention, using the Montgomery-Åsberg Depression Rating Scale (MADRS). Blood samples were collected before infusion, 24 hours, and 7 days afterwards. Results: There were no significant changes in BDNF levels at post-infusion evaluation points, and no difference in BDNF levels comparing ketamine and esketamine. Both drugs exhibited similar therapeutic effect. There was no association between BDNF levels and response to treatment or severity of depressive symptoms. Conclusion: There was no significant treatment impact on BDNF serum levels - neither with ketamine nor esketamine - despite therapeutic response. These results suggest that ketamine or esketamine intervention for TRD has no impact on BDNF levels measured at 24 hours and 7 days after the infusion.
MeSH term(s)	Humans ; Brain-Derived Neurotrophic Factor ; Ketamine/therapeutic use ; Depression ; Depressive Disorder, Treatment-Resistant/drug therapy
Chemical Substances	Esketamine (50LFG02TXD) ; Brain-Derived Neurotrophic Factor ; Ketamine (690G0D6V8H)
Language	English
Publishing date	2023-03-07
Publishing country	Brazil
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2708374-3
ISSN	2238-0019 ; 2238-0019
ISSN (online)	2238-0019
ISSN	2238-0019
DOI	10.47626/2237-6089-2021-0298
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Article ; Online: A prognostic value of CD45RA

Fernandes, Ana Teresa G / Carvalho, Maria Odete O / Avvad-Portari, Elyzabeth / Rocha, Natália P / Russomano, Fabio / Roma, Eric Henrique / Bonecini-Almeida, Maria da Gloria

Scientific reports

2021 Volume 11, Issue 1, Page(s) 8782

Abstract: The interplay between cervical cancer (CC) and immune cells, mainly intratumoral lymphocytes, has a pivotal role in carcinogenesis. In this context, we evaluated the distribution of ... ...

Abstract	The interplay between cervical cancer (CC) and immune cells, mainly intratumoral lymphocytes, has a pivotal role in carcinogenesis. In this context, we evaluated the distribution of CD45RA
MeSH term(s)	Adult ; Alphapapillomavirus/pathogenicity ; Case-Control Studies ; Chemokine CCL20 ; Female ; Humans ; Leukocyte Common Antigens/immunology ; Papillomavirus Infections/immunology ; Papillomavirus Infections/pathology ; Papillomavirus Infections/virology ; Prognosis ; Receptors, CCR6 ; Uterine Cervical Neoplasms/immunology ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/virology
Chemical Substances	CCL20 protein, human ; Chemokine CCL20 ; Receptors, CCR6 ; Leukocyte Common Antigens (EC 3.1.3.48)
Language	English
Publishing date	2021-04-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-88248-x
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Article: Microplastics in Internal Tissues of Companion Animals from Urban Environments.

Prata, Joana C / Silva, Ana L Patrício / da Costa, João P / Dias-Pereira, Patrícia / Carvalho, Alexandre / Fernandes, António José Silva / da Costa, Florinda Mendes / Duarte, Armando C / Rocha-Santos, Teresa

Animals : an open access journal from MDPI

2022 Volume 12, Issue 15

Abstract: Companion animals living in urban areas are exposed to environmental contaminants, which may include microplastics. A preliminary study was conducted by collecting postmortem samples from the internal tissue (lungs, ileum, liver, kidney, and blood clots) ...

Abstract	Companion animals living in urban areas are exposed to environmental contaminants, which may include microplastics. A preliminary study was conducted by collecting postmortem samples from the internal tissue (lungs, ileum, liver, kidney, and blood clots) of 25 dogs (
Language	English
Publishing date	2022-08-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani12151979
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Article ; Online: Development of pH-Sensitive Magnetoliposomes Containing Shape Anisotropic Nanoparticles for Potential Application in Combined Cancer Therapy

Ana Rita F. Pacheco / Beatriz D. Cardoso / Ana Pires / André M. Pereira / João P. Araújo / Violeta M. Carvalho / Raquel O. Rodrigues / Paulo J. G. Coutinho / Teresa Castelo-Grande / Paulo A. Augusto / Domingos Barbosa / Rui A. Lima / Senhorinha F. C. F. Teixeira / Ana Rita O. Rodrigues / Elisabete M. S. Castanheira

Nanomaterials, Vol 13, Iss 1051, p

2023 Volume 1051

Abstract	Late diagnosis and systemic toxicity associated with conventional treatments make oncological therapy significantly difficult. In this context, nanomedicine emerges as a new approach in the prevention, diagnosis and treatment of cancer. In this work, pH-sensitive solid magnetoliposomes (SMLs) were developed for controlled release of the chemotherapeutic drug doxorubicin (DOX). Shape anisotropic magnetic nanoparticles of magnesium ferrite with partial substitution by calcium (Mg 0.75 Ca 0.25 Fe 2 O 4 ) were synthesized, with and without calcination, and their structural, morphological and magnetic properties were investigated. Their superparamagnetic properties were evaluated and heating capabilities proven, either by exposure to an alternating magnetic field (AMF) (magnetic hyperthermia) or by irradiation with near-infrared (NIR) light (photothermia). The Mg 0.75 Ca 0.25 Fe 2 O 4 calcined nanoparticles were selected to integrate the SMLs, surrounded by a lipid bilayer of DOPE:Ch:CHEMS (45:45:10). DOX was encapsulated in the nanosystems with an efficiency above 98%. DOX release assays showed a much more efficient release of the drug at pH = 5 compared to the release kinetics at physiological pH. By subjecting tumor cells to DOX-loaded SMLs, cell viability was significantly reduced, confirming that they can release the encapsulated drug. These results point to the development of efficient pH-sensitive nanocarriers, suitable for a synergistic action in cancer therapy with magnetic targeting, stimulus-controlled drug delivery and dual hyperthermia (magnetic and plasmonic) therapy.
Keywords	combined cancer therapy ; drug release ; pH-sensitive magnetoliposomes ; shape anisotropic nanoparticles ; superparamagnetism ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Clinical and laboratory markers associated with anti-TNF-alpha trough levels and anti-drug antibodies in patients with inflammatory bowel diseases.

Grinman, Ana B / de Souza, Maria das Graças C / Bouskela, Eliete / Carvalho, Ana Teresa P / de Souza, Heitor S P

Medicine

2020 Volume 99, Issue 10, Page(s) e19359

Abstract: ... relative serum IFX levels (<3 μg/mL) (P = .028). In contrast, higher concentrations of anti-IFX antibodies ... were found in patients who were not on concomitant immunomodulators (P = .022) and who had more ... biological-related adverse events (P = .001) and higher levels of CRP (P = .042). Serum CRP levels were also ...

Abstract	Monitoring anti-TNF agents in inflammatory bowel disease (IBD) patients may be helpful in optimizing outcomes. We aimed to evaluate potential correlations among demographic, clinical, laboratory, or imaging parameters, as well as serum levels of infliximab (IFX) and adalimumab (ADA) and their respective antibodies, in the clinical management of IBD patients.A cross-sectional study of 95 patients with Crohn's disease (CD) or ulcerative colitis (UC) in maintenance therapy with infliximab or adalimumab was performed. Drug trough levels and anti-drug levels were determined using ELISA-based assays.Regarding the serum IFX dosage, patients with higher relative C-reactive protein (CRP) levels had significantly lower relative serum IFX levels (<3 μg/mL) (P = .028). In contrast, higher concentrations of anti-IFX antibodies were found in patients who were not on concomitant immunomodulators (P = .022) and who had more biological-related adverse events (P = .001) and higher levels of CRP (P = .042). Serum CRP levels were also negatively correlated with IFX (CC = -0.315; P = .033) but positively correlated with the presence of IFX antibodies (CC = 0.327; P = .027). Serum albumin dosage showed a positive correlation with levels of both IFX (CC = 0.379; P = .004) and ADA (CC = 0.699; P = .003).Although anti-TNF-α trough levels and immunogenicity do not show a significant correlation with disease outcome, our results reinforce the use of combination therapy for patients treated with infliximab. Moreover, we confirmed the presence of significant associations between anti-TNF-α trough levels and immunogenicity with body mass index (BMI), the concomitant use of immunomodulators, the rates of side effects, and laboratory markers, including serum albumin and CRP.
MeSH term(s)	Adalimumab/analysis ; Adalimumab/blood ; Adalimumab/therapeutic use ; Adult ; Biomarkers/analysis ; Biomarkers/blood ; Body Mass Index ; C-Reactive Protein/analysis ; Cross-Sectional Studies ; Female ; Humans ; Inflammatory Bowel Diseases/blood ; Infliximab/analysis ; Infliximab/blood ; Infliximab/therapeutic use ; Male ; Middle Aged ; Tumor Necrosis Factor-alpha/analysis ; Tumor Necrosis Factor-alpha/blood
Chemical Substances	Biomarkers ; Tumor Necrosis Factor-alpha ; C-Reactive Protein (9007-41-4) ; Infliximab (B72HH48FLU) ; Adalimumab (FYS6T7F842)
Language	English
Publishing date	2020-03-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000019359
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Identification of clinical and radiographic predictors of central nervous system injury in genetic skeletal disorders.

Cunha, Antônio L / Champs, Ana P S / Mello, Carla M / Navarro, Mônica M M / Godinho, Frederico J C / Carvalho, Cássia M B / Ferrari, Teresa C A

Scientific reports

2021 Volume 11, Issue 1, Page(s) 11402

Abstract: Some studies report neurological lesions in patients with genetic skeletal disorders (GSDs). However, none of them describe the frequency of neurological lesions in a large sample of patients or investigate the associations between clinical and/or ... ...

Abstract	Some studies report neurological lesions in patients with genetic skeletal disorders (GSDs). However, none of them describe the frequency of neurological lesions in a large sample of patients or investigate the associations between clinical and/or radiological central nervous system (CNS) injury and clinical, anthropometric and imaging parameters. The project was approved by the institution's ethics committee (CAAE 49433215.5.0000.0022). In this cross-sectional observational analysis study, 272 patients aged four or more years with clinically and radiologically confirmed GSDs were prospectively included. Genetic testing confirmed the diagnosis in the FGFR3 chondrodysplasias group. All patients underwent blinded and independent clinical, anthropometric and neuroaxis imaging evaluations. Information on the presence of headache, neuropsychomotor development (NPMD), low back pain, joint deformity, ligament laxity and lower limb discrepancy was collected. Imaging abnormalities of the axial skeleton and CNS were investigated by whole spine digital radiography, craniocervical junction CT and brain and spine MRI. The diagnostic criteria for CNS injury were abnormal clinical and/or radiographic examination of the CNS. Brain injury included malacia, encephalopathies and malformation. Spinal cord injury included malacia, hydrosyringomyelia and spinal cord injury without radiographic abnormalities. CNS injury was diagnosed in more than 25% of GSD patients. Spinal cord injury was found in 21.7% of patients, and brain injury was found in 5.9%. The presence of low back pain, os odontoideum and abnormal NPMD remained independently associated with CNS injury in the multivariable analysis. Early identification of these abnormalities may have some role in preventing compressive CNS injury, which is a priority in GSD patients.
MeSH term(s)	Adolescent ; Adult ; Aged ; Bone Diseases/genetics ; Central Nervous System/injuries ; Child ; Child, Preschool ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Wounds and Injuries/diagnostic imaging ; Wounds and Injuries/genetics ; Wounds and Injuries/pathology ; Young Adult
Language	English
Publishing date	2021-05-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-87058-5
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Article: Prognostic factors for early relapse in non-metastatic triple negative breast cancer - real world data.

Soares, Rita Félix / Garcia, Ana Rita / Monteiro, Ana Raquel / Macedo, Filipa / Pereira, Tatiana Cunha / Carvalho, Joana Cunha / Pêgo, António / Mariano, Mónica / Madeira, Pedro / Póvoa, Sara / Broco, Sofia / Carvalho, Teresa / Pazos, Isabel / Sousa, Gabriela

Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

2021 Volume 26, Issue 4, Page(s) 563–572

Abstract: ... In multivariate analysis, being submitted to neoadjuvant radiotherapy [HR 2.8 (95% CI: 1.2-6.4), p = 0.017] and not ... achieving pathologic complete response [HR 0.3 (95% CI: 0.1-1.7), p = 0.011] were associated with higher ...

Abstract	Background: Triple negative breast cancer (TNBC) has the worst prognosis amongst all subtypes. Studies have shown that the achievement of pathologic complete response in the breast and axilla correlates with improved survival. The aim of this study was to identify clinical or pathological features of real-life TNBC patients with a higher risk of early relapse. Materials and methods: Single-centre retrospective analysis of 127 women with TNBC, stage II-III, submitted to neoadjuvant treatment and surgery between January 2016 and 2020. Multivariate Cox regression analysis for disease free survival (DFS) at 2 years was performed and statistically significant variables were computed into a prognostic model for early relapse. Results: After 29 months of median follow-up, 105 patients (82.7%) were alive and, in total, 38 patients (29.9%) experienced recurrence. The 2-year DFS was 73% (95% CI: 21.3-22.7). In multivariate analysis, being submitted to neoadjuvant radiotherapy [HR 2.8 (95% CI: 1.2-6.4), p = 0.017] and not achieving pathologic complete response [HR 0.3 (95% CI: 0.1-1.7), p = 0.011] were associated with higher risk of recurrence. In our prognostic model, the presence of at least one of these variables defined a subgroup of patients with a worse 2-year DFS than those without these features (59% Conclusions: In this real-life non-metastatic TNBC cohort, neoadjuvant radiotherapy (performed due to insufficient clinical response to neoadjuvant chemotherapy or significant toxicity) impacted as an independent prognostic factor for relapse along with the absence of pathologic complete response identifying a subgroup of higher risk patients for early relapse that might merit a closer follow-up.
Language	English
Publishing date	2021-08-12
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2188087-6
ISSN	1507-1367
ISSN	1507-1367
DOI	10.5603/RPOR.a2021.0073
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Article: Bioactive Lipids of Seaweeds from the Portuguese North Coast: Health Benefits versus Potential Contamination.

Soares, Cristina / Sousa, Sara / Machado, Susana / Vieira, Elsa / Carvalho, Ana P / Ramalhosa, Maria João / Morais, Simone / Correia, Manuela / Oliva-Teles, Teresa / Domingues, Valentina F / Delerue-Matos, Cristina

Foods (Basel, Switzerland)

2021 Volume 10, Issue 6

Abstract: The total lipid content and lipidic profile of seaweeds harvested in the North Coast and purchased in Portugal were determined in this paper. The amount of total lipids in the different species of seaweeds varied between 0.7 ± 0.1% ( ...

Abstract	The total lipid content and lipidic profile of seaweeds harvested in the North Coast and purchased in Portugal were determined in this paper. The amount of total lipids in the different species of seaweeds varied between 0.7 ± 0.1% (
Language	English
Publishing date	2021-06-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods10061366
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