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Article: Effect of phorbol myristate acetate (PMA) on P-glycoprotein mediated vincristine resistance of L1210 cells.

Barancík, M / Stefanková, Z / Breier, A

1995 Volume 14, Issue 2, Page(s) 171–175

Abstract: Effect of phorbol myristate acetate (PMA) on P-glycoprotein (P-GP)-mediated vincristine resistance ...

Abstract	Effect of phorbol myristate acetate (PMA) on P-glycoprotein (P-GP)-mediated vincristine resistance of the multidrug resistant mouse leukemic cell line L1210/VCR was studied by one hour lasting incubation of cells in the presence of PMA, and after three days of cultivation in the presence of the same substance. After the incubation with 100 micrograms.1-1 PMA the accumulation of [3H]-vincristine by the above cells was significantly depressed. Moreover, full reverse of verapamil-induced stimulation of [3H]-vincristine accumulation was observed in the presence of PMA. In contrary, when cells were cultivated three days in the presence of PMA, only slight but non-significant increase of [3H]-vincristine accumulation was observed. Slight increase of vincristine accumulation by cells cultivated in the presence of PMA was also supported by higher sensitivity of these cells to vincristine.
MeSH term(s)	ATP-Binding Cassette, Sub-Family B, Member 1/drug effects ; ATP-Binding Cassette, Sub-Family B, Member 1/metabolism ; Animals ; Biological Transport/drug effects ; Cell Survival/drug effects ; Drug Resistance, Multiple ; Leukemia L1210 ; Mice ; Tetradecanoylphorbol Acetate/pharmacology ; Tumor Cells, Cultured ; Verapamil/pharmacology ; Vincristine/metabolism ; Vincristine/toxicity
Chemical Substances	ATP-Binding Cassette, Sub-Family B, Member 1 ; Vincristine (5J49Q6B70F) ; Verapamil (CJ0O37KU29) ; Tetradecanoylphorbol Acetate (NI40JAQ945)
Language	English
Publishing date	1995-04
Publishing country	Slovakia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	791184-1
ISSN	0231-5882
ISSN	0231-5882
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Article ; Online: Metrical evaluation of Slovak patients with pectus excavatum.

Štefánková, Eva / Omaník, Pavol / Neščáková, Eva / Stanová, Barbara / Cingel, Vladimír

Surgical and radiologic anatomy : SRA

2016 Volume 38, Issue 6, Page(s) 663–674

Abstract: Purpose: We have started to assess the severity of pectus excavatum by means of anthropometric methods prior to CT examination since 2012. The aim of the study was to establish a significance of anthropometry as first-line diagnostic method. Afterwards, ...

Abstract	Purpose: We have started to assess the severity of pectus excavatum by means of anthropometric methods prior to CT examination since 2012. The aim of the study was to establish a significance of anthropometry as first-line diagnostic method. Afterwards, we analyzed statistical significance of differences in selected anthropometric indicators before and after surgical intervention. The analysis was also focused on the data from CT scans. Methods: The followed group represented 27 patients, including 6 girls and 21 boys aged 7-18 years (mean age 15.59 years). Evaluation of anthropometric measurements was realized by somatometry, and other metrical measurements were calculated from thoracic CT scans of patients. All measurements were managed with the approval of the Ethics Committee. Results: The significant differences were found in sagittal diameter and thoracic index in 64.0 % of the patients. Data analyzed from CT showed that flat chest prevailed in both gender (100 %). The largest group represented asymmetric type of pectus excavatum (40.74 %). The superiority of the asymmetric type to the right was confirmed. The values of the Haller index were in range 2.00-5.17 (mean value 3.64). 81.5 % of patients met criterion for surgical correction. Most patients with pectus excavatum had a milder form of deformation. Conclusions: Anthropometry provides feasible and non-invasive method of pectus deformities evaluation. Based on the study results, anthropometry should be performed prior to CT examination in order to select patients for surgical treatment. Anthropometric measurements are helpful in accurate documentation of growth, longitudinal observation of the patient, and can support decision concerning the type of surgery.
MeSH term(s)	Adolescent ; Anthropometry/methods ; Child ; Decision Support Techniques ; Female ; Funnel Chest/diagnosis ; Funnel Chest/surgery ; Humans ; Male ; Severity of Illness Index ; Slovakia ; Sternum/abnormalities ; Sternum/pathology ; Tomography, X-Ray Computed
Language	English
Publishing date	2016-08
Publishing country	Germany
Document type	Evaluation Studies ; Journal Article
ZDB-ID	632839-8
ISSN	1279-8517 ; 0930-312X ; 0930-1038
ISSN (online)	1279-8517
ISSN	0930-312X ; 0930-1038
DOI	10.1007/s00276-015-1594-5
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Article: Time dependence of [3H]-vincristine accumulation by L1210 mouse leukemic cells. Effect of P-glycoprotein overexpression.

Breier, A / Stefanková, Z / Barancík, M / Tribulová, N

General physiology and biophysics

1994 Volume 13, Issue 4, Page(s) 287–298

Abstract: Overexpression of P-glycoprotein (P-GP) accompanied by multidrug resistance (MDR) to diverse groups ... for vincristine around 0.01 mg/l. Overexpression of P-GP induced by the adaptation procedure was found to be ...

Abstract	Overexpression of P-glycoprotein (P-GP) accompanied by multidrug resistance (MDR) to diverse groups of cytostatics was developed by long-term adaptation of mouse leukemic cell line L1210 to vincristine. Two resistant sublines of cells characterized by ID50 values for vincristine 1.05 mg/l (L1210/VCR-1) and 2.3 mg/l (L1210/VCR-2), respectively, were used. The sensitive parental cell line L1210 had the ID50 value for vincristine around 0.01 mg/l. Overexpression of P-GP induced by the adaptation procedure was found to be accompanied by an increase in the mean cell diameter from 10.28 +/- 1.60 microns (mean +/- SD, n = 122) for sensitive L1210 cells to 17.82 +/- 2.59 microns (n = 120) and 37.26 +/- 5.72 microns (n = 121) for L1210/VCR-1 and L1210/VCR-2 resistant cell sublines, respectively. Significant decrease in ability to accumulate [3H]-vincristine from cultivation medium was observed for both resistant cell sublines in comparison to sensitive cells. Accumulation of [3H]-vincristine by sensitive cells is secured only by passive diffusion of the drug across the plasma membrane. Contrary to that, active efflux of drug operating against its diffusion across the plasma membrane should be assumed as a factor influencing the [3H]-vincristine accumulation by resistant cells. Indeed, the time dependence of [3H]-vincristine accumulation by sensitive cells could be fitted using simple monoexponential kinetic dependence in contrast to biexponential kinetic dependences that are necessary for fitting [3H]-vincristine accumulation by both resistant cell sublines. Kinetic analysis of the experimental data indicates that accumulation of [3H]-vincristine by sensitive cells grows to a plateau reflecting probably the equilibrium of drug concentration in the intracellular and extracellular space. On the contrary, accumulation of [3H]-vincristine by both resistant cell sublines was stabilized after an initial growth on a considerably lower level than it was observed for the sensitive cells in the equilibrium.
MeSH term(s)	ATP-Binding Cassette, Sub-Family B, Member 1/metabolism ; Animals ; Biological Transport, Active ; Drug Resistance, Multiple ; Kinetics ; Leukemia L1210/drug therapy ; Leukemia L1210/metabolism ; Leukemia L1210/pathology ; Mice ; Microscopy, Electron ; Tumor Cells, Cultured/drug effects ; Tumor Cells, Cultured/metabolism ; Tumor Cells, Cultured/ultrastructure ; Vincristine/pharmacokinetics ; Vincristine/pharmacology
Chemical Substances	ATP-Binding Cassette, Sub-Family B, Member 1 ; Vincristine (5J49Q6B70F)
Language	English
Publishing date	1994-08
Publishing country	Slovakia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	791184-1
ISSN	0231-5882
ISSN	0231-5882
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Article: Overcoming of P-glycoprotein mediated vincristine resistance of L1210/VCR mouse leukemic cells could be induced by pentoxifyline but not by theophylline and caffeine.

Stefanková, Z / Barancík, M / Breier, A

Neoplasma

1996 Volume 43, Issue 1, Page(s) 11–15

Abstract: ... isobutylxanthine) on P-glycoprotein mediated vincristine resistance of L1210/VCR mouse leukemic cell subline were ...

Abstract	Effects of xanthine derivatives (pentoxifylline, caffeine, theophylline, 1-methyl-3-isobutylxanthine) on P-glycoprotein mediated vincristine resistance of L1210/VCR mouse leukemic cell subline were studied. From the applied xanthines only PTX was found to reverse the vincristine resistance of the above cells. Moreover, only PTX, but not other xanthine, increased the accumulation of [3H]vincristine by L1210/VCR cells. Thus it may be concluded that PTX-induced reversal of vincristine resistance could not be explained from the point of known pharmacological effects of PTX that are common for other xanthines such as inhibition of phosphodiesterase activity, calcium mobilizing effect, inhibition of tumor necrosis factor alpha (TNF), etc.
MeSH term(s)	ATP-Binding Cassette, Sub-Family B, Member 1/physiology ; Animals ; Caffeine/pharmacology ; Calcium/metabolism ; Calcium Channels/metabolism ; Drug Interactions ; Drug Resistance, Neoplasm ; Leukemia L1210/drug therapy ; Leukemia L1210/metabolism ; Mice ; Pentoxifylline/pharmacology ; Phosphodiesterase Inhibitors/pharmacology ; Theophylline/pharmacology ; Tumor Necrosis Factor-alpha/biosynthesis ; Vincristine/pharmacokinetics ; Vincristine/pharmacology
Chemical Substances	ATP-Binding Cassette, Sub-Family B, Member 1 ; Calcium Channels ; Phosphodiesterase Inhibitors ; Tumor Necrosis Factor-alpha ; Caffeine (3G6A5W338E) ; Vincristine (5J49Q6B70F) ; Theophylline (C137DTR5RG) ; Pentoxifylline (SD6QCT3TSU) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	1996
Publishing country	Slovakia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	415445-9
ISSN	0028-2685
ISSN	0028-2685
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Article: Effect of pentoxifylline on P-glycoprotein mediated vincristine resistance of L1210 mouse leukemic cell line.

Breier, A / Barancík, M / Stefanková, Z / Uhrík, B / Tribulová, N

Neoplasma

1994 Volume 41, Issue 5, Page(s) 297–303

Abstract: ... to be accompanied with overexpression of drug transporting P-glycoprotein. Indeed, lower level of 3H ...

Abstract	Effect of pentoxifylline (PTX) on vincristine (VCR) resistance of multidrug resistant L1210/VCR mouse leukemic cell line was studied. Reversal effect of PTX (in concentration 50-150 mg/l) on vincristine resistance, i.e. potentiation of vincristine cytotoxicity on L1210/VCR cells by PTX was found. PTX alone in the above concentration did not exert any significant cytotoxic effect on sensitive or resistant cell lines in the absence of vincristine. Resistance of L1210/VCR cell line was found previously to be accompanied with overexpression of drug transporting P-glycoprotein. Indeed, lower level of 3H-vincristine accumulation by resistant L1210/VCR cell line in comparison with sensitive L1210 cell line was observed. Accumulation of 3H-vincristine by L1210/VCR cell line was significantly increased in the presence of PTX. PTX in the same condition did not exert any considerable effect on accumulation of 3H-vincristine by nonresistant L1210 cells. Observable morphological damage was observed in L1210/VCR cells cultivated in medium containing vincristine (0.2 mg/l) and pentoxifylline (100 mg/l) in comparison with the non-damaged cells in the presence of vincristine or pentoxifylline alone. The results obtained indicate that pentoxifylline may be considered as a reversal agent in multidrug resistance.
MeSH term(s)	ATP-Binding Cassette, Sub-Family B, Member 1/physiology ; Animals ; Dactinomycin/pharmacology ; Drug Resistance, Multiple ; Drug Synergism ; Leukemia L1210/drug therapy ; Leukemia L1210/metabolism ; Mice ; Pentoxifylline/pharmacology ; Tritium ; Tumor Cells, Cultured/drug effects ; Vinblastine/pharmacology ; Vincristine/pharmacokinetics ; Vincristine/pharmacology
Chemical Substances	ATP-Binding Cassette, Sub-Family B, Member 1 ; Tritium (10028-17-8) ; Dactinomycin (1CC1JFE158) ; Vincristine (5J49Q6B70F) ; Vinblastine (5V9KLZ54CY) ; Pentoxifylline (SD6QCT3TSU)
Language	English
Publishing date	1994
Publishing country	Slovakia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	415445-9
ISSN	0028-2685
ISSN	0028-2685
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Article: Human race as indicator of 3D planning of soft tissue of face and multidisciplinary approach.

Nadazdyova, A / Samohyl, M / Stefankova, E / Pintesova, S / Stanko, P

Bratislavske lekarske listy

2017 Volume 118, Issue 7, Page(s) 431–436

Abstract: ... Li) and pupils - mid-face (right). The statistically significant level was determined at p values < 0 ...

Abstract	Objective: The aim of this study was to determine the optimal parameters for 3D soft tissue planning for ortognatic treatment by gender and increases the effectiveness of multidisciplinary cooperation. Methods: Craniofacial parameters which were analysed: nose breadth (al-al), bi-entocanthion breadth (en-en), bi-zygomatic breadth (zy-zy), bi-gonial breadth (go-go), total facial height (n-gn), mouth breadth (ch-ch), morphologic face height (sn-gn), upper-lip height (Ls-Stm), lower-lip height (Stm-Li) and pupils - mid-face (right). The statistically significant level was determined at p values < 0.05. Results: We have determined the optimal parameters of chosen proportions for men and women as the common goal for ortodontist and maxilofacial surgeon. The gender and age influenced the variability of following parameters: bi-gonial breadth, total facial height and morphologic face height. Conclusion: The soft tissue values for craniofacial parameters can be used to identify the surgical-orthodontic goal for patient - europoid race. Due to the immigration and the mix of races it is necessary to take this fact into account (Tab. 3, Fig. 1, Ref. 41).
MeSH term(s)	Adult ; Anatomic Landmarks/anatomy & histology ; Anthropometry ; Cephalometry ; Connective Tissue/anatomy & histology ; Face/anatomy & histology ; Female ; Humans ; Imaging, Three-Dimensional/methods ; Lip/anatomy & histology ; Male ; Nose/anatomy & histology ; Reference Values
Language	English
Publishing date	2017
Publishing country	Slovakia
Document type	Journal Article
ZDB-ID	127421-1
ISSN	0006-9248
ISSN	0006-9248
DOI	10.4149/BLL_2017_084
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Article: Anthropometry of craniosynostosis.

Štefánková, Eva / Horn, František / Neščáková, Eva / Kabát, Michal / Petrík, Michal / Trnka, Ján

Neurologia i neurochirurgia polska

2015 Volume 49, Issue 4, Page(s) 229–238

Abstract: ... for evaluating differences in the trend of growth in craniosynostosis (p<0.001) and also for evaluating post ... operative results. Significance was found in width of the head (p=0.038) for scaphocephaly and in length ... of the head for trigonocephaly (p=0.001) in surgically treated patients. Trend of cranial growth in operated ...

Abstract	Background: Anthropometry is becoming a popular method for diagnostics of various diseases in pediatric clinical practice. The aim of this study was to assess the growth changes in craniofacial parameters in patients with craniosynostosis and positional plagiocephaly. Methods: Inclusion criteria for the study were presence of craniostenosis or positional plagiocephaly in a patient with at least three anthropometric evaluations at our department. Studied patients were aged from 1.0 month to 2.5 years with median age at the first and last anthropometric evaluation as 1.83 and 25.27 months, respectively. Further anthropometric results in patients older than 2.5 years were excluded from the study. Statistical significance was tested by the Mann-Whitney test. Results: The studied group consisted of 70.5% male patients. The type of craniosynostosis was represented by scaphocephaly in 44.1%, by trigonocephaly in 45.6% and by coronal craniosynostosis in 10.3% of the cases. Cranial index was proven as a suitable parameter for evaluating differences in the trend of growth in craniosynostosis (p<0.001) and also for evaluating post-operative results. Significance was found in width of the head (p=0.038) for scaphocephaly and in length of the head for trigonocephaly (p=0.001) in surgically treated patients. Trend of cranial growth in operated patients copied the curve of the norm but in higher or lower values which depends on the type of prematurely closed suture. Conclusion: Longitudinal anthropometric follow-up is an objective and measurable method that can accurately non-invasively and non-expensively assess skull growth in pediatric patients with cranial deformity.
MeSH term(s)	Anthropometry/methods ; Child, Preschool ; Craniosynostoses/pathology ; Female ; Follow-Up Studies ; Humans ; Infant ; Male
Language	English
Publishing date	2015
Publishing country	Poland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	415519-1
ISSN	1897-4260 ; 0028-3843
ISSN (online)	1897-4260
ISSN	0028-3843
DOI	10.1016/j.pjnns.2015.05.006
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Article: Diabetes mellitus a jaterní cirhóza.

Fejfar, T / Safka, V / Jirkovský, V / Stefánková, J / Hůlek, P

Vnitrni lekarstvi

2011 Volume 57, Issue 4, Page(s) 368–371

Abstract: Patients with liver cirrhosis have increased risk of diabetes mellitus development, especially when the underlying disease is hereditary hemochromatosis, autoimmune hepatitis, non-alcoholic steatohepatitis or chronic hepatitis C. Patients with associated ...

Title translation	Diabetes mellitus and the liver cirrhosis.
Abstract	Patients with liver cirrhosis have increased risk of diabetes mellitus development, especially when the underlying disease is hereditary hemochromatosis, autoimmune hepatitis, non-alcoholic steatohepatitis or chronic hepatitis C. Patients with associated diabetes according to liver cirrhosis complications have worse prognosis and the therapy is influenced by both diseases. The authors bring short review of particular diseases, diagnosis and treatment strategy.
MeSH term(s)	Diabetes Complications/physiopathology ; Hemochromatosis/complications ; Hemochromatosis/etiology ; Hemochromatosis/genetics ; Hepatitis, Autoimmune/complications ; Hepatitis, Autoimmune/physiopathology ; Humans ; Liver Cirrhosis/etiology ; Liver Cirrhosis/physiopathology
Language	Czech
Publishing date	2011-04
Publishing country	Czech Republic
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	138213-5
ISSN	1801-7592 ; 0042-773X
ISSN (online)	1801-7592
ISSN	0042-773X
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Article: The thioredoxin system from Streptomyces coelicolor.

Stefanková, Petra / Perecko, Dusan / Barák, Imrich / Kollárová, Marta

Journal of basic microbiology

2006 Volume 46, Issue 1, Page(s) 47–55

Abstract: This paper describes the cloning, purification and characterization of thioredoxin (TrxA) and thioredoxin reductase (TrxR) from bacterial strain Streptomyces coelicolor . The genes of S. coelicolor encoding TrxA and TrxR were amplified by polymerase ... ...

Abstract	This paper describes the cloning, purification and characterization of thioredoxin (TrxA) and thioredoxin reductase (TrxR) from bacterial strain Streptomyces coelicolor . The genes of S. coelicolor encoding TrxA and TrxR were amplified by polymerase chain reaction, inserted into pET expression vector and used to overexpress these proteins in Escherichia coli . TrxA and TrxR were produced as the hexahistidine fusion proteins and were recovered from the cytoplasm as the soluble proteins. The activity of the purified recombinant proteins was demonstrated. The activity of TrxA was shown by efficient reduction of insulin and activity of NADPH-dependent TrxR was revealed by catalyses of 5,5'-dithiobis (2-nitrobenzoic acid) (DTNB) reduction reaction. The reduction reaction was fully dependent upon the presence of TrxA as intermediate electron carrier with the pH optimum 7.5 and the temperature optimum 29 degrees C. Km value of TrxR for TrxA was 0.217 +/- 0.02 microM.
MeSH term(s)	Amino Acid Sequence ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Dithionitrobenzoic Acid/metabolism ; Escherichia coli/metabolism ; Insulin/metabolism ; Molecular Sequence Data ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/metabolism ; Sequence Alignment ; Streptomyces coelicolor/enzymology ; Streptomyces coelicolor/genetics ; Substrate Specificity ; Thioredoxin-Disulfide Reductase/genetics ; Thioredoxin-Disulfide Reductase/metabolism ; Thioredoxins/genetics ; Thioredoxins/metabolism
Chemical Substances	Bacterial Proteins ; Insulin ; Recombinant Proteins ; Thioredoxins (52500-60-4) ; Dithionitrobenzoic Acid (9BZQ3U62JX) ; Thioredoxin-Disulfide Reductase (EC 1.8.1.9)
Language	English
Publishing date	2006
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632513-0
ISSN	1521-4028 ; 0233-111X
ISSN (online)	1521-4028
ISSN	0233-111X
DOI	10.1002/jobm.200510036
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Article: Thioredoxin - structural and functional complexity.

Stefanková, P / Kollárová, M / Barák, I

General physiology and biophysics

2005 Volume 24, Issue 1, Page(s) 3–11

Abstract: Thioredoxins are small globular proteins that proved to be excellent model for investigating the relationship between the structure of protein and their physico-chemical and functional properties. The results from the experiments on thioredoxins offer ... ...

Abstract	Thioredoxins are small globular proteins that proved to be excellent model for investigating the relationship between the structure of protein and their physico-chemical and functional properties. The results from the experiments on thioredoxins offer the basic for the development of the new paradigms in the field of chemistry, biophysics and biology of proteins, with special attention to redox reaction in living cells, protein stability and design. It is a good example of broad class of sulphur-containing redox proteins.
MeSH term(s)	Animals ; Binding Sites ; Humans ; Models, Chemical ; Models, Molecular ; Oxidation-Reduction ; Protein Binding ; Protein Conformation ; Signal Transduction/physiology ; Structure-Activity Relationship ; Thioredoxins/chemistry ; Thioredoxins/metabolism
Chemical Substances	Thioredoxins (52500-60-4)
Language	English
Publishing date	2005-03
Publishing country	Slovakia
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	791184-1
ISSN	0231-5882
ISSN	0231-5882
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