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  1. Article ; Online: Insights on effects of Wnt pathway modulation on insulin signaling and glucose homeostasis for the treatment of type 2 diabetes mellitus: Wnt activation or Wnt inhibition?

    Yadav, Ruchi / Patel, Bhumika

    International journal of biological macromolecules

    2024  Volume 261, Issue Pt 1, Page(s) 129634

    Abstract: Type 2 diabetes mellitus (T2DM) is a major worldwide chronic disease and can lead to serious diabetic complications. Despite the availability of many anti-diabetic agents in the market, they are unable to meet the long-term treatment goals. Also, they ... ...

    Abstract Type 2 diabetes mellitus (T2DM) is a major worldwide chronic disease and can lead to serious diabetic complications. Despite the availability of many anti-diabetic agents in the market, they are unable to meet the long-term treatment goals. Also, they cause many side effects which justify the need for novel class of anti-diabetic drugs with newer mechanism of action. Wnt signaling is one of such novel target pathways which can be explored for metabolic disorders. Many key components of the Wnt signaling are involved in the regulation of glucose homeostasis. Polymorphism in the Transcription factor 7-like 2 (TCF7L2) gene, and mutations in the LRP5 (LDL Receptor Related Protein 5) gene lead to disturbed glucose metabolism and obesity. Despite of several years of research in this field, there is no concrete proof of concept available on whether Wnt activation or Wnt inhibition is the beneficial approach for the treatment of T2DM. Here, we have summarized the conclusions of relevant published research studies to give structured insights into possibilities to explore Wnt modulation as a novel target pathway for the treatment of T2DM. The review also highlights the present challenges and future opportunities towards the development of anti-diabetic small molecules targeting the Wnt signaling pathway.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/genetics ; Wnt Signaling Pathway ; Insulin/pharmacology ; Homeostasis ; Glucose/metabolism
    Chemical Substances Insulin ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2024-01-23
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.129634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Integrative computational approach for gene expression profiling of metastatic breast cancer

    Aaliya Ashraf / Ruchi Yadav

    Current Medicine Research and Practice, Vol 13, Iss 3, Pp 100-

    2023  Volume 110

    Abstract: Background: Breast cancer (BC) is one of the most common cancers in women worldwide, including an estimated 570,000 deaths in 2015. More than 1.5 million women (25% of all women with cancer) are diagnosed with BC every year worldwide. BC is a metastatic ... ...

    Abstract Background: Breast cancer (BC) is one of the most common cancers in women worldwide, including an estimated 570,000 deaths in 2015. More than 1.5 million women (25% of all women with cancer) are diagnosed with BC every year worldwide. BC is a metastatic cancer and usually spreads to distant organs such as bone, liver, lungs and the brain. Early detection of the disease can lead to better prognosis and higher survival rates. After genome sequencing, DNA microarray analysis has become the most widely used source of genome scale data in life sciences. Microarray's definition studies produce a large number of genetic expression and other genomics performance data, which promises to provide key information on genetic functioning and interaction within and within metabolic pathways. Aim: Prediction and functional enrichment of significant genes expressed in Breast Cancer. Materials and Methods: Microarray data for this study were downloaded from NCBI gene expression omnibus (GEO) database (http://www.ncbi.nlm.nih.gov/geo), with accession number of GSE157737. It includes four different kind sets of samples, i.e., healthy control neutrophils, healthy donor monocytes, metastatic BC patient G-myeloid-derived suppressor cell (G-MDSCs) and sepsis patient G-MDSCs. The statistical method was applied to identify the differentially expressed gene (DEGs) using Limma package and significant analysis of microarray (SAM) test. Results: The top ten DEGs were identified between different sample sets using Limma package. Out of 32,321 genes, 93 genes were identified to be the significant genes through SAM test. The functional annotation of significant genes was done using different databases such as gene ontology, Kyoto Encyclopedia of Genes and Genomes and Database for Annotation, Visualisation and Integrated Discovery. Significant genes were found to be enriched in haematopoietic cell lineage pathway and the cancer-causing pathway. Conclusions: This research identifies the important genes that have function in BC and regulation of ...
    Keywords breast cancer ; differentially expressed gene ; gene ontology ; limma ; microarray ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Cu(I)/

    Jain, Swati / Anmol / Sharma, Ruchi / Karmakar, Tarak / Yadav, M Ramu

    Organic letters

    2023  Volume 25, Issue 29, Page(s) 5437–5442

    Abstract: We have developed an efficient Cu/ ...

    Abstract We have developed an efficient Cu/
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c01735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Unusual Observations in Leishmaniasis-An Overview.

    Yadav, Priya / Azam, Mudsser / Ramesh, V / Singh, Ruchi

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: Leishmaniasis significantly affects the population of the tropics and subtropics. Clinical features and infective species ... ...

    Abstract Leishmaniasis significantly affects the population of the tropics and subtropics. Clinical features and infective species of
    Language English
    Publishing date 2023-02-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12020297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Probing plasmon-induced surface reactions using two-dimensional correlation vibrational spectroscopy.

    Singh, Ruchi / Yadav, Vikas / Siddhanta, Soumik

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 8, Page(s) 6032–6043

    Abstract: Surface plasmon resonance (SPR) has the ability to drive catalytic conversion of the reactant ... ...

    Abstract Surface plasmon resonance (SPR) has the ability to drive catalytic conversion of the reactant molecules
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d2cp05705k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: In silico

    Yadav, Gulshan / Singh, Ruchi

    Frontiers in microbiology

    2022  Volume 13, Page(s) 909886

    Abstract: Introduction: Acinetobacter baumannii: Methods: This study investigated 4,977 RefSeq genomes of : Results: Approximately 13.84% (: Conclusion: Our observation suggests that the co-existence of type I-F1 and F2 is more effective in constraining ... ...

    Abstract Introduction: Acinetobacter baumannii
    Methods: This study investigated 4,977 RefSeq genomes of
    Results: Approximately 13.84% (
    Conclusion: Our observation suggests that the co-existence of type I-F1 and F2 is more effective in constraining the horizontal gene transfer and phage invasion in
    Language English
    Publishing date 2022-08-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.909886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Astrotactin-2: Docking with flavoinoids, functional, pathway and disease associations

    Yadav, Ruchi

    Current trends in biotechnology and pharmacy. 2021 Apr., v. 15, no. 2

    2021  

    Abstract: Astrotactin protein that is ASTN-1 and ASTN-2 are important perforin proteins that are involved in neurodevelopment. Mutations in this protein is associated with neurodevelopmental disorders and has been found functional in Alzheimer's, schizophrenia, ... ...

    Abstract Astrotactin protein that is ASTN-1 and ASTN-2 are important perforin proteins that are involved in neurodevelopment. Mutations in this protein is associated with neurodevelopmental disorders and has been found functional in Alzheimer's, schizophrenia, Parkinson's diseases, Autism Spectrum Disorder, cancer etc. Genes for ASTN protein expressed in brain and functional in brain development any mutation in this gene leads to abnormal growth and functioning of brain. ASTN-2 protein id functional in protein trafficking and regulation of neuronal growth and development increased expression of this protein can also result in neurodevelopmental disorders. In this study detailed analysis has been done on ASTROTACTIN-2 protein to identify potential ligands that show strong interaction with ASTN-2 protein. 7 ligands were selected from PubChem database and Docking was performed to analyze the protein-Ligand interaction map. Result shows that Morin and Quercetin shows the best interaction with the Glide Score of -8.26 and -8.15 and at positions GLN790, LEU833, THR878 and EU833, GLN962 respectively. Protein -Protein interaction study was also done to identify interacting proteins that are functional in neurodevelopment and can be associated with neuronal disorders. This study detailed about the ligand interaction, protein function and protein interaction Astrotactin-2 protein.
    Keywords Alzheimer disease ; autism ; biotechnology ; brain ; databases ; genes ; ligands ; mutation ; neurodevelopment ; neurons ; quercetin ; schizophrenia
    Language English
    Dates of publication 2021-04
    Size p. 189-197.
    Publishing place Association of Biotechnology and Pharmacy
    Document type Article
    ISSN 2230-7303
    DOI 10.5530/ctbp.2021.2.21
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Phage derived lytic peptides, a secret weapon against

    Nandi, Abhishek / Yadav, Ruchi / Singh, Aditi

    Frontiers in medicine

    2022  Volume 9, Page(s) 1047752

    Abstract: Acinetobacter ... ...

    Abstract Acinetobacter baumannii
    Language English
    Publishing date 2022-11-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.1047752
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  9. Article ; Online: Ligand-free Pd-catalyzed double Heck reaction of

    Sharma, Ruchi / Jain, Swati / Sihag, Naveen / Yadav, M Ramu

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 58, Page(s) 8945–8948

    Abstract: Herein, we have demonstrated an operationally simple Pd-catalyzed double-Heck reaction ... ...

    Abstract Herein, we have demonstrated an operationally simple Pd-catalyzed double-Heck reaction between
    Language English
    Publishing date 2023-07-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc01740k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Cardiac Arrest (CA) as the Initial Presentation of Cocaine-Induced Takotsubo Cardiomyopathy (TCM): A Case Report and Review of Literature.

    Almalouf, Catherina / Hakobyan, Narek / Yadav, Vivek / Gandhi, Anjula / Yadav, Ruchi

    Cureus

    2023  Volume 15, Issue 5, Page(s) e38525

    Abstract: Cocaine is used as an illicit substance responsible for the most common cause of drug-related death. It is a stimulant that acts on the sympathetic nervous system and cardiovascular system leading to exaggerated, prolonged sympathetic activity due to the ...

    Abstract Cocaine is used as an illicit substance responsible for the most common cause of drug-related death. It is a stimulant that acts on the sympathetic nervous system and cardiovascular system leading to exaggerated, prolonged sympathetic activity due to the accumulation of neurotransmitters. Cardiovascular side effects of cocaine are coronary artery spasms, myocarditis, arrhythmias, and congestive heart failure. Takotsubo cardiomyopathy (TCM) is characterized by transient hypokinesis, akinesis, or dyskinesis of the left ventricle (LV) wall with or without apical involvement in the absence of obstructive coronary artery disease. Cocaine-induced TCM is an extremely rare condition emphasizing the need of its prompt diagnosis by the physicians. We present a case report of a 54-year-old male, brought to the emergency department (ED) after an out-of-hospital cardiac arrest (CA), found to have TCM in the setting of cocaine use. Clinicians need to understand the association between cocaine use and the development of TCM as cardiomyopathy of this type can result in complete remission after discontinuing the offending agent.
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.38525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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