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  1. Article ; Online: Metastatic Anal Carcinoma: The Role of Radiotherapy.

    Chen, Yi-Jen

    Journal of the National Comprehensive Cancer Network : JNCCN

    2019  Volume 17, Issue 1, Page(s) 98–100

    MeSH term(s) Anus Neoplasms ; Humans
    Language English
    Publishing date 2019-01-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2250759-0
    ISSN 1540-1413 ; 1540-1405
    ISSN (online) 1540-1413
    ISSN 1540-1405
    DOI 10.6004/jnccn.2018.7112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6365: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Protocol for assessing total antioxidant capacity in minimal volumes of varying clinical human samples.

    Tsao, Yu-Ting / Hsueh, Yi-Jen / Chen, Hung-Chi / Cheng, Chao-Min

    STAR protocols

    2024  Volume 5, Issue 1, Page(s) 102822

    Abstract: Total antioxidant capacity (TAC), representative of the capacity to combat oxidative stress, is closely linked to numerous diseases. Here, we present a protocol for measuring TAC using minimal samples that are stable across varying pH levels and at room ... ...

    Abstract Total antioxidant capacity (TAC), representative of the capacity to combat oxidative stress, is closely linked to numerous diseases. Here, we present a protocol for measuring TAC using minimal samples that are stable across varying pH levels and at room temperature. We describe steps for preparing and loading samples and working solutions and conducting and analyzing the colorimetric reaction. Sample sources include aqueous humor, vitreous, tears, and plasma, which allow the protocol to be used in various clinical diagnostic settings. For complete details on the use and execution of this protocol, please refer to publications by Tsao et al. (2022).
    MeSH term(s) Humans ; Antioxidants ; Colorimetry
    Chemical Substances Antioxidants
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2023.102822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Ventricular response as a predictor of the termination of sustained paroxysmal atrial fibrillation.

    Huang, Jen-Hung / Lin, Yung-Kuo / Hsieh, Ming-Hsiung / Chen, Shih-Ann / Chen, Yi-Jen

    Pacing and clinical electrophysiology : PACE

    2024  

    Abstract: Background: Atrial fibrillation (AF) is the most common sustained atrial arrhythmia. Accurate detection of the timing and possibility of AF termination is vital for optimizing rhythm and rate control strategies. The present study evaluated whether the ... ...

    Abstract Background: Atrial fibrillation (AF) is the most common sustained atrial arrhythmia. Accurate detection of the timing and possibility of AF termination is vital for optimizing rhythm and rate control strategies. The present study evaluated whether the ventricular response (VR) in AF offers a distinctive electrocardiographic indicator for predicting AF termination.
    Methods: Patients experiencing sustained paroxysmal AF for more than 3 h were observed using 24-h ambulatory Holter monitoring. VR within 5 min before AF termination (VR
    Results: Data from 37 episodes of paroxysmal AF revealed that the minimum VR
    Conclusions: Elevated VR rates during AF episodes may be predictors for the termination of AF, especially during the daytime and in patients with nondilated left atria. These findings may guide the development of clinical approaches to rhythm control in AF.
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 424437-0
    ISSN 1540-8159 ; 0147-8389
    ISSN (online) 1540-8159
    ISSN 0147-8389
    DOI 10.1111/pace.14985
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1466: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 399: Show issues

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  4. Article ; Online: Protocol for assessing total antioxidant capacity in minimal volumes of varying clinical human samples

    Yu-Ting Tsao / Yi-Jen Hsueh / Hung-Chi Chen / Chao-Min Cheng

    STAR Protocols, Vol 5, Iss 1, Pp 102822- (2024)

    2024  

    Abstract: Summary: Total antioxidant capacity (TAC), representative of the capacity to combat oxidative stress, is closely linked to numerous diseases. Here, we present a protocol for measuring TAC using minimal samples that are stable across varying pH levels and ...

    Abstract Summary: Total antioxidant capacity (TAC), representative of the capacity to combat oxidative stress, is closely linked to numerous diseases. Here, we present a protocol for measuring TAC using minimal samples that are stable across varying pH levels and at room temperature. We describe steps for preparing and loading samples and working solutions and conducting and analyzing the colorimetric reaction. Sample sources include aqueous humor, vitreous, tears, and plasma, which allow the protocol to be used in various clinical diagnostic settings.For complete details on the use and execution of this protocol, please refer to publications by Tsao et al. (2022).1,2 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
    Keywords Clinical Protocol ; Metabolism ; Biotechnology and bioengineering ; Chemistry ; Science (General) ; Q1-390
    Language English
    Publishing date 2024-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: Psychometric properties of the Chinese version of the Centrality of Event Scale across multiple trauma-exposed Taiwanese samples.

    Kung, Yi-Wen / Su, Yi-Jen / Chen, Sue-Huei

    Journal of traumatic stress

    2022  Volume 35, Issue 3, Page(s) 813–826

    Abstract: The widely used Centrality of Event Scale (CES) measures the extent that a traumatic event serves as a central component of self-identity, a reference point, and a turning point in an individual's life story. The present study aimed to develop a Chinese ... ...

    Abstract The widely used Centrality of Event Scale (CES) measures the extent that a traumatic event serves as a central component of self-identity, a reference point, and a turning point in an individual's life story. The present study aimed to develop a Chinese version of the CES and assess its reliability, criterion validity, and factor structure. Data were collected from three samples of trauma-exposed Taiwanese individuals (N = 939), including 420 earthquake survivors, 300 trauma-exposed community adults, and 219 trauma-exposed undergraduate students. We conducted an exploratory factor analysis and confirmatory factor analysis and compared the resulting models with a one-factor model and the originally proposed model. The results indicated that a new three-factor model, S-Bχ
    MeSH term(s) Adult ; China ; Factor Analysis, Statistical ; Humans ; Multiple Trauma ; Psychometrics/methods ; Reproducibility of Results ; Stress Disorders, Post-Traumatic ; Surveys and Questionnaires
    Language English
    Publishing date 2022-02-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639478-4
    ISSN 1573-6598 ; 0894-9867
    ISSN (online) 1573-6598
    ISSN 0894-9867
    DOI 10.1002/jts.22788
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2386: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Editorial: Transcription factors and arrhythmogenesis.

    Kao, Yu-Hsun / Chen, Yi-Jen / Higa, Satoshi / Chattipakorn, Nipon / Santulli, Gaetano

    Frontiers in physiology

    2023  Volume 14, Page(s) 1169747

    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1169747
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  7. Article ; Online: Editorial

    Yu-Hsun Kao / Yi-Jen Chen / Satoshi Higa / Nipon Chattipakorn / Gaetano Santulli

    Frontiers in Physiology, Vol

    Transcription factors and arrhythmogenesis

    2023  Volume 14

    Keywords cardiovascular medicine ; induced pluripotent stem cell (iPSC) ; LMNA ; ZFHX3 ; bioengineering ; cardiac arrhythmia ; Physiology ; QP1-981
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Gastric vagal afferent signaling to the basolateral amygdala mediates anxiety-like behaviors in experimental colitis mice.

    Chen, Chin-Hao / Tsai, Tsung-Chih / Wu, Yi-Jen / Hsu, Kuei-Sen

    JCI insight

    2023  Volume 8, Issue 12

    Abstract: Inflammatory bowel disease (IBD) is a relapsing-remitting disorder characterized by chronic inflammation of the gastrointestinal (GI) tract. Anxiety symptoms are commonly observed in patients with IBD, but the mechanistic link between IBD and anxiety ... ...

    Abstract Inflammatory bowel disease (IBD) is a relapsing-remitting disorder characterized by chronic inflammation of the gastrointestinal (GI) tract. Anxiety symptoms are commonly observed in patients with IBD, but the mechanistic link between IBD and anxiety remains elusive. Here, we sought to characterize gut-to-brain signaling and brain circuitry responsible for the pathological expression of anxiety-like behaviors in male dextran sulfate sodium-induced (DSS-induced) experimental colitis mice. We found that DSS-treated mice displayed increased anxiety-like behaviors, which were prevented by bilateral GI vagal afferent ablation. The locus coeruleus (LC) is a relay center connecting the nucleus tractus solitarius to the basolateral amygdala (BLA) in controlling anxiety-like behaviors. Chemogenetic silencing of noradrenergic LC projections to the BLA reduced anxiety-like behaviors in DSS-treated mice. This work expands our understanding of the neural mechanisms by which IBD leads to comorbid anxiety and emphasizes a critical role of gastric vagal afferent signaling in gut-to-brain regulation of emotional states.
    MeSH term(s) Mice ; Male ; Animals ; Basolateral Nuclear Complex/metabolism ; Colitis/chemically induced ; Anxiety ; Inflammatory Bowel Diseases/metabolism ; Solitary Nucleus/metabolism
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.161874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Telocytes: Supporting cells participating in ventricular arrhythmogenesis?

    Lin, Yung-Kuo / Chen, Yi-Jen

    Journal of arrhythmia

    2019  Volume 35, Issue 3, Page(s) 522–523

    Language English
    Publishing date 2019-04-15
    Publishing country Japan
    Document type Editorial
    ZDB-ID 2696593-8
    ISSN 1883-2148 ; 1880-4276
    ISSN (online) 1883-2148
    ISSN 1880-4276
    DOI 10.1002/joa3.12181
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  10. Article ; Online: A narrative review of combining radiation and immunotherapy in gastroesophageal cancers.

    Yoon, Kevin / Chen, Yi-Jen / Chao, Joseph

    Translational cancer research

    2022  Volume 10, Issue 5, Page(s) 2586–2595

    Abstract: Despite advances in chemotherapy, radiation, and surgery, prognosis in gastroesophageal cancers (GEC) remains poor. Recent studies have demonstrated that immune checkpoint inhibitors specific to the PD-1/PD-L1 axis can improve survival with dramatic ... ...

    Abstract Despite advances in chemotherapy, radiation, and surgery, prognosis in gastroesophageal cancers (GEC) remains poor. Recent studies have demonstrated that immune checkpoint inhibitors specific to the PD-1/PD-L1 axis can improve survival with dramatic durability for a subset of patients with GEC. Radiation therapy (RT) has been shown to enhance priming and anti-tumor immunogenicity. The combination of these two treatments has shown promising results acting synergistically in pre-clinical and clinical models. Much of this synergy appears linked to in-field radiation responses, but also the abscopal response where out-of-field tumors demonstrate regression. In this review, we summarize the current role of immunotherapy and radiation in GEC. We also highlight progress from preclinical studies and translational biomarker analyses that provide rationale for ongoing efforts combining immune checkpoint inhibition and radiotherapy specifically in GECs. Questions that remain unanswered in the clinic are the optimal radiation dosing, timing, and fractionation strategies to augment abscopal immune responses. Increasing recognition of the heterogeneity of immunosuppressive mechanisms that can arise in response to radiation indicates the need for novel immune checkpoint inhibitors that target beyond the PD-1/PD-L1 axis. Smartly designed prospective trials incorporating these two approaches with ongoing translational analyses will be critical in increasing the success of combinatorial radiation and immunotherapy strategies in this disease.
    Language English
    Publishing date 2022-01-20
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr-20-2210
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