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Article ; Online: Self-Assembly of the Chiral Donor-Acceptor Molecule DCzDCN on Cu(100).

Ranecki, Robert / Baumann, Benedikt / Lach, Stefan / Ziegler, Christiane

ACS applied materials & interfaces

2024 Volume 16, Issue 7, Page(s) 9108–9116

Abstract: Donor-acceptor (D-A) structured molecules are essential components of organic electronics. The respective molecular structures of these molecules and their synthesis are primarily determined by the intended area of application. Typically, D-A molecules ... ...

Abstract	Donor-acceptor (D-A) structured molecules are essential components of organic electronics. The respective molecular structures of these molecules and their synthesis are primarily determined by the intended area of application. Typically, D-A molecules promote charge separation and transport in organic photovoltaics or organic field-effect transistors. D-A molecules showing a larger twist angle between D and A units are, e.g., essential for the development of high internal quantum efficiency in organic light-emitting diodes. A prototypical molecule of this D-A type is DCzDCN (5-(4,6-diphenyl-1,3,5-triazine-2-yl)benzene-1,3-dinitrile). In most cases, these molecules are only investigated regarding their electronic and structural interaction in bulk aggregates but not in ultrathin films supported by a metallic substrate. Here, we present growth and electronic structure studies of DCzDCN on a Cu(100) surface. We used a complementary approach through the use of scanning tunneling microscopy/spectroscopy (STM and STS), ultraviolet/inverse photoemission spectroscopy (UPS and IPES), and single-molecule density functional theory (DFT) calculations. This method combination enabled us to investigate the adsorption geometry (STM) and the local electronic states near the Fermi energy (
Language	English
Publishing date	2024-02-11
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c16918
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Article ; Online: The risk of developing motor complications with Levodopa immediate versus dual release upon treatment initiation in Parkinson's disease.

Ineichen, Christian / Baumann-Vogel, Heide / Sitzler, Matthias / Baumann, Christian R

Clinical parkinsonism & related disorders

2023 Volume 9, Page(s) 100209

Abstract: Introduction: Motor complications (MCs) compromise therapy in many patients suffering from Parkinson's Disease. By achieving more physiologic stimulation of dopamine-receptors, the continuous dopamine stimulation hypothesis suggests that longer-acting ... ...

Abstract	Introduction: Motor complications (MCs) compromise therapy in many patients suffering from Parkinson's Disease. By achieving more physiologic stimulation of dopamine-receptors, the continuous dopamine stimulation hypothesis suggests that longer-acting levodopa formulations may improve outcome. The aim of this study was to compare the duration until onset of MCs and motor disease progression in patients during their treatment initiation with either an immediate (IR) or a combined rapid- and sustained-release (i.e. dual-release; DR) levodopa formulation. Methods: Using a sample of 69 patients, we applied time-varying survival regression analyses and linear mixed effect models to analyze the data. The latter involved preprocessing of the data to temporally align the response and predictors, including analyzing the extent of visit irregularity and potential predictors of visit intensity. Results: This retrospective study suggests that levodopa-benserazide DR is not superior to levodopa-benserazide IR in affecting duration until MCs and disease progression. Conversely, using DR levodopa-benserazide, similar disease progression was achieved with lower and more constant doses. Conclusions: The effects of DR levodopa-benserazide might not be strong enough to delay onset of MCs. The development of more powerful levodopa formulations remains a pressing clinical need.
Language	English
Publishing date	2023-07-04
Publishing country	England
Document type	Journal Article
ISSN	2590-1125
ISSN (online)	2590-1125
DOI	10.1016/j.prdoa.2023.100209
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Article: SARS-CoV-2 Infektionen und das autonome Nervensystem.

Buchhorn, R / Willaschek, C / Baumann, C

Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde

2021 Volume 169, Issue 7, Page(s) 645–648

Abstract: ... inflammation syndrome in children (MIS-C) and a 16-year-old girl with postural orthostatic tachycardia syndrome ...

Title translation	SARS-CoV-2 infections and the autonomic nervous system.
Abstract	Investigations of the heart rate variability (HRV) in an 11-year-old boy with multisystemic inflammation syndrome in children (MIS-C) and a 16-year-old girl with postural orthostatic tachycardia syndrome (POTS) after SARS-CoV‑2 infections are presented.
Language	German
Publishing date	2021-04-27
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	137102-2
ISSN	1433-0474 ; 0026-9298
ISSN (online)	1433-0474
ISSN	0026-9298
DOI	10.1007/s00112-021-01197-7
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Um IV Zs.45: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The Importance of a Detailed Geriatric Functional Assessment of Older Patients with Cancer.

Baumann, Christina / Baumann, Raban / Wedding, Ulrich

Oncology research and treatment

2021 Volume 44, Issue 5, Page(s) 221–231

Abstract: Background: For older patients with cancer, maintaining or regaining their ability to care of themselves is of major interest. Which tools are appropriate to measure this? Different tools to assess functional status (FS) are established in geriatric and ...

Abstract	Background: For older patients with cancer, maintaining or regaining their ability to care of themselves is of major interest. Which tools are appropriate to measure this? Different tools to assess functional status (FS) are established in geriatric and oncological care, but they have been compared poorly in the past. Patients and methods: Within a prospective cohort trial, we included 483 patients: 198 older patients with cancer, 156 younger patients with cancer, and 129 older patients with benign disease. FS was assessed as Eastern Cooperative Oncology Group performance status (ECOG-PS), activities of daily living (ADL), and instrumental activities of daily living (IADL). Results were compared for their differences in identifying patients as functionally compromised. Summary: The relative frequency of cancer patients with limitations in ECOG-PS, ADL, and IADL, respectively, increased from 25.7, 13.5, and 17.9% in those <60 years of age to 50.0, 47.1, and 66.7% in those ≥80 years. Results in older patients with cancer were comparable to older patients with benign disease. In older patients with cancer, 20.7 and 21.6% with a good ECOG-PS had limitations in ADL and IADL, respectively; of those without limitations in ADL and IADL, 34.7 and 26.0%, respectively, had a poor ECOG-PS. Treatment approach (curative vs. palliative) was found to be significantly associated with functional limitations. Key Messages: Geriatric and oncological measure of FS report differences in functional impairment. Geriatric functional measures are more sensitive to age-related changes and should be included as patient-reported outcomes in clinical trials and care.
MeSH term(s)	Activities of Daily Living ; Aged ; Geriatric Assessment ; Humans ; Medical Oncology ; Middle Aged ; Neoplasms ; Prospective Studies
Language	English
Publishing date	2021-04-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2760274-6
ISSN	2296-5262 ; 2296-5270
ISSN (online)	2296-5262
ISSN	2296-5270
DOI	10.1159/000514712
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Article ; Online: Worsening of Parkinson's Disease After Termination of COVID-19 Quarantine Cannot Be Reversed Despite Resumption of Physiotherapy.

Ineichen, Christian / Vogel-Baumann, Heide / Sitzler, Matthias / Deuschl, Günther / Baumann, Christian R

Journal of Parkinson's disease

2023 Volume 13, Issue 5, Page(s) 845–848

Abstract: In a retrospective analysis, we recently reported findings on the detrimental motor effects of interrupted physiotherapy following the COVID-19 pandemic in parkinsonian patients. Using an extended follow-up period, we investigated the beneficial effect ... ...

Abstract	In a retrospective analysis, we recently reported findings on the detrimental motor effects of interrupted physiotherapy following the COVID-19 pandemic in parkinsonian patients. Using an extended follow-up period, we investigated the beneficial effect of reinstated physiotherapy on patients' disease severity and reversal of interruption-induced motor deterioration. Compared to before the COVID-19 outbreak, we observed persistence of motor disease worsening despite full resumption of state-of-the-art physical therapy suggesting that motor deterioration after discontinuation of physical therapy could not be compensated for. Therefore, and considering possible future crises, establishing means to safeguard continuation of physical therapy and to foster remote provision of care should be major goals.
MeSH term(s)	Humans ; Parkinson Disease/therapy ; Retrospective Studies ; Pandemics/prevention & control ; Quarantine ; COVID-19/prevention & control ; Physical Therapy Modalities
Language	English
Publishing date	2023-06-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2620609-2
ISSN	1877-718X ; 1877-7171
ISSN (online)	1877-718X
ISSN	1877-7171
DOI	10.3233/JPD-230061
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Article ; Online: Evolution of Cd2+ and Cu+ binding in Helix pomatia metallothioneins.

Valsecchi, Renato / Baumann, Christian / Lila, Ardit / Zerbe, Oliver

Metallomics : integrated biometal science

2023 Volume 15, Issue 10

Abstract: ... in the lineages leading to the unspecific and the Cu+-specific HpMT isoforms. C-terminal domains are generally ... level of specialization of the C-domain. Our findings provide new insights into snail MT evolution ...

Abstract	Metallothioneins (MTs) are small proteins present in all kingdoms of life. Their high cysteine content enables them to bind metal ions, such as Zn2+, Cd2+, and Cu+, providing means for detoxification and metal homeostasis. Three MT isoforms with distinct metal binding preferences are present in the Roman Snail Helix pomatia. Here, we use nuclear magnetic resonance (NMR) to follow the evolution of Cd2+ and Cu+ binding from the reconstructed ancestral Stylommatophora MT to the three H. pomatia MT (HpMT) isoforms. Information obtained from [15N,1H]-HSQC spectra and T2 relaxation times are combined to describe the conformational stability of the MT-metal complexes. A well-behaved MT-metal complex adopts a unique structure and does not undergo additional conformational exchange. The ancestor to all three HpMTs forms conformationally stable Cd2+ complexes and closely resembles the Cd2+-specific HpCdMT isoform, suggesting a role in Cd2+ detoxification for the ancestral protein. All Cu+-MT complexes, including the Cu+-specific HpCuMT isoform, undergo a considerable amount of conformational exchange. The unspecific HpCd/CuMT and the Cu+-specific HpCuMT isoforms form Cu+ complexes with comparable characteristics. It is possible to follow how Cd2+ and Cu+ binding changed throughout evolution. Interestingly, Cu+ binding improved independently in the lineages leading to the unspecific and the Cu+-specific HpMT isoforms. C-terminal domains are generally less capable of coordinating the non-cognate metal ion than N-terminal domains, indicating a higher level of specialization of the C-domain. Our findings provide new insights into snail MT evolution, helping to understand the interplay between biological function and structural features toward a comprehensive understanding of metal preference.
Language	English
Publishing date	2023-09-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2474317-3
ISSN	1756-591X ; 1756-5901
ISSN (online)	1756-591X
ISSN	1756-5901
DOI	10.1093/mtomcs/mfad057
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Article ; Online: The Utilization of Preoperative Steroids Safely Decreases the Risk of Postoperative Delirium in Geriatric Patients After Hip Fracture Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Baumann, Anthony N / Talaski, Grayson M / Uhler, Mathias A / Anastasio, Albert T / Walley, Kempland C / Pean, Christian A / Tampi, Rajesh R / Farivar, Michel

Journal of orthopaedic trauma

2024 Volume 38, Issue 5, Page(s) e182–e190

MeSH term(s)	Adult ; Humans ; Aged ; Aged, 80 and over ; Emergence Delirium ; Randomized Controlled Trials as Topic ; Hip Fractures/surgery ; Postoperative Complications ; Steroids
Chemical Substances	Steroids
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	639099-7
ISSN	1531-2291 ; 0890-5339
ISSN (online)	1531-2291
ISSN	0890-5339
DOI	10.1097/BOT.0000000000002781
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Zs.A 2234: Show issues

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Article ; Online: Do values and political attitudes affect help-seeking? Exploring reported help-seeking for mental health problems in a general population sample using a milieu framework.

Spahlholz, J / Baumann, E / Müller-Hilmer, R / Hilmer, R / Sander, C / Schindler, S / Speerforck, S / Angermeyer, M C / Schomerus, G

Epidemiology and psychiatric sciences

2023 Volume 32, Page(s) e49

Abstract: Aims: Help-seeking for mental health problems is facilitated and hindered by several factors at the individual, interpersonal and community level. The most frequently researched factors contributing to differences in help-seeking behaviour are based on ... ...

Abstract	Aims: Help-seeking for mental health problems is facilitated and hindered by several factors at the individual, interpersonal and community level. The most frequently researched factors contributing to differences in help-seeking behaviour are based on classical socio-demographic variables, such as age, gender and education, but explanations for the observed differences are often absent or remain vague. The present study complements traditional approaches in help-seeking research by introducing a milieu approach, focusing on values and political attitudes as a possible explanation for differences in help-seeking for emotional mental health problems. Methods: A representative cross-sectional survey of Results: Multivariate logistic regression analyses indicated that belonging to a cosmopolitan intellectual milieu group was significantly associated with an increased likelihood of past help-seeking for mental health issues (psychotherapeutic/psychological help-seeking [OR = 2.09, 95% CI: 1.11-3.93, Conclusions: We discuss how milieu-specific patterns were relevant for explaining differences in mental health service use in addition to socio-demographic factors. It seems promising to consider help-seeking from a milieu perspective to improve disparities in access to and the use of psychotherapy as well as to resource allocation.
MeSH term(s)	Humans ; Female ; Mental Health ; Cross-Sectional Studies ; Attitude ; Population Groups ; Mental Health Services ; Mental Disorders/epidemiology ; Mental Disorders/therapy ; Mental Disorders/psychology ; Social Stigma
Language	English
Publishing date	2023-08-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2607964-1
ISSN	2045-7979 ; 2045-7960
ISSN (online)	2045-7979
ISSN	2045-7960
DOI	10.1017/S2045796023000641
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Article ; Online: Comparison of quality and interpretation of newborn ultrasound screening examinations for developmental dysplasia of the hip by basically trained nurses and junior physicians with no previous ultrasound experience.

Ulziibat, Munkhtulga / Munkhuu, Bayalag / Schmid, Raoul / Wyder, Corinne / Baumann, Thomas / Essig, Stefan

PloS one

2024 Volume 19, Issue 4, Page(s) e0300753

Abstract: Background: We are obliged to give babies the chance to profit from a nationwide screening of developmental dysplasia of the hip in very rural areas of Mongolia, where trained physicians are scarce. This study aimed to compare the quality and ... ...

Abstract	Background: We are obliged to give babies the chance to profit from a nationwide screening of developmental dysplasia of the hip in very rural areas of Mongolia, where trained physicians are scarce. This study aimed to compare the quality and interpretation of hip ultrasound screening examinations performed by nurses and junior physicians. Methods: A group of 6 nurses and 6 junior physician volunteers with no previous ultrasound experience underwent Graf's standard training in hands-on practice. Newborns were examined before discharge from the hospital, according to the national guideline. Two standard documentation images of each hip were saved digitally. The groups were compared on the proportion of good quality of sonograms and correct interpretation. Two Swiss supervisors' agreed diagnosis according to Graf was considered the final reference for the study purposes. Results: A total of 201 newborns (402 hips or 804 sonograms) were examined in the study, with a mean age of 1.3±0.8 days at examination. Junior physicians examined 100 newborns (200 hips or 400 sonograms), while nurses examined 101 newborns (202 hips or 404 sonograms). The study subjects of the two groups were well balanced for the distribution of baseline characteristics. The study observed no statistically significant difference in the quality of Graf's standard plane images between the providers. Eventually, 92.0% (92) of the physician group and 89.1% (90) of the nurse group were correctly diagnosed as "Group A" (Graf's Type 1 hip) or "Non-Group A" hips (p = 0.484). The most common errors among the groups were a missing lower limb, wrong measurement lines, and technical problems. Conclusion: Our study provides evidence that while there might be a trend of slightly more technical mistakes in the nurse group, the overall diagnosis accuracy is similar to junior physicians after receiving standard training in Graf's hip ultrasound method. However, after basic training, regular quality control is a must and all participants should receive refresher trainings. More specifically, nurses need training in the identification of anatomical structures.
MeSH term(s)	Infant ; Humans ; Infant, Newborn ; Hip Dislocation, Congenital/diagnostic imaging ; Developmental Dysplasia of the Hip ; Ultrasonography/methods ; Neonatal Screening/methods ; Hip Joint/diagnostic imaging
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0300753
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Article ; Online: Tumor Cell-Specific Retention and Photodynamic Action of Erlotinib-Pyropheophorbide Conjugates.

Tracy, Erin C / Cheruku, Ravindra R / Pandey, Ravindra K / Baumann, Heinz

International journal of molecular sciences

2022 Volume 23, Issue 19

Abstract: To enhance uptake of photosensitizers by epithelial tumor cells by targeting these to EGFR, pyropheophorbide derivatives were synthesized that had erlotinib attached to different positions on the macrocycle. Although the addition of erlotinib reduced ... ...

Abstract	To enhance uptake of photosensitizers by epithelial tumor cells by targeting these to EGFR, pyropheophorbide derivatives were synthesized that had erlotinib attached to different positions on the macrocycle. Although the addition of erlotinib reduced cellular uptake, several compounds showed prolonged cellular retention and maintained photodynamic efficacy. The aim of this study was to identify whether erlotinib moiety assists in tumor targeting through interaction with EGFR and whether this interaction inhibits EGFR kinase activity. The activity of the conjugates was analyzed in primary cultures of human head and neck tumor cells with high-level expression of EGFR, and in human carcinomas grown as xenografts in mice. Uptake of erlotinib conjugates did not correlate with cellular expression of EGFR and none of the compounds exerted EGFR-inhibitory activity. One derivative with erlotinib at position 3, PS-10, displayed enhanced tumor cell-specific retention in mitochondria/ER and improved PDT efficacy in a subset of tumor cases. Moreover, upon treatment of the conjugates with therapeutic light, EGFR-inhibitory activity was recovered that attenuated EGFR signal-dependent tumor cell proliferation. This finding suggests that tumor cell-specific deposition of erlotinib-pyropheophorbides, followed by light triggered release of EGFR-inhibitory activity, may improve photodynamic therapy by attenuating tumor growth that is dependent on EGFR-derived signals.
MeSH term(s)	Animals ; Cell Line, Tumor ; ErbB Receptors/metabolism ; Erlotinib Hydrochloride/pharmacology ; Erlotinib Hydrochloride/therapeutic use ; Humans ; Mice ; Photochemotherapy ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Signal Transduction
Chemical Substances	Photosensitizing Agents ; Protein Kinase Inhibitors ; Erlotinib Hydrochloride (DA87705X9K) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2022-09-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms231911081
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