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Book ; Online: Air pollution trends in the EMEP region between 1990 and 2012. Joint Report of the EMEP Task Force on Measurements and Modelling (TFMM), Chemical Co-ordinating Centre (CCC), Meteorological Synthesizing Centre-East (MSC-E), Meteorological Synthesizing Centre-West (MSC-W).

Augustin Colette / Wenche Aas / Lindsay Banin / Christine F. Braban / Martin Ferm / Alberto González Ortiz / Ilia Ilyin / Kathleen A. Mar / Marco Pandolfi / Jean-Philippe Putaud / Victor Shatalov / Sverre Solberg / Gerald Spindler / Oksana Tarasova / Milan Vana / Mario Adani / Paul Almodovar / Eva Berton / Bertrand Bessagnet /

Pernilla Bohlin-Nizzetto / Jana Boruvkova / Knut Breivik / Gino Briganti / Andrea Cappelletti / Kees Cuvelier / Richard Derwent / Massimo D'Isidoro / Hilde Fagerli / Clara Funk / Marta Garcia Vivanco / Richard Haeuber / Christoph Hueglin / Scott Jenkins / Jennifer Kerr / Frank de Leeuw / Jason Lynch / Astrid Manders / Mihaela Mircea / Maria Teresa Pay / Dominique Pritula / Xavier Querol / Valentin Raffort / Ilze Reiss / Yelva Roustan / Stéphane Sauvage / Kimber Scavo / David Simpson / Ron I. Smith / Yuk Sim Tang / Mark Theobald / Kjetil Tørseth / Svetlana Tsyro / Addo van Pul / Sonja Vidic / Markus Wallasch / Peter Wind

EMEP/CCC-Report

2016

Language	English
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bilateral macular edema associated with high altitude: an unusual clinical presentation.

Looareesuwan, Panita / Sim, Pek E / Matsee, Wasin

Journal of travel medicine

2023 Volume 30, Issue 4

MeSH term(s)	Humans ; Macular Edema/etiology ; Macular Edema/complications ; Altitude ; Altitude Sickness/complications ; Altitude Sickness/diagnosis ; Mountaineering
Language	English
Publishing date	2023-05-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1212504-0
ISSN	1708-8305 ; 1195-1982
ISSN (online)	1708-8305
ISSN	1195-1982
DOI	10.1093/jtm/taad070
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Zs.A 4120: Show issues

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Article ; Online: The in vivo measurement of replication fork velocity and pausing by lag-time analysis.

Huang, Dean / Johnson, Anna E / Sim, Brandon S / Lo, Teresa W / Merrikh, Houra / Wiggins, Paul A

Nature communications

2023 Volume 14, Issue 1, Page(s) 1762

Abstract: An important step towards understanding the mechanistic basis of the central dogma is the quantitative characterization of the dynamics of nucleic-acid-bound molecular motors in the context of the living cell. To capture these dynamics, we develop lag- ... ...

Abstract	An important step towards understanding the mechanistic basis of the central dogma is the quantitative characterization of the dynamics of nucleic-acid-bound molecular motors in the context of the living cell. To capture these dynamics, we develop lag-time analysis, a method for measuring in vivo dynamics. Using this approach, we provide quantitative locus-specific measurements of fork velocity, in units of kilobases per second, as well as replisome pause durations, some with the precision of seconds. The measured fork velocity is observed to be both locus and time dependent, even in wild-type cells. In this work, we quantitatively characterize known phenomena, detect brief, locus-specific pauses at ribosomal DNA loci in wild-type cells, and observe temporal fork velocity oscillations in three highly-divergent bacterial species.
MeSH term(s)	DNA Replication/genetics ; Chromosomes ; DNA, Ribosomal
Chemical Substances	DNA, Ribosomal
Language	English
Publishing date	2023-03-30
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-37456-2
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Article ; Online: Synthesis of tapioca starch/palm oil encapsulated urea-impregnated biochar derived from peppercorn waste as a sustainable controlled-release fertilizer.

Sim, D H H / Tan, I A W / Lim, L L P / Lau, E T / Hameed, B H

Waste management (New York, N.Y.)

2023 Volume 173, Page(s) 51–61

Abstract: Nutrient leaching and volatilization cause environmental pollution, thus the pursuit of developing controlled-release fertilizer formulation is necessary. Biochar-based fertilizer exhibits slow-release characteristic, however the nutrient release ... ...

Abstract	Nutrient leaching and volatilization cause environmental pollution, thus the pursuit of developing controlled-release fertilizer formulation is necessary. Biochar-based fertilizer exhibits slow-release characteristic, however the nutrient release mechanism needs to be improved. To overcome this limitation, the approach of applying encapsulation technology with biochar-based fertilizer has been implemented in this study. Black peppercorn waste was used to synthesize urea-impregnated biochar (UIB). Central composite design was used to investigate the effects of pyrolysis temperature, residence time and urea:biochar ratio on nitrogen content of UIB. The optimum condition to synthesize UIB was at 400 °C pyrolysis temperature, 120 min residence time and 0.6:1 urea:biochar ratio, which resulted in 16.07% nitrogen content. The tapioca starch/palm oil (PO) biofilm formulated using 8 g of tapioca starch and 0.12 µL of PO was coated on the UIB to produce encapsulated urea-impregnated biochar (EUIB). The UIB and EUIB pellets achieved complete release of nitrogen in water after 90 min and 330 min, respectively. The nutrient release mechanism of UIB and EUIB was best described by the Higuchi model and Korsmeyer-Peppas model, respectively. The improvement of water retention ratio of UIB and EUIB pellets was more significant in sandy-textural soil as compared to clayey-textural soil. The EUIB derived from peppercorn waste has the potential to be utilized as a sustainable controlled-release fertilizer for agriculture.
MeSH term(s)	Fertilizers/analysis ; Manihot ; Palm Oil ; Delayed-Action Preparations ; Urea ; Charcoal ; Soil ; Nitrogen/analysis ; Water ; Starch
Chemical Substances	biochar ; Fertilizers ; Palm Oil (5QUO05548Z) ; Delayed-Action Preparations ; Urea (8W8T17847W) ; Charcoal (16291-96-6) ; Soil ; Nitrogen (N762921K75) ; Water (059QF0KO0R) ; Starch (9005-25-8)
Language	English
Publishing date	2023-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2001471-5
ISSN	1879-2456 ; 0956-053X
ISSN (online)	1879-2456
ISSN	0956-053X
DOI	10.1016/j.wasman.2023.11.006
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Article ; Online: Inhibition of Photoaging by Anthocyanin Metabolites Derived from Rose Petal Extract.

Sim, Woo-Jin / Lee, Eunjung / Lee, Gakyung / Lim, Wonchul / Lim, Tae-Gyu

Molecular nutrition & food research

2024 Volume 68, Issue 5, Page(s) e2300611

Abstract: Scope: Rose petal extract (RPE) shows a significant antioxidant effect through its anthocyanin content. However, the mechanism underlying the anti-aging effects of orally administered RPE remains unclear. This study aims to describe the anti-aging ... ...

Abstract	Scope: Rose petal extract (RPE) shows a significant antioxidant effect through its anthocyanin content. However, the mechanism underlying the anti-aging effects of orally administered RPE remains unclear. This study aims to describe the anti-aging effect and mechanism of action of orally administered RPE in ultraviolet (UV)B-induced skin aging. Methods and results: This study evaluates the protein expression of collagen type I alpha 1 (COL1A1) and matrix metalloproteinase 1 (MMP-1) and the mRNA expression of hyaluronic synthase 2 (HAS2) in human dermal fibroblasts. In addition, the hyaluronidase and collagenase inhibitory activities of RPE are confirmed. To evaluate the anti-aging effects of RPE, SKH-1 hairless mice are administered RPE daily for 12 weeks. Wrinkle formation, transepidermal water loss (TEWL), and skin moisture loss induced by UVB irradiation are suppressed in the dorsal skin of SKH-1 hairless mice orally administered RPE. Oral administration of RPE suppresses UVB irradiation-induced collagen disruption and reduction of hyaluronic acid. To find the bioactive compound in the RPE, serum protocatechuic acid (PCA), an anthocyanin metabolite, is analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Conclusion: Anthocyanins in RPE are metabolized to PCA in the body and circulated through the bloodstream to exhibit anti-aging effects on the skin.
MeSH term(s)	Animals ; Mice ; Humans ; Anthocyanins/pharmacology ; Skin Aging ; Mice, Hairless ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Skin ; Ultraviolet Rays/adverse effects ; Plant Extracts/pharmacology
Chemical Substances	Anthocyanins ; Plant Extracts
Language	English
Publishing date	2024-02-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2160372-8
ISSN	1613-4133 ; 1613-4125
ISSN (online)	1613-4133
ISSN	1613-4125
DOI	10.1002/mnfr.202300611
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Article ; Online: Meaning in life measure: a five-Item short form and its measurement invariance across gender, age, and cultural contexts.

Li, Xu / Sim, Wonjin / Hill, Clara E

publication RETRACTED

Psychotherapy research : journal of the Society for Psychotherapy Research

2022 Volume 33, Issue 3, Page(s) 387–400

Abstract: Objective: The aims of this study were to develop a revised version of the Meaning In Life Measure (MILM; Hill et al., 2019) and investigate its multilevel measurement invariance at the between-person and within-person levels and multi-group measurement ...

Abstract	Objective: The aims of this study were to develop a revised version of the Meaning In Life Measure (MILM; Hill et al., 2019) and investigate its multilevel measurement invariance at the between-person and within-person levels and multi-group measurement invariance across gender, age, and cultural groups. Methods: We analyzed an international dataset including data from 1600 sessions with 384 clients in five continents (Africa, Asia, Europe, Latin America, and North America) using multilevel item response theory and multilevel factor analysis. Results: We found that the revised 5-item MILM-5 had satisfactory reliability and structural validity with the overall sample. Further, it demonstrated measurement invariance across the between- and within-person levels, and also across gender and age groups. Across representative countries within continents, the MILM-5 had the same overall factor structure but all factor loadings and item intercepts significantly differed across cultural contexts. Implications are discussed regarding the assessment of meaning in life in international clinical settings.
MeSH term(s)	Humans ; Reproducibility of Results ; Psychometrics ; Factor Analysis, Statistical ; Surveys and Questionnaires
Language	English
Publishing date	2022-07-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
ZDB-ID	1080323-3
ISSN	1468-4381 ; 1050-3307
ISSN (online)	1468-4381
ISSN	1050-3307
DOI	10.1080/10503307.2022.2098077
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Zs.A 3316: Show issues

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Article ; Conference proceedings: SAFETY OF INDEPENDENT DISCHARGE POST- ENDOSCOPY WITH SEDATION

Ng, W.k. / Lim, E. / Tan, Q.r. / Sung Yi Sim, E. / Lim, P.y.

Endoscopy

2022 Volume 54, Issue S 01

Event/congress	ESGE Days 2022, Prague, Czech Republic, 2022-04-28
Language	English
Publishing date	2022-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0042-1744998
Database	Thieme publisher's database

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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Online: Tissue factor release following traumatic brain injury drives thrombin generation.

Hubbard, W Brad / Sim, Martha M S / Saatman, Kathryn E / Sullivan, Patrick G / Wood, Jeremy P

Research and practice in thrombosis and haemostasis

2022 Volume 6, Issue 4, Page(s) e12734

Abstract: Background: Traumatic brain injury (TBI) results in neurovascular damage that initiates intrinsic mechanisms of hypercoagulation, which can contribute to the development of life-threatening complications, such as coagulopathy and delayed thrombosis. ... ...

Abstract	Background: Traumatic brain injury (TBI) results in neurovascular damage that initiates intrinsic mechanisms of hypercoagulation, which can contribute to the development of life-threatening complications, such as coagulopathy and delayed thrombosis. Clinical studies have hypothesized that tissue factor (TF) induces hypercoagulability after TBI; however, none have directly shown this relationship. Objectives: In the current study, we took a stepwise approach to understand what factors are driving thrombin generation following experimental TBI. Methods: We employed the contusion-producing controlled cortical impact (CCI) model and the diffuse closed head injury (CHI) model to investigate these mechanisms as a function of injury severity and modality. Whole blood was collected at 6 hours and 24 hours after injury, and platelet-poor plasma was used to measure thrombin generation and extracellular vesicle (EV) TF. Results: We found that plasma thrombin generation, dependent on TF present in the plasma, was greater in CCI-injured animals compared to sham at both 6 hours (120.4 ± 36.9 vs 0.0 ± 0.0 nMmin endogenous thrombin potential) and 24 hours (131.0 ± 34.0 vs 32.1 ± 20.6 nMmin) after injury. This was accompanied by a significant increase in EV TF at 24 hours (328.6 ± 62.1 vs 167.7 ± 20.8 fM) after CCI. Further, EV TF is also increased at 6 hours (126.6 ± 17.1 vs 63.3 ± 14.4 fM) but not 24 hours following CHI. Conclusion: TF-mediated thrombin generation is time-dependent after injury and TF increases resolve earlier following CHI as compared to CCI. Taken together, these data support a TF-mediated pathway of thrombin generation after TBI and pinpoint TF as a major player in TBI-induced coagulopathy.
Language	English
Publishing date	2022-06-08
Publishing country	United States
Document type	Journal Article
ISSN	2475-0379
ISSN (online)	2475-0379
DOI	10.1002/rth2.12734
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Article ; Online: Cobas HPV Genotyping of FNA Sample Supernatant and Frozen Section Scrapings of Suspected Head and Neck Cancer.

Jones, Kelly J / Dougherty, Rachel E / Randolph, Melissa / Sim, Michael W / Mesa, Hector

Applied immunohistochemistry & molecular morphology : AIMM

2022 Volume 31, Issue 1, Page(s) 51–56

Abstract: The human papillomavirus (HPV) status of squamous cell carcinomas (SCCs) of the head and neck is relevant for therapy planning, staging, and follow-up. Immunohistochemistry (IHC) for p16 is a surrogate marker of HPV status in oropharyngeal SCC, but not ... ...

Abstract	The human papillomavirus (HPV) status of squamous cell carcinomas (SCCs) of the head and neck is relevant for therapy planning, staging, and follow-up. Immunohistochemistry (IHC) for p16 is a surrogate marker of HPV status in oropharyngeal SCC, but not at other head and neck sites. We tested if the cobas HPV test was feasible and superior to p16-IHC on fine-needle aspiration (FNA) supernatants and frozen section (FS) scrapings of suspected SCC. A 500 μL aliquots of postcentrifugation supernatant CytoRich Red media of FNA cellblock specimens and scrapings of FS suspended in SurePath media vials were tested with the cobas HPV test and compared with p16-IHC and/or HPV in situ hybridization (ISH) performed on cellblock and/or resections. Twenty-nine (n=29) FNAs were tested for a cobas HPV test, p16, and/or HPV-ISH. The mean collection to testing time was 6.3 days (range: 0 to 24 d). Cobas yielded valid results in all cases; p16-IHC could not be interpreted in 4 (13%) cellblocks; correlation was performed on subsequent resections. Cohen κ correlation for cobas versus p16-IHC/HPV-ISH on FNA samples was 0.9, perfect agreement, sensitivity 100%, specificity 92.3%, positive predictive value 94.1%, negative predictive value 100%. Thirty-four (n=34) scrapings from FS were tested for cobas, p16, and/or HPV-ISH. The mean collection to testing time was 10.4 days (range: 1 to 28 d). Cohen κ correlation for cobas versus p16-IHC/HPV-ISH on FS scrapings was 1, perfect agreement. Sensitivity, specificity, positive predictive value, and negative predictive value was 100%. Cobas genotype was HPV-16 in 87%, HPV-18 in 3%, and HPV-other in 10%. Cobas HPV test in FNA supernatant and FS scrapings outperformed or was equivalent to p16-IHC and provided genotyping information.
MeSH term(s)	Humans ; Biopsy, Fine-Needle ; Genotype ; Papillomavirus Infections/diagnosis ; Head and Neck Neoplasms/diagnosis
Language	English
Publishing date	2022-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1473273-7
ISSN	1533-4058 ; 1062-3345 ; 1541-2016
ISSN (online)	1533-4058
ISSN	1062-3345 ; 1541-2016
DOI	10.1097/PAI.0000000000001066
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Zs.A 3783: Show issues

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Article ; Online: Oral health impact of sugar-sweetened beverage consumption among Korean adolescents.

Sim, EunBi / Sohn, Woosung / Choi, EunSil / Noh, Hiejin

International journal of dental hygiene

2022 Volume 20, Issue 4, Page(s) 721–731

Abstract: Objectives: This study aimed to investigate the association between the frequency of SSB consumption and the prevalence of oral symptoms in adolescents.: Methods: We analysed the data collected from the 2017 (13th) Korea Youth Risk Behaviour Web- ... ...

Abstract	Objectives: This study aimed to investigate the association between the frequency of SSB consumption and the prevalence of oral symptoms in adolescents. Methods: We analysed the data collected from the 2017 (13th) Korea Youth Risk Behaviour Web-based Survey (KYRBWS). KYRBS collected beverage consumption data from 64,991 Korean adolescents. Self-reported oral symptoms including sensitivity to food, sharp aches and pains in the teeth, and painful or bleeding gums were also collected. Multivariable logistic regression modelling was used to test the association between the frequency of SSB consumption and oral symptoms groups. Results: It was found that Korean adolescents who consumed SSB at least once a week (94.4%) experienced more subjective oral symptoms (46.5%) even after controlling for confounding variables. In addition, as the frequency of SSB intake in adolescents increased, the subjective oral symptoms increased. Conclusions: The results of this study clearly revealed that the SSB consumption impacted adolescents' subjective oral symptoms. Compared with those who did not consume SSBs, those who consumed SSBs showed increased for developing subjective oral symptoms.
MeSH term(s)	Adolescent ; Humans ; Beverages ; Oral Health ; Republic of Korea/epidemiology ; Self Report ; Sugar-Sweetened Beverages
Language	English
Publishing date	2022-08-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2252118-5
ISSN	1601-5037 ; 1601-5029
ISSN (online)	1601-5037
ISSN	1601-5029
DOI	10.1111/idh.12604
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