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  1. Book: Rosen's breast pathology

    Hoda, Syed Amir Fazal / Koerner, Frederick C. / Brogi, Edi / Rosen, Paul Peter

    2021  

    Title variant Breast pathology
    Author's details Syed A. Hoda, MD, New York, New York, Frederick C. Koerner, MD, Boston, Massachusetts, Edi Brogi, MD, PhD, New York, New York, Paul P. Rosen, MD, New York, New York
    Language English
    Size xxxiv, 1505 Seiten, Illustrationen
    Edition Fifth edition
    Publisher Wolters Kluwer
    Publishing place Philadelphia
    Publishing country United States
    Document type Book
    Note Zugang zu Online-Ausgabe über Code
    HBZ-ID HT021375564
    ISBN 1-4963-9891-2 ; 978-1-4963-9891-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 A 667 on loan 0 Vormerkungen
    Zugang zu Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Book: Rosen's diagnosis of breast pathology by needle core biopsy

    Brogi, Edi / Hoda, Syed Amir Fazal / Koerner, Frederick C. / Rosen, Paul Peter

    2017  

    Abstract: Intended as the companion book to Rosen's Breast Pathology, this heavily illustrated text offers essential guidance on diagnostic evaluation of needle core biopsies"--Provided by ... ...

    Author's details Edi Brogi,MD, Syed A. Hoda,MD, Frederick C. Koerner,MD, Paul P. Rosen,MD,
    Abstract "Intended as the companion book to Rosen's Breast Pathology, this heavily illustrated text offers essential guidance on diagnostic evaluation of needle core biopsies"--Provided by publisher
    Keywords Breast Neoplasms / pathology ; Breast / pathology ; Biopsy, Needle
    Language English
    Size xxix, 513 Seiten, Illustrationen
    Edition fourth edition
    Publisher Wolters Kluwer
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    Note Zugang zu Online-Ausgabe über Code
    Old title Vorangegangen ist
    HBZ-ID HT019427070
    ISBN 978-1-4963-0725-5 ; 1-4963-0725-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 A 1514 available for loan (reading room) Lesesaal EG
    Zugang zu Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  3. Article: Are Biasing Factors Idiosyncratic to Measures? A Comparison of Interpersonal Conflict, Organizational Constraints, and Workload.

    Spector, Paul E / Gray, Cheryl E / Rosen, Christopher C

    Journal of business and psychology

    2022  , Page(s) 1–20

    Abstract: Widespread concern has been raised about the possibility of potential biasing factors influencing the measurement of organizational variables and distorting inferences and conclusions reached about them. Recent research calls for a measure-centric ... ...

    Abstract Widespread concern has been raised about the possibility of potential biasing factors influencing the measurement of organizational variables and distorting inferences and conclusions reached about them. Recent research calls for a measure-centric approach in which every measure is independently evaluated to assess what factor(s) may uniquely bias it. This paper examines three popular stressor measures from this perspective. Across three studies, we examine factors that may bias three popular measures of job stressors: The Interpersonal Conflict at Work Scale (ICAWS), the Organizational Constraints Scale (OCS), and the Quantitative Workload Inventory (QWI). The first study used a two-wave design to survey 276 MTurk workers to assess the three stressor scales, four strains, and five measures of potential bias sources: hostile attribution bias, negative affectivity, mood, neutral objects satisfaction, and social desirability. The second study used an experimental design with 439 MTurk workers who were randomly assigned to a positive, negative, or no mood induction condition to assess effects on means of the three stressor measures and their correlations with strains. The third study surveyed 161 employee-supervisor dyads to explore the convergence of results involving the three stressor measures across sources. Based on several forms of evidence we conclude that potential biasing factors affect the three stressor measures differently, supporting the merits of a measure centric approach, even among measures in the same domain.
    Language English
    Publishing date 2022-08-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016738-6
    ISSN 1573-353X ; 0889-3268
    ISSN (online) 1573-353X
    ISSN 0889-3268
    DOI 10.1007/s10869-022-09838-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Quantification of surgical workflow during robotic proctectomy.

    Gillani, Mishal / Rupji, Manali / Devin, Courtney L / Purvis, Lilia A / Paul Olson, Terrah J / Jarc, Anthony / Shields, Mallory C / Liu, Yuan / Rosen, Seth A

    The international journal of medical robotics + computer assisted surgery : MRCAS

    2024  Volume 20, Issue 2, Page(s) e2625

    Abstract: Background: Surgical workflow assessments offer insight regarding procedure variability. We utilised an objective method to evaluate workflow during robotic proctectomy (RP).: Methods: We annotated 31 RPs and used Spearman's correlation to measure ... ...

    Abstract Background: Surgical workflow assessments offer insight regarding procedure variability. We utilised an objective method to evaluate workflow during robotic proctectomy (RP).
    Methods: We annotated 31 RPs and used Spearman's correlation to measure the correlation of step time and step visit frequency with console time (CT) and total operative time (TOT).
    Results: Strong correlations were seen with CT and step times for inferior mesenteric vein dissection and ligation (ρ = 0.60, ρ = 0.60), lateral-to-medial splenic flexure mobilisation (SFM) (ρ = 0.63), left rectal dissection (ρ = 0.64) and mesorectal division (ρ = 0.71). CT correlated strongly with medial-to-lateral (ρ = 0.75) and supracolic SFM visit frequency (ρ = 0.65). TOT correlated strongly with initial exposure time (ρ = 0.60), and medial-to-lateral (ρ = 0.67) and supracolic SFM visit frequency (ρ = 0.65).
    Conclusion: This study correlates surgical steps with CT and TOT through standardised annotation, providing an objective approach to quantify workflow.
    MeSH term(s) Humans ; Robotic Surgical Procedures ; Workflow ; Dissection ; Proctectomy ; Operative Time
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2151860-9
    ISSN 1478-596X ; 1478-5951
    ISSN (online) 1478-596X
    ISSN 1478-5951
    DOI 10.1002/rcs.2625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6382: Show issues Location:
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  5. Article ; Online: Though Much Is Taken, Much Abides: Finding New Antibiotics Using Old Ones.

    Rosen, Paul C / Seyedsayamdost, Mohammad R

    Biochemistry

    2017  Volume 56, Issue 37, Page(s) 4925–4926

    Language English
    Publishing date 2017-09-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.7b00782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 217: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book ; Online: AutoSlicer

    Liu, Zifan / Rosen, Evan / C, Paul Suganthan G.

    Scalable Automated Data Slicing for ML Model Analysis

    2022  

    Abstract: Automated slicing aims to identify subsets of evaluation data where a trained model performs anomalously. This is an important problem for machine learning pipelines in production since it plays a key role in model debugging and comparison, as well as ... ...

    Abstract Automated slicing aims to identify subsets of evaluation data where a trained model performs anomalously. This is an important problem for machine learning pipelines in production since it plays a key role in model debugging and comparison, as well as the diagnosis of fairness issues. Scalability has become a critical requirement for any automated slicing system due to the large search space of possible slices and the growing scale of data. We present Autoslicer, a scalable system that searches for problematic slices through distributed metric computation and hypothesis testing. We develop an efficient strategy that reduces the search space through pruning and prioritization. In the experiments, we show that our search strategy finds most of the anomalous slices by inspecting a small portion of the search space.

    Comment: 11 pages, 5 figures, NeurIPS 2022 Workshop on Challenges in Deploying and Monitoring Machine Learning Systems
    Keywords Computer Science - Machine Learning ; Computer Science - Databases ; I.2.0 ; H.2.0
    Subject code 006
    Publishing date 2022-12-18
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: Piperacillin triggers virulence factor biosynthesis via the oxidative stress response in

    Li, Anran / Okada, Bethany K / Rosen, Paul C / Seyedsayamdost, Mohammad R

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 26

    Abstract: Natural products have been an important source of therapeutic agents and chemical tools. The recent realization that many natural product biosynthetic genes are silent or sparingly expressed during standard laboratory growth has prompted efforts to ... ...

    Abstract Natural products have been an important source of therapeutic agents and chemical tools. The recent realization that many natural product biosynthetic genes are silent or sparingly expressed during standard laboratory growth has prompted efforts to investigate their regulation and develop methods to induce their expression. Because it is difficult to intuit signals that induce a given biosynthetic locus, we recently implemented a forward chemical-genetic approach to identify such inducers. In the current work, we applied this approach to nine silent biosynthetic loci in the model bacterium
    MeSH term(s) Antibiosis/drug effects ; Biosynthetic Pathways/drug effects ; Burkholderia/drug effects ; Burkholderia/genetics ; Burkholderia/physiology ; Gene Expression Regulation, Bacterial/drug effects ; Models, Biological ; Oxidation-Reduction/drug effects ; Oxidative Stress/drug effects ; Piperacillin/pharmacology ; Reactive Oxygen Species/metabolism ; Secondary Metabolism/drug effects ; Transcription, Genetic/drug effects ; Virulence Factors/biosynthesis ; beta-Lactams/pharmacology
    Chemical Substances Reactive Oxygen Species ; Virulence Factors ; beta-Lactams ; Piperacillin (X00B0D5O0E)
    Language English
    Publishing date 2021-06-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2021483118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: The Johns Hopkins Physician-Scientist Training Program to Enhance Institutional Retention and Entry Into Academic Positions: An Evaluation of Program Effectiveness and Outcomes.

    Rincon-Torroella, Jordina / Feghali, James / Antar, Albert / Azad, Tej D / Rosen, Antony / Ziegelstein, Roy C / Rothman, Paul B / Burns, Kathleen H / Bienstock, Jessica L / Cox, Andrea L / Bettegowda, Chetan

    Academic medicine : journal of the Association of American Medical Colleges

    2024  

    Abstract: Purpose: The Johns Hopkins Physician-Scientist Training Program (PSTP) was implemented to overcome well-documented challenges in training and retaining physician-scientists by providing physician-scientist pathway training for residents and clinical ... ...

    Abstract Purpose: The Johns Hopkins Physician-Scientist Training Program (PSTP) was implemented to overcome well-documented challenges in training and retaining physician-scientists by providing physician-scientist pathway training for residents and clinical fellows. The program's core tenets include monthly seminars, individualized feedback on project proposals, access to mentors, and institutional funding opportunities. This study evaluated the effectiveness and outcomes of the PTSP and provides a framework for replication.
    Method: A query of institutional demographic data and bibliometric variables of the PSTP participants (2017-2020) at a single academic medical center was conducted in 2021. In addition, a voluntary survey collected personal and program evaluation information.
    Results: Of 145 PSTP scholars, 59 (41%) were women, and 41 (31%), 8 (6%), and 6 (5%) of scholars self-identified as Asian, Hispanic, and Black, respectively. Thirty-three (23%) scholars received PSTP research support or career development microgrants. Of 66 PSTP graduates, 29 (44%) remained at Johns Hopkins as clinical fellows or faculty. Of 48 PSTP graduates in a post-training position, 42 (88%) were in academia, with the majority, 29 (76%), holding the rank of assistant professor. Fifty-nine of 140 available participants responded to the survey (42% response rate). The top-cited reason for joining the PSTP was exposure to mentors and administration (50/58 respondents, 86%), followed by seeking scholarly opportunities (37/58 respondents, 64%). Most scholars intended to continue a career as a physician-scientist.
    Conclusions: The PSTP provides internal research support and institutional oversight. Although establishing close mentor-mentee relationships requires individualized approaches, the PSTP provided structured academic pathways that enhanced participating scholars' ability to apply for grants and jobs. The vast majority continued their careers as physician-scientists after training. In light of the national evidence of a "leaky physician-scientist pipeline," programs such as the PSTP can be critical to entry into early academic career positions and institutional retention.
    Language English
    Publishing date 2024-04-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0000000000005748
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 112: Show issues Location:
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  9. Article ; Online: Fact or fiction? Does the position of the end-to-end (EEA) stapler spike matter for colorectal anastomoses using a double-stapled technique?

    Cavallaro, Paul / Lee, Grace C / Kanters, Arielle / Valente, Michael / Holubar, Stefan D / Champagne, Bradley / Rosen, David / Gorgun, Emre / Steele, Scott

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2023  Volume 26, Issue 1, Page(s) 137–144

    Abstract: Aim: Surgeons often have strong opinions about how to perform colorectal anastomoses with little data to support variations in technique. The aim of this study was to determine if location of the end-to-end (EEA) stapler spike relative to the rectal ... ...

    Abstract Aim: Surgeons often have strong opinions about how to perform colorectal anastomoses with little data to support variations in technique. The aim of this study was to determine if location of the end-to-end (EEA) stapler spike relative to the rectal transection line is associated with anastomotic integrity.
    Method: This study was a retrospective analysis of a quality collaborative database at a quaternary centre and regional hospitals. Patients with any left-sided colon resection with double-stapled anastomosis were included (December 2019 to August 2022). Our primary endpoint was a composite outcome including positive air insufflation test, incomplete anastomotic donut, or thin/eccentric donut. Our secondary endpoint was clinical leak.
    Results: Overall, 633 patients were included and stratified by location of the stapler spike relative to the rectal transection line. Of note, 86 patients had an end-colon to anterior rectum ("reverse Baker") anastomosis with no crossing staple lines. The rates of the composite endpoint based on position of the stapler spike were 12.4% (anterior), 8.1% (through), 12.8% (posterior), 5.1% (corner), and 2.3% for the "reverse Baker" (p = 0.03). The overall rate of clinical leak was 3.8% and there were no differences between methods. In a multivariate analysis, the "reverse Baker" anastomosis was associated with decreased odds of poor anastomotic integrity when compared to anastomoses with crossing staple lines (OR 0.20, 95% CI: 0.05-0.87, p = 0.03).
    Conclusions: For anastomoses with crossing staple lines, the position of the stapler spike relative to the rectal staple line is not associated with differences in anastomotic integrity. In contrast, anastomoses with no crossing staple lines resulted in significantly lower rates of poor anastomotic integrity, but no difference in clinical leaks.
    MeSH term(s) Humans ; Rectum/surgery ; Colon/surgery ; Retrospective Studies ; Surgical Stapling/methods ; Anastomosis, Surgical/methods ; Colorectal Neoplasms/surgery ; Anastomotic Leak/etiology ; Anastomotic Leak/prevention & control ; Anastomotic Leak/surgery
    Language English
    Publishing date 2023-12-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.16833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5799: Show issues Location:
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  10. Article ; Online: SLIDE: Significant Latent Factor Interaction Discovery and Exploration across biological domains.

    Rahimikollu, Javad / Xiao, Hanxi / Rosengart, AnnaElaine / Rosen, Aaron B I / Tabib, Tracy / Zdinak, Paul M / He, Kun / Bing, Xin / Bunea, Florentina / Wegkamp, Marten / Poholek, Amanda C / Joglekar, Alok V / Lafyatis, Robert A / Das, Jishnu

    Nature methods

    2024  

    Abstract: Modern multiomic technologies can generate deep multiscale profiles. However, differences in data modalities, multicollinearity of the data, and large numbers of irrelevant features make analyses and integration of high-dimensional omic datasets ... ...

    Abstract Modern multiomic technologies can generate deep multiscale profiles. However, differences in data modalities, multicollinearity of the data, and large numbers of irrelevant features make analyses and integration of high-dimensional omic datasets challenging. Here we present Significant Latent Factor Interaction Discovery and Exploration (SLIDE), a first-in-class interpretable machine learning technique for identifying significant interacting latent factors underlying outcomes of interest from high-dimensional omic datasets. SLIDE makes no assumptions regarding data-generating mechanisms, comes with theoretical guarantees regarding identifiability of the latent factors/corresponding inference, and has rigorous false discovery rate control. Using SLIDE on single-cell and spatial omic datasets, we uncovered significant interacting latent factors underlying a range of molecular, cellular and organismal phenotypes. SLIDE outperforms/performs at least as well as a wide range of state-of-the-art approaches, including other latent factor approaches. More importantly, it provides biological inference beyond prediction that other methods do not afford. Thus, SLIDE is a versatile engine for biological discovery from modern multiomic datasets.
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2169522-2
    ISSN 1548-7105 ; 1548-7091
    ISSN (online) 1548-7105
    ISSN 1548-7091
    DOI 10.1038/s41592-024-02175-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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