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  1. Article ; Online: Replication licensing during S phase: breaking the law to prevent breaking DNA.

    Gilbert, David M

    Nature structural & molecular biology

    2023  Volume 30, Issue 4, Page(s) 406–408

    MeSH term(s) S Phase ; DNA ; DNA Replication ; Cell Cycle Proteins/metabolism ; Replication Origin ; Cell Cycle
    Chemical Substances DNA (9007-49-2) ; Cell Cycle Proteins
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2126708-X
    ISSN 1545-9985 ; 1545-9993
    ISSN (online) 1545-9985
    ISSN 1545-9993
    DOI 10.1038/s41594-023-00962-4
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  2. Article ; Online: Replication timing and transcriptional control: beyond cause and effect - part IV.

    Vouzas, Athanasios E / Gilbert, David M

    Current opinion in genetics & development

    2023  Volume 79, Page(s) 102031

    Abstract: Decades of work on the spatiotemporal organization of mammalian DNA replication timing (RT) continues to unveil novel correlations with aspects of transcription and chromatin organization but, until recently, mechanisms regulating RT and the biological ... ...

    Abstract Decades of work on the spatiotemporal organization of mammalian DNA replication timing (RT) continues to unveil novel correlations with aspects of transcription and chromatin organization but, until recently, mechanisms regulating RT and the biological significance of the RT program had been indistinct. We now know that the RT program is both influenced by and necessary to maintain chromatin structure, forming an epigenetic positive feedback loop. Moreover, the discovery of specific cis-acting elements regulating mammalian RT at both the domain and the whole-chromosome level has revealed multiple cell-type-specific and developmentally regulated mechanisms of RT control. We review recent evidence for diverse mechanisms employed by different cell types to regulate their RT programs and the biological significance of RT regulation during development.
    MeSH term(s) Animals ; DNA Replication Timing/genetics ; Chromatin/genetics ; DNA Replication/genetics ; Mammals/genetics
    Chemical Substances Chromatin
    Language English
    Publishing date 2023-03-09
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1077312-5
    ISSN 1879-0380 ; 0959-437X
    ISSN (online) 1879-0380
    ISSN 0959-437X
    DOI 10.1016/j.gde.2023.102031
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  3. Book: Fischer's Mastery of Surgery. (2 Vol Sets)

    Ellison, E. Christopher / Galandiuk, Susan / Pawlik, Timothy M. / Chapman, William C. / Poulose, Benjamin Kuttikatt / Henke, Peter K. / Mohr, Alicia / Islam, Mirza Saleem / Agur, Anne M. R. / Scott-Conner, Carol E. H. / Renton, David / Upchurch, Gilbert R. / Efron, Philip Alexander / Wexner, Steven D. / Perrier, Nancy D. / Klimberg, V. Suzanne / Stewart, John H. / Rusch, Valerie W. / Gould, Jon C.

    (Biopsy Interpretation Series)

    2023  

    Series title Biopsy Interpretation Series
    Keywords Surgery ; Surgical textbook ; General surgery reference ; Surgical techniques ; Surgical procedures ; Surgical education ; Surgical training ; Surgical skills ; Surgical knowledge ; Surgical practice ; Surgical principles ; Surgical specialties ; Surgical subspecialties ; Operative procedures ; Surgical cases ; Surgical guidelines ; Surgical best practices ; Surgical reviews ; Surgical updates ; Surgical board exams
    Language English
    Size 2810 p.
    Edition 8
    Publisher Lippincott Williams
    Document type Book
    Note PDA Manuell_24
    Format 237 x 301 x 147
    ISBN 9781975176433 ; 197517643X
    Database PDA

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  4. Article ; Online: Web Exclusive. Annals On Call - Procalcitonin in the Diagnosis of Bacterial Infection.

    Centor, Robert M / Gilbert, David N

    Annals of internal medicine

    2022  Volume 175, Issue 3, Page(s) OC1

    Language English
    Publishing date 2022-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/A21-0006
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  5. Article ; Online: Effects of nicotine patches on early and late attentional bias to smoking cues: We may know less than we think.

    Stone, Bryant M / Hammersley, Jonathan J / Rabinovich, Norka E / Gilbert, David G

    Experimental and clinical psychopharmacology

    2024  

    Abstract: In contrast to overnight deprivation versus satiety studies, a small number of placebo-controlled studies have failed to find that nicotine administration reduces attentional bias (AB) to smoking cues. To assess the reliability of this failure and to ... ...

    Abstract In contrast to overnight deprivation versus satiety studies, a small number of placebo-controlled studies have failed to find that nicotine administration reduces attentional bias (AB) to smoking cues. To assess the reliability of this failure and to address the duration and salience of AB in smokers versus never-smokers, we used a longer-than-typical (i.e., 3,000 ms) smoking cue-presentation time in a placebo-controlled trial of smokers and never-smokers. We aimed to assess whether a nicotine patch (i.e., active vs. placebo) attenuates continuously assessed eye gaze-measured AB to smoking cues across 3,000 ms in 32 habitual, overnight-deprived smokers and smoker-nonsmoker differences compared to 32 never-smokers. We presented a series of picture pairs (i.e., one smoking-related and one affectively neutral control picture) simultaneously to assess AB. Participants attended a 14 mg nicotine patch and a placebo patch session in a randomized order. The habitual smokers were 12-18 hr nicotine-deprived during both sessions. Smokers demonstrated a stronger AB toward smoking cues than never-smokers across the entire 3,000 ms cue-presentation time. Nicotine did not significantly reduce the AB to smoking cues but the AB was strongly and positively related to deprivation-associated cravings in smokers. Patch-delivered nicotine did not reduce AB to smoking cues presented for up to 3,000 ms, even though smoker-nonsmoker differences in bias remained. Assessments of longer cue presentations and more subtle cues may provide nuance not currently captured by existing studies, because of potential demand effects in designs that contrast overnight versus sated state effects on AB. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1209960-0
    ISSN 1936-2293 ; 1064-1297
    ISSN (online) 1936-2293
    ISSN 1064-1297
    DOI 10.1037/pha0000707
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  6. Article: Anhedonia in Nicotine Dependence.

    Gilbert, David G / Stone, Bryant M

    Current topics in behavioral neurosciences

    2022  Volume 58, Page(s) 167–184

    Abstract: ... of nicotine's effects and nicotine dependence (Gilbert, Smoking individual differences, psychopathology, and ... emotion. Taylor and Francis, Washington, DC, 1995; Gilbert, Hum Psychopharmacol Clin Exp 12:S89-S102, 1997 ...

    Abstract Prior findings indicate that trait anhedonia enhances the likelihood of becoming a tobacco smoker, and preliminary evidence suggests that smoking abstinence leads to anhedonic states in some individuals and situations, and nicotine administration reduces anhedonic states. Nevertheless, many vital questions exist concerning relationships between anhedonia and nicotine dependence, including situational and individual difference factors that may moderate the strength of these associations. This chapter provides a critical review of the literature assessing relationships of anhedonia to nicotine dependence and the effects of acute nicotine through the lenses of the Research Domain Criteria's (RDoC) Positive Valence Systems (NIMH, RDoC changes to the matrix (CMAT) workgroup update: proposed positive valence domain revisions. A report by the national advisory mental health council workgroup on changes to the research domain criteria matrix, 2018) and the Situation x Trait Affective Response (STAR) model of nicotine's effects and nicotine dependence (Gilbert, Smoking individual differences, psychopathology, and emotion. Taylor and Francis, Washington, DC, 1995; Gilbert, Hum Psychopharmacol Clin Exp 12:S89-S102, 1997). The effects of nicotine and nicotine withdrawal on subjective, behavioral, and brain indices vary across the three RDoC Positive Valences Systems (Reward Responsiveness, Reward Learning, and Reward Valuation) in a manner that supports the research and potential clinical utility of using RDoC criteria and the STAR model to guide research and clinical innovation. We provide a revision of the STAR model that incorporates the three RDoC Positive Valence Systems with evidence that nicotine's effects on hedonic and affective processes vary as a function of the dominance/salience of (1) situational hedonic and affective cues and task/active coping cues, and (2) state executive functioning level/capacity and state reward sensitivity such that these effects of nicotine are maximal during states of suboptimal cognitive functioning and reward sensitivity, combined with low situational stimulus salience and low task-related cues/demands.
    MeSH term(s) Anhedonia ; Humans ; Nicotine/pharmacology ; Reward ; Smoking/psychology ; Tobacco Use Disorder/psychology
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2022-05-04
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 1866-3370
    ISSN 1866-3370
    DOI 10.1007/7854_2022_320
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  7. Article ; Online: Molecular Insights into Chemical Reactions at Aqueous Aerosol Interfaces.

    Limmer, David T / Götz, Andreas W / Bertram, Timothy H / Nathanson, Gilbert M

    Annual review of physical chemistry

    2024  

    Abstract: Atmospheric aerosols facilitate reactions between ambient gases and dissolved species. Here, we review our efforts to interrogate the uptake of these gases and the mechanisms of their reactions both theoretically and experimentally. We highlight the ... ...

    Abstract Atmospheric aerosols facilitate reactions between ambient gases and dissolved species. Here, we review our efforts to interrogate the uptake of these gases and the mechanisms of their reactions both theoretically and experimentally. We highlight the fascinating behavior of N
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1470474-2
    ISSN 1545-1593 ; 0066-426X
    ISSN (online) 1545-1593
    ISSN 0066-426X
    DOI 10.1146/annurev-physchem-083122-121620
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  8. Article ; Online: Mammalian DNA Replication Timing.

    Vouzas, Athanasios E / Gilbert, David M

    Cold Spring Harbor perspectives in biology

    2021  Volume 13, Issue 7

    Abstract: Immediately following the discovery of the structure of DNA and the semi-conservative replication of the parental DNA sequence into two new DNA strands, it became apparent that DNA replication is organized in a temporal and spatial fashion during the S ... ...

    Abstract Immediately following the discovery of the structure of DNA and the semi-conservative replication of the parental DNA sequence into two new DNA strands, it became apparent that DNA replication is organized in a temporal and spatial fashion during the S phase of the cell cycle, correlated with the large-scale organization of chromatin in the nucleus. After many decades of limited progress, technological advances in genomics, genome engineering, and imaging have finally positioned the field to tackle mechanisms underpinning the temporal and spatial regulation of DNA replication and the causal relationships between DNA replication and other features of large-scale chromosome structure and function. In this review, we discuss these major recent discoveries as well as expectations for the coming decade.
    MeSH term(s) Animals ; DNA Packaging ; DNA Replication Timing ; Genome ; Humans ; Mammals/genetics
    Language English
    Publishing date 2021-07-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 1943-0264
    ISSN (online) 1943-0264
    DOI 10.1101/cshperspect.a040162
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  9. Article: Nutritional epigenetics education improves diet and attitude of parents of children with autism or attention deficit/hyperactivity disorder.

    Dufault, Renee J / Adler, Katherine M / Carpenter, David O / Gilbert, Steven G / Crider, Raquel A

    World journal of psychiatry

    2024  Volume 14, Issue 1, Page(s) 159–178

    Abstract: Background: Unhealthy maternal diet leads to heavy metal exposures from the consumption of ultra-processed foods that may impact gene behavior across generations, creating conditions for the neurodevelopmental disorders known as autism and attention ... ...

    Abstract Background: Unhealthy maternal diet leads to heavy metal exposures from the consumption of ultra-processed foods that may impact gene behavior across generations, creating conditions for the neurodevelopmental disorders known as autism and attention deficit/hyperactivity disorder (ADHD). Children with these disorders have difficulty metabolizing and excreting heavy metals from their bloodstream, and the severity of their symptoms correlates with the heavy metal levels measured in their blood. Psychiatrists may play a key role in helping parents reduce their ultra-processed food and dietary heavy metal intake by providing access to effective nutritional epigenetics education.
    Aim: To test the efficacy of nutritional epigenetics instruction in reducing parental ultra-processed food intake.
    Methods: The study utilized a semi-randomized test and control group pretest-posttest pilot study design with participants recruited from parents having a learning-disabled child with autism or ADHD. Twenty-two parents who met the inclusion criteria were randomly selected to serve in the test (
    Results: There was a significant difference in the diet scores of the test group between the pre- and post-intervention periods. The parents in the test group significantly reduced their intake of ultra-processed foods with a pre-intervention diet score of 70 (mean = 5.385, SD = 2.534) and a post-intervention diet score of 113 (mean = 8.692, SD = 1.750) and the paired
    Conclusion: Here we show nutritional epigenetics education can be used to reduce ultra-processed food intake and improve attitude among parents having learning-disabled children with autism or ADHD.
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ISSN 2220-3206
    ISSN 2220-3206
    DOI 10.5498/wjp.v14.i1.159
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  10. Article ; Online: Smoking Progression and Nicotine-Enhanced Reward Sensitivity Predicted by Resting-State Functional Connectivity in Salience and Executive Control Networks.

    Gunn, Matthew P / Rose, Gregory M / Whitton, Alexis E / Pizzagalli, Diego A / Gilbert, David G

    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

    2024  

    Abstract: ... 18-24, M = 1.89 cigarettes/day) participated in the study. These individuals smoked between 5 to 35 ...

    Abstract Introduction: The neural underpinnings underlying individual differences in nicotine-enhanced reward sensitivity and smoking progression are poorly understood. Thus, we investigated whether brain resting-state functional connectivity (rsFC) during smoking abstinence predicts nicotine-enhanced reward sensitivity and smoking progression in young light smokers. We hypothesized that high rsFC between brain areas with high densities of nicotinic receptors (insula, anterior cingulate cortex [ACC], hippocampus, thalamus) and areas involved in reward-seeking (nucleus accumbens [NAcc], prefrontal cortex [PFC]) would predict nicotine-enhanced reward sensitivity and smoking progression.
    Methods: Young light smokers (N=64, age 18-24, M = 1.89 cigarettes/day) participated in the study. These individuals smoked between 5 to 35 cigarettes per week and lifetime use never exceeded 35 cigarettes per week. Their rsFC was assessed using functional magnetic resonance imaging after 14-hour nicotine-deprivation. Subjects also completed a probabilistic reward task after smoking a placebo on one day and a regular cigarette on another day.
    Results: The probabilistic-reward-task assessed greater nicotine-enhanced reward sensitivity was associated with greater rsFC between the right anterior PFC and right NAcc, but with reduced rsFC between the ACC and left inferior prefrontal gyrus and the insula and ACC. Decreased rsFC within the salience network (ACC and insula) predicted increased smoking progression across 18 months and greater nicotine-enhanced reward sensitivity.
    Conclusions: These findings provide the first evidence that differences in rsFCs in young light smokers are associated with nicotine-enhanced reward sensitivity and smoking progression.
    Implications: Weaker rsFC within the salience network predicted greater nicotine-enhanced reward sensitivity and smoking progression. These findings suggest that salience network rsFC and drug-enhanced reward sensitivity may be useful tools and potential endophenotypes for reward sensitivity and drug-dependence research.
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1452315-2
    ISSN 1469-994X ; 1462-2203
    ISSN (online) 1469-994X
    ISSN 1462-2203
    DOI 10.1093/ntr/ntae084
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