LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 7 of total 7

Search options

  1. Article ; Online: Corrigendum to Adolescent Vaping-Associated Trauma in the Western United States [J Surg Res. 2022 Aug;276:251-255].

    Russell, Katie W / Katz, Micah G / Phillips, Ryan C / Kelley-Quon, Lorraine I / Acker, Shannon N / Shahi, Niti / Lee, Justin H / Fialkowski, Elizabeth A / Nacharaju, Deepthi / Smith, Caitlin A / Jensen, Aaron R / Mueller, Claudia M / Padilla, Benjamin E / Ignacio, Romeo C / Ourshalimian, Shadassa / Wang, Kasper S / Ostlie, Daniel J / Fenton, Stephen J / Kastenberg, Zachary J

    The Journal of surgical research

    2023  Volume 294, Page(s) 247–248

    Language English
    Publishing date 2023-11-03
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2023.09.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 178: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Three-Dimensional Printed Ventilators: A Rapid Solution to Coronavirus Disease 2019-Induced Supply-Chain Shortages.

    Nacharaju, Deepthi / Menzel, Whitney / Fontaine, Evan / Child, Dennis / El Haddi, S James / Nonas, Stephanie / Chi, Albert

    Critical care explorations

    2020  Volume 2, Issue 10, Page(s) e0226

    Abstract: Objective: To examine rapidly emerging ventilator technologies during coronavirus disease 2019 and highlight the role of CRISIS, a novel 3D printed solution.: Data sources: Published articles, literature, and government guidelines that describe and ... ...

    Abstract Objective: To examine rapidly emerging ventilator technologies during coronavirus disease 2019 and highlight the role of CRISIS, a novel 3D printed solution.
    Data sources: Published articles, literature, and government guidelines that describe and review emergency use ventilator technologies.
    Study selection: Literature was chosen from peer-reviewed journals and articles were limited to recent publications.
    Data extraction: All information regarding ventilator technology was extracted from primary sources.
    Data synthesis: Analysis of technology and relevance to coronavirus disease 2019 physiology was collectively synthesized by all authors.
    Conclusions: The coronavirus disease 2019 pandemic has placed massive stress on global supply chains for ventilators due to the critical damage the virus causes to lung function. There is an urgent need to increase supply, as hospitals become inundated with patients requiring intensive respiratory support. Coalitions across the United States have formed in order to create new devices that can be manufactured quickly, with minimal resources, and provide consistent and safe respiratory support. Due to threats to public health and the vulnerability of the U.S. population, the Food and Drug Administration released Emergency Use Authorizations for new or repurposed devices, shortening the approval timeline from years to weeks. The list of authorized devices varies widely in complexity, from automated bagging techniques to repurposed sleep apnea machines. Three-dimensional printed ventilators, such as "CRISIS," propose a potential solution to increase the available number of vents for the United States and abroad, one that is dynamic and able to absorb the massive influx of hospitalized patients for the foreseeable future.
    Keywords covid19
    Language English
    Publishing date 2020-10-02
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000226
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: Protect Our Kids: a novel program bringing hemorrhage control to schools.

    Tobias, Joseph / Cunningham, Aaron / Krakauer, Kelsi / Nacharaju, Deepthi / Moss, Lori / Galindo, Carlos / Roberts, Michael / Hamilton, Nicholas A / Olsen, Kyle / Emmons, Molly / Quackenbush, Jim / Schreiber, Martin A / Burns, Beech S / Sheridan, David / Hoffman, Benjamin / Gallardo, Adrienne / Jafri, Mubeen A

    Injury epidemiology

    2021  Volume 8, Issue Suppl 1, Page(s) 31

    Abstract: Background: Following the shooting at Sandy Hook Elementary School, the Hartford Consensus produced the Stop the Bleed program to train bystanders in hemorrhage control. In our region, the police bureau delivers critical incident training to public ... ...

    Abstract Background: Following the shooting at Sandy Hook Elementary School, the Hartford Consensus produced the Stop the Bleed program to train bystanders in hemorrhage control. In our region, the police bureau delivers critical incident training to public schools, offering instruction in responding to violent or dangerous situations. Until now, widespread training in hemorrhage control has been lacking. Our group developed, implemented and evaluated a novel program integrating hemorrhage control into critical incident training for school staff in order to blunt the impact of mass casualty events on children.
    Methods: The staff of 25 elementary and middle schools attended a 90-minute course incorporating Stop the Bleed into the critical incident training curriculum, delivered on-site by police officers, nurses and doctors over a three-day period. The joint program was named Protect Our Kids. At the conclusion of the course, hemorrhage control kits and educational materials were provided and a four-question survey to assess the quality of training using a ten-point Likert scale was completed by participants and trainers.
    Results: One thousand eighteen educators underwent training. A majority were teachers (78.2%), followed by para-educators (5.8%), counselors (4.4%) and principals (2%). Widely covered by local and state media, the Protect Our Kids program was rated as excellent and effective by a majority of trainees and all trainers rated the program as excellent.
    Conclusions: Through collaboration between trauma centers, police and school systems, a large-scale training program for hemorrhage control and critical incident response can be effectively delivered to schools.
    Language English
    Publishing date 2021-09-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2764253-7
    ISSN 2197-1714
    ISSN 2197-1714
    DOI 10.1186/s40621-021-00318-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Adolescent Vaping-Associated Trauma in the Western United States.

    Russell, Katie W / Katz, Micah G / Phillips, Ryan C / Kelley-Quon, Lorraine I / Acker, Shannon N / Shahi, Niti / Lee, Justin H / Fialkowski, Elizabeth A / Nacharaju, Deepthi / Smith, Caitlin A / Jensen, Aaron R / Mueller, Claudia M / Padilla, Benjamin E / Ignacio, Romeo C / Ourshalimian, Shadassa / Wang, Kasper S / Ostlie, Daniel J / Fenton, Stephen J / Kastenberg, Zachary J

    The Journal of surgical research

    2022  Volume 276, Page(s) 251–255

    Abstract: Introduction: Electronic cigarettes (e-cigarettes) are handheld, battery-powered vaporizing devices. It is estimated that more than 25% of youth have used these devices recreationally. While vaping-associated lung injury is an increasingly recognized ... ...

    Abstract Introduction: Electronic cigarettes (e-cigarettes) are handheld, battery-powered vaporizing devices. It is estimated that more than 25% of youth have used these devices recreationally. While vaping-associated lung injury is an increasingly recognized risk, little is known about the risk of traumatic injuries associated with e-cigarette malfunction.
    Methods: A multi-institutional retrospective study was performed by querying the electronic health records at nine children's hospitals. Patients who sustained traumatic injuries while vaping from January 2016 through December 2019 were identified. Patient demographics, injury characteristics, and the details of trauma management were reviewed.
    Results: 15 children sustained traumatic injuries due to e-cigarette explosion. The median age was 17 y (range 13-18). The median injury severity score was 2 (range 1-5). Three patients reported that their injury coincided with their first vaping experience. Ten patients required hospital admission, three of whom required intensive care unit admission. Admitted patients had a median length of stay of 3 d (range 1-6). The injuries sustained were: facial burns (6), loss of multiple teeth (5), thigh and groin burns (5), hand burns (4), ocular burns (4), a radial nerve injury, a facial laceration, and a mandible fracture. Six children required operative intervention, one of whom required multiple operations for a severe hand injury.
    Conclusions: In addition to vaping-associated lung injury, vaping-associated traumatic injuries are an emerging and worrisome injury pattern sustained by adolescents in the United States. This report highlights another means by which e-cigarettes pose an increasing risk to a vulnerable youth population.
    MeSH term(s) Adolescent ; Child ; Electronic Nicotine Delivery Systems ; Hospitalization ; Humans ; Lung Injury/etiology ; Retrospective Studies ; United States/epidemiology ; Vaping/adverse effects ; Vaping/epidemiology
    Language English
    Publishing date 2022-04-05
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2022.02.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 178: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Protect Our Kids

    Joseph Tobias / Aaron Cunningham / Kelsi Krakauer / Deepthi Nacharaju / Lori Moss / Carlos Galindo / Michael Roberts / Nicholas A. Hamilton / Kyle Olsen / Molly Emmons / Jim Quackenbush / Martin A. Schreiber / Beech S. Burns / David Sheridan / Benjamin Hoffman / Adrienne Gallardo / Mubeen A. Jafri

    Injury Epidemiology, Vol 8, Iss S1, Pp 1-

    a novel program bringing hemorrhage control to schools

    2021  Volume 6

    Abstract: Abstract Background Following the shooting at Sandy Hook Elementary School, the Hartford Consensus produced the Stop the Bleed program to train bystanders in hemorrhage control. In our region, the police bureau delivers critical incident training to ... ...

    Abstract Abstract Background Following the shooting at Sandy Hook Elementary School, the Hartford Consensus produced the Stop the Bleed program to train bystanders in hemorrhage control. In our region, the police bureau delivers critical incident training to public schools, offering instruction in responding to violent or dangerous situations. Until now, widespread training in hemorrhage control has been lacking. Our group developed, implemented and evaluated a novel program integrating hemorrhage control into critical incident training for school staff in order to blunt the impact of mass casualty events on children. Methods The staff of 25 elementary and middle schools attended a 90-minute course incorporating Stop the Bleed into the critical incident training curriculum, delivered on-site by police officers, nurses and doctors over a three-day period. The joint program was named Protect Our Kids. At the conclusion of the course, hemorrhage control kits and educational materials were provided and a four-question survey to assess the quality of training using a ten-point Likert scale was completed by participants and trainers. Results One thousand eighteen educators underwent training. A majority were teachers (78.2%), followed by para-educators (5.8%), counselors (4.4%) and principals (2%). Widely covered by local and state media, the Protect Our Kids program was rated as excellent and effective by a majority of trainees and all trainers rated the program as excellent. Conclusions Through collaboration between trauma centers, police and school systems, a large-scale training program for hemorrhage control and critical incident response can be effectively delivered to schools.
    Keywords Stop the Bleed ; Hemorrhage control ; Intentional mass casualty event ; Active shooter event ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; Public aspects of medicine ; RA1-1270
    Subject code 796 ; 370
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Nitric oxide nanoparticles: pre-clinical utility as a therapeutic for intramuscular abscesses.

    Schairer, David / Martinez, Luis R / Blecher, Karin / Chouake, Jason / Nacharaju, Parimala / Gialanella, Philip / Friedman, Joel M / Nosanchuk, Joshua D / Friedman, Adam

    Virulence

    2012  Volume 3, Issue 1, Page(s) 62–67

    Abstract: ... architecture. These data suggest that the NO-np may be an effective addition to our armament for deep ...

    Abstract Nitric oxide (NO) is a critical component of host defense against invading pathogens; however, its therapeutic utility is limited due to a lack of practical delivery systems. Recently, a NO-releasing nanoparticulate platform (NO-np) was shown to have in vitro broad-spectrum antimicrobial activity and in vivo pre-clinical efficacy in a dermal abscess model. To extend these findings, both topical (TP) and intralesional (IL) NO-np administration was evaluated in a MRSA intramuscular murine abscess model and compared with vancomycin. All treatment arms accelerated abscess clearance clinically, histologically, and by microbiological assays on both days 4 and 7 following infection. However, abscesses treated with NO-np via either route demonstrated a more substantial, statistically significant decrease in bacterial survival based on colony forming unit assays and histologically revealed less inflammatory cell infiltration and preserved muscular architecture. These data suggest that the NO-np may be an effective addition to our armament for deep soft tissue infections.
    MeSH term(s) Abscess/drug therapy ; Abscess/microbiology ; Animals ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/chemistry ; Drug Carriers/chemistry ; Drug Delivery Systems ; Drug Evaluation, Preclinical ; Female ; Humans ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Methicillin-Resistant Staphylococcus aureus/physiology ; Mice ; Mice, Inbred BALB C ; Nanoparticles/chemistry ; Nitric Oxide/administration & dosage ; Nitric Oxide/chemistry ; Pyomyositis/drug therapy ; Pyomyositis/microbiology
    Chemical Substances Anti-Bacterial Agents ; Drug Carriers ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2012-01-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.4161/viru.3.1.18816
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein.

    Lewis, J / McGowan, E / Rockwood, J / Melrose, H / Nacharaju, P / Van Slegtenhorst, M / Gwinn-Hardy, K / Paul Murphy, M / Baker, M / Yu, X / Duff, K / Hardy, J / Corral, A / Lin, W L / Yen, S H / Dickson, D W / Davies, P / Hutton, M

    Nature genetics

    2000  Volume 25, Issue 4, Page(s) 402–405

    Abstract: ... deep cerebellar nuclei and spinal cord, with tau-immunoreactive pre-tangles in the cortex, hippocampus ...

    Abstract Neurofibrillary tangles (NFT) composed of the microtubule-associated protein tau are prominent in Alzheimer disease (AD), Pick disease, progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Mutations in the gene (Mtapt) encoding tau protein cause frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), thereby proving that tau dysfunction can directly result in neurodegeneration. Expression of human tau containing the most common FTDP-17 mutation (P301L) results in motor and behavioural deficits in transgenic mice, with age- and gene-dose-dependent development of NFT. This phenotype occurred as early as 6.5 months in hemizygous and 4.5 months in homozygous animals. NFT and Pick-body-like neuronal lesions occurred in the amygdala, septal nuclei, pre-optic nuclei, hypothalamus, midbrain, pons, medulla, deep cerebellar nuclei and spinal cord, with tau-immunoreactive pre-tangles in the cortex, hippocampus and basal ganglia. Areas with the most NFT had reactive gliosis. Spinal cord had axonal spheroids, anterior horn cell loss and axonal degeneration in anterior spinal roots. We also saw peripheral neuropathy and skeletal muscle with neurogenic atrophy. Brain and spinal cord contained insoluble tau that co-migrated with insoluble tau from AD and FTDP-17 brains. The phenotype of mice expressing P301L mutant tau mimics features of human tauopathies and provides a model for investigating the pathogenesis of diseases with NFT.
    MeSH term(s) Amino Acid Substitution ; Animals ; Brachial Plexus Neuritis/genetics ; Brain Stem/metabolism ; Brain Stem/pathology ; Brain Stem/ultrastructure ; Cell Count ; Gene Expression ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Mice, Transgenic ; Movement Disorders/genetics ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Muscle, Skeletal/ultrastructure ; Mutation ; Neurofibrillary Tangles/genetics ; Neurons/pathology ; Neurons/ultrastructure ; Spinal Cord/metabolism ; Spinal Cord/pathology ; Spinal Cord/ultrastructure ; tau Proteins/genetics
    Chemical Substances tau Proteins
    Language English
    Publishing date 2000-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/78078
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3613: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 46: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top