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Article ; Online: Management of pregnancy in a patient with congenital hyperinsulinism treated with association of diazoxide/calcium channel blocker.

Lemaitre, Madleen / Douillard, Claire / Froguel, Philippe / Bonnefond, Amélie / Vambergue, Anne

2022 Volume 59, Issue 8, Page(s) 1117–1120

MeSH term(s)	Calcium Channel Blockers/therapeutic use ; Congenital Hyperinsulinism/complications ; Congenital Hyperinsulinism/drug therapy ; Diazoxide/therapeutic use ; Female ; Humans ; Hyperinsulinism ; Infant ; Pregnancy
Chemical Substances	Calcium Channel Blockers ; Diazoxide (O5CB12L4FN)
Language	English
Publishing date	2022-05-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1097676-0
ISSN	1432-5233 ; 0940-5429
ISSN (online)	1432-5233
ISSN	0940-5429
DOI	10.1007/s00592-022-01898-9
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Article ; Online: Case report: Non-PTH-dependent hypercalcemia in pregnancy: Consider CYP24A1 mutations.

Lemaitre, Madleen / Lionet, Arnaud / Fages, Victor / Vantyghem, Marie-Christine / Subtil, Damien / Vambergue, Anne

Annales d'endocrinologie

2023 Volume 84, Issue 6, Page(s) 758–760

MeSH term(s)	Pregnancy ; Female ; Humans ; Hypercalcemia/genetics ; Vitamin D3 24-Hydroxylase/genetics ; Mutation ; Calcium ; Vitamin D
Chemical Substances	Vitamin D3 24-Hydroxylase (EC 1.14.15.16) ; Calcium (SY7Q814VUP) ; Vitamin D (1406-16-2) ; CYP24A1 protein, human (EC 1.14.15.16)
Language	English
Publishing date	2023-06-13
Publishing country	France
Document type	Case Reports ; Letter
ZDB-ID	299-9
ISSN	2213-3941 ; 0003-4266
ISSN (online)	2213-3941
ISSN	0003-4266
DOI	10.1016/j.ando.2023.05.009
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Article ; Online: Pre-gestational diabetes and the risk of congenital heart defects in the offspring: A French nationwide study.

Lemaitre, Madleen / Bourdon, Gurvan / Bruandet, Amélie / Lenne, Xavier / Subtil, Damien / Rakza, Thameur / Vambergue, Anne

Diabetes & metabolism

2023 Volume 49, Issue 4, Page(s) 101446

Abstract: Aim: To compare the frequencies and types of congenital heart defects for infants of women without and with pre-gestational diabetes, type 1 and type 2 diabetes (T1DM, T2DM) and to identify risk factors.: Methods: All live births between 2012 and ... ...

Abstract	Aim: To compare the frequencies and types of congenital heart defects for infants of women without and with pre-gestational diabetes, type 1 and type 2 diabetes (T1DM, T2DM) and to identify risk factors. Methods: All live births between 2012 and 2020 were screened for maternal diabetes and infant congenital heart defects using the French Medical Information System Program in Medicine, Surgery and Obstetrics database (PMSI-MCO). Incidences of these defects were estimated, and a logistic model evaluated maternal and fetal prognostic risk factors. Results: Overall, 6,038,703 mothers did not have pre-gestational diabetes (no-diabetes), 23,147 had T1DM, and 14,401 had T2DM. The incidence of infant congenital disease was 6.2% for the no-diabetes group, 8.0%, for women with T1DM, and 8.4% for women with T2DM (P < 0.001); for congenital heart defects, incidences were respectively 0.8%, 3.0% and 2.7% (P < 0.001). In comparison with the no-diabetes group, the odds ratios (95%CI) of coronary heart defects were 2.07 (1.91;2.24) (P < 0.001) for women with T1DM and 2.20 (1.99;2.44) (P < 0.001) for women with T2DM, with no difference between T1DM and T2DM (P = 0.336). cesarian section, small and large for gestational age, and prematurity were also associated with an increased risk of congenital heart defects. Conclusion: In this study we observed higher incidences of congenital heart defects in infants of women with pre-gestational diabetes compared to women without pre-gestational diabetes, with no difference between women with T1DM or T2DM. These data call for intensifying preconception care and justify systematic cardiac echography in selected fetuses.
MeSH term(s)	Pregnancy ; Female ; Humans ; Diabetes, Gestational/epidemiology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 1/complications ; Heart Defects, Congenital/epidemiology ; Heart Defects, Congenital/complications ; Risk Factors
Language	English
Publishing date	2023-04-07
Publishing country	France
Document type	Journal Article
ZDB-ID	1315751-6
ISSN	1878-1780 ; 1262-3636 ; 0338-1684
ISSN (online)	1878-1780
ISSN	1262-3636 ; 0338-1684
DOI	10.1016/j.diabet.2023.101446
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Zs.A 1267: Show issues

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Article ; Online: Cross-sectional study examining factors impacting on uptake of postpartum type 2 diabetes screening among women diagnosed with hyperglycaemia in pregnancy.

Tang, Luveon / Lebreton, Elodie / Vambergue, Anne / Fosse-Edorh, Sandrine / Olié, Valérie / Barry, Yaya / Weill, Alain / Cosson, Emmanuel / Regnault, Nolwenn

Diabetes research and clinical practice

2024 Volume 208, Page(s) 111116

Abstract: Aims: Early postpartum glucose screening of women with hyperglycaemia in pregnancy (HIP) can identify women who have the highest risk of developing impaired glucose tolerance and T2DM. This study examines the association between demographics, events ... ...

Abstract	Aims: Early postpartum glucose screening of women with hyperglycaemia in pregnancy (HIP) can identify women who have the highest risk of developing impaired glucose tolerance and T2DM. This study examines the association between demographics, events during pregnancy, socioeconomic status and postpartum T2DM screening. Methods: Using the French National Health Data System, this cross-sectional study included all deliveries where the mother had HIP in France in 2015, (n = 76,862). The odds ratio (OR) for attending postpartum screening was calculated via multi-level logistic regression. Results: T2DM screening uptake at six months postpartum was 42·9% [95 % Confidence Interval: 42·6-43·3]. Several characteristics were associated with lower uptake: living in the most deprived area(OR = 0·78[0·74-0·83]); being < 25 years-old (reference age group 25-29;≤17: 0.53 [0·31-0·90];18-24: 0.73[0·69-0·78]); smoking (0·65[0·62-0·68]); obesity (0·93[0·89-0·97]); caesarean delivery (0·95[0·92-0·99]). Factors associated with higher uptake included primiparity (1·30[1·26-1·34]); having followed the French recommendations for HIP screening (1·24[1·20-1·28]); insulin prescription (1·75[1·69-1·81]) and pre-eclampsia (1·30[1·19-1·42]). p < 0.01 is justified due to sample size. Conclusion: Improving identification of factors affecting postpartum T2DM screening uptake, such as demographics, socioeconomic context and events during pregnancy, may lead to development of target interventions to aide adherence to screening regime and thereby diagnosis of women with prediabetes or diabetes, for whom secondary and tertiary prevention is crucial.
MeSH term(s)	Pregnancy ; Female ; Humans ; Adult ; Hyperglycemia/diagnosis ; Hyperglycemia/epidemiology ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Cross-Sectional Studies ; Diabetes, Gestational/diagnosis ; Diabetes, Gestational/epidemiology ; Glucose Tolerance Test ; Postpartum Period
Language	English
Publishing date	2024-01-23
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632523-3
ISSN	1872-8227 ; 0168-8227
ISSN (online)	1872-8227
ISSN	0168-8227
DOI	10.1016/j.diabres.2024.111116
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Zs.A 2047: Show issues

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Article ; Online: Intermittently scanned continuous glucose monitoring is associated with lower spontaneous abortion rate compared with conventional blood glucose monitoring in pregnant women with type 1 diabetes: An observational study.

Lemaitre, Madleen / Faiz, Kenza / Baudoux, Florence / Subtil, Damien / Vambergue, Anne

Diabetes & vascular disease research

2022 Volume 19, Issue 6, Page(s) 14791641221136837

Abstract: Aim: The objective of the present real-life study in France was to assess and compare characteristics and outcomes in a cohort of pregnant women with type 1 diabetes (T1D) using intermittently scanned continuous glucose monitoring (isCGM) or ... ...

Abstract	Aim: The objective of the present real-life study in France was to assess and compare characteristics and outcomes in a cohort of pregnant women with type 1 diabetes (T1D) using intermittently scanned continuous glucose monitoring (isCGM) or conventional blood glucose monitoring (BGM). Material and methods: We performed an observational study of a cohort of 153 women with T1D: 77 women were using isCGM, and 76 were using BGM. We compared the groups' maternal characteristics and maternal-fetal complications. The level of HbA1c was measured before pregnancy and then four times (after 8-12, 24-28, 30-33, and 35-37 weeks of gestation). Results: The two groups were similar in terms of age, prepregnancy BMI, diabetes duration, and diabetic vascular complications. There were no significant intergroup differences in the obstetric history. The spontaneous abortion rate was lower in the isCGM group than in the blood glucose monitoring group (5.3% vs. 20%, respectively; Conclusions: This observational study demonstrates that isCGM use is associated with lower spontaneous abortion compared with conventional BGM. Large prospective studies are needed to corroborate our findings and fully understand the relationship between glucose data at the time of conception/early pregnancy and foetal outcome.
MeSH term(s)	Female ; Humans ; Pregnancy ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/diagnosis ; Blood Glucose Self-Monitoring ; Blood Glucose ; Glycated Hemoglobin ; Abortion, Spontaneous/diagnosis ; Abortion, Spontaneous/etiology ; Pregnant Women ; Hypoglycemic Agents
Chemical Substances	Blood Glucose ; Glycated Hemoglobin ; Hypoglycemic Agents
Language	English
Publishing date	2022-12-14
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2250793-0
ISSN	1752-8984 ; 1479-1641
ISSN (online)	1752-8984
ISSN	1479-1641
DOI	10.1177/14791641221136837
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Article ; Online: Le diabète gestationnel : diagnostic et prise en charge à court et à long terme.

Vambergue, Anne

Presse medicale (Paris, France : 1983)

2013 Volume 42, Issue 5, Page(s) 893–899

Abstract: Universal consensus on the diagnosis methods and thresholds has long been lacking. The recently published Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study has been used to confirm the link between hyperglycemia and materno-fetal complications. ... ...

Title translation	Gestational diabetes: diagnosis, short and long term management.
Abstract	Universal consensus on the diagnosis methods and thresholds has long been lacking. The recently published Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study has been used to confirm the link between hyperglycemia and materno-fetal complications. Consequently, in France, the Société francophone du diabète (SFD) and the Collège national des gynécologues et obstétriciens français (CNGOF) proposed an expert consensus on gestational diabetes mellitus for clinical practice. Fasting blood glucose should be measured at the first visit during early pregnancy for women with risk factors to identify the women with pregestational diabetes. It is proposed a selective screening on risk factors rather than universal screening. Specific treatment of gestational diabetes reduced materno-fetal complications compared to the absence of therapy. Women with a history of gestational diabetes mellitus are characterized by a high risk of type 2 diabetes mellitus.
MeSH term(s)	Blood Glucose/analysis ; Combined Modality Therapy ; Contraindications ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes, Gestational/diagnosis ; Diabetes, Gestational/epidemiology ; Diabetes, Gestational/therapy ; Diet, Diabetic ; Disease Management ; Disease Progression ; Early Diagnosis ; Exercise ; Expert Testimony ; Female ; Glucose Tolerance Test ; Humans ; Hypoglycemic Agents/therapeutic use ; Infant, Newborn ; Metabolic Syndrome/embryology ; Metabolic Syndrome/epidemiology ; Practice Guidelines as Topic ; Pregnancy ; Pregnancy Complications/epidemiology ; Pregnancy Complications/prevention & control ; Prenatal Diagnosis ; Prenatal Exposure Delayed Effects ; Risk Factors
Chemical Substances	Blood Glucose ; Hypoglycemic Agents
Language	French
Publishing date	2013-05
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	120943-7
ISSN	2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0032-7867 ; 0755-4982 ; 0301-1518
DOI	10.1016/j.lpm.2013.02.316
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Article: Is the Development of Gestational Diabetes Associated With the ABO Blood Group/Rhesus Phenotype?

Lemaitre, M / Passet, M / Ghesquière, L / Martin, C / Drumez, E / Subtil, D / Vambergue, A

Frontiers in endocrinology

2022 Volume 13, Page(s) 916903

Abstract: Aims: There are few published data on the putative association between the ABO blood group/rhesus (Rh) factor and the risk of developing gestational diabetes mellitus (GDM). Our aim was to explore the link between each one factor and GDM development.: ...

Abstract	Aims: There are few published data on the putative association between the ABO blood group/rhesus (Rh) factor and the risk of developing gestational diabetes mellitus (GDM). Our aim was to explore the link between each one factor and GDM development. Methods: All women having given birth at Lille University Medical Center (Lille, France) between August 1 Results: 1194 women had at least one GDM risk factor. The percentage of GDM varied with the ABO group (p=0.013). Relative to group O women, group AB women were more likely to develop GDM (OR = 2.50, 95% CI [1.43 to 4.36], p=0.001). Compared with the Rh-positive O group, only the Rh-positive AB group had an elevated risk of developing GDM (OR = 3.02, 95% CI [1.69 to 5.39], p < 0.001). Conclusions: Our results showed that Rh-positive group AB women have a greater risk of GDM. With a view to preventing GDM, at-risk individuals could be identified by considering the ABO blood group phenotype either as a single risk factor or in combination with other risk factors.
MeSH term(s)	ABO Blood-Group System ; Diabetes, Gestational ; Female ; Humans ; Logistic Models ; Phenotype ; Pregnancy ; Risk Factors
Chemical Substances	ABO Blood-Group System
Language	English
Publishing date	2022-06-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.916903
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Article ; Online: Expert consensus on gestational diabetes mellitus.

Vambergue, A

Diabetes & metabolism

2010 Volume 36, Issue 6 Pt 2, Page(s) 511

MeSH term(s)	Consensus Development Conferences as Topic ; Diabetes, Gestational/diagnosis ; Female ; France ; Humans ; Mass Screening/standards ; Pregnancy
Language	English
Publishing date	2010-12
Publishing country	France
Document type	Editorial
ZDB-ID	1315751-6
ISSN	1878-1780 ; 1262-3636 ; 0338-1684
ISSN (online)	1878-1780
ISSN	1262-3636 ; 0338-1684
DOI	10.1016/j.diabet.2010.11.003
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Article ; Online: The impact of lockdown on maternal and neonatal morbidity in gestational diabetes mellitus.

Tollini, Valentine / Lemaître, Madleen / Garabedian, Charles / Martin, Claire / Bengler, Cyril / Vambergue, Anne / Ghesquière, Louise

American journal of obstetrics and gynecology

2022 Volume 227, Issue 5, Page(s) 775–777

Language	English
Publishing date	2022-06-25
Publishing country	United States
Document type	Letter
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/j.ajog.2022.06.033
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Article ; Online: Implementation of a clinical decision support system for the optimization of antidiabetic drug orders by pharmacists.

Robert, Laurine / Quindroit, Paul / Henry, Héloïse / Perez, Maxime / Rousselière, Chloé / Lemaitre, Madleen / Vambergue, Anne / Décaudin, Bertrand / Beuscart, Jean-Baptiste

British journal of clinical pharmacology

2023 Volume 90, Issue 1, Page(s) 239–246

Abstract: Aims: The objective of the study was to describe the impact of a clinical decision support system (CDSS) on antidiabetic drug management by clinical pharmacists for hospitalized patients with T2DM.: Methods: We performed a retrospective, single- ... ...

Abstract	Aims: The objective of the study was to describe the impact of a clinical decision support system (CDSS) on antidiabetic drug management by clinical pharmacists for hospitalized patients with T2DM. Methods: We performed a retrospective, single-centre study in a teaching hospital, where clinical pharmacists analysed prescriptions and issued pharmacist interventions (PIs) through a computerized physician order entry (CPOE) system. A CDSS was integrated into the pharmacists' workflow in July 2019. We analysed PIs during 2 periods of interest: one before the introduction of the CDSS (from November 2018 to April 2019, PIs issued through the CPOE alone) and one afterwards (from November 2020 to April 2021, PIs issued through the CPOE and/or the CDSS). The study covered nondiabetology wards as endocrinology, diabetes and metabolism departments were not computerized at the time of the study. Results: There were 203 PIs related to antidiabetic drugs in period 1 and 319 in period 2 (a 57.5% increase). Sixty-four of the 319 PIs were generated by the CDSS. Noncompliance/contraindication was the main problem identified by the CDSS (41 PIs, 68.4%), and 57.8% led to discontinuation of the drug. Most of the PIs issued through the CDSS corresponded to orders that had not been flagged up by clinical pharmacists using the CPOE. Conversely, most alerts about indications that were not being treated were detected by the clinical pharmacists using the CPOE and not by the CDSS. Conclusion: Use of CDSS by clinical pharmacists improved antidiabetic drug management for hospitalized patients with T2DM. The CDSS might add value to diabetes care in nondiabetology wards by decreasing the frequency of potentially inappropriate prescriptions and adverse drug reactions.
MeSH term(s)	Humans ; Pharmacists ; Decision Support Systems, Clinical ; Hypoglycemic Agents/adverse effects ; Retrospective Studies ; Pharmacy Service, Hospital ; Diabetes Mellitus, Type 2/drug therapy
Chemical Substances	Hypoglycemic Agents
Language	English
Publishing date	2023-09-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188974-6
ISSN	1365-2125 ; 0306-5251 ; 0264-3774
ISSN (online)	1365-2125
ISSN	0306-5251 ; 0264-3774
DOI	10.1111/bcp.15898
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