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Article ; Online: Effect of hydrated C

Türk, Gaffari / Koca, Recep H / Güngör, İbrahim H / Dayan Cinkara, Serap / Acısu, Tutku C / Erdem Erişir, Figen / Arkalı, Gözde / Özer Kaya, Şeyma / Kızıl, Meltem / Sönmez, Mustafa / Gür, Seyfettin / Yılmaz, Ökkeş / Yüce, Abdurrauf / Karatepe, Mustafa

Animal reproduction science

2022 Volume 238, Page(s) 106939

Abstract: This study was conducted to investigate the effect of different doses of hydrated C ...

Abstract	This study was conducted to investigate the effect of different doses of hydrated C
MeSH term(s)	Amino Acids/pharmacology ; Animals ; Cryopreservation/veterinary ; Cryoprotective Agents/chemistry ; Cryoprotective Agents/pharmacology ; Fullerenes/pharmacology ; Lipids ; Male ; Semen ; Semen Preservation/veterinary ; Sheep ; Sperm Motility ; Spermatozoa ; Vitamins/pharmacology
Chemical Substances	Amino Acids ; Cryoprotective Agents ; Fullerenes ; Lipids ; Vitamins
Language	English
Publishing date	2022-02-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	429674-6
ISSN	1873-2232 ; 0378-4320
ISSN (online)	1873-2232
ISSN	0378-4320
DOI	10.1016/j.anireprosci.2022.106939
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Article ; Online: Prognostic gene biomarkers for c-Src inhibitor Si162 sensitivity in melanoma cells.

Türk, Seyhan / Yilmaz, Ayşegül / Malkan, Ümit Yavuz / Uçar, Gülberk / Türk, Can

Turkish journal of biology = Turk biyoloji dergisi

2023 Volume 48, Issue 1, Page(s) 13–23

Abstract: ... targeted therapies for precise and effective treatment. This study focuses on Si162, a newly synthesized c ...

Abstract	Background/aim: Early detection and treatment are crucial in combating malignant melanoma. Src is an important therapeutic target in melanoma due to its association with cancer progression. However, developing effective Src-targeting drugs remains challenging and personalized medicine relies on biomarkers and targeted therapies for precise and effective treatment. This study focuses on Si162, a newly synthesized c-Src inhibitor, to identify reliable biomarkers for predicting Si162 sensitivity and explore associated biological characteristics and pathways in melanoma cells. Materials and methods: Primary melanoma cells (M1, M21, M24, M84, M133, M307, and M2025) were obtained from patients diagnosed with melanoma. Si162 cytotoxicity tests were performed using luminescent adenosine triphosphate detection and the half-maximal inhibitory concentration (IC Results: The cells revealed significant differences in response to Si162 based on the IC Conclusion: These findings contribute to our understanding of the underlying biological differences among melanoma cells and suggest potential biomarkers and pathways associated with Si162 response and resistance.
Language	English
Publishing date	2023-11-06
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2046470-8
ISSN	1303-6092 ; 1303-6092
ISSN (online)	1303-6092
ISSN	1303-6092
DOI	10.55730/1300-0152.2678
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Article ; Online: In vitro c

Şahbazoğlu, Kemal Burak / Demirbilek, Murat / Bayarı, Sevgi Haman / Buber, Esra / Toklucu, Selçuk / Türk, Mustafa / Karabulut, Erdem / Akalın, Ferda Alev

Connective tissue research

2021 Volume 63, Issue 2, Page(s) 183–197

Abstract: ... with other scaffold materials, such as Poly lactic-co-glycolic-acid (PLGA) and collagen (C). The main target ... using PLGA/C/HA. Subgroups with BMP-2 signal molecule and without HA were also created. The scaffolds ...

Abstract	Purpose/aim of the study: The ultimate goal of periodontal treatment is to regenerate the lost periodontal tissues. The interest in nanomaterials in dentistry is growing rapidly and has focused on improvements in various biomedical applications, such as periodontal regeneration and periodontal tissue engineering. To enhance periodontal tissue regeneration, hydroxyapatite (HA) was used in conjunction with other scaffold materials, such as Poly lactic-co-glycolic-acid (PLGA) and collagen (C). The main target of this study was to compare the effects of nano and macrostructures of the tissue scaffolds on cell behavior Materials and methods: Nanofibrillar and macroporous-spongious composite tissue scaffolds were produced using PLGA/C/HA. Subgroups with BMP-2 signal molecule and without HA were also created. The scaffolds were characterized by FTIR, SEM/EDX techniques, and mechanical tests. The scaffolds were compared in the periodontal ligament (PDL) and MCT3-E1 cell cultures. The cell behaviors; adhesions by SEM, proliferation by WST-1, differentiation by ALP and mineralization with Alizarin Red Tests were determined. Results: Cell adhesion and mineralization were higher in the nanofibrillar scaffolds compared to the macroporous-spongious scaffolds. Macroporous-spongious scaffolds seemed better for the proliferation of PDL cells and differentiation of MC3T3-E1-preosteoblastic cells, while nanofibrillar scaffolds were more convenient for the differentiation of PDL cells and proliferation of MC3T3-E1-preosteoblastic cells. Conclusions: In general, nanofibrillar scaffolds showed more favorable results in cell behaviors, compared to the macroporous-spongious scaffolds, and mostly, BMP-2 and HA promoted the activities of the cells.
MeSH term(s)	Cell Proliferation ; Durapatite/chemistry ; Lactic Acid ; Osteogenesis ; Periodontal Ligament ; Tissue Engineering/methods ; Tissue Scaffolds/chemistry
Chemical Substances	Lactic Acid (33X04XA5AT) ; Durapatite (91D9GV0Z28)
Language	English
Publishing date	2021-04-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	185551-7
ISSN	1607-8438 ; 0091-1690 ; 0300-8207
ISSN (online)	1607-8438
ISSN	0091-1690 ; 0300-8207
DOI	10.1080/03008207.2021.1912029
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Article ; Online: Structure of Reelin repeat 8 and the adjacent C-terminal region.

Turk, Liam S / Currie, Michael J / Dobson, Renwick C J / Comoletti, Davide

Biophysical journal

2022 Volume 121, Issue 13, Page(s) 2526–2537

Abstract: ... and C-terminal fragments that each have distinct roles in Reelin's function and regulation. The C ... amino acid residues termed the C-terminal region (CTR), influences Reelin signaling intensity, and has been ...

Abstract	Neuronal development and function are dependent in part on the several roles of the secreted glycoprotein Reelin. Endogenous proteases process this 400 kDa, modular protein, yielding N-terminal, central, and C-terminal fragments that each have distinct roles in Reelin's function and regulation. The C-terminal fragment comprises Reelin repeat (RR) domains seven and eight, as well as a basic stretch of 32 amino acid residues termed the C-terminal region (CTR), influences Reelin signaling intensity, and has been reported to bind to Neuropilin-1, which serves as a co-receptor in the canonical Reelin signaling pathway. Here, we present a crystal structure of RR8 at 3.0 Å resolution. Analytical ultracentrifugation and small-angle x-ray scattering confirmed that RR8 is monomeric and enabled us to identify the CTR as a flexible, yet compact subdomain. We conducted structurally informed protein engineering to design a chimeric RR8 construct guided by the structural similarities with RR6. Experimental results support a mode of Reelin-receptor interaction reliant on the multiple interfaces coordinating the binding event. Structurally, RR8 resembles other individual RRs, but its structure does show discrete differences that may account for Reelin receptor specificity toward RR6.
MeSH term(s)	Cell Adhesion Molecules, Neuronal/chemistry ; Extracellular Matrix Proteins/genetics ; Nerve Tissue Proteins/chemistry ; Neurons/metabolism ; Reelin Protein ; Serine Endopeptidases/chemistry ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism
Chemical Substances	Cell Adhesion Molecules, Neuronal ; Extracellular Matrix Proteins ; Nerve Tissue Proteins ; Reelin Protein ; Serine Endopeptidases (EC 3.4.21.-)
Language	English
Publishing date	2022-06-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	218078-9
ISSN	1542-0086 ; 0006-3495
ISSN (online)	1542-0086
ISSN	0006-3495
DOI	10.1016/j.bpj.2022.06.002
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Zs.A 235: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 2: Show issues

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Article ; Online: Impact of C-Reactive Protein on Cognition and Alzheimer Disease Biomarkers in Homozygous

Tao, Qiushan / Alvin Ang, Ting Fang / Akhter-Khan, Samia C / Itchapurapu, Indira Swetha / Killiany, Ronald / Zhang, Xiaoling / Budson, Andrew E / Turk, Katherine W / Goldstein, Lee / Mez, Jesse / Alosco, Michael L / Qiu, Wei Qiao

Neurology

2021 Volume 97, Issue 12, Page(s) e1243–e1252

Abstract: Background and objectives: Previous research has shown that elevated blood C-reactive protein (CRP ...

Abstract	Background and objectives: Previous research has shown that elevated blood C-reactive protein (CRP) is associated with increased Alzheimer disease (AD) risk only in Methods: Data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study were analyzed, including Results: Among 566 ADNI participants, 274 (48.4%) had no, 222 (39.2%) had 1, and 70 (12.4%) had 2 Discussion: CRP released during peripheral inflammation could be a mediator in
Language	English
Publishing date	2021-09-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000012512
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Ui II Zs.153: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: The Role of Therapeutic Plasma Exchange (TPE) in Multisystem Inflammatory Syndrome in Children (MIS-C).

Atay, Gurkan / Hasbal, Canan / Türk, Mücahit / Erdoğan, Seher / Sözeri, Betül

Children (Basel, Switzerland)

2021 Volume 8, Issue 6

Abstract: Multisystemic inflammatory syndrome in children (MIS-C) is a new potentially life-threatening ... the clinical and laboratory results of MIS-C and the role of therapeutic plasma exchange (TPE) in its treatment ... ward and pediatric intensive care unit (PICU) of a tertiary hospital with a diagnosis of MIS-C between ...

Abstract	Multisystemic inflammatory syndrome in children (MIS-C) is a new potentially life-threatening disease that is related to coronavirus disease 2019 (COVID-19). The aim of this study is to reveal the clinical and laboratory results of MIS-C and the role of therapeutic plasma exchange (TPE) in its treatment. Clinical, laboratory and radiological characteristics of the patients who were admitted to the pediatric ward and pediatric intensive care unit (PICU) of a tertiary hospital with a diagnosis of MIS-C between April 2020 and March 2021 were included in the study. Forty-one patients were admitted to our hospital with a diagnosis of MIS-C. Twenty-one (51.2%) patients were admitted to the PICU. Six patients needed invasive mechanical ventilation (14.6%), 10 patients (24.4%) TPE and 3 patients (7.3%) needed extracorporeal membrane oxygenation (ECMO). The patients were grouped according to need for PICU admission (Group 1: no need for PICU, Group 2: need for PICU admission). Group 2 had significantly higher levels of C-reactive protein (CRP), alanine aminotransferase (ALT), ferritin, D-dimer, pro-B type natriuretic peptide (pro BNP) and lactate (
Language	English
Publishing date	2021-06-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children8060498
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Article ; Online: The Role of Cysteine Protease Cathepsins B, H, C, and X/Z in Neurodegenerative Diseases and Cancer.

Stoka, Veronika / Vasiljeva, Olga / Nakanishi, Hiroshi / Turk, Vito

International journal of molecular sciences

2023 Volume 24, Issue 21

Abstract: ... cathepsins B, H, C, and X/Z exhibit exopeptidase activity. Recently, cysteine cathepsins have been found ... of cysteine cathepsins B, H, C, and X in neurodegenerative diseases and cancer. Further advances ...

Abstract	Papain-like cysteine proteases are composed of 11 human cysteine cathepsins, originally located in the lysosomes. They exhibit broad specificity and act as endopeptidases and/or exopeptidases. Among them, only cathepsins B, H, C, and X/Z exhibit exopeptidase activity. Recently, cysteine cathepsins have been found to be present outside the lysosomes and often participate in various pathological processes. Hence, they have been considered key signalling molecules. Their potentially hazardous proteolytic activities are tightly regulated. This review aims to discuss recent advances in understanding the structural aspects of these four cathepsins, mechanisms of their zymogen activation, regulation of their activities, and functional aspects of these enzymes in neurodegeneration and cancer. Neurodegenerative effects have been evaluated, particularly in Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, and neuropsychiatric disorders. Cysteine cathepsins also participate in tumour progression and metastasis through the overexpression and secretion of proteases, which trigger extracellular matrix degradation. To our knowledge, this is the first review to provide an in-depth analysis regarding the roles of cysteine cathepsins B, H, C, and X in neurodegenerative diseases and cancer. Further advances in understanding the functions of cysteine cathepsins in these conditions will result in the development of novel, targeted therapeutic strategies.
MeSH term(s)	Humans ; Cysteine Proteases ; Neurodegenerative Diseases ; Cysteine/metabolism ; Cathepsin B ; Neoplasms ; Lysosomes/metabolism
Chemical Substances	Cysteine Proteases (EC 3.4.-) ; Cysteine (K848JZ4886) ; Cathepsin B (EC 3.4.22.1)
Language	English
Publishing date	2023-10-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242115613
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Article ; Online: Reduction of cryopreservation-induced structural, functional and molecular damages in ram sperm by hydrated C

Güngör, İbrahim Halil / Türk, Gaffari / Dayan Cinkara, Serap / Acisu, Tutku Can / Tektemur, Ahmet / Yeni, Deniz / Avdatek, Fatih / Arkali, Gözde / Koca, Recep Hakkı / Özer Kaya, Şeyma / Sagiroglu, Meltem / Etem Önalan, Ebru / Sönmez, Mustafa / Gür, Seyfettin / Yüce, Abdurrauf

Reproduction in domestic animals = Zuchthygiene

2023 Volume 59, Issue 1, Page(s) e14513

Abstract: ... thawed ram sperm using an extender containing different concentrations of hydrated carbon 60 fullerene (C ...

Abstract	This study aimed to investigate the morphological, functional and molecular changes in frozen-thawed ram sperm using an extender containing different concentrations of hydrated carbon 60 fullerene (C
MeSH term(s)	Male ; Sheep ; Animals ; Semen ; Fullerenes/pharmacology ; Sperm Motility ; Cryoprotective Agents/pharmacology ; Spermatozoa ; Cryopreservation/veterinary ; Cryopreservation/methods ; Sheep, Domestic ; Semen Preservation/veterinary ; Semen Preservation/methods ; Nitrogen/pharmacology ; MicroRNAs
Chemical Substances	Fullerenes ; Cryoprotective Agents ; Nitrogen (N762921K75) ; MicroRNAs
Language	English
Publishing date	2023-12-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1015187-4
ISSN	1439-0531 ; 0936-6768
ISSN (online)	1439-0531
ISSN	0936-6768
DOI	10.1111/rda.14513
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Article ; Online: Zaluzanin C Alleviates Inflammation and Lipid Accumulation in Kupffer Cells and Hepatocytes by Regulating Mitochondrial ROS.

Jung, Ji-Won / Wang, Feng / Turk, Ayman / Park, Jeong-Su / Ma, Hwan / Ma, Yuanqiang / Noh, Hye-Rin / Sui, Guoyan / Shin, Dong-Su / Lee, Mi-Kyeong / Roh, Yoon Seok

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 22

Abstract: Zaluzanin C (ZC), a sesquiterpene lactone isolated from ...

Abstract	Zaluzanin C (ZC), a sesquiterpene lactone isolated from
MeSH term(s)	Humans ; Kupffer Cells/metabolism ; Reactive Oxygen Species/metabolism ; Hepatocytes ; Inflammation/drug therapy ; Inflammation/metabolism ; Mitochondria/metabolism ; RNA, Messenger/metabolism ; Lipids/pharmacology ; Liver ; Lipid Metabolism
Chemical Substances	Reactive Oxygen Species ; zaluzanin C ; RNA, Messenger ; Lipids
Language	English
Publishing date	2023-11-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28227484
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Article ; Online: The Role of Cysteine Protease Cathepsins B, H, C, and X/Z in Neurodegenerative Diseases and Cancer

Veronika Stoka / Olga Vasiljeva / Hiroshi Nakanishi / Vito Turk

International Journal of Molecular Sciences, Vol 24, Iss 21, p

2023 Volume 15613

Abstract	Papain-like cysteine proteases are composed of 11 human cysteine cathepsins, originally located in the lysosomes. They exhibit broad specificity and act as endopeptidases and/or exopeptidases. Among them, only cathepsins B, H, C, and X/Z exhibit exopeptidase activity. Recently, cysteine cathepsins have been found to be present outside the lysosomes and often participate in various pathological processes. Hence, they have been considered key signalling molecules. Their potentially hazardous proteolytic activities are tightly regulated. This review aims to discuss recent advances in understanding the structural aspects of these four cathepsins, mechanisms of their zymogen activation, regulation of their activities, and functional aspects of these enzymes in neurodegeneration and cancer. Neurodegenerative effects have been evaluated, particularly in Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and neuropsychiatric disorders. Cysteine cathepsins also participate in tumour progression and metastasis through the overexpression and secretion of proteases, which trigger extracellular matrix degradation. To our knowledge, this is the first review to provide an in-depth analysis regarding the roles of cysteine cathepsins B, H, C, and X in neurodegenerative diseases and cancer. Further advances in understanding the functions of cysteine cathepsins in these conditions will result in the development of novel, targeted therapeutic strategies.
Keywords	cathepsins ; lysosomal exopeptidases ; neurodegeneration ; Alzheimer’s disease ; Parkinson’s disease ; Huntington’s disease ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610 ; 572
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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