LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 104

Search options

  1. Article ; Online: Utilization of glucagon-like peptide-1 receptor agonists and changes in clinical characteristics in patients with type 2 diabetes by chronic kidney disease stage in Japan: A descriptive observational study using a nationwide electronic medical records database.

    Hirose, Naoki / Tsujimoto, Naoto / Katayose, Taeko / Chin, Rina

    Diabetes, obesity & metabolism

    2021  Volume 24, Issue 3, Page(s) 486–498

    Abstract: Aim: To describe the utilization of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and changes in clinical characteristics before and after GLP-1 RA initiation in patients with type 2 diabetes (T2D) by chronic kidney disease (CKD) stage.: ... ...

    Abstract Aim: To describe the utilization of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and changes in clinical characteristics before and after GLP-1 RA initiation in patients with type 2 diabetes (T2D) by chronic kidney disease (CKD) stage.
    Materials and methods: In this retrospective descriptive study using a nationwide electronic medical records database in Japan, we included patients with GLP-1 RA prescriptions from June 2010 to October 2019. Clinical characteristics at GLP-1 RA initiation, persistence proportion, and changes in clinical measurements after GLP-1 RA initiation were described for all patients and by CKD stage, defined by baseline estimated glomerular filtration rate (eGFR).
    Results: We included 8049 patients. During the study period, the proportion of patients with T2D initiating GLP-1 RAs increased from 1.5% in 2010 to 3.3% in 2019. Also, the mean (95% confidence interval) of baseline age and eGFR ranged from 58.6 (56.7-60.4) to 66.3 (65.5-67.2) years and from 72.9 (68.0-77.9) to 64.0 (62.2-65.8) mL/min/1.73m
    Conclusions: The utilization of GLP-1 RAs has been increasing over the past decade, and GLP-1 RAs have been used in patients with limited treatment options, such as the elderly or those with CKD. In T2D patients with CKD, the persistence proportion of GLP-1 RAs was not low, and the renal dysfunction may be moderated by GLP-1 RA initiation.
    MeSH term(s) Aged ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Electronic Health Records ; Glucagon-Like Peptide-1 Receptor/agonists ; Humans ; Hypoglycemic Agents/therapeutic use ; Japan/epidemiology ; Middle Aged ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Renal Insufficiency, Chronic/epidemiology ; Retrospective Studies
    Chemical Substances Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents
    Language English
    Publishing date 2021-12-05
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.14600
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5442: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Rapid progression of mitral stenosis during watchful waiting for the asymptomatic degenerative severe aortic stenosis: a case of caseous calcification of mitral annulus.

    Tsujimoto, Daiki / Sumi, Naoki / Kobara, Satoshi / Inoue, Yoshiaki / Nakamura, Yoshinobu / Shirota, Kinya

    Journal of echocardiography

    2022  Volume 21, Issue 4, Page(s) 175–176

    MeSH term(s) Humans ; Mitral Valve Stenosis/diagnostic imaging ; Mitral Valve Stenosis/surgery ; Watchful Waiting ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Calcinosis/diagnosis ; Calcinosis/diagnostic imaging ; Aortic Valve Stenosis/complications ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery
    Language English
    Publishing date 2022-08-09
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 2209473-8
    ISSN 1880-344X ; 1349-0222
    ISSN (online) 1880-344X
    ISSN 1349-0222
    DOI 10.1007/s12574-022-00585-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Organized Registration for the Assessment of Dementia by the Nationwide General Consortium Toward Effective Treatment (ORANGE) Registry: Current Status and Perspectives of Mild Cognitive Impairment.

    Tsujimoto, Masashi / Suzuki, Keisuke / Saji, Naoki / Sakurai, Takashi / Ito, Kengo / Toba, Kenji

    Journal of Alzheimer's disease : JAD

    2022  Volume 88, Issue 4, Page(s) 1423–1433

    Abstract: Background: With increasingly aging societies, a comprehensive strategy for dementia research is important. The Organized Registration for the Assessment of dementia by the Nationwide General consortium toward Effective treatment (ORANGE) Registry is ... ...

    Abstract Background: With increasingly aging societies, a comprehensive strategy for dementia research is important. The Organized Registration for the Assessment of dementia by the Nationwide General consortium toward Effective treatment (ORANGE) Registry is the first longitudinal multicenter prospective trial-ready cohort in Japan.
    Objective: To establish a large cohort for use in clinical trials and research in Japan.
    Methods: This registry, based on communities, hospitals, and nursing homes, covers three dementia stages (preclinical, mild cognitive impairment [MCI], and advanced dementia), and includes more than 30 hospitals. We analyzed enrollment and 1-year follow-up data for disease progression.
    Results: There were 1450 registered patients (649 men, 801 women; mean age, 77.92±6.70 years; mean Mini-Mental State Examination [MMSE] score, 25.19±2.76). The conversion rates from MCI to dementia and MCI to normal were 14.3% and 1.1%, respectively. High Clinical Dementia Rating score (odds ratio [OR] = 11.085, 95% confidence interval [CI]:1.619-75.913, p = 0.014), low MMSE score (OR = 0.835, 95% CI: 0.761-0.917, p < 0.001), high Geriatric Depression Scale score (OR = 1.093, 95% CI: 1.005-1.189, p = 0.038), and low body mass index (OR = 0.895, 95% CI: 0.829-0.967, p = 0.005) at enrollment were significant factors for conversion.
    Conclusion: The ORANGE MCI Registry is an established registry that facilitates creation of trial-ready cohorts to accelerate promotion of clinical trials with low reversion rates as it originates from a hospital. One-year follow-up analysis suggested assessing various factors for conversion risk. Further analyses will be possible in future with registry expansion. We will continue to refine this registry, including how it can be used more efficiently.
    MeSH term(s) Aged ; Aged, 80 and over ; Alzheimer Disease/psychology ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/therapy ; Disease Progression ; Female ; Humans ; Male ; Prospective Studies ; Registries
    Language English
    Publishing date 2022-07-11
    Publishing country Netherlands
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-220039
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6084: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Effects of the Cortisol Milieu on Tumor-Infiltrating Immune Cells in Corticotroph Tumors.

    Kanzawa, Maki / Shichi, Hiroki / Kanie, Keitaro / Yamamoto, Masaaki / Yamamoto, Naoki / Tsujimoto, Yasutaka / Bando, Hironori / Iguchi, Genzo / Kitano, Shigehisa / Inoshita, Naoko / Yamada, Shozo / Ogawa, Wataru / Itoh, Tomoo / Fukuoka, Hidenori

    Endocrinology

    2024  Volume 165, Issue 4

    Abstract: Context: Corticotrophs are susceptible to lymphocyte cytotoxicity, as seen in hypophysitis, suggesting that an immunological approach may be a potential strategy for corticotroph-derived tumors.: Objective: We aimed to clarify whether corticotroph ... ...

    Abstract Context: Corticotrophs are susceptible to lymphocyte cytotoxicity, as seen in hypophysitis, suggesting that an immunological approach may be a potential strategy for corticotroph-derived tumors.
    Objective: We aimed to clarify whether corticotroph tumors that induce hypercortisolemia (ACTHomas) could be targets for immunotherapy.
    Methods: Tumor-infiltrating immune cells were immunohistochemically analyzed. ACTHomas were compared with other pituitary tumors, and further divided into 3 different cortisol-exposed milieus: Naïve (ACTHomas without preoperative treatment), Met (ACTHomas with preoperative metyrapone), and SCA (silent corticotroph adenomas). A 3-dimensional cell culture of resected tumors was used to analyze the effects of immune checkpoint inhibitors.
    Results: The number of tumor-infiltrating lymphocytes (TILs) was low in ACTHomas. Among these, the number of CD8+ cells was lower in ACTHomas than in both somatotroph and gonadotroph tumors (both P < .01). Then we compared the differences in TILs among Naïve, Met, and SCA. The number of CD4+ cells, but not CD8+ cells, was higher in both Met and SCA than in Naïve. Next, we investigated tumor-associated macrophages, which could negatively affect T cell infiltration. The numbers of CD163+ and CD204+ cells were positively associated with cortisol levels. Moreover, tumor size was positively correlated with the number of CD204+ cells.
    Conclusion: We found the possibility that ACTHomas were immunologically cold in a cortisol-independent manner. In contrast, the tumor infiltration of CD4+ cells and M2-macrophages were associated with the cortisol milieu. Future studies are needed to validate these results and develop effective immunotherapy while considering the cortisol milieu.
    MeSH term(s) Humans ; Hydrocortisone ; Corticotrophs ; ACTH-Secreting Pituitary Adenoma/pathology ; Pituitary Neoplasms/pathology ; Adenoma/pathology
    Chemical Substances Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqae016
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.72: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Fluctuations in plasma adrenocorticotropic hormone concentration may predict the onset of immune checkpoint inhibitor-related hypophysitis.

    Bando, Hironori / Yamamoto, Masaaki / Urai, Shin / Motomura, Yuma / Sasaki, Yuriko / Ohmachi, Yuka / Kobatake, Masaki / Tsujimoto, Yasutaka / Oi-Yo, Yuka / Suzuki, Masaki / Yamamoto, Naoki / Takahashi, Michiko / Fukuoka, Hidenori / Iguchi, Genzo / Ogawa, Wataru

    Journal for immunotherapy of cancer

    2024  Volume 12, Issue 2

    Abstract: Immune checkpoint inhibitor (ICI)-related hypophysitis (RH) is a common immune-related adverse event. The early detection of ICI-RH prevents life-threatening adrenal insufficiency. However, good predictors of secondary adrenal insufficiency in ICI-RH ... ...

    Abstract Immune checkpoint inhibitor (ICI)-related hypophysitis (RH) is a common immune-related adverse event. The early detection of ICI-RH prevents life-threatening adrenal insufficiency. However, good predictors of secondary adrenal insufficiency in ICI-RH have not yet been reported. We hypothesized that fluctuations in serum adrenocorticotropic hormone (ACTH) and cortisol levels occur similarly to those in thyroid-stimulating hormone and thyroid hormone (thyroxine and triiodothyronine) levels in ICI-related thyroiditis. Here, we sought to test this hypothesis. Patients who used ICI and had a history of measurement of serum ACTH and cortisol concentrations were retrieved from electronic medical records, and those with a history of glucocorticoid use were excluded from the analysis. We evaluated fluctuations in serum ACTH and cortisol concentrations and the development of ICI-RH. For patients with ICI-RH, data at three points (before ICI administration (pre), maximum ACTH concentration (peak), and onset of ICI-RH) were analyzed to evaluate hormone fluctuations. A total of 202 patients were retrieved from the medical record. Forty-three patients were diagnosed with ICI-RH. Twenty-six out of 43 patients had sufficient data to evaluate fluctuations in serum ACTH and cortisol concentrations and no history of glucocorticoid use. ACTH concentrations changed from 37.4 (29.9-48.3) (pre) to 64.4 (46.5-106.2) (peak) pg/mL (1.72-fold increase, p=0.0026) in the patients with ICI-RH before the onset. There were no differences in cortisol concentrations between the pre and peak values in patients with ICI-RH. We also evaluated the fluctuations in serum ACTH and cortisol levels in patients who did not receive ICI-RH (62 cases). However, elevation of serum ACTH levels was not observed in patients without ICI-RH, suggesting that transient elevation of serum ACTH levels is a unique phenomenon in patients with ICI-RH. In conclusion, serum ACTH levels were transiently elevated in some patients with ICI-RH before the onset of secondary adrenal insufficiency. Monitoring the ACTH levels and their fluctuations may help predict the onset of ICI-RH.
    MeSH term(s) Humans ; Adrenal Insufficiency/chemically induced ; Adrenal Insufficiency/diagnosis ; Adrenocorticotropic Hormone ; Glucocorticoids/therapeutic use ; Hydrocortisone ; Hypophysitis/chemically induced ; Immune Checkpoint Inhibitors/adverse effects ; Immune Checkpoint Inhibitors/therapeutic use
    Chemical Substances Adrenocorticotropic Hormone (9002-60-2) ; Glucocorticoids ; Hydrocortisone (WI4X0X7BPJ) ; Immune Checkpoint Inhibitors
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1136/jitc-2023-008634
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Spontaneous mitral valve perforation associated with mitral annular calcification-related calcified amorphous tumor assessed by three-dimensional transesophageal echocardiography.

    Haruki, Nobuhiko / Sumi, Naoki / Kobara, Satoshi / Tsujimoto, Daiki / Inoue, Yoshiaki / Saito, Yuhei / Shirota, Kinya

    Journal of medical ultrasonics (2001)

    2020  Volume 47, Issue 3, Page(s) 481–482

    Language English
    Publishing date 2020-05-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1396630-3
    ISSN 1613-2254 ; 0287-0592 ; 1346-4523
    ISSN (online) 1613-2254
    ISSN 0287-0592 ; 1346-4523
    DOI 10.1007/s10396-020-01023-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2695: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.B 2695 -Engl.Ausg.-: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Differentiating Dementia with Lewy Bodies from Alzheimer's Disease Using the Fall Risk Evaluation Questionnaire.

    Tsujimoto, Masashi / Suzuki, Keisuke / Takeda, Akinori / Saji, Naoki / Sakurai, Takashi / Washimi, Yukihiko

    Internal medicine (Tokyo, Japan)

    2021  Volume 61, Issue 11, Page(s) 1687–1692

    Abstract: Objective Dementia with Lewy bodies (DLB) is the second-most common form of neurodegenerative dementia after Alzheimer's disease (AD). Falls are a vital prognostic factor in patients with dementia and are a characteristic feature of DLB. This study ... ...

    Abstract Objective Dementia with Lewy bodies (DLB) is the second-most common form of neurodegenerative dementia after Alzheimer's disease (AD). Falls are a vital prognostic factor in patients with dementia and are a characteristic feature of DLB. This study investigated the screening potential of the fall risk evaluation for DLB and compared it with that of AD to facilitate an accurate diagnosis. Methods We enrolled patients diagnosed with DLB (n=410) and AD (n=2,683) and categorized the participants into 3 groups depending on their physical ability, age, cognitive function, and fall events. Using the Fall Risk Index-21 (FRI-21) questionnaire, we evaluated and comparatively analyzed the fall risk between DLB and AD patients in three defined groups of participants. Results The FRI-21 score was significantly higher in DLB patients than in AD patients in every group. Using this score, we were able to distinguish between DLB and AD patients in each group. Among the three groups, the group with a young age, relatively mild cognitive dysfunction, and no fall events exhibited the best specificity for DLB (0.895). Conclusions The FRI-21 is a useful tool for screening for DLB and differentiating it from AD. This questionnaire can be used at a relatively early stage of the disease in young patients with mild cognitive dysfunction and no history of falling. These preliminary results need to be validated in an interventional study to evaluate the effectiveness of rehabilitative measures and daily environmental changes carried out to prevent falls using this tool.
    MeSH term(s) Alzheimer Disease/diagnosis ; Cognitive Dysfunction/diagnosis ; Diagnosis, Differential ; Humans ; Lewy Body Disease/diagnosis ; Surveys and Questionnaires
    Language English
    Publishing date 2021-10-26
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.8383-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 240: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Acid invertase activities of dahlia ‘Kokucho’ petals during flower opening and following cutting and treatment with 6-benzylaminopurine

    Shimizu-Yumoto, Hiroko / Tsujimoto, Naoki / Naka, Terufumi

    Scientia horticulturae. 2020 Oct. 15, v. 272

    2020  

    Abstract: Extending the vase life of cut dahlia ‘Kokucho’ flowers through enhanced activities of acid invertases (cell wall, CWIN and vacuolar, VIN) on flower opening and senescence after harvest was investigated. The activities of CWIN and VIN were very low in ... ...

    Abstract Extending the vase life of cut dahlia ‘Kokucho’ flowers through enhanced activities of acid invertases (cell wall, CWIN and vacuolar, VIN) on flower opening and senescence after harvest was investigated. The activities of CWIN and VIN were very low in the outer petals at the tight bud stage (stage 1), increased markedly at the half-open stage (stage 2), and decreased at the fully open stage (stage 3) to levels lower than at stage 2. Glucose and fructose concentrations were very low at stage 1, markedly increased at stage 2, and further increased at stage 3. These results suggest that acid invertase activities play a very important role in increasing soluble sugars of petals during flower opening. Following harvest at stage 3, florets or cut flowers were treated with 50 μmol L⁻¹ 6-benzylaminopurine (BA) by dipping or spraying, respectively. These treatments extended vase life longer than in the controls. In the florets experiment, CWIN and VIN activities were significantly higher with a BA dip than in the control for petals at 3 and 6 d, but there were no significant differences in sugar concentrations between the control and BA dip groups. In cut flowers at 3 d after cutting, VIN activity and glucose concentration were higher in the outer petals treated with BA spray than in control petals. From these results, application of exogenous cytokinin has some effect of maintaining high acid invertase activity, and high invertase activity itself may be important for delaying senescence in cut dahlia flowers. BA application is useful for extending petal longevity and is expected to be a popular post-harvest treatment in cut dahlia flowers.
    Keywords benzyladenine ; beta-fructofuranosidase ; cell walls ; cytokinins ; florets ; fructose ; glucose ; longevity ; postharvest treatment ; vacuoles ; vase life
    Language English
    Dates of publication 2020-1015
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 185557-8
    ISSN 0304-4238
    ISSN 0304-4238
    DOI 10.1016/j.scienta.2020.109525
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 2810: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Excessive excitability of inhibitory cortical circuit and disturbance of ballistic targeting movement in degenerative cerebellar ataxia.

    Matsugi, Akiyoshi / Nishishita, Satoru / Bando, Kyota / Kikuchi, Yutaka / Tsujimoto, Keigo / Tanabe, Yuto / Yoshida, Naoki / Tanaka, Hiroaki / Douchi, Shinya / Honda, Takeru / Odagaki, Masato / Nakano, Hideki / Okada, Yohei / Mori, Nobuhiko / Hosomi, Koichi

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 13917

    Abstract: This study aimed to investigate abnormalities in inhibitory cortical excitability and motor control during ballistic-targeting movements in individuals with degenerative cerebellar ataxia (DCA). Sixteen participants took part in the study (DCA group [n =  ...

    Abstract This study aimed to investigate abnormalities in inhibitory cortical excitability and motor control during ballistic-targeting movements in individuals with degenerative cerebellar ataxia (DCA). Sixteen participants took part in the study (DCA group [n = 8] and healthy group [n = 8]). The resting motor-threshold and cortical silent period (cSP) were measured in the right-hand muscle using transcranial magnetic stimulation over the left primary motor cortex. Moreover, the performance of the ballistic-targeting task with right wrist movements was measured. The Scale for the Assessment and Rating of Ataxia was used to evaluate the severity of ataxia. The results indicated that the cSP was significantly longer in participants with DCA compared to that in healthy controls. However, there was no correlation between cSP and severity of ataxia. Furthermore, cSP was linked to the ballistic-targeting task performance in healthy participants but not in participants with DCA. These findings suggest that there is excessive activity in the gamma-aminobutyric acid-mediated cortical inhibitory circuit in individuals with DCA. However, this increase in inhibitory activity not only fails to contribute to the control of ballistic-targeting movement but also shows no correlation with the severity of ataxia. These imply that increased excitability in inhibitory cortical circuits in the DCA may not contribute the motor control as much as it does in healthy older adults under limitations associated with a small sample size. The study's results contribute to our understanding of motor control abnormalities in people with DCA and provide potential evidence for further research in this area.
    MeSH term(s) Humans ; Aged ; Cerebellar Ataxia ; Ataxia ; Movement ; Cortical Excitability ; Hand
    Language English
    Publishing date 2023-08-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-41088-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Case report: Late middle-aged features of

    Ohmachi, Yuka / Urai, Shin / Bando, Hironori / Yokoi, Jun / Yamamoto, Masaaki / Kanie, Keitaro / Motomura, Yuma / Tsujimoto, Yasutaka / Sasaki, Yuriko / Oi, Yuka / Yamamoto, Naoki / Suzuki, Masaki / Shichi, Hiroki / Iguchi, Genzo / Uehara, Natsumi / Fukuoka, Hidenori / Ogawa, Wataru

    Frontiers in endocrinology

    2023  Volume 13, Page(s) 1073173

    Abstract: Kenny-Caffey syndrome type 2 (KCS2) is an extremely rare skeletal disorder involving hypoparathyroidism and short stature. It has an autosomal dominant pattern of inheritance and is caused by variants in the FAM111 trypsin-like peptidase A ( ...

    Abstract Kenny-Caffey syndrome type 2 (KCS2) is an extremely rare skeletal disorder involving hypoparathyroidism and short stature. It has an autosomal dominant pattern of inheritance and is caused by variants in the FAM111 trypsin-like peptidase A (
    MeSH term(s) Female ; Humans ; Child ; Middle Aged ; Follow-Up Studies ; Dwarfism ; Hyperostosis, Cortical, Congenital/genetics ; Hypoparathyroidism ; Receptors, Virus/genetics
    Chemical Substances FAM111A protein, human ; Receptors, Virus
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Review ; Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.1073173
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top