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  1. Article: Peroral cholangioscopy for the evaluation of bile duct stricture in hepatocellular carcinoma on a preoperative examination.

    Chiba, Mitsuru / Aokawa, Masaki / Goto, Takashi / Sato, Wataru / Takahashi, Kenichi / Minami, Shinichiro / Iijima, Katsunori

    Journal of rural medicine : JRM

    2024  Volume 19, Issue 1, Page(s) 44–48

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2024-01-01
    Publishing country Japan
    Document type Case Reports
    ZDB-ID 2768933-5
    ISSN 1880-4888 ; 1880-487X
    ISSN (online) 1880-4888
    ISSN 1880-487X
    DOI 10.2185/jrm.2023-022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Identification of Angelica acutiloba, A. sinensis, and other Chinese medicinal Apiaceae plants by DNA barcoding.

    Minami, Motoyasu / Tanaka, Ryusaku / Mori, Takako / Fujii, Taichi / Tsuchida, Takashi

    Journal of natural medicines

    2024  

    Abstract: Crude drug Angelicae acutilobae radix is one of the most important crude drugs in Japanese traditional medicine and is used mainly for the treatment of gynecological disorders. In the listing in the Japanese Pharmacopoeia XVIII, Angelicae acutilobae ... ...

    Abstract Crude drug Angelicae acutilobae radix is one of the most important crude drugs in Japanese traditional medicine and is used mainly for the treatment of gynecological disorders. In the listing in the Japanese Pharmacopoeia XVIII, Angelicae acutilobae radix is defined as the root of Angelica acutiloba (Apiaceae), which has long been produced on an industrial scale in Japan. With the aging of farmers and depopulation of production areas, the domestic supply has recently declined and the majority of the supply is now imported from China. Due to having only slightly different morphological and chemical characteristics for the Apiaceae roots used to produce dried roots for Chinese medicines, the plant species originating the crude drug Apiaceae roots may be incorrectly identified. In particular, Angelicae sinensis radix, which is widely used in China, and Angelicae acutilobae radix are difficult to accurately identify by morphology and chemical profiles. Thus, in order to differentiate among Angelicae acutilobae radix and other radixes originated from Chinese medicinal Apiaceae plants, we established DNA markers. Using DNA sequences for the chloroplast psbA-trnH intergenic spacer and nuclear internal transcribed spacer regions, Angelicae acutilobae radix and other Chinese Apiaceae roots, including Angelicae sinensis radix, can be definitively identified.
    Language English
    Publishing date 2024-03-01
    Publishing country Japan
    Document type Letter
    ZDB-ID 2227540-X
    ISSN 1861-0293 ; 1340-3443
    ISSN (online) 1861-0293
    ISSN 1340-3443
    DOI 10.1007/s11418-024-01796-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2692: Show issues Location:
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  3. Article ; Online: Pathophysiology Derived from Down Syndrome Related Genes on the 21st Chromosome.

    Minami, Takashi

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2017  Volume 137, Issue 7, Page(s) 791–793

    Language Japanese
    Publishing date 2017
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.16-00236-F
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 643: Show issues Location:
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  4. Article: [A Case of Achieving CR through Chemoradiotherapy for Postoperative Oligo Lymph Node Metastasis in Gastric Cancer].

    Makari, Yoichi / Nakatsuka, Rie / Minami, Kensuke / Nagaoka, Satoshi / Kusu, Takashi / Hirota, Masanori / Shingai, Tatsushi / Matsumoto, Takashi / Matsui, Masanori / Oshima, Satoshi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2024  Volume 50, Issue 13, Page(s) 1683–1684

    Abstract: We present a case of oligo lymph node metastasis in a 70s man who had previously undergone subtotal gastrectomy for advanced gastric cancer in the prepylorus. Postoperatively, adjuvant chemotherapy was administered for a duration of 1 year. During the ... ...

    Abstract We present a case of oligo lymph node metastasis in a 70s man who had previously undergone subtotal gastrectomy for advanced gastric cancer in the prepylorus. Postoperatively, adjuvant chemotherapy was administered for a duration of 1 year. During the third postoperative year, elevated tumor markers and lymph node enlargement prompted a diagnosis of lymph node metastasis. Subsequent chemoradiotherapy resulted in a complete response(CR), which has been sustained for 2 years without any recurrence. The outcomes of this case indicate that chemoradiotherapy stands as a viable treatment option for oligo lymphatic recurrence in gastric cancer.
    MeSH term(s) Humans ; Male ; Chemoradiotherapy ; Chemotherapy, Adjuvant ; Gastrectomy ; Lymph Node Excision ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Lymphadenopathy ; Lymphatic Metastasis ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/surgery ; Aged
    Language Japanese
    Publishing date 2024-02-01
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
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    Zs.B 2573: Show issues Location:
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  5. Article ; Online: FOXO1 stimulates tip cell-enriched gene expression in endothelial cells.

    Miyamura, Yuri / Kamei, Shunsuke / Matsuo, Misaki / Yamazaki, Masaya / Usuki, Shingo / Yasunaga, Keiichiro / Uemura, Akiyoshi / Satou, Yorifumi / Ohguchi, Hiroto / Minami, Takashi

    iScience

    2024  Volume 27, Issue 3, Page(s) 109161

    Abstract: ... ...

    Abstract Forkhead
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109161
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  6. Article: Correction to: Renal complications in coronavirus disease 2019: a systematic review.

    Minami, Taichiro / Iwata, Yasunori / Wada, Takashi

    Inflammation and regeneration

    2021  Volume 41, Issue 1, Page(s) 24

    Language English
    Publishing date 2021-07-23
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2051471-2
    ISSN 1880-9693 ; 0389-4290
    ISSN 1880-9693 ; 0389-4290
    DOI 10.1186/s41232-021-00171-w
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    Zs.B 2929: Show issues Location:
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  7. Article ; Online: In silico optimization of peptides that inhibit Wnt/β-catenin signaling.

    Fujita, Minami / Tsuchiya, Keisuke / Kurohara, Takashi / Fukuhara, Kiyoshi / Misawa, Takashi / Demizu, Yosuke

    Bioorganic & medicinal chemistry

    2023  Volume 84, Page(s) 117264

    Abstract: The Wnt/β-catenin signaling pathway causes transcriptional activation through the interaction between β-catenin and T cell-specific transcription factor (TCF) and regulates a wide variety of cellular responses, including proliferation, differentiation ... ...

    Abstract The Wnt/β-catenin signaling pathway causes transcriptional activation through the interaction between β-catenin and T cell-specific transcription factor (TCF) and regulates a wide variety of cellular responses, including proliferation, differentiation and cell motility. Excessive transcriptional activation of the Wnt/β-catenin pathway is implicated in developing or exacerbating various cancers. We have recently reported that liver receptor homolog-1 (LRH-1)-derived peptides inhibit the β-catenin/TCF interaction. In addition, we developed a cell-penetrating peptide (CPP)-conjugated LRH-1-derived peptide that inhibits the growth of colon cancer cells and specifically inhibits the Wnt/β-catenin pathway. Nonetheless, the inhibitory activity of the CPP-conjugated LRH-1-derived peptide was unsatisfactory (ca. 20 μM), and improving the bioactivity of peptide inhibitors is required for their in vivo applications. In this study, we optimized the LRH-1-derived peptide using in silico design to enhance its activity further. The newly designed peptides showed binding affinity toward β-catenin comparable to the parent peptide. In addition, the CPP-conjugated stapled peptide, Penetratin-st6, showed excellent inhibition (ca. 5 μM). Thus, the combination of in silico design by MOE and MD calculations has revealed that logical molecular design of PPI inhibitory peptides targeting β-catenin is possible. This method can be also applied to the rational design of peptide-based inhibitors targeting other proteins.
    MeSH term(s) beta Catenin/metabolism ; TCF Transcription Factors/genetics ; TCF Transcription Factors/metabolism ; Transcriptional Activation ; Wnt Proteins/metabolism ; Wnt Signaling Pathway ; Cell-Penetrating Peptides/chemistry ; Cell-Penetrating Peptides/pharmacology ; Computer Simulation
    Chemical Substances beta Catenin ; TCF Transcription Factors ; Wnt Proteins ; Cell-Penetrating Peptides ; NR5A2 protein, human
    Language English
    Publishing date 2023-03-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2023.117264
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    Zs.A 3815: Show issues Location:
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  8. Article ; Online: Did the Randomized Phase III KEYNOTE-181 Study of Pembrolizumab for Esophageal Cancer Yield Negative or Positive Results?

    Minami, Hironobu / Kiyota, Naomi / Omori, Takashi

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2021  Volume 39, Issue 20, Page(s) 2317–2318

    MeSH term(s) Antibodies, Monoclonal, Humanized/adverse effects ; Esophageal Neoplasms/drug therapy ; Humans
    Chemical Substances Antibodies, Monoclonal, Humanized ; pembrolizumab (DPT0O3T46P)
    Language English
    Publishing date 2021-04-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.20.03262
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  9. Article ; Online: Reply.

    Ono, Takashi / Mori, Yosai / Minami, Keiichiro / Miyata, Kazunori

    Cornea

    2020  Volume 40, Issue 3, Page(s) e7

    MeSH term(s) Cornea ; Humans ; Japan ; Prostheses and Implants
    Language English
    Publishing date 2020-12-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604826-2
    ISSN 1536-4798 ; 0277-3740
    ISSN (online) 1536-4798
    ISSN 0277-3740
    DOI 10.1097/ICO.0000000000002630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1790: Show issues Location:
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  10. Article ; Online: Hydroxymethylfurfural as an Intermediate of Cellulose Carbonization.

    Nomura, Takashi / Minami, Eiji / Kawamoto, Haruo

    ChemistryOpen

    2021  Volume 10, Issue 6, Page(s) 609

    Abstract: Invited for this month's cover is the group of Haruo Kawamoto at Kyoto University (Japan). The cover picture shows the carbonization pathway of cellulose via 5-hydroxymethylfurfural as an important intermediate. Thermochemical conversion is one of the ... ...

    Abstract Invited for this month's cover is the group of Haruo Kawamoto at Kyoto University (Japan). The cover picture shows the carbonization pathway of cellulose via 5-hydroxymethylfurfural as an important intermediate. Thermochemical conversion is one of the promising technologies to convert cellulose, which is the main component of lignocellulosic biomass, into biofuels and biochemicals. Understanding the molecular mechanism of thermal degradation of cellulose is important for developing efficient conversion techniques by controlling the reaction. Read the full text of their Full Paper at 10.1002/open.202000314.
    Language English
    Publishing date 2021-05-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2655605-4
    ISSN 2191-1363 ; 2191-1363
    ISSN (online) 2191-1363
    ISSN 2191-1363
    DOI 10.1002/open.202100115
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