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Article ; Online: Binge drinking alcohol with caffeinated "energy drinks", prolonged emesis and spontaneous coronary artery dissection: a case report, review of the literature and postulation of a pathomechanism.

Zacher, Jonas / May, Erik / Horlitz, Marc / Pingel, Simon

Clinical research in cardiology : official journal of the German Cardiac Society

2018 Volume 107, Issue 10, Page(s) 975–979

MeSH term(s)	Adult ; Binge Drinking/complications ; Coronary Angiography ; Coronary Vessel Anomalies/diagnosis ; Coronary Vessel Anomalies/etiology ; Coronary Vessel Anomalies/physiopathology ; Echocardiography ; Electrocardiography ; Energy Drinks/adverse effects ; Humans ; Male ; Vascular Diseases/congenital ; Vascular Diseases/diagnosis ; Vascular Diseases/etiology ; Vascular Diseases/physiopathology ; Vomiting/diagnosis ; Vomiting/etiology
Language	English
Publishing date	2018-05-04
Publishing country	Germany
Document type	Case Reports ; Letter ; Review
ZDB-ID	2213295-8
ISSN	1861-0692 ; 1861-0684
ISSN (online)	1861-0692
ISSN	1861-0684
DOI	10.1007/s00392-018-1262-y
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Article: Gene expressions in cerebral palsy subjects reveal structural and functional changes in the gastrocnemius muscle that are closely associated with passive muscle stiffness

Pingel, Jessica / Kampmann, Marie-Louise / Andersen, Jeppe Dyrberg / Wong, Christian / Døssing, Simon / Børsting, Claus / Nielsen, Jens Bo

Cell and tissue research. 2021 May, v. 384, no. 2

2021

Abstract: Cerebral palsy (CP) is a non-progressive motor disorder that affects posture and gait due to contracture development. The purpose of this study is to analyze a possible relation between muscle stiffness and gene expression levels in muscle tissue of ... ...

Abstract	Cerebral palsy (CP) is a non-progressive motor disorder that affects posture and gait due to contracture development. The purpose of this study is to analyze a possible relation between muscle stiffness and gene expression levels in muscle tissue of children with CP. Next-generation sequencing (NGS) of gene transcripts was carried out in muscle biopsies from gastrocnemius muscle (n = 13 children with CP and n = 13 typical developed (TD) children). Passive stiffness of the ankle plantarflexors was measured. Structural changes of the basement membranes and the sarcomere length were measured. Twelve pre-defined gene target sub-categories of muscle function, structure and metabolism showed significant differences between muscle tissue of CP and TD children. Passive stiffness was significantly correlated to gene expression levels of HSPG2 (p = 0.02; R² = 0.67), PRELP (p = 0.002; R² = 0.84), RYR3 (p = 0.04; R² = 0.66), C COL5A3 (p = 0.0007; R² = 0.88), ASPH (p = 0.002; R² = 0.82) and COL4A6 (p = 0.03; R² = 0.97). Morphological differences in the basement membrane were observed between children with CP and TD children. The sarcomere length was significantly increased in children with CP when compared with TD (p = 0.04). These findings show that gene targets in the categories: calcium handling, basement membrane and collagens, were significantly correlated to passive muscle stiffness. A Reactome pathway analysis showed that pathways involved in DNA repair, ECM proteoglycans and ion homeostasis were amongst the most upregulated pathways in CP, while pathways involved in collagen fibril crosslinking, collagen fibril assembly and collagen turnover were amongst the most downregulated pathways when compared with TD children. These results underline that contracture formation and motor impairment in CP is an interplay between multiple factors.
Keywords	DNA repair ; basement membrane ; calcium ; cerebral palsy ; collagen ; contracture ; crosslinking ; gait ; gene expression ; genes ; homeostasis ; metabolism ; muscles ; posture ; proteoglycans ; research ; sarcomeres
Language	English
Dates of publication	2021-05
Size	p. 513-526.
Publishing place	Springer Berlin Heidelberg
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	125067-x
ISSN	1432-0878 ; 0302-766X
ISSN (online)	1432-0878
ISSN	0302-766X
DOI	10.1007/s00441-020-03399-z
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Article ; Online: Gene expressions in cerebral palsy subjects reveal structural and functional changes in the gastrocnemius muscle that are closely associated with passive muscle stiffness.

Pingel, Jessica / Kampmann, Marie-Louise / Andersen, Jeppe Dyrberg / Wong, Christian / Døssing, Simon / Børsting, Claus / Nielsen, Jens Bo

Cell and tissue research

2021 Volume 384, Issue 2, Page(s) 513–526

Abstract	Cerebral palsy (CP) is a non-progressive motor disorder that affects posture and gait due to contracture development. The purpose of this study is to analyze a possible relation between muscle stiffness and gene expression levels in muscle tissue of children with CP. Next-generation sequencing (NGS) of gene transcripts was carried out in muscle biopsies from gastrocnemius muscle (n = 13 children with CP and n = 13 typical developed (TD) children). Passive stiffness of the ankle plantarflexors was measured. Structural changes of the basement membranes and the sarcomere length were measured. Twelve pre-defined gene target sub-categories of muscle function, structure and metabolism showed significant differences between muscle tissue of CP and TD children. Passive stiffness was significantly correlated to gene expression levels of HSPG2 (p = 0.02; R
MeSH term(s)	Cerebral Palsy/genetics ; Cerebral Palsy/pathology ; Child ; Child, Preschool ; Gene Expression/genetics ; Humans ; Muscle Strength/physiology ; Muscle, Skeletal/pathology
Language	English
Publishing date	2021-01-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	125067-x
ISSN	1432-0878 ; 0302-766X
ISSN (online)	1432-0878
ISSN	0302-766X
DOI	10.1007/s00441-020-03399-z
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Article ; Online: Long-term incidence of upper extremity venous obstruction in implantable cardioverter defibrillator patients.

Horlbeck, Fritz W / Eckerth, Christopher / Linhart, Markus / Schaefer, Christian / Jakob, Mark / Pingel, Simon / Klarmann-Schulz, Ute / Nickenig, Georg / Schwab, Joerg O

Pacing and clinical electrophysiology : PACE

2021 Volume 44, Issue 6, Page(s) 1027–1032

Abstract: Background: Very little is known about the long-term prevalence of severe venous obstruction and occlusion in patients with transvenous implantable cardioverter-defibrillator leads. The objective of the current investigation was to elucidate the ... ...

Abstract	Background: Very little is known about the long-term prevalence of severe venous obstruction and occlusion in patients with transvenous implantable cardioverter-defibrillator leads. The objective of the current investigation was to elucidate the incidence and prevalence and to identify predisposing conditions in an ICD cohort over a long follow-up period. Methods: Based on a prospective database, we analyzed consecutive patients who received an ICD implantation in our hospital between 06/1988 and 2009 as well as all corresponding follow-up data until 02/2018. Cavographies were used for analysis, and all patients with at least one device replacement and one follow-up cavography were included. Results: Over a mean follow-up period of 94 ± 50 months, severe venous obstruction was found in 147 (33%) of 448 patients. Kaplan-Meier analysis shows a severe obstruction or occlusion in 50% of patients after a period of 14.3 years. The total number of leads (p < .001, HR 2.01, CI 2.000-2.022), an advanced age (p = .004, HR 1.023 per year, CI 1.022-1.024) and the presence of dilated cardiomyopathy (p = .035, HR 1.49, CI 1.47-1.51) were predictive of venous obstruction whereas the presence of anticoagulation was not. Conclusion: Severe obstruction of the access veins after ICD implantation occurs frequently and its prevalence shows a nearly linear increase over long-time follow-up. Multiple leads, an advanced age and DCM as underlying disease are associated with an increased risk of venous obstruction while the role of anticoagulation to prevent venous obstruction in ICD patients is unclear.
MeSH term(s)	Constriction, Pathologic/epidemiology ; Constriction, Pathologic/etiology ; Defibrillators, Implantable/adverse effects ; Female ; Germany/epidemiology ; Humans ; Incidence ; Male ; Middle Aged ; Peripheral Vascular Diseases/epidemiology ; Peripheral Vascular Diseases/etiology ; Prospective Studies ; Upper Extremity/blood supply
Language	English
Publishing date	2021-05-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	424437-0
ISSN	1540-8159 ; 0147-8389
ISSN (online)	1540-8159
ISSN	0147-8389
DOI	10.1111/pace.14266
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Book ; Online ; Thesis: Retrospektive Analyse potentieller Beeinflussungsmodelle auf die Reoperationsrate nach mechanischem und biologischem Herzklappenersatz

Pingel, Simon [Verfasser]

2009

Author's details	vorgelegt von Simon Bernd Pingel
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: TAVR outcome after reclassification of aortic valve stenosis by using a hybrid continuity equation that combines computed tomography and echocardiography data.

Weber, Marcel / Jaenisch, Max / Spilker, Marie / Pingel, Simon / Schueler, Robert / Stundl, Anja / Sedaghat, Alexander / Hammerstingl, Christoph / Mellert, Fritz / Grube, Eberhard / Nickenig, Georg / Werner, Nikos / Sinning, Jan-Malte

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

2020 Volume 96, Issue 4, Page(s) 958–967

Abstract: Background: In the continuity equation, assumption of a round-shaped left ventricular outflow tract (LVOT) leads to underestimation of the true aortic valve area in two-dimensional echocardiography. The current study evaluated whether inclusion of the ... ...

Abstract	Background: In the continuity equation, assumption of a round-shaped left ventricular outflow tract (LVOT) leads to underestimation of the true aortic valve area in two-dimensional echocardiography. The current study evaluated whether inclusion of the LVOT area, as measured by computed tomography (CT), reclassifies the degree of aortic stenosis (AS) and assessed the impact on patient outcome after transcatheter aortic valve replacement (TAVR). Methods and results: Four hundred and twenty-two patients with indexed aortic valve area index (AVAi) of <0.6 cm Conclusion: The hybrid AVAi reclassifies a significant portion of low-gradient severe AS patients into moderate AS. Reclassified patients showed increased fibrosis and heart failure markers at baseline compared to non-reclassified patients. But reclassification had no significant impact on mortality up to 2 years after TAVR. Routine assessment of hybrid AVAi seems not to improve further risk stratification of TAVR patients.
MeSH term(s)	Aged ; Aged, 80 and over ; Aortic Valve/diagnostic imaging ; Aortic Valve/physiopathology ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/mortality ; Aortic Valve Stenosis/physiopathology ; Aortic Valve Stenosis/surgery ; Clinical Decision-Making ; Decision Support Techniques ; Echocardiography, Doppler, Pulsed ; Female ; Humans ; Male ; Multidetector Computed Tomography ; Postoperative Complications/mortality ; Predictive Value of Tests ; Recovery of Function ; Registries ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Time Factors ; Transcatheter Aortic Valve Replacement/adverse effects ; Transcatheter Aortic Valve Replacement/mortality ; Treatment Outcome
Language	English
Publishing date	2020-03-19
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/ccd.28852
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Article ; Online: Systemic inflammatory markers in individuals with cerebral palsy

Jessica Pingel / Lee Barber / Ida Torp Andersen / Ferdinand Von Walden / Christian Wong / Simon Døssing / Jens Bo Nielsen

European Journal of Inflammation, Vol

2019 Volume 17

Abstract: Individuals with cerebral palsy (CP) develop skeletal muscle contractures that impair muscle function. In turn, contractures affect the ability to ambulate and often promote a sedentary lifestyle. The aim of the present study was to investigate the ... ...

Abstract	Individuals with cerebral palsy (CP) develop skeletal muscle contractures that impair muscle function. In turn, contractures affect the ability to ambulate and often promote a sedentary lifestyle. The aim of the present study was to investigate the systemic inflammatory markers transforming growth factor beta-1 (TGFβ1), C-reactive protein (CRP), and interleukin-6 (IL-6) in children and adults with CP. Blood samples of n = 34 participants (24 individuals with CP (n = 14 children with CP age 10.36 ± 1.1 and n = 10 adults with CP age 38.80 ± 3.6) and 10 healthy adults age 36.63 ± 3.8) were analyzed for circulating levels of TGFβ1, CRP, and IL-6 using Sandwich Enzyme linked immunosorbent assay (ELISA) analyses (R&D systems). TGFβ1 and CRP levels were significantly higher in children with CP compared to both adults with CP (TGFβ1: P < 0.0005 and P < 0.0002, respectively) and healthy adults (CRP: P < 0.0001 and P < 0.0001, respectively), while no differences were observed between the adults with CP and healthy adults in TGFβ1 ( P = 0.29) and CRP ( P = 0.59), respectively. Furthermore, IL-6 levels showed no significant differences between the groups. The present findings indicate that the level of systemic inflammation is increased in children with CP. We speculate that persisting inflammation in children with CP might influence the development of muscle contractures, resulting in reduced muscle mass and marked muscle weakness in adults with CP.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Ein verzwicktes Schneckenrennen

Pingel, Stefanie

ein Lese- und Mitmachbuch für Kinder mit Illustrationen von Simone Zoll

(Garten der Kindheit)

2009

Author's details	Stefanie Pingel
Series title	Garten der Kindheit
Size	52 Seiten: Illustrationen
Publisher	Books on Demand; Norderstedt
Document type	Book
HBZ-ID	HT017502705
ISBN	978-3-8370-9975-1 ; 3-8370-9975-X
Database	Central Library of Sport Science of the German Sport University Cologne

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Article ; Online: Asthma is associated with atherosclerotic artery changes.

Tuleta, Izabela / Skowasch, Dirk / Aurich, Florian / Eckstein, Nicolas / Schueler, Robert / Pizarro, Carmen / Schahab, Nadjib / Nickenig, Georg / Schaefer, Christian / Pingel, Simon

PloS one

2017 Volume 12, Issue 10, Page(s) e0186820

Abstract: Asthma is a chronic airway inflammation with a potential systemic impact. Atherosclerosis is a chronic inflammatory artery disease. The aim of our study was to prove if there is a correlation between the occurrence of asthma and increased atherosclerotic ...

Abstract	Asthma is a chronic airway inflammation with a potential systemic impact. Atherosclerosis is a chronic inflammatory artery disease. The aim of our study was to prove if there is a correlation between the occurrence of asthma and increased atherosclerotic vessel disorders. Vessel status was compared between mild-to-moderate, severe allergic asthma and matched controls. Measurements of artery stiffness were calculated by central pulse wave velocity, ultrasonographic strain imaging and ankle-brachial index. Atherosclerotic plaque burden was assessed by colour-coded duplex sonography. Additionally, analysis of cardiovascular and asthma blood markers was conducted. Arterial stiffness expressed as an increased central pulse wave velocity and decreased circumferential and radial strains as well as the prevalence of media sclerosis were significantly higher among asthma patients compared to controls. Atherosclerotic plaque burden was relevantly increased in asthma groups vs. controls (severe asthma: 43.1%, mild-to-moderate asthma: 25.0%, control: 14.3% of study participants). Except for the elevated IgE and fibrinogen concentrations as well as leukocyte number there were no relevant differences in the blood parameters between the groups. Allergic asthma is associated with distinct atherosclerotic artery changes compared to the respectively matched control collective. The severity of asthma correlates with more pronounced pathological vessel alternations.
MeSH term(s)	Adult ; Arteries/diagnostic imaging ; Arteries/metabolism ; Arteries/physiopathology ; Asthma/blood ; Asthma/complications ; Asthma/diagnostic imaging ; Asthma/physiopathology ; Atherosclerosis/blood ; Atherosclerosis/diagnostic imaging ; Atherosclerosis/etiology ; Atherosclerosis/physiopathology ; Biomarkers/blood ; Female ; Fibrinogen/metabolism ; Humans ; Immunoglobulin E/blood ; Leukocyte Count ; Male ; Middle Aged ; Pulse Wave Analysis ; Ultrasonography, Doppler, Duplex
Chemical Substances	Biomarkers ; Immunoglobulin E (37341-29-0) ; Fibrinogen (9001-32-5)
Language	English
Publishing date	2017
Publishing country	United States
Document type	Clinical Trial ; Comparative Study ; Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0186820
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: High prevalence of COPD in atherosclerosis patients.

Tuleta, Izabela / Farrag, Tarik / Busse, Laura / Pizarro, Carmen / Schaefer, Christian / Pingel, Simon / Nickenig, Georg / Skowasch, Dirk / Schahab, Nadjib

International journal of chronic obstructive pulmonary disease

2017 Volume 12, Page(s) 3047–3053

Abstract: Atherosclerosis and COPD are both systemic inflammatory diseases that may influence each other. The aim of the present study was to determine the prevalence of COPD in patients with cerebral and/or peripheral artery disease and to assess factors ... ...

Abstract	Atherosclerosis and COPD are both systemic inflammatory diseases that may influence each other. The aim of the present study was to determine the prevalence of COPD in patients with cerebral and/or peripheral artery disease and to assess factors associated with the presence of COPD. Following the diagnosis of cerebral and/or peripheral artery disease by means of duplex sonography, 166 consecutive patients underwent body plethysmography with capillary blood gas analysis. Thereafter, blood tests with determination of different parameters such as lipid profile, inflammatory and coagulation markers were conducted in remaining 136 patients who fulfilled inclusion criteria of the study. Thirty-six out of 136 patients suffered from COPD, mostly in early stages of the disease. Residual volume indicating emphysema was increased (162.9%±55.9% vs 124.5%±37.0%,
MeSH term(s)	Aged ; Aged, 80 and over ; Anemia/epidemiology ; Biomarkers/blood ; Comorbidity ; Diabetes Mellitus/epidemiology ; Female ; Forced Expiratory Volume ; Germany/epidemiology ; Humans ; Inflammation/epidemiology ; Inflammation Mediators/blood ; Intracranial Arteriosclerosis/blood ; Intracranial Arteriosclerosis/diagnosis ; Intracranial Arteriosclerosis/epidemiology ; Lung/physiopathology ; Male ; Middle Aged ; Peripheral Arterial Disease/blood ; Peripheral Arterial Disease/diagnosis ; Peripheral Arterial Disease/epidemiology ; Prevalence ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Risk Factors ; Vital Capacity
Chemical Substances	Biomarkers ; Inflammation Mediators
Language	English
Publishing date	2017-10-19
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2212419-6
ISSN	1178-2005 ; 1176-9106
ISSN (online)	1178-2005
ISSN	1176-9106
DOI	10.2147/COPD.S141988
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