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  1. Article ; Online: Thromboembolic Findings in COVID-19 Autopsies: Pulmonary Thrombosis or Embolism?

    Deshpande, Charuhas

    Annals of internal medicine

    2020  Volume 173, Issue 5, Page(s) 394–395

    MeSH term(s) Autopsy ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Embolism ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Thromboembolism
    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M20-3255
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.178/2: Show issues Location:
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  3. Article ; Online: Anterior Mediastinal Neuroblastoma Associated with Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Morphologic, Immunohistochemical, and Genetic Case Report and Review of the Literature.

    Kennedy, Gregory T / Sande, Christopher M / Surrey, Lea F / Azari, Feredun S / Deshpande, Charuhas / Singhal, Sunil

    International journal of surgical pathology

    2022  Volume 30, Issue 6, Page(s) 689–696

    Abstract: We report a mediastinal neuroblastoma in an octogenarian with paraneoplastic syndrome of inappropriate antidiuretic hormone secretion (SIADH). Neuroblastomas are very rare tumors in adults, with thoracic or mediastinal locations being especially uncommon. ...

    Abstract We report a mediastinal neuroblastoma in an octogenarian with paraneoplastic syndrome of inappropriate antidiuretic hormone secretion (SIADH). Neuroblastomas are very rare tumors in adults, with thoracic or mediastinal locations being especially uncommon. These neoplasms have been occasionally associated with the SIADH. Given the rarity of incidence and paucity of diagnostic and outcomes data, the significance of standard neuroblastoma prognostic characteristics is unclear, and no treatment paradigms exist for these patients. Further studies are needed to inform future clinical guidelines.
    MeSH term(s) Adult ; Aged, 80 and over ; Humans ; Inappropriate ADH Syndrome/complications ; Inappropriate ADH Syndrome/diagnosis ; Mediastinal Neoplasms/complications ; Neuroblastoma/complications ; Neuroblastoma/diagnosis ; Vasopressins/therapeutic use
    Chemical Substances Vasopressins (11000-17-2)
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/10668969221080061
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4500: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Epithelial cell size dysregulation in human lung adenocarcinoma.

    Sandlin, Clifford W / Gu, Song / Xu, Jun / Deshpande, Charuhas / Feldman, Michael D / Good, Matthew C

    PloS one

    2022  Volume 17, Issue 10, Page(s) e0274091

    Abstract: Human cells tightly control their dimensions, but in some cancers, normal cell size control is lost. In this study we measure cell volumes of epithelial cells from human lung adenocarcinoma progression in situ. By leveraging artificial intelligence (AI), ...

    Abstract Human cells tightly control their dimensions, but in some cancers, normal cell size control is lost. In this study we measure cell volumes of epithelial cells from human lung adenocarcinoma progression in situ. By leveraging artificial intelligence (AI), we reconstruct tumor cell shapes in three dimensions (3D) and find airway type 2 cells display up to 10-fold increases in volume. Surprisingly, cell size increase is not caused by altered ploidy, and up to 80% of near-euploid tumor cells show abnormal sizes. Size dysregulation is not explained by cell swelling or senescence because cells maintain cytoplasmic density and proper organelle size scaling, but is correlated with changes in tissue organization and loss of a novel network of processes that appear to connect alveolar type 2 cells. To validate size dysregulation in near-euploid cells, we sorted cells from tumor single-cell suspensions on the basis of size. Our study provides data of unprecedented detail for cell volume dysregulation in a human cancer. Broadly, loss of size control may be a common feature of lung adenocarcinomas in humans and mice that is relevant to disease and identification of these cells provides a useful model for investigating cell size control and consequences of cell size dysregulation.
    MeSH term(s) Adenocarcinoma of Lung ; Alveolar Epithelial Cells/metabolism ; Animals ; Artificial Intelligence ; Cell Size ; Humans ; Lung Neoplasms/pathology ; Mice
    Language English
    Publishing date 2022-10-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0274091
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  5. Article ; Online: Severe Acute Cellular Rejection With High-Grade Lymphocytic Bronchiolitis Following Transition from Tacrolimus to Belatacept in a Lung Transplantation Recipient: A Case Report.

    Nachiappan, Arun / Fallah, Tara / Willert, Rebecca / Chojnowski, Donna / Deshpande, Charuhas / Courtwright, Andrew

    Transplantation proceedings

    2021  Volume 54, Issue 1, Page(s) 165–168

    Abstract: This case report describes a lung transplantation recipient who developed severe acute cellular rejection with high-grade lymphocytic bronchiolitis after transition to a calcineurin-free regimen using belatacept. A 53-year-old man who had undergone lung ... ...

    Abstract This case report describes a lung transplantation recipient who developed severe acute cellular rejection with high-grade lymphocytic bronchiolitis after transition to a calcineurin-free regimen using belatacept. A 53-year-old man who had undergone lung transplantation 3 years prior developed progressive chronic kidney disease related to tacrolimus. He was transitioned off tacrolimus to belatacept to prevent the need for dialysis. He was admitted 2 months later with acute hypoxemic respiratory failure. Video-assisted thoracic surgery biopsy showed acute fibrinous and organizing pneumonia and A4B2 rejection. He subsequently developed chronic lung allograft dysfunction. This case illustrates the potential increased risk of acute rejection associated with belatacept maintenance immunosuppression.
    MeSH term(s) Abatacept ; Bronchiolitis ; Graft Rejection/prevention & control ; Graft Survival ; Humans ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation/adverse effects ; Lung ; Lung Transplantation/adverse effects ; Male ; Middle Aged ; Renal Dialysis ; Tacrolimus/adverse effects
    Chemical Substances Immunosuppressive Agents ; Abatacept (7D0YB67S97) ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2021-10-28
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2021.08.051
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 835: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Diagnosis of cardiac amyloidosis in patients undergoing catheter ablation for atrial arrhythmias.

    Liang, Jackson J / Frankel, David S / Pieretti, Janice / Deshpande, Charuhas / Nazarian, Saman

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

    2020  Volume 57, Issue 3, Page(s) 489–490

    MeSH term(s) Amyloidosis/diagnostic imaging ; Amyloidosis/surgery ; Arrhythmias, Cardiac/surgery ; Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/surgery ; Catheter Ablation ; Humans
    Language English
    Publishing date 2020-03-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1329179-8
    ISSN 1572-8595 ; 1383-875X
    ISSN (online) 1572-8595
    ISSN 1383-875X
    DOI 10.1007/s10840-020-00719-9
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    Zs.A 5214: Show issues Location:
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  7. Article: Pulmonary adenomyoma presenting as a right cardiophrenic angle mass.

    Iyalomhe, Osigbemhe / Sadigh, Sam / Deshpande, Charuhas / Litzky, Leslie / Moran, Anna / Simpson, Scott

    Radiology case reports

    2020  Volume 15, Issue 5, Page(s) 502–506

    Abstract: Pulmonary adenomyomas are rare adenomyomatous hamartomas. In the few cases described in the literature, these benign tumors are encapsulated by lung parenchyma. We describe a case of a 59 year-old woman with acetylcholine receptor antibody-negative ... ...

    Abstract Pulmonary adenomyomas are rare adenomyomatous hamartomas. In the few cases described in the literature, these benign tumors are encapsulated by lung parenchyma. We describe a case of a 59 year-old woman with acetylcholine receptor antibody-negative myasthenia gravis and a right cardiophrenic mass initially thought to be a thymoma. Histopathology surprisingly revealed a pulmonary adenomyoma which involved the mediastinal fat at the cardiophrenic angle.
    Language English
    Publishing date 2020-02-26
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2019.12.025
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  8. Article ; Online: Three-Dimensional Near-Infrared Specimen Mapping Can Identify the Distance from the Tumor to the Surgical Margin During Resection of Pulmonary Ground Glass Opacities.

    Kennedy, Gregory T / Azari, Feredun S / Bernstein, Elizabeth / Deshpande, Charuhas / Kucharczuk, John C / Delikatny, Edward J / Singhal, Sunil

    Molecular imaging and biology

    2022  Volume 25, Issue 1, Page(s) 203–211

    Abstract: Background: Lung cancers can recur locally due to inadequate resection margins. Achieving adequate margin distances is challenging in pulmonary ground glass opacities (GGOs) because they are not easily palpable. To improve margin assessment during ... ...

    Abstract Background: Lung cancers can recur locally due to inadequate resection margins. Achieving adequate margin distances is challenging in pulmonary ground glass opacities (GGOs) because they are not easily palpable. To improve margin assessment during resection of GGOs, we propose a novel technique, three-dimensional near-infrared specimen mapping (3D-NSM).
    Methods: Twenty patients with a cT1 GGO were enrolled and received a fluorescent tracer preoperatively. After resection, specimens underwent 3D-NSM in the operating room. Margins were graded as positive or negative based upon fluorescence at the staple line. Images were analyzed using ImageJ to quantify the distance from the tumor edge to the nearest staple line. This margin distance calculated by 3D-NSM was compared to the margin distance reported on final pathology several days postoperatively.
    Results: 3D-NSM identified 20/20 GGOs with no false positive or false negative diagnoses. Mean fluorescence intensity for lesions was 110.92 arbitrary units (A.U.) (IQR: 77.77-122.03 A.U.) compared to 23.68 A.U. (IQR: 19.60-27.06 A.U.) for background lung parenchyma (p < 0.0001). There were 4 tumor-positive or close margins in the study cohort, and all 4 (100%) were identified by 3D-NSM. 3D-NSM margin distances were nearly identical to margin distances reported on final pathology (R
    Conclusions: 3D-NSM rapidly localizes GGOs by fluorescence and detects tumor-positive or close surgical margins. 3D-NSM can accurately quantify the resection margin distance as compared to formal pathology, which allows surgeons to rapidly determine whether sublobar resection margin distances are adequate.
    MeSH term(s) Humans ; Margins of Excision ; Lung/pathology ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/surgery ; Lung Neoplasms/pathology
    Language English
    Publishing date 2022-07-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2079160-4
    ISSN 1860-2002 ; 1536-1632
    ISSN (online) 1860-2002
    ISSN 1536-1632
    DOI 10.1007/s11307-022-01750-0
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    Zs.A 6468: Show issues Location:
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  9. Article ; Online: Invasive Aspergillosis Causing Aortic Pseudoaneurysm and Endocarditis After Heart Transplantation.

    Reza, Nosheen / Genuardi, Michael V / Weikert, Blair C / McLean, Rhondalyn / Deshpande, Charuhas / Jagasia, Dinesh / Tiku Owens, Anjali

    Circulation. Cardiovascular imaging

    2021  Volume 14, Issue 6, Page(s) e012370

    MeSH term(s) Adult ; Aneurysm, False/diagnosis ; Aneurysm, False/etiology ; Aneurysm, Infected/diagnosis ; Aneurysm, Infected/etiology ; Aorta, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/complications ; Aortic Aneurysm, Thoracic/diagnosis ; Aspergillosis/diagnosis ; Aspergillosis/etiology ; Biopsy ; Endocarditis/diagnosis ; Endocarditis/etiology ; Heart Transplantation/adverse effects ; Humans ; Male ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-06-04
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2435045-X
    ISSN 1942-0080 ; 1941-9651
    ISSN (online) 1942-0080
    ISSN 1941-9651
    DOI 10.1161/CIRCIMAGING.120.012370
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    Zs.A 6743: Show issues Location:
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  10. Article ; Online: Molecular imaging can identify the location to perform a frozen biopsy during intraoperative frozen section consultation.

    Bryski, Mitchell G / Frenzel-Sulyok, Lydia G / Delikatny, E James / Deshpande, Charuhas / Litzky, Leslie A / Singhal, Sunil

    PloS one

    2021  Volume 16, Issue 6, Page(s) e0252731

    Abstract: Background: Intraoperative frozen section (FS) consultation is an important tool in surgical oncology that suffers from sampling error because the pathologist does not always know where to perform a biopsy of the surgical specimen. Intraoperative ... ...

    Abstract Background: Intraoperative frozen section (FS) consultation is an important tool in surgical oncology that suffers from sampling error because the pathologist does not always know where to perform a biopsy of the surgical specimen. Intraoperative molecular imaging is a technology used in the OR to visualize lesions during surgery. We hypothesized that molecular imaging can address this pathology challenge in FS by visualizing the cancer cells in the specimen in the pathology suite. Here, we report the development and validation of a molecular-imaging capable cryostat called Smart-Cut.
    Methods: A molecular imaging capable cryostat prototype was developed and tested using a murine model. Tumors grown in mice were targeted with a NIR contrast agent, indocyanine green (ICG), via tail vein injection. Tumors and adjacent normal tissue samples were frozen sectioned with Smart-Cut. Fluorescent sections and non-fluorescent sections were prepared for H&E and fluorescent microscopy. Fluorescent signal was quantified by tumor-to-background ratio (TBR). NIR fluorescence was tested in one patient enrolled in a clinical trial.
    Results: The Smart-Cut prototype has a small footprint and fits well in the pathology suite. Fluorescence imaging with Smart-Cut identified cancerous tissue in the specimen in all 12 mice. No false positives or false negatives were seen, as confirmed by H&E. The mean TBR in Smart-Cut positive tissue sections was 6.8 (SD±3.8). In a clinical application in the pathology suite, NIR imaging identified two lesions in a pulmonary resection specimen, where traditional grossing only identified one.
    Conclusion: Molecular imaging can be integrated into the pathology suite via the Smart-Cut device, and can detect cancer in frozen tissue sections using molecular imaging in a murine model.
    MeSH term(s) Animals ; Biopsy ; Frozen Sections ; Humans ; Mice ; Molecular Imaging ; Optical Imaging
    Language English
    Publishing date 2021-06-04
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0252731
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