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  1. Article: Indications, evidence, and controversy in the closure of the left atrial appendage.

    Patti, Giuseppe / Ghiglieno, Chiara

    European heart journal supplements : journal of the European Society of Cardiology

    2023  Volume 25, Issue Suppl B, Page(s) B126–B130

    Abstract: Closure of the left atrial appendage (LAAO) represents a valid option for the prevention of cardio-embolic stroke in patients with atrial fibrillation (AF) at high bleeding risk. Previous studies had shown that the atrial appendage represents the site of ...

    Abstract Closure of the left atrial appendage (LAAO) represents a valid option for the prevention of cardio-embolic stroke in patients with atrial fibrillation (AF) at high bleeding risk. Previous studies had shown that the atrial appendage represents the site of atrial thrombus formation in about 90% of cases in the presence of non-valvular AF. In all patients with AF and higher thromboembolic risk (in particular with CHA2DS2VASc score ≥2 in women and ≥1 in men) there is an indication for thromboembolic prophylaxis with AOC (oral anti-coagulants). The main guidelines and international consensus documents place the indication for the LAAO in patients with the need for thromboembolic prophylaxis who have contraindications to oral anticoagulant therapy (class of recommendation IIb).
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1463769-8
    ISSN 1554-2815 ; 1520-765X
    ISSN (online) 1554-2815
    ISSN 1520-765X
    DOI 10.1093/eurheartjsupp/suad091
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    Zs.A 1563 -Suppl.-: Show issues Location:
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  2. Article ; Online: Intracardiac Versus Transesophageal Echocardiography for Assisting Percutaneous Left Atrial Appendage Occlusion?: "Veni, vidi, vICE"!

    Patti, Giuseppe

    JACC. Cardiovascular interventions

    2019  Volume 12, Issue 11, Page(s) 1040–1043

    MeSH term(s) Atrial Appendage ; Atrial Fibrillation ; Echocardiography, Transesophageal ; Humans ; Septal Occluder Device ; Treatment Outcome
    Language English
    Publishing date 2019-06-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2019.04.031
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    Zs.A 6669: Show issues Location:
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  3. Article ; Online: A machine-learning-based prediction model in patients with takotsubo syndrome: 'You can't stop change any more than you can stop the suns from setting!'

    D'Amario, Domenico / Borovac, Josip Angelo / Patti, Giuseppe

    European journal of heart failure

    2023  Volume 25, Issue 12, Page(s) 2312–2315

    MeSH term(s) Humans ; Takotsubo Cardiomyopathy/diagnosis ; Heart Failure
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Editorial
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.3069
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    Zs.A 5299: Show issues Location:
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  4. Article: Why can primary angioplastics be ineffective despite the precocity of the intervention?

    Patti, Giuseppe / Ghiglieno, Chiara

    European heart journal supplements : journal of the European Society of Cardiology

    2022  Volume 24, Issue Suppl I, Page(s) I114–I118

    Abstract: Early coronary revascularization is a first choice therapeutic strategy in the case of acute myocardial infarction (MI). Despite an early coronary angioplasty, however, in some cases, there is a lower efficacy of revascularization, with less favourable ... ...

    Abstract Early coronary revascularization is a first choice therapeutic strategy in the case of acute myocardial infarction (MI). Despite an early coronary angioplasty, however, in some cases, there is a lower efficacy of revascularization, with less favourable clinical outcome in the short and long terms. Various elements participate in the distant prognosis after primary coronary angioplasty (PCI). Among the clinical risk factors that predispose to a recurrence of ischaemic cardiovascular events are advanced age, diabetes mellitus, chronic renal failure, peripheral vascular disease, atrial fibrillation and the multiplicity of cardiovascular risk factors, which identify a higher baseline risk profile. The risk factors associated with the percutaneous interventional procedure include the presence of diffuse or complex coronary lesions, the use of small diameter stents or a suboptimal post procedural thrombolysis in MI flow. The occurrence of procedural complications, such as no-reflow, is in fact associated with an increase in the infarct area and a worse prognosis, as it favours negative ventricular remodelling. The presence of concomitant right ventricular dysfunction, the high ventricular arrhythmic burden in the acute phase, the presence of risk factors for thrombosis or intra-stent restenosis also affect the outcome after primary PCI.
    Language English
    Publishing date 2022-11-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1463769-8
    ISSN 1554-2815 ; 1520-765X
    ISSN (online) 1554-2815
    ISSN 1520-765X
    DOI 10.1093/eurheartjsupp/suac102
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    Zs.A 1563 -Suppl.-: Show issues Location:
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  5. Article ; Online: COVID-19 vaccine-induced cutaneous lupus erythematosus.

    Famularo, Giuseppe / Patti, Anna Linda / Macciomei, Maria Cristina

    Dermatology online journal

    2023  Volume 29, Issue 5

    MeSH term(s) Humans ; COVID-19 Vaccines/adverse effects ; COVID-19/prevention & control ; Lupus Erythematosus, Cutaneous/chemically induced ; Skin ; Lupus Erythematosus, Systemic
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-10-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2026239-5
    ISSN 1087-2108 ; 1087-2108
    ISSN (online) 1087-2108
    ISSN 1087-2108
    DOI 10.5070/D329562421
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  6. Article ; Online: Variability of the anticoagulant effect according to body weight in patients treated with direct oral anticoagulants.

    Belli, Lorenzo / Radico, Francesco / Auciello, Raffaella / Patti, Giuseppe / Gallina, Sabina / Renda, Giulia

    Internal and emergency medicine

    2024  

    Language English
    Publishing date 2024-02-09
    Publishing country Italy
    Document type Letter
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-024-03553-3
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    Zs.A 6673: Show issues Location:
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  7. Article ; Online: Patients with atrial fibrillation and coronary events: are we any closer to coming out from the labyrinth of the various antithrombotic strategies?

    Patti, Giuseppe

    Heart (British Cardiac Society)

    2017  Volume 104, Issue 11, Page(s) 878–879

    MeSH term(s) Anticoagulants ; Atrial Fibrillation ; Fibrinolytic Agents ; Humans
    Chemical Substances Anticoagulants ; Fibrinolytic Agents
    Language English
    Publishing date 2017-11-25
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2017-312576
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  8. Article ; Online: Massive myocardial infiltration by primary anaplastic T-cell lymphoma: a case report.

    Cumitini, Luca / Rossi, Lidia / Giubertoni, Ailia / Patti, Giuseppe

    European heart journal. Case reports

    2023  Volume 7, Issue 5, Page(s) ytad234

    Abstract: Background: Myocardial infiltration by primary cardiac neoplasm is a rare entity, providing diagnostic and therapeutic challenges. The pathological spectrum includes more frequently benign forms. Refractory heart failure, pericardial effusion, and ... ...

    Abstract Background: Myocardial infiltration by primary cardiac neoplasm is a rare entity, providing diagnostic and therapeutic challenges. The pathological spectrum includes more frequently benign forms. Refractory heart failure, pericardial effusion, and arrhythmias due to infiltrative mass are the most common clinical manifestations.
    Case summary: We describe the case of a 35-year-old man complaining of shortness of breath and weight loss in the last 2 months. A previous acute myeloid leukaemia treated with allogenic bone marrow transplant was reported. Transthoracic echocardiography revealed an apical thrombus in the left ventricle, with inferior and septal hypokinesia conditioning a mildly reduced ejection fraction, circumferential pericardial effusion, and abnormal right ventricular thickening. Cardiac magnetic resonance confirmed diffuse thickening of the right ventricular free wall due to myocardial infiltration. Positron emission tomography showed the presence of neoplastic tissue with increased metabolic activity. A pericardiectomy was performed showing a widespread cardiac neoplastic infiltration. Histopathological analysis done on right ventricular pathological samples obtained during cardiac surgery revealed the presence of a rare and aggressive cardiac anaplastic T-cell non-Hodgkin lymphoma. Few days after the operation, the patient developed refractory cardiogenic shock and unluckily died before initiating an adequate antineoplastic therapy.
    Discussion: Primary cardiac lymphoma is not frequent, and the lack of specific symptoms makes the diagnosis extremely challenging and often limited to autopsy findings. Our case highlights the importance of an appropriate diagnostic algorithm, requiring non-invasive multimodality assessment imaging and then invasive cardiac biopsy. This approach may allow an early diagnosis and an adequate therapy for this otherwise fatal pathology.
    Language English
    Publishing date 2023-05-09
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytad234
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  9. Article ; Online: Impaired Culprit-Vessel Flow Affects Percutaneous Coronary Intervention Outcomes in Spontaneous Coronary Artery Dissections.

    Benenati, Stefano / Giacobbe, Federico / Macaya, Fernando / Patti, Giuseppe / Musumeci, Giuseppe / Gonzalo, Nieves / Escaned, Javier / Varbella, Ferdinando / Cerrato, Enrico / Porto, Italo

    The American journal of cardiology

    2024  Volume 219, Page(s) 35–37

    MeSH term(s) Humans ; Percutaneous Coronary Intervention/methods ; Coronary Vessel Anomalies/surgery ; Coronary Vessel Anomalies/physiopathology ; Coronary Vessel Anomalies/diagnosis ; Male ; Vascular Diseases/congenital ; Vascular Diseases/physiopathology ; Vascular Diseases/surgery ; Female ; Middle Aged ; Coronary Angiography ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/physiopathology ; Coronary Vessels/surgery ; Coronary Circulation/physiology ; Treatment Outcome ; Adult
    Language English
    Publishing date 2024-03-16
    Publishing country United States
    Document type Letter ; Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2024.03.014
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  10. Article: Left Atrial Appendage Occlusion and Post-procedural Antithrombotic Management.

    Kramer, Anders / Patti, Giuseppe / Nielsen-Kudsk, Jens Erik / Berti, Sergio / Korsholm, Kasper

    Journal of clinical medicine

    2024  Volume 13, Issue 3

    Abstract: Left atrial appendage occlusion (LAAO) is an established alternative to oral anticoagulation for stroke prevention in atrial fibrillation. Antithrombotic therapy is used in the post-procedural period to prevent device-related thrombosis (DRT). The risk ... ...

    Abstract Left atrial appendage occlusion (LAAO) is an established alternative to oral anticoagulation for stroke prevention in atrial fibrillation. Antithrombotic therapy is used in the post-procedural period to prevent device-related thrombosis (DRT). The risk of DRT is considered highest in the first 45-90 days after device implantation, based on animal studies of the device healing process. Clinically applied antithrombotic regimens vary greatly across studies, continents, and centers. This article gives an overview of the evidence behind current antithrombotic regimens, ongoing randomized trials, and future post-procedural management.
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13030803
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