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Article ; Online: Study of Pressure Distribution in Floor Tiles with Printed P(VDF:TrFE) Sensors for Smart Surface Applications.

Alvarez Rueda, Asier / Schäffner, Philipp / Petritz, Andreas / Groten, Jonas / Tschepp, Andreas / Petersen, Frank / Zirkl, Martin / Stadlober, Barbara

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 2

Abstract: Pressure sensors integrated in surfaces, such as the floor, can enable movement, event, and object detection with relatively little effort and without raising privacy concerns, such as video surveillance. Usually, this requires a distributed array of ... ...

Abstract	Pressure sensors integrated in surfaces, such as the floor, can enable movement, event, and object detection with relatively little effort and without raising privacy concerns, such as video surveillance. Usually, this requires a distributed array of sensor pixels, whose design must be optimized according to the expected use case to reduce implementation costs while providing sufficient sensitivity. In this work, we present an unobtrusive smart floor concept based on floor tiles equipped with a printed piezoelectric sensor matrix. The sensor element adds less than 130 µm in thickness to the floor tile and offers a pressure sensitivity of 36 pC/N for a 1 cm
MeSH term(s)	Touch ; Touch Perception
Language	English
Publishing date	2023-01-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23020603
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Article ; Online: Modeling the temporal evolution of plasma p-tau in relation to amyloid beta and tau PET.

Cogswell, Petrice M / Lundt, Emily S / Therneau, Terry M / Wiste, Heather J / Graff-Radford, Jonathan / Algeciras-Schimnich, Alicia / Lowe, Val J / Mielke, Michelle M / Schwarz, Christopher G / Senjem, Matthew L / Gunter, Jeffrey L / Knopman, David S / Vemuri, Prashanthi / Petersen, Ronald C / Jack, Clifford R

Alzheimer's & dementia : the journal of the Alzheimer's Association

2023 Volume 20, Issue 2, Page(s) 1225–1238

Abstract: ... tau PET, plasma p-tau217, p-tau181, and glial fibrillary acidic protein (GFAP) as endpoints ... Results: Individual timing of plasma p-tau progression was strongly associated with Aβ PET and GFAP ... progression. In the population, GFAP became abnormal first, then Aβ PET, plasma p-tau, and tau PET temporal ...

Abstract	Introduction: The timing of plasma biomarker changes is not well understood. The goal of this study was to evaluate the temporal co-evolution of plasma and positron emission tomography (PET) Alzheimer's disease (AD) biomarkers. Methods: We included 1408 Mayo Clinic Study of Aging and Alzheimer's Disease Research Center participants. An accelerated failure time (AFT) model was fit with amyloid beta (Aβ) PET, tau PET, plasma p-tau217, p-tau181, and glial fibrillary acidic protein (GFAP) as endpoints. Results: Individual timing of plasma p-tau progression was strongly associated with Aβ PET and GFAP progression. In the population, GFAP became abnormal first, then Aβ PET, plasma p-tau, and tau PET temporal meta-regions of interest when applying cut points based on young, cognitively unimpaired participants. Discussion: Plasma p-tau is a stronger indicator of a temporally linked response to elevated brain Aβ than of tau pathology. While Aβ deposition and a rise in GFAP are upstream events associated with tau phosphorylation, the temporal link between p-tau and Aβ PET was the strongest. Highlights: Plasma p-tau progression was more strongly associated with Aβ than tau PET. Progression on plasma p-tau was associated with Aβ PET and GFAP progression. P-tau181 and p-tau217 become abnormal after Aβ PET and before tau PET. GFAP became abnormal first, before plasma p-tau and Aβ PET.
MeSH term(s)	Humans ; Amyloid beta-Peptides ; Alzheimer Disease/diagnostic imaging ; Positron-Emission Tomography ; Aging ; Brain/diagnostic imaging ; tau Proteins ; Biomarkers ; Cognitive Dysfunction
Chemical Substances	Amyloid beta-Peptides ; tau Proteins ; Biomarkers
Language	English
Publishing date	2023-11-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.13539
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Article ; Online: Revision of pyrophilous taxa of Pholiota described from North America reveals four species-P. brunnescens, P. castanea, P. highlandensis, and P. molesta.

Matheny, P Brandon / Swenie, Rachel A / Miller, Andrew N / Petersen, Ronald H / Hughes, Karen W

Mycologia

2018 Volume 110, Issue 6, Page(s) 997–1016

Abstract: ... surrounds application of the names P. brunnescens, P. carbonaria, P. castanea, P. fulvozonata, P ... highlandensis, P. molesta, and P. subsaponacea, with multiple names applied to a single species and multiple ... the following heterotypic synonymies are proposed: P. highlandensis (syn. P. carbonaria and P. fulvozonata); P ...

Abstract	A systematic reevaluation of North American pyrophilous or "burn-loving" species of Pholiota is presented based on molecular and morphological examination of type and historical collections. Confusion surrounds application of the names P. brunnescens, P. carbonaria, P. castanea, P. fulvozonata, P. highlandensis, P. molesta, and P. subsaponacea, with multiple names applied to a single species and multiple species described more than once. Molecular annotations using nuc rDNA ITS1-5.8S-ITS2 (internal transcribed spacer [ITS] barcode) and RPB2 (RNA polymerase II second largest subunit) are used to aid in application of these names in a phylogenetic context. Based on ITS molecular annotations of 13 types, the following heterotypic synonymies are proposed: P. highlandensis (syn. P. carbonaria and P. fulvozonata); P. molesta (syn. P. subsaponacea); and P. brunnescens (syn. P. luteobadia). In addition, we observed that the species P. castanea, known previously only from the type collection in Tennessee, is found commonly on burned sites near the Gulf Coast and other southeast regions of the United States. Overall, the pyrophilous trait is evolutionarily derived in Pholiota. Endophytic and endolichenic stages were deduced for P. highlandensis, the most widely distributed of the pyrophilous Pholiota. As a result, we introduce the "body snatchers" hypothesis that explains the maintenance of some pyrophilous fungi in ecosystems as endophytes and/or endolichenic fungi. Photographs, taxonomic descriptions, and a dichotomous key to pyrophilous species of Pholiota that occur in North America are presented.
MeSH term(s)	DNA, Fungal/genetics ; DNA, Ribosomal Spacer/genetics ; Mycological Typing Techniques ; North America ; Pholiota/classification ; Phylogeny ; RNA Polymerase II/genetics ; RNA, Ribosomal, 5.8S/genetics ; Sequence Analysis, DNA
Chemical Substances	DNA, Fungal ; DNA, Ribosomal Spacer ; RNA, Ribosomal, 5.8S ; RNA Polymerase II (EC 2.7.7.-)
Language	English
Publishing date	2018-11-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	281335-x
ISSN	1557-2536 ; 0027-5514
ISSN (online)	1557-2536
ISSN	0027-5514
DOI	10.1080/00275514.2018.1516960
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Article ; Online: Surface EMG-based quantification of inspiratory effort: a quantitative comparison with P

Graßhoff, Jan / Petersen, Eike / Farquharson, Franziska / Kustermann, Max / Kabitz, Hans-Joachim / Rostalski, Philipp / Walterspacher, Stephan

Critical care (London, England)

2021 Volume 25, Issue 1, Page(s) 441

Abstract: Background: Inspiratory patient effort under assisted mechanical ventilation is an important quantity for assessing patient-ventilator interaction and recognizing over and under assistance. An established clinical standard is respiratory muscle pressure ...

Abstract	Background: Inspiratory patient effort under assisted mechanical ventilation is an important quantity for assessing patient-ventilator interaction and recognizing over and under assistance. An established clinical standard is respiratory muscle pressure [Formula: see text], derived from esophageal pressure ([Formula: see text]), which requires the correct placement and calibration of an esophageal balloon catheter. Surface electromyography (sEMG) of the respiratory muscles represents a promising and straightforward alternative technique, enabling non-invasive monitoring of patient activity. Methods: A prospective observational study was conducted with patients under assisted mechanical ventilation, who were scheduled for elective bronchoscopy. Airway flow and pressure, esophageal/gastric pressures and sEMG of the diaphragm and intercostal muscles were recorded at four levels of pressure support ventilation. Patient efforts were quantified via the [Formula: see text]-time product ([Formula: see text]), the transdiaphragmatic pressure-time product ([Formula: see text]) and the EMG-time products (ETP) of the two sEMG channels. To improve the signal-to-noise ratio, a method for automatically selecting the more informative of the sEMG channels was investigated. Correlation between ETP and [Formula: see text] was assessed by determining a neuromechanical conversion factor [Formula: see text] between the two quantities. Moreover, it was investigated whether this scalar can be reliably determined from airway pressure during occlusion maneuvers, thus allowing to quantify inspiratory effort based solely on sEMG measurements. Results: In total, 62 patients with heterogeneous pulmonary diseases were enrolled in the study, 43 of which were included in the data analysis. The ETP of the two sEMG channels was well correlated with [Formula: see text] ([Formula: see text] and [Formula: see text] for diaphragm and intercostal recordings, respectively). The proposed automatic channel selection method improved correlation with [Formula: see text] ([Formula: see text]). The neuromechanical conversion factor obtained by fitting ETP to [Formula: see text] varied widely between patients ([Formula: see text]) and was highly correlated with the scalar determined during occlusions ([Formula: see text], [Formula: see text]). The occlusion-based method for deriving [Formula: see text] from ETP showed a breath-wise deviation to [Formula: see text] of [Formula: see text] across all datasets. Conclusion: These results support the use of surface electromyography as a non-invasive alternative for monitoring breath-by-breath inspiratory effort of patients under assisted mechanical ventilation.
MeSH term(s)	Diaphragm ; Electromyography ; Humans ; Positive-Pressure Respiration ; Respiration, Artificial ; Ventilators, Mechanical
Language	English
Publishing date	2021-12-20
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-021-03833-w
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Article: Revision of pyrophilous taxa of Pholiota described from North America reveals four species—P. brunnescens, P. castanea, P. highlandensis, and P. molesta

Matheny, P. Brandon / Swenie, Rachel A / Miller, Andrew N / Petersen, Ronald H / Hughes, Karen W

Mycologia. 2018 Nov. 2, v. 110, no. 6

2018

Abstract	A systematic reevaluation of North American pyrophilous or “burn-loving” species of Pholiota is presented based on molecular and morphological examination of type and historical collections. Confusion surrounds application of the names P. brunnescens, P. carbonaria, P. castanea, P. fulvozonata, P. highlandensis, P. molesta, and P. subsaponacea, with multiple names applied to a single species and multiple species described more than once. Molecular annotations using nuc rDNA ITS1-5.8S-ITS2 (internal transcribed spacer [ITS] barcode) and RPB2 (RNA polymerase II second largest subunit) are used to aid in application of these names in a phylogenetic context. Based on ITS molecular annotations of 13 types, the following heterotypic synonymies are proposed: P. highlandensis (syn. P. carbonaria and P. fulvozonata); P. molesta (syn. P. subsaponacea); and P. brunnescens (syn. P. luteobadia). In addition, we observed that the species P. castanea, known previously only from the type collection in Tennessee, is found commonly on burned sites near the Gulf Coast and other southeast regions of the United States. Overall, the pyrophilous trait is evolutionarily derived in Pholiota. Endophytic and endolichenic stages were deduced for P. highlandensis, the most widely distributed of the pyrophilous Pholiota. As a result, we introduce the “body snatchers” hypothesis that explains the maintenance of some pyrophilous fungi in ecosystems as endophytes and/or endolichenic fungi. Photographs, taxonomic descriptions, and a dichotomous key to pyrophilous species of Pholiota that occur in North America are presented.
Keywords	DNA-directed RNA polymerase ; Pholiota ; coasts ; endophytes ; internal transcribed spacers ; phylogeny ; taxonomic keys ; Tennessee
Language	English
Dates of publication	2018-1102
Size	p. 997-1016.
Publishing place	Taylor & Francis
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	281335-x
ISSN	1557-2536 ; 0027-5514
ISSN (online)	1557-2536
ISSN	0027-5514
DOI	10.1080/00275514.2018.1516960
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Quantification of Biologically and Chemically Bound Phosphorus in Activated Sludge from Full-Scale Plants with Biological P-Removal.

Petriglieri, Francesca / Petersen, Jette F / Peces, Miriam / Nierychlo, Marta / Hansen, Kamilla / Baastrand, Cecilie E / Nielsen, Ulla Gro / Reitzel, Kasper / Nielsen, Per Halkjær

Environmental science & technology

2022 Volume 56, Issue 8, Page(s) 5132–5140

Abstract: Phosphorus (P) is present in activated sludge from wastewater treatment plants in the form ... as intracellular polyphosphate (poly-P). Several methods for a reliable quantification of the different P-fractions ... have recently been developed, and this study combines them to obtain a comprehensive P mass-balance ...

Abstract	Phosphorus (P) is present in activated sludge from wastewater treatment plants in the form of metal salt precipitates, extracellular polymeric substances, or bound into the biomass, for example, as intracellular polyphosphate (poly-P). Several methods for a reliable quantification of the different P-fractions have recently been developed, and this study combines them to obtain a comprehensive P mass-balance of activated sludge from four enhanced biological phosphate removal (EBPR) plants. Chemical characterization by ICP-OES and sequential P fractionation showed that chemically bound P constituted 38-69% of total P, most likely in the form of Fe, Mg, or Al minerals. Raman microspectroscopy, solution state
MeSH term(s)	Bioreactors/microbiology ; In Situ Hybridization, Fluorescence ; Phosphorus ; Polyphosphates ; Sewage/microbiology
Chemical Substances	Polyphosphates ; Sewage ; Phosphorus (27YLU75U4W)
Language	English
Publishing date	2022-03-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.1c02642
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Article ; Online: Sperm Aneuploidy in Faroese Men with Lifetime Exposure to Dichlorodiphenyldichloroethylene (p,p´-DDE) and Polychlorinated Biphenyl (PCB) Pollutants.

Perry, Melissa J / Young, Heather A / Grandjean, Philippe / Halling, Jónrit / Petersen, Maria Skaalum / Martenies, Sheena E / Karimi, Parisa / Weihe, Pál

Environmental health perspectives

2016 Volume 124, Issue 7, Page(s) 951–956

Abstract: ... J, Petersen MS, Martenies SE, Karimi P, Weihe P. 2016. Sperm aneuploidy in Faroese men with lifetime ... dichlorodiphenyldicholorethylene (p,p´-DDE) and polychlorinated biphenyls (PCBs), and sperm aneuploidy in men from the general ... studies were analyzed for p,p´-DDE and PCBs 118, 138, 153, and 180 and adjusted for total lipids ...

Abstract	Background: Although it is known that sperm aneuploidy contributes to early pregnancy losses and congenital abnormalities, the causes are unknown and environmental contaminants are suspected. Objectives: Our goal was to evaluate associations between lifetime exposure to organochlorines, specifically dichlorodiphenyldicholorethylene (p,p´-DDE) and polychlorinated biphenyls (PCBs), and sperm aneuploidy in men from the general population of the Faroe Islands, a population with a known history of organochlorine exposures. Methods: Serum and semen samples from men (n = 90) 22-44 years old who participated in Faroe Islands health studies were analyzed for p,p´-DDE and PCBs 118, 138, 153, and 180 and adjusted for total lipids. Cord blood and age-14 serum were available for a subgroup (n = 40) and were also analyzed for p,p´-DDE and PCBs. Sperm fluorescence in situ hybridization (FISH) for chromosomes X, Y, and 18 was used to determine rates of XX18, XY18, YY18, and total disomy. Multivariable adjusted Poisson models were used to estimate the relationship between organochlorine exposure and sperm disomy outcomes. Results: Adult p,p´-DDE and total PCB serum concentrations were both associated with significantly increased rates of XX18, XY18, and total disomy. Age-14 p,p´-DDE and PCB concentrations were both associated with significantly increased rates of XX, XY, and total disomy in adulthood. Associations between cord blood concentrations of p,p´-DDE and PCBs and sperm disomy in adulthood were not consistently significant. Conclusions: Organochlorine exposures measured at age 14 and in adulthood were associated with sperm disomy in this sample of high-exposure men, suggesting that the impacts of persistent pollutants on testicular maturation and function require further investigation. Citation: Perry MJ, Young HA, Grandjean P, Halling J, Petersen MS, Martenies SE, Karimi P, Weihe P. 2016. Sperm aneuploidy in Faroese men with lifetime exposure to dichlorodiphenyldichloroethylene (p,p´-DDE) and polychlorinated biphenyl (PCB) pollutants. Environ Health Perspect 124:951-956; http://dx.doi.org/10.1289/ehp.1509779.
MeSH term(s)	Adult ; Aneuploidy ; Denmark ; Dichlorodiphenyl Dichloroethylene/blood ; Environmental Exposure/statistics & numerical data ; Environmental Pollutants/blood ; Humans ; Male ; Polychlorinated Biphenyls/blood ; Spermatozoa/drug effects ; Spermatozoa/pathology
Chemical Substances	Environmental Pollutants ; Dichlorodiphenyl Dichloroethylene (4M7FS82U08) ; Polychlorinated Biphenyls (DFC2HB4I0K)
Language	English
Publishing date	2016-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/ehp.1509779
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Article: P-tau/Aβ42 and Aβ42/40 ratios in CSF are equally predictive of amyloid PET status.

Campbell, Michelle R / Ashrafzadeh-Kian, Susan / Petersen, Ronald C / Mielke, Michelle M / Syrjanen, Jeremy A / van Harten, Argonde C / Lowe, Val J / Jack, Clifford R / Bornhorst, Joshua A / Algeciras-Schimnich, Alicia

Alzheimer's & dementia (Amsterdam, Netherlands)

2021 Volume 13, Issue 1, Page(s) e12190

Abstract: Introduction: Measurement of amyloid beta (Aβ40 and Aβ42) and tau (phosphorylated tau [p-tau] and ... Research Center. P-tau/Aβ42 (Roche Elecsys, Fujirebio LUMIPULSE) and Aβ42/40 (Fujirebio LUMIPULSE) ratios ... Results: Strong correlation was observed between LUMIPULSE p-tau/Aβ42 and Aβ42/40, as well as Elecsys and ...

Abstract	Introduction: Measurement of amyloid beta (Aβ40 and Aβ42) and tau (phosphorylated tau [p-tau] and total tau [t-tau]) in cerebrospinal fluid (CSF) can be utilized to differentiate clinical and preclinical Alzheimer's disease dementia (AD) from other neurodegenerative processes. Methods: CSF biomarkers were measured in 150 participants from the Mayo Clinic Study of Aging and the Alzheimer's Disease Research Center. P-tau/Aβ42 (Roche Elecsys, Fujirebio LUMIPULSE) and Aβ42/40 (Fujirebio LUMIPULSE) ratios were compared to one another and to amyloid positron emission tomography (PET) classification. Results: Strong correlation was observed between LUMIPULSE p-tau/Aβ42 and Aβ42/40, as well as Elecsys and LUMIPULSE p-tau/Aβ42 and Aβ42/40 (Spearman's ρ = -0.827, -0.858, and 0.960, respectively). Concordance between LUMIPULSE p-tau/Aβ42 and Aβ42/40 was 96% and between Elecsys p-tau/Aβ42 and both LUMIPULSE ratios was 97%. All ratios had > 94% overall, positive, and negative percent agreement with amyloid PET classification. Discussion: These data suggest that p-tau/Aβ42 and Aβ42/40 ratios provide similar clinical information in the assessment of amyloid pathology.
Language	English
Publishing date	2021-05-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2832898-X
ISSN	2352-8729
ISSN	2352-8729
DOI	10.1002/dad2.12190
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Article ; Online: Detection of Alzheimer's disease amyloid beta 1-42, p-tau, and t-tau assays.

van Harten, Argonde C / Wiste, Heather J / Weigand, Stephen D / Mielke, Michelle M / Kremers, Walter K / Eichenlaub, Udo / Dyer, Roy B / Algeciras-Schimnich, Alicia / Knopman, David S / Jack, Clifford R / Petersen, Ronald C

Alzheimer's & dementia : the journal of the Alzheimer's Association

2021 Volume 18, Issue 4, Page(s) 635–644

Abstract: ... hyperphosphorylated tau (p-tau), and t-tau/Aβ42 and p-tau/Aβ42 ratios were evaluated in Mayo Clinic Study of Aging (n ... Aβ42 and p-tau/Aβ42 ratios had a higher percent agreement with normal/abnormal amyloid ... were 0.26 (0.24-0.27) for t-tau/Aβ42 and 0.023 (0.020-0.025) for p-tau/Aβ42. Ratio cut points derived ...

Abstract	Introduction: We aimed to provide cut points for the automated Elecsys Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers. Methods: Cut points for Elecsys amyloid beta 42 (Aβ42), total tau (t-tau), hyperphosphorylated tau (p-tau), and t-tau/Aβ42 and p-tau/Aβ42 ratios were evaluated in Mayo Clinic Study of Aging (n = 804) and Mayo Clinic Alzheimer's Disease Research Center (n = 70) participants. Results: The t-tau/Aβ42 and p-tau/Aβ42 ratios had a higher percent agreement with normal/abnormal amyloid positron emission tomography (PET) than the individual CSF markers. Reciever Operating Characteristic (ROC)-based cut points were 0.26 (0.24-0.27) for t-tau/Aβ42 and 0.023 (0.020-0.025) for p-tau/Aβ42. Ratio cut points derived from other cohorts performed as well in our cohort as our own did. Individual biomarkers had worse diagnostic properties and more variable results in terms of positive and negative percent agreement (PPA and NPA). Conclusion: CSF t-tau/Aβ42 and p-tau/Aβ42 ratios are very robust indicators of AD. For individual biomarkers, the intended use should determine which cut point is chosen.
MeSH term(s)	Alzheimer Disease/cerebrospinal fluid ; Alzheimer Disease/diagnostic imaging ; Amyloid ; Amyloid beta-Peptides/cerebrospinal fluid ; Biomarkers/cerebrospinal fluid ; Humans ; Peptide Fragments/cerebrospinal fluid ; tau Proteins/cerebrospinal fluid
Chemical Substances	Amyloid ; Amyloid beta-Peptides ; Biomarkers ; Peptide Fragments ; tau Proteins
Language	English
Publishing date	2021-07-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.12406
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Article ; Online: Selective cephalic upregulation of p-ERK, CamKII and p-CREB in response to glyceryl trinitrate infusion.

Ramachandran, Roshni / Pedersen, Sara Hougaard / Amrutkar, Dipak Vasantrao / Petersen, Steffen / Jacobsen, Julie Mie / Hay-Schmidt, Anders / Olesen, Jes / Jansen-Olesen, Inger

Cephalalgia : an international journal of headache

2017 Volume 38, Issue 6, Page(s) 1057–1070

Abstract: ... in the dura mater and nucleus caudalis ( P < 0.05) and at 2 h in the trigeminal ganglion with very few expressions ... Cam KII increased 2.6-fold and 3.2-fold, respectively, at 2 h after glycerytrinitrate infusion ( P < 0 ... 01). p-CREB/ATF-1 upregulation was observed only at 30 min ( P < 0.05) in the nucleus caudalis. None ...

Abstract	Background A common characteristic of migraine-inducing substances is that they cause headache and no pain in other areas of the body. Few studies have compared pain mechanisms in the trigeminal and spinal systems and, so far, no major differences have been noted. We compared signalling molecules in the trigeminal and spinothalamic system after infusion of the migraine-provoking substance glyceryltrinitrate. Method A catheter was placed in the femoral vein of rats and one week later glyceryltrinitrate 4 µg/kg/min was infused for 20 min. Protein expression in the dura mater, trigeminal ganglion, nucleus caudalis, dorsal root ganglion and the dorsal horn of the thoracic spinal cord was analysed at different time points using western blotting and immunohistochemistry. Results Glyceryltrinitrate caused a threefold increase in expression of phosphorylated extracellular signal-regulated kinases at 30 min in the dura mater and nucleus caudalis ( P < 0.05) and at 2 h in the trigeminal ganglion with very few expressions in the dorsal root ganglion. In the nucleus caudalis, expression of phosphorylated extracellular signal-regulated kinases and Cam KII increased 2.6-fold and 3.2-fold, respectively, at 2 h after glycerytrinitrate infusion ( P < 0.01). p-CREB/ATF-1 upregulation was observed only at 30 min ( P < 0.05) in the nucleus caudalis. None of these markers showed increased expression in the regions of thoracic spinal cord dorsal horn. Conclusion The dura, trigeminal ganglion and nucleus caudalis are activated shortly after glycerytrinitrate infusion with long-lasting expression of phosphorylated extracellular signal-regulated kinases observed in the nucleus caudalis. These activations were not observed at the spinal level.
MeSH term(s)	Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/biosynthesis ; Cyclic AMP Response Element-Binding Protein/biosynthesis ; Dura Mater/drug effects ; Extracellular Signal-Regulated MAP Kinases/biosynthesis ; Male ; Migraine Disorders/chemically induced ; Migraine Disorders/metabolism ; Migraine Disorders/physiopathology ; Nitroglycerin/toxicity ; Rats ; Rats, Sprague-Dawley ; Spinal Cord/drug effects ; Spinal Cord/metabolism ; Trigeminal Caudal Nucleus/drug effects ; Trigeminal Caudal Nucleus/metabolism ; Trigeminal Ganglion/drug effects ; Trigeminal Ganglion/metabolism ; Up-Regulation ; Vasodilator Agents/toxicity
Chemical Substances	Creb1 protein, rat ; Cyclic AMP Response Element-Binding Protein ; Vasodilator Agents ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Nitroglycerin (G59M7S0WS3)
Language	English
Publishing date	2017-07-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604567-4
ISSN	1468-2982 ; 0333-1024
ISSN (online)	1468-2982
ISSN	0333-1024
DOI	10.1177/0333102417722511
Database	MEDical Literature Analysis and Retrieval System OnLINE

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