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  1. Article: Traumatic Aneurysm Involving the Posterior Communicating Artery.

    Napoletano, Gabriele / Di Fazio, Nicola / Delogu, Giuseppe / Del Duca, Fabio / Maiese, Aniello

    Healthcare (Basel, Switzerland)

    2024  Volume 12, Issue 2

    Abstract: Traumatic intracranial aneurysms (TICAs) are rare, accounting for less than 1% of all intracranial aneurysms. However, they are associated with a mortality rate of over 50%. The case presented herein focuses on a posterior communicating artery TICA ... ...

    Abstract Traumatic intracranial aneurysms (TICAs) are rare, accounting for less than 1% of all intracranial aneurysms. However, they are associated with a mortality rate of over 50%. The case presented herein focuses on a posterior communicating artery TICA caused by violent aggression. A 41-year-old man with massive subarachnoid hemorrhage (SAH), on admission to hospital, had a CT angiography that showed a ruptured left posterior communicating artery aneurysm with continuous blood loss and underwent neurosurgical cooling. The CT scan also showed fractures of the mandible, mastoid and left styloid process, as well as brain contusions caused by blows and kicks. Despite medical treatment and surgery, after four days, he died. The assault dynamics were recorded by a camera in the bar. The damage was caused by kicks to the neck and head. The forensic neuropathological examination showed the primary injury (SAH, subdural hemorrhage, cerebral contusions, head-neck fractures), as well as secondary damage following the attack (cerebral infarcts, edema, supratentorial hernia, midbrain hemorrhage). The coil was intact and well positioned. In this case, circumstantial information, medical records, and the type of injury could shed light on the mechanism of the production of a TICA. In addition, the CT angiography and histological investigations helped to distinguish a recent and traumatic aneurysm from a pre-existing one. Following precise steps, the study of aneurysms can be helpful in clarifying their traumatic origin even when the victim was taking drugs. The aim of this study is also to share the diagnostic process that we used in the forensic field for the assessment of suspected traumatic aneurysms.
    Language English
    Publishing date 2024-01-13
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare12020192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Butane-related deaths in post-mortem investigations: A systematic review.

    Iacoponi, Naomi / Del Duca, Fabio / Marcacci, Ilaria / Occhipinti, Carla / Napoletano, Gabriele / Spadazzi, Federica / La Russa, Raffaele / Maiese, Aniello

    Legal medicine (Tokyo, Japan)

    2024  Volume 69, Page(s) 102442

    Abstract: Volatile substance abuse is widespread among adolescents due to its easy availability and methods of consumption. Inhalant abuse represents a current problematic issue, causing significant morbidity and mortality due to direct toxicity on several target ... ...

    Abstract Volatile substance abuse is widespread among adolescents due to its easy availability and methods of consumption. Inhalant abuse represents a current problematic issue, causing significant morbidity and mortality due to direct toxicity on several target organs and displacement of gas which results in a lack of oxygen. This review aims to evaluate post-mortem and toxicological investigations in cases of suspected butane intoxication. We performed comprehensive research using the Preferred Reporting Items for Systematic Review (PRISMA) standards. Forty scientific papers fulfilled the inclusion criteria. A total of 58 cases of butane-related deaths were found. Among these, we found 11 cases of suicide (18%), 1 case of homicide (2%), 44 cases of accidental poisoning (76%), and 2 cases of work-related deaths (4%). Autopsy and post-mortem examinations were performed in 54 cases, whereas toxicological analyses were presented in 56 cases. In autopsy, pulmonary edema (51%) and poli-visceral congestion (59%) were the most common findings. When death by butane inhalation is hypothesized, autopsy and histological findings may be nonspecific, therefore toxicological investigations assume a crucial role along with attention to the methods used to collect biological samples.
    Language English
    Publishing date 2024-03-30
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 2019555-2
    ISSN 1873-4162 ; 1344-6223
    ISSN (online) 1873-4162
    ISSN 1344-6223
    DOI 10.1016/j.legalmed.2024.102442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Introduction of a New Diagnostic Tool in Forensic Pathology: LiDAR Sensor for 3D Autopsy Documentation.

    Maiese, Aniello / Manetti, Alice Chiara / Ciallella, Costantino / Fineschi, Vittorio

    Biosensors

    2022  Volume 12, Issue 2

    Abstract: Autopsy is a complex and unrepeatable procedure. It is essential to have the possibility of reviewing the autoptic findings, especially when it is done for medico-legal purposes. Traditional photography is not always adequate to record forensic practice ... ...

    Abstract Autopsy is a complex and unrepeatable procedure. It is essential to have the possibility of reviewing the autoptic findings, especially when it is done for medico-legal purposes. Traditional photography is not always adequate to record forensic practice since two-dimensional images could lead to distortion and misinterpretation. Three-dimensional (3D) reconstructions of autoptic findings could be a new way to document the autopsy. Besides, nowadays, smartphones and tablets equipped with a LiDAR sensor make it extremely easy to elaborate a 3D model directly in the autopsy room. Herein, a quality and trustworthiness evaluation of 3D models obtained during ten autopsies is made comparing 3D models and conventional autopsy photographic records. Three-dimensional models were realistic and accurate and allowed precise measurements. The review of the autoptic report was facilitated by the 3D model. Conclusions: The LiDAR sensor and 3D models have been demonstrated to be a valid tool to introduce some kind of reproducibility into the autoptic practice.
    MeSH term(s) Autopsy/methods ; Documentation ; Forensic Medicine ; Imaging, Three-Dimensional ; Photography/methods ; Reproducibility of Results
    Language English
    Publishing date 2022-02-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios12020132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Dark Side of Energy Drinks: A Comprehensive Review of Their Impact on the Human Body.

    Costantino, Andrea / Maiese, Aniello / Lazzari, Julia / Casula, Chiara / Turillazzi, Emanuela / Frati, Paola / Fineschi, Vittorio

    Nutrients

    2023  Volume 15, Issue 18

    Abstract: In recent years, the consumption of energy drinks by young adults and athletes has risen significantly, but concerns have been raised about the potential health risks associated with excessive consumption. These concerns include cardiovascular problems, ... ...

    Abstract In recent years, the consumption of energy drinks by young adults and athletes has risen significantly, but concerns have been raised about the potential health risks associated with excessive consumption. These concerns include cardiovascular problems, nervous system disorders, and the potential for addiction. This review aims to examine the reported effects of acute or chronic abuse of energy drinks on human health. The analysis shows a significant prevalence of adverse effects, particularly on the cardiovascular and neurovegetative systems. In particular, the analysis identified nine cases of cardiac arrest, three of which were fatal. The aetiology of these adverse effects is attributed to the inherent neurostimulant properties of these beverages, of which caffeine is the predominant component. A comparison of documented effects in humans with experimental studies in animal models showed an overlap in results. This review highlights the need for greater rigour in the assessment of sudden cardiac death, particularly in young people, as legal substances such as energy drinks may be involved. We propose stricter limits on the consumption of these beverages than for caffeine, based on the evidence found and the data in the literature. This review also calls for the establishment of regulations governing the consumption of these products in view of their potential impact on human health.
    MeSH term(s) Animals ; Young Adult ; Humans ; Adolescent ; Energy Drinks/adverse effects ; Human Body ; Caffeine/adverse effects ; Drug-Related Side Effects and Adverse Reactions ; Athletes
    Chemical Substances Caffeine (3G6A5W338E)
    Language English
    Publishing date 2023-09-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15183922
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Death Due to Anaphylactic Reaction: The Role of the Forensic Pathologist in an Accurate Postmortem Diagnosis.

    Del Duca, Fabio / Manetti, Alice Chiara / Maiese, Aniello / Napoletano, Gabriele / Ghamlouch, Alessandro / Pascale, Natascha / Giorgio, Bolino / Paola, Frati / Russa, Raffaele La

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 12

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Tryptases/metabolism ; Anaphylaxis/diagnosis ; Pathologists ; Mast Cells/metabolism ; Lung
    Chemical Substances Tryptases (EC 3.4.21.59)
    Language English
    Publishing date 2023-12-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59122184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Insulin and Oral Hypoglycemic Drug Overdose in Post-Mortem Investigations: A Literature Review.

    Manetti, Alice Chiara / Visi, Giacomo / Spina, Federica / De Matteis, Alessandra / Del Duca, Fabio / Turillazzi, Emanuela / Maiese, Aniello

    Biomedicines

    2022  Volume 10, Issue 11

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    Language English
    Publishing date 2022-11-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10112823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Point-of-Care Ultrasound (POCUS) in Adult Cardiac Arrest: Clinical Review.

    Magon, Federica / Longhitano, Yaroslava / Savioli, Gabriele / Piccioni, Andrea / Tesauro, Manfredi / Del Duca, Fabio / Napoletano, Gabriele / Volonnino, Gianpietro / Maiese, Aniello / La Russa, Raffaele / Di Paolo, Marco / Zanza, Christian

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 4

    Abstract: Point-of-Care Ultrasound (POCUS) is a rapid and valuable diagnostic tool available in emergency and intensive care units. In the context of cardiac arrest, POCUS application can help assess cardiac activity, identify causes of arrest that could be ... ...

    Abstract Point-of-Care Ultrasound (POCUS) is a rapid and valuable diagnostic tool available in emergency and intensive care units. In the context of cardiac arrest, POCUS application can help assess cardiac activity, identify causes of arrest that could be reversible (such as pericardial effusion or pneumothorax), guide interventions like central line placement or pericardiocentesis, and provide real-time feedback on the effectiveness of resuscitation efforts, among other critical applications. Its use, in addition to cardiovascular life support maneuvers, is advocated by all resuscitation guidelines. The purpose of this narrative review is to summarize the key applications of POCUS in cardiac arrest, highlighting, among others, its prognostic, diagnostic, and forensic potential. We conducted an extensive literature review utilizing PubMed by employing key search terms regarding ultrasound and its use in cardiac arrest. Apart from its numerous advantages, its limitations and challenges such as the potential for interruption of chest compressions during image acquisition and operator proficiency should be considered as well and are discussed herein.
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14040434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Autoimmune Heart Disease: A Comprehensive Summary for Forensic Practice.

    Mezzetti, Eleonora / Costantino, Andrea / Leoni, Matteo / Pieretti, Rebecca / Di Paolo, Marco / Frati, Paola / Maiese, Aniello / Fineschi, Vittorio

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 8

    Abstract: Autoimmune heart disease is a non-random condition characterised by immune system-mediated aggression against cardiac tissue. Cardiac changes often exhibit nonspecific features and, if unrecognised, can result in fatal outcomes even among seemingly ... ...

    Abstract Autoimmune heart disease is a non-random condition characterised by immune system-mediated aggression against cardiac tissue. Cardiac changes often exhibit nonspecific features and, if unrecognised, can result in fatal outcomes even among seemingly healthy young individuals. In the absence of reliable medical history, the primary challenge lies in differentiating between the various cardiopathies. Numerous immunohistochemical and genetic studies have endeavoured to characterise distinct types of cardiopathies, facilitating their differentiation during autopsy examinations. However, the presence of a standardised protocol that forensic pathologists can employ to guide their investigations would be beneficial. Hence, this summary aims to present the spectrum of autoimmune cardiopathies, including emerging insights such as SARS-CoV-2-induced cardiopathies, and proposes the utilisation of practical tools, such as blood markers, to aid forensic pathologists in their routine practice.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Heart ; Heart Diseases ; Autoimmune Diseases/diagnosis
    Language English
    Publishing date 2023-07-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59081364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Autoptic Findings in Cases of Sudden Death Due to Kawasaki Disease.

    Visi, Giacomo / Spina, Federica / Del Duca, Fabio / Manetti, Alice Chiara / Maiese, Aniello / La Russa, Raffaele / Frati, Paola / Fineschi, Vittorio

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 11

    Abstract: Kawasaki disease (KD) is the second-most-common childhood vasculitis, and its etiology is still unknown today. Even though the acute illness is usually self-limiting, sometimes, it can generate complications, such as coronary artery aneurysms (CAA), ... ...

    Abstract Kawasaki disease (KD) is the second-most-common childhood vasculitis, and its etiology is still unknown today. Even though the acute illness is usually self-limiting, sometimes, it can generate complications, such as coronary artery aneurysms (CAA), acute myocardial infarction (AMI), heart failure, or arrhythmias, and can rarely cause sudden or unexpected deaths. We present a review of the literature, which collects autoptic and histopathological data relating to many of the cases of these deaths. On the basis of the titles and abstracts, we selected 54 scientific publications for a total of 117 cases. Among them, as expected, the majority of the deaths were due to AMI (41.03%), arrhythmia (8.55%), acute coronary syndrome (8.55%), and CAA rupture (11.97%), involving mostly 20-year-olds or younger individuls (69.23%). This is not surprising since the CAs are the most involved arteries. Gross autoptic and histopathological findings are reported in the paper. Our work revealed that, when compared with the incidence of KD, only a few cases suffered from sudden death, underwent an autoptic examination, and were then described in the literature. We suggest that researchers should perform autopsies to gain a better understanding of the molecular pathways involved in KD so as to propose further innovative therapeutic protocols or implement more appropriate prevention schemes.
    Language English
    Publishing date 2023-05-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13111831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: FOXO3 Depletion as a Marker of Compression-Induced Apoptosis in the Ligature Mark: An Immunohistochemical Study.

    Maiese, Aniello / Manetti, Alice Chiara / Santoro, Paola / Del Duca, Fabio / De Matteis, Alessandra / Turillazzi, Emanuela / Frati, Paola / Fineschi, Vittorio

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: One of the most challenging issues in forensic pathology is lesion vitality demonstration, particularly in cases of hanging. Over the past few years, immunohistochemistry has been applied to this field with promising results. In particular, protein and ... ...

    Abstract One of the most challenging issues in forensic pathology is lesion vitality demonstration, particularly in cases of hanging. Over the past few years, immunohistochemistry has been applied to this field with promising results. In particular, protein and transcription factors involved in the apoptotic process have been studied as vitality markers for the ligature mark. This study represents an implementation of our previous studies on ligature mark vitality demonstration. In this study, we evaluated the FOXO3 expression in post-mortem cervical skin samples through an immunohistochemical analysis. To evaluate FOXO3 expression, anti-FOXO3 antibodies (GTX100277) were used. The study group comprised 21 cases, 8 women and 13 men, whereas the control group consisted of 13 cases of subjects who died due to other causes. Decomposition and no clear circumstantial data were exclusion criteria. We found that FOXO3 is decreased in hanging cases compared with normal skin in other causes of death (p-value < 0.05). No differences were seen concerning the type of hanging material (hard or soft), type of hanging (complete or incomplete), and position of the knot. Our results suggest that FOXO3 depletion could be a valid immunohistochemical marker of ligature mark vitality.
    MeSH term(s) Male ; Humans ; Female ; Suicide ; Asphyxia/pathology ; Forensic Pathology ; Autopsy ; Apoptosis ; Forkhead Box Protein O3
    Chemical Substances FOXO3 protein, human ; Forkhead Box Protein O3
    Language English
    Publishing date 2023-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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