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  1. Article ; Online: Study of platelet kinetics in immune thrombocytopenia to predict splenectomy response.

    Mendoza, Ana / Álvarez-Román, María Teresa / Monzón-Manzano, Elena / Acuña, Paula / Arias-Salgado, Elena G / Rivas-Pollmar, Isabel / Martín-Salces, Mónica / Martínez de Miguel, Bárbara / Martínez Montalbán, Elena / Jiménez-Yuste, Víctor / Butta, Nora

    British journal of haematology

    2023  Volume 204, Issue 1, Page(s) 315–323

    Abstract: Despite the efficacy of splenectomy for chronic immune thrombocytopenia (ITP), its considerable failure rate and its possible related complications prove the need for further research into potential predictors of response. The platelet sequestration site ...

    Abstract Despite the efficacy of splenectomy for chronic immune thrombocytopenia (ITP), its considerable failure rate and its possible related complications prove the need for further research into potential predictors of response. The platelet sequestration site determined by
    MeSH term(s) Humans ; Purpura, Thrombocytopenic, Idiopathic/surgery ; Splenectomy ; Kinetics ; Blood Platelets/physiology ; Thrombocytopenia ; Hypersplenism
    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19145
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  2. Article ; Online: Thromboprophylaxis in a patient with COVID-19 and severe hemophilia A on emicizumab prophylaxis.

    Rivas-Pollmar, María Isabel / Álvarez-Román, María Teresa / Butta-Coll, Nora V / Martín Salces, Mónica / García-Barcenilla, Sara / Jiménez-Yuste, Victor

    Journal of thrombosis and haemostasis : JTH

    2020  Volume 18, Issue 9, Page(s) 2202–2204

    Abstract: COVID-19 can be associated with coagulopathy (CAC, COVID-19-associated coagulopathy) with a high prothrombotic risk based on an intense inflammatory response to viral infection leading to immunothrombosis through different procoagulant pathways. Emerging ...

    Abstract COVID-19 can be associated with coagulopathy (CAC, COVID-19-associated coagulopathy) with a high prothrombotic risk based on an intense inflammatory response to viral infection leading to immunothrombosis through different procoagulant pathways. Emerging evidence suggests that the use of heparin in these patients could be associated with lower mortality. Emicizumab is a bispecific humanized monoclonal antibody that bridges activated factor IX and factor X, thereby restoring the function of missing factor VIIIa in hemophilia A. The use of emicizumab has been associated with thrombotic events in patients who also received high cumulative amounts of activated prothrombin complex concentrates. Although this risk is extremely low, there is a lack of evidence on whether CAC increases the thrombotic risk in patients on emicizumab prophylaxis. We present the case of a patient with severe hemophilia A in prophylaxis treatment with emicizumab; due to the potential thrombotic risk we decided to administer low molecular weight heparin as prophylaxis treatment without any thrombotic or bleeding complications.
    MeSH term(s) Antibodies, Bispecific/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Anticoagulants/therapeutic use ; Blood Coagulation ; COVID-19/complications ; Coagulants ; Factor IXa/chemistry ; Factor X/chemistry ; Follow-Up Studies ; HIV Infections/complications ; Hemophilia A/complications ; Hemophilia A/drug therapy ; Hepatitis C/complications ; Humans ; Inflammation ; Lymphoma, Non-Hodgkin/complications ; Male ; Middle Aged ; Thrombosis ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/prevention & control
    Chemical Substances Antibodies, Bispecific ; Antibodies, Monoclonal, Humanized ; Anticoagulants ; Coagulants ; emicizumab (7NL2E3F6K3) ; Factor X (9001-29-0) ; Factor IXa (EC 3.4.21.22)
    Keywords covid19
    Language English
    Publishing date 2020-07-06
    Publishing country England
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.14954
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  3. Article ; Online: Clinical trials and Haemophilia during the COVID-19 pandemic: Madrid's experience.

    Álvarez-Román, Maria Teresa / García-Barcenilla, Sara / Cebanu, Tamara / González-Zorrilla, Elena / Butta, Nora V / Fernandez-Bello, Ihosvany / Martín-Salces, Monica / Rivas-Pollmar, Maria Isabel / Jiménez-Yuste, Victor

    Haemophilia : the official journal of the World Federation of Hemophilia

    2020  Volume 26, Issue 5, Page(s) e247–e249

    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/virology ; Clinical Trials as Topic/methods ; Delivery of Health Care/methods ; Delivery of Health Care/trends ; Hemophilia A/therapy ; Humans ; Pandemics ; SARS-CoV-2/physiology ; Spain/epidemiology ; Telemedicine/methods
    Keywords covid19
    Language English
    Publishing date 2020-06-12
    Publishing country England
    Document type Letter
    ZDB-ID 1229713-6
    ISSN 1365-2516 ; 1351-8216 ; 1355-0691
    ISSN (online) 1365-2516
    ISSN 1351-8216 ; 1355-0691
    DOI 10.1111/hae.14055
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  4. Article: Thromboprophylaxis in a patient with COVID-19 and severe hemophilia A on emicizumab prophylaxis

    Rivas-Pollmar, María Isabel / Álvarez-Román, María Teresa / Butta-Coll, Nora V / Martín Salces, Mónica / García-Barcenilla, Sara / Jiménez-Yuste, Victor

    J. thromb. haemost

    Abstract: COVID-19 can be associated with coagulopathy (CAC, COVID-19-associated coagulopathy) with a high prothrombotic risk based on an intense inflammatory response to viral infection leading to immunothrombosis through different procoagulant pathways. Emerging ...

    Abstract COVID-19 can be associated with coagulopathy (CAC, COVID-19-associated coagulopathy) with a high prothrombotic risk based on an intense inflammatory response to viral infection leading to immunothrombosis through different procoagulant pathways. Emerging evidence suggests that the use of heparin in these patients could be associated with lower mortality. Emicizumab is a bispecific humanized monoclonal antibody that bridges activated factor IX and factor X, thereby restoring the function of missing factor VIIIa in hemophilia A. The use of emicizumab has been associated with thrombotic events in patients who also received high cumulative amounts of activated prothrombin complex concentrates. Although this risk is extremely low, there is a lack of evidence on whether CAC increases the thrombotic risk in patients on emicizumab prophylaxis. We present the case of a patient with severe hemophilia A in prophylaxis treatment with emicizumab; due to the potential thrombotic risk we decided to administer low molecular weight heparin as prophylaxis treatment without any thrombotic or bleeding complications.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #593310
    Database COVID19

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  5. Article ; Online: Thromboprophylaxis in a patient with COVID‐19 and severe hemophilia A on emicizumab prophylaxis

    Rivas‐Pollmar, María Isabel / Álvarez‐Román, María Teresa / Butta‐Coll, Nora V. / Martín Salces, Mónica / García‐Barcenilla, Sara / Jiménez‐Yuste, Victor

    Journal of Thrombosis and Haemostasis

    2020  Volume 18, Issue 9, Page(s) 2202–2204

    Keywords Hematology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.14954
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  6. Article: Clinical trials and Haemophilia during the COVID-19 pandemic: Madrid's experience

    Álvarez-Román, Maria Teresa / García-Barcenilla, Sara / Cebanu, Tamara / González-Zorrilla, Elena / Butta, Nora V / Fernandez-Bello, Ihosvany / Martín-Salces, Monica / Rivas-Pollmar, Maria Isabel / Jiménez-Yuste, Victor

    Haemophilia

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32415870
    Database COVID19

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  7. Article ; Online: Clinical trials and Haemophilia during the COVID‐19 pandemic

    Álvarez‐Román, Maria Teresa / García‐Barcenilla, Sara / Cebanu, Tamara / González‐Zorrilla, Elena / Butta, Nora V. / Fernandez‐Bello, Ihosvany / Martín‐Salces, Monica / Rivas‐Pollmar, Maria Isabel / Jiménez‐Yuste, Victor

    Haemophilia

    Madrid's experience

    2020  Volume 26, Issue 5

    Keywords Genetics(clinical) ; Hematology ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1229713-6
    ISSN 1365-2516 ; 1351-8216 ; 1355-0691
    ISSN (online) 1365-2516
    ISSN 1351-8216 ; 1355-0691
    DOI 10.1111/hae.14055
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  8. Article: Knee replacement surgery in a patient with acquired von Willebrand disease: a case study with recommendations for patient management.

    Álvarez Román, María Teresa / Rivas Pollmar, María Isabel / De la Corte-Rodríguez, Hortensia / Gómez-Cardero, Primitivo / Rodríguez-Merchán, E Carlos / Gutiérrez-Alvariño, Mar / García-Pérez, Eduardo / Martín-Salces, Mónica / Zagrean, Damaris / Butta-Coll, Nora V / Jiménez-Yuste, Víctor

    Annals of medicine and surgery (2012)

    2024  Volume 86, Issue 3, Page(s) 1681–1686

    Abstract: Introduction and importance: Acquired von Willebrand disease (AvWD) is a rare underdiagnosed bleeding disorder caused by alterations in the levels of the major blood-clotting protein von Willebrand factor (vWF). The clinical and laboratory parameters of ...

    Abstract Introduction and importance: Acquired von Willebrand disease (AvWD) is a rare underdiagnosed bleeding disorder caused by alterations in the levels of the major blood-clotting protein von Willebrand factor (vWF). The clinical and laboratory parameters of AvWD are similar to congenital vWD, but it is found in individuals with no positive family history with no underlying genetic basis. The disease remains multifactorial and incompletely understood. Proposed mechanisms include the development of autoantibodies to vWF, absorption of high molecular weight vWF multimers that impair normal function, shear stress induced vWF cleavage and increased proteolysis.The aetiology of the disease is variable, the most common being hematoproliferation, lymophoproliferation, myeloproliferation and autoimmune and cardiovascular disorders. Consensus and protocols for AvWD patients that require major surgery are currently lacking. Patients with AvWD can experience thrombotic events during surgery as a result of therapeutic interactions with pro-thrombotic risk factors.
    Case presentation: Here, the authors report a patient with AvWD requiring a knee prosthesis implantation due to chronic pain, limited range of motion and functional impairment. The patient had a high risk of bleeding during surgery and was at risk of thrombosis due to age and obesity.
    Clinical discussion: Perioperative care required a collaborative approach and the management of bleeding. The patient was administered vWF concentrate Willfact lacking Factor VIII to prevent haemorrhage and to minimize the risk of thrombosis.
    Conclusion: The treatment was effective and well-tolerated. The authors use this information to provide recommendations for AvWD patients for whom major surgery is indicated.
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Case Reports
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1097/MS9.0000000000001690
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  9. Article ; Online: COVID-19 and telemedicine in haemophilia in a patient with severe haemophilia A and orthopaedic surgery.

    Álvarez-Román, María Teresa / De la Corte-Rodríguez, Hortensia / Rodríguez-Merchán, Emérito Carlos / Martín-Salces, Mónica / Rivas-Pollmar, María Isabel / Butta, Nora V / García-Barcenilla, Sara / Acuña, Paula / Cebanu, Tamara / González, Elena / Monzón-Manzano, María Elena / Jiménez-Yuste, Víctor

    Haemophilia : the official journal of the World Federation of Hemophilia

    2020  Volume 27, Issue 1, Page(s) e137–e139

    MeSH term(s) COVID-19/epidemiology ; COVID-19/therapy ; Hemophilia A/physiopathology ; Humans ; Male ; Middle Aged ; Orthopedic Procedures/methods ; Pandemics ; Postoperative Care/methods ; SARS-CoV-2/isolation & purification ; Telemedicine/methods
    Keywords covid19
    Language English
    Publishing date 2020-11-03
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1229713-6
    ISSN 1365-2516 ; 1351-8216 ; 1355-0691
    ISSN (online) 1365-2516
    ISSN 1351-8216 ; 1355-0691
    DOI 10.1111/hae.14087
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  10. Book ; Online: Clinical trials and Haemophilia during the COVID-19 pandemic

    Álvarez-Román, María Teresa / García-Barcenilla, Sara / Cebanu, Tamara / González-Zorrilla, Elena / Butta, Nora V. / Fernández-Bello, Ihosvany / Martín-Salces, Mónica / Rivas-Pollmar, María Isabel / Jiménez-Yuste, Victor

    Madrid's experience

    2020  

    Abstract: This is the peer reviewed version of the following article: "Clinical trials and Haemophilia during the COVID‐19 pandemic: Madrid's experience". Haemophilia (2020): 16 May, which has been published in final form at https://doi.org/10.1111/hae.14055. This ...

    Abstract This is the peer reviewed version of the following article: "Clinical trials and Haemophilia during the COVID‐19 pandemic: Madrid's experience". Haemophilia (2020): 16 May, which has been published in final form at https://doi.org/10.1111/hae.14055. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
    Keywords COVID-19 ; Madrid ; clinical trials ; COVID‐19 pandemic ; Medicina ; covid19
    Language English
    Publishing date 2020-09-09T08:39:24Z
    Publisher Wiley
    Publishing country es
    Document type Book ; Online
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