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  1. Article ; Online: The authors reply.

    Tomas, Nicola M / Zahner, Gunther

    Kidney international

    2023  Volume 103, Issue 3, Page(s) 639–641

    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.12.014
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
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  2. Article ; Online: Editorial: Immune dysfunction in nephrotic syndrome - recent advances and new roads ahead.

    Seitz-Polski, Barbara / Audard, Vincent / Ghiggeri, Gian Marco / Tomas, Nicola M

    Frontiers in immunology

    2022  Volume 13, Page(s) 985925

    MeSH term(s) Glomerulosclerosis, Focal Segmental ; Humans ; Immune System Diseases ; Nephrosis, Lipoid ; Nephrotic Syndrome
    Language English
    Publishing date 2022-08-02
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.985925
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  3. Article ; Online: Strategies Towards Antigen-Specific Treatments for Membranous Nephropathy.

    Köllner, Sarah M S / Seifert, Larissa / Zahner, Gunther / Tomas, Nicola M

    Frontiers in immunology

    2022  Volume 13, Page(s) 822508

    Abstract: Membranous nephropathy (MN) is a rare but potentially severe autoimmune disease and a major cause of nephrotic syndrome in adults. Traditional treatments for patients with MN include steroids with alkylating agents such as cyclophosphamide or calcineurin ...

    Abstract Membranous nephropathy (MN) is a rare but potentially severe autoimmune disease and a major cause of nephrotic syndrome in adults. Traditional treatments for patients with MN include steroids with alkylating agents such as cyclophosphamide or calcineurin inhibitors such as cyclosporine, which have an undesirable side effect profile. Newer therapies like rituximab, although superior to cyclosporine in maintaining disease remission, do not only affect pathogenic B or plasma cells, but also inhibit the production of protective antibodies and therefore the ability to fend off foreign organisms and to respond to vaccination. These are undesired effects of general B or plasma cell-targeted treatments. The discovery of several autoantigens in patients with MN offers the great opportunity for more specific treatment approaches. Indeed, such treatments were recently developed for other autoimmune diseases and tested in different preclinical models, and some are about to jump to clinical practice. As such treatments have enormous potential to enhance specificity, efficacy and compatibility also for MN, we will discuss two promising strategies in this perspective: The elimination of pathogenic antibodies through endogenous degradation systems and the depletion of pathogenic B cells through chimeric autoantibody receptor T cells.
    MeSH term(s) Animals ; Autoantibodies/immunology ; B-Lymphocytes/pathology ; Cyclosporine/therapeutic use ; Glomerulonephritis, Membranous/drug therapy ; Glomerulonephritis, Membranous/immunology ; Humans ; Immunosuppressive Agents/therapeutic use ; Remission Induction ; Rituximab/therapeutic use
    Chemical Substances Autoantibodies ; Immunosuppressive Agents ; Rituximab (4F4X42SYQ6) ; Cyclosporine (83HN0GTJ6D)
    Language English
    Publishing date 2022-02-03
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.822508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Perspectives in membranous nephropathy.

    Tomas, Nicola M / Huber, Tobias B / Hoxha, Elion

    Cell and tissue research

    2021  Volume 385, Issue 2, Page(s) 405–422

    Abstract: The identification of the phospholipase A2 receptor 1 (PLA2R) and thrombospondin type-1 domain-containing protein 7A (THSD7A) as podocyte antigens in adult patients with membranous nephropathy (MN) has strongly impacted both experimental and clinical ... ...

    Abstract The identification of the phospholipase A2 receptor 1 (PLA2R) and thrombospondin type-1 domain-containing protein 7A (THSD7A) as podocyte antigens in adult patients with membranous nephropathy (MN) has strongly impacted both experimental and clinical research on this disease. Evidence has been furnished that podocyte-directed autoantibodies can cause MN, and novel PLA2R- and THSD7A-specific animal models have been developed. Today, measurement of serum autoantibody levels and staining of kidney biopsies for the target antigens guides MN diagnosis and treatment worldwide. Additionally, anti-PLA2R antibodies have been proven to be valuable prognostic biomarkers in MN. Despite these impressive advances, a variety of questions regarding the disease pathomechanisms, clinical use of antibody measurement, and future treatments remain unanswered. In this review, we will outline recent advances made in the field of MN and discuss open questions and perspectives with a focus on novel antigen identification, mechanisms of podocyte injury, clinical use of antibody measurement to guide diagnosis and treatment, and the potential of innovative, pathogenesis-based treatment strategies.
    MeSH term(s) Animals ; Glomerulonephritis, Membranous/immunology ; Glomerulonephritis, Membranous/pathology ; Humans
    Language English
    Publishing date 2021-04-06
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-021-03429-4
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  5. Article ; Online: Erratum zu: Imitation eines Felty-Syndroms durch eine viszerale Leishmaniasis bei rheumatoider Arthritis unter Therapie mit Methotrexat und Etanercept.

    Ruffer, Nikolas / Tomas, Nicola M / Schmiedel, Stefan / Jordan, Sabine / Kötter, Ina

    Zeitschrift fur Rheumatologie

    2022  Volume 81, Issue 3, Page(s) 244

    Title translation Erratum to: Visceral leishmaniasis mimicking Felty's syndrome in rheumatoid arthritis treated with methotrexate and etanercept.
    Language German
    Publishing date 2022-01-04
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 124985-x
    ISSN 1435-1250 ; 0340-1855 ; 0301-6382
    ISSN (online) 1435-1250
    ISSN 0340-1855 ; 0301-6382
    DOI 10.1007/s00393-021-01143-8
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  6. Article ; Online: An antigen-specific chimeric autoantibody receptor (CAAR) NK cell strategy for the elimination of anti-PLA2R1 and anti-THSD7A antibody-secreting cells.

    Seifert, Larissa / Riecken, Kristoffer / Zahner, Gunther / Hambach, Julia / Hagenstein, Julia / Dubberke, Gudrun / Huber, Tobias B / Koch-Nolte, Friedrich / Fehse, Boris / Tomas, Nicola M

    Kidney international

    2024  Volume 105, Issue 4, Page(s) 886–889

    MeSH term(s) Humans ; Autoantibodies ; Kidney ; Glomerulonephritis, Membranous ; Antibody-Producing Cells ; Receptors, Phospholipase A2
    Chemical Substances Autoantibodies ; Receptors, Phospholipase A2
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2024.01.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article: Perspectives in membranous nephropathy

    Tomas, Nicola M. / Huber, Tobias B. / Hoxha, Elion

    Cell and tissue research. 2021 Aug., v. 385, no. 2

    2021  

    Abstract: The identification of the phospholipase A2 receptor 1 (PLA2R) and thrombospondin type-1 domain-containing protein 7A (THSD7A) as podocyte antigens in adult patients with membranous nephropathy (MN) has strongly impacted both experimental and clinical ... ...

    Abstract The identification of the phospholipase A2 receptor 1 (PLA2R) and thrombospondin type-1 domain-containing protein 7A (THSD7A) as podocyte antigens in adult patients with membranous nephropathy (MN) has strongly impacted both experimental and clinical research on this disease. Evidence has been furnished that podocyte-directed autoantibodies can cause MN, and novel PLA2R- and THSD7A-specific animal models have been developed. Today, measurement of serum autoantibody levels and staining of kidney biopsies for the target antigens guides MN diagnosis and treatment worldwide. Additionally, anti-PLA2R antibodies have been proven to be valuable prognostic biomarkers in MN. Despite these impressive advances, a variety of questions regarding the disease pathomechanisms, clinical use of antibody measurement, and future treatments remain unanswered. In this review, we will outline recent advances made in the field of MN and discuss open questions and perspectives with a focus on novel antigen identification, mechanisms of podocyte injury, clinical use of antibody measurement to guide diagnosis and treatment, and the potential of innovative, pathogenesis-based treatment strategies.
    Keywords adults ; animals ; antigens ; autoantibodies ; biomarkers ; biomedical research ; blood serum ; kidney diseases ; kidneys ; phospholipase A2
    Language English
    Dates of publication 2021-08
    Size p. 405-422.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    Note Review
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-021-03429-4
    Database NAL-Catalogue (AGRICOLA)

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    Z 46/352: Show issues

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  8. Article ; Online: Across scales: novel insights into kidney health and disease by structural biology.

    Tomas, Nicola M / Mortensen, Simon A / Wilmanns, Matthias / Huber, Tobias B

    Kidney international

    2021  Volume 100, Issue 2, Page(s) 281–288

    Abstract: Over the past decades, structural biology methods such as X-ray crystallography and cryo-electron microscopy have been increasingly used to study protein functions, molecular interactions, physiological processes, and disease mechanisms. This review ... ...

    Abstract Over the past decades, structural biology methods such as X-ray crystallography and cryo-electron microscopy have been increasingly used to study protein functions, molecular interactions, physiological processes, and disease mechanisms. This review outlines a selection of structural biology methods, highlights recent examples of how structural analyses have contributed to a more profound understanding of the machinery of life, and gives a perspective on how these methods can be applied to investigate functions of kidney molecules and pathogenic mechanisms of renal diseases.
    MeSH term(s) Biology ; Cryoelectron Microscopy ; Crystallography, X-Ray ; Kidney ; Proteins
    Chemical Substances Proteins
    Language English
    Publishing date 2021-04-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2021.03.042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Combined intranasal and intramuscular parainfluenza 5-, simian adenovirus ChAdOx1- and poxvirus MVA-vectored vaccines induce synergistically HIV-1-specific T cells in the mucosa.

    Beavis, Ashley C / Wee, Edmund G-T / Akis Yildirim, Belkis M / Borthwick, Nicola / He, Biao / Hanke, Tomáš

    Frontiers in immunology

    2023  Volume 14, Page(s) 1186478

    Abstract: Introduction: The primary goal of this work is to broaden and enhance the options for induction of protective CD8: Methods: We explored the advantages of the parainfluenza virus 5 (PIV5) vector for delivery of pathogen-derived transgenes alone and in ...

    Abstract Introduction: The primary goal of this work is to broaden and enhance the options for induction of protective CD8
    Methods: We explored the advantages of the parainfluenza virus 5 (PIV5) vector for delivery of pathogen-derived transgenes alone and in combination with the in-human potent regimen of simian adenovirus ChAdOx1 prime-poxvirus MVA boost delivering bi-valent mosaic of HIV-1 conserved regions designated HIVconsvX.
    Results: We showed in BALB/c mice that the PIV5 vector expressing the HIVconsvX immunogens could be readily incorporated with the other two vaccine modalities into a single regimen and that for specific vector combinations, mucosal CD8
    Discussion: Encouraging safety and immunogenicity data from phase 1 human trials of ChAdOx1- and MVA-vectored vaccines for HIV-1, and PIV5-vectored vaccines for SARS-CoV-2 and respiratory syncytial virus pave the way for combining these vectors for HIV-1 and other indications in humans.
    MeSH term(s) Mice ; Animals ; Humans ; Adenoviruses, Simian/genetics ; HIV-1 ; CD8-Positive T-Lymphocytes ; COVID-19 Vaccines ; COVID-19 ; SARS-CoV-2 ; Respiratory Syncytial Virus, Human
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-07-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1186478
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  10. Article ; Online: Imitation eines Felty-Syndroms durch eine viszerale Leishmaniasis bei rheumatoider Arthritis unter Therapie mit Methotrexat und Etanercept.

    Ruffer, Nikolas / Tomas, Nicola M / Schmiedel, Stefan / Jordan, Sabine / Kötter, Ina

    Zeitschrift fur Rheumatologie

    2021  Volume 81, Issue 3, Page(s) 240–243

    Abstract: Visceral leishmaniasis (VL) is a chronic parasitic disease caused by pathogens of the genus Leishmania, which can mimic numerous diseases. The leading symptoms of VL (splenomegaly, pancytopenia, fever) can be misinterpreted, especially if autoantibodies ... ...

    Title translation Visceral leishmaniasis mimicking Felty's syndrome in rheumatoid arthritis treated with methotrexate and etanercept.
    Abstract Visceral leishmaniasis (VL) is a chronic parasitic disease caused by pathogens of the genus Leishmania, which can mimic numerous diseases. The leading symptoms of VL (splenomegaly, pancytopenia, fever) can be misinterpreted, especially if autoantibodies are detected, and lead to the misdiagnosis of an underlying rheumatic disease (e.g. systemic lupus erythematosus, Felty's syndrome). Proinflammatory cytokines such as tumour necrosis factor alpha (TNF-α) play an important role in infection control. In this context, there are increasing reports of VL as an opportunistic infection during treatment with anti-TNF‑α agents. A case of VL mimicking Felty's syndrome in a patient with rheumatoid arthritis treated with methotrexate and etanercept is presented.
    MeSH term(s) Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Etanercept/adverse effects ; Felty Syndrome/diagnosis ; Felty Syndrome/drug therapy ; Humans ; Leishmaniasis, Visceral/diagnosis ; Leishmaniasis, Visceral/drug therapy ; Methotrexate/adverse effects ; Tumor Necrosis Factor Inhibitors
    Chemical Substances Tumor Necrosis Factor Inhibitors ; Etanercept (OP401G7OJC) ; Methotrexate (YL5FZ2Y5U1)
    Language German
    Publishing date 2021-10-11
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 124985-x
    ISSN 1435-1250 ; 0340-1855 ; 0301-6382
    ISSN (online) 1435-1250
    ISSN 0340-1855 ; 0301-6382
    DOI 10.1007/s00393-021-01105-0
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