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Article: Evaluation of a new procalcitonin assay for the Siemens ADVIA Centaur with the established method on the B.R.A.H.M.S Kryptor.

Sanders, Robert-Jan / Schoorl, Marianne / Dekker, Ellen / Snijders, Dominic / Boersma, Wim G / Ten Boekel, Edwin

2011 Volume 57, Issue 5-6, Page(s) 415–420

Abstract: Background: In this study, we compared the B.R.A.H.M.S Kryptor procalcitonin (PCT) assay ... with the newly developed ADVIA Centaur B.R.A.H.M-S PCT assay. Furthermore, the long-term stability of PCT at - 20 ... Conclusions: The ADVIA Centaur B.R.A.H.M.S PCT assay showed good correlation with the established Kryptor ...

Abstract	Background: In this study, we compared the B.R.A.H.M.S Kryptor procalcitonin (PCT) assay with the newly developed ADVIA Centaur B.R.A.H.M-S PCT assay. Furthermore, the long-term stability of PCT at - 20 degrees C was assessed. Methods: Samples from 97 patients with lower respiratory tract infections were retested on both systems and compared with Passing-Bablok regression over two clinically relevant cutoff ranges for PCT, 0 - 2.0 microg/L and > 2.0 microg/L. Results: After storage for 2.5 to 4 years, PCT levels in patient sera declined only 3.7%. Passing-Bablok regression analysis of the total sample range (n = 97) showed that both methods correlated well (r = 0.9944), although with a deviation from the line of identity (y = 0.880x - 0.025 microg/L). Comparison of both methods within the clinically important interval of 0 - 2.0 microg/L showed acceptable correlation (y = 0.943x + 0.010 microg/L). Conclusions: The ADVIA Centaur B.R.A.H.M.S PCT assay showed good correlation with the established Kryptor method. Therefore, this new technique can be used in clinical routine with the same clinical interpretation.
MeSH term(s)	Antibodies, Monoclonal/immunology ; Automation ; Biomarkers ; Blood Preservation ; Calcitonin/blood ; Calcitonin Gene-Related Peptide ; Community-Acquired Infections/blood ; Cryopreservation ; Humans ; Immunoassay/instrumentation ; Luminescent Measurements/instrumentation ; Pneumonia/blood ; Protein Precursors/blood ; Reproducibility of Results ; Sensitivity and Specificity ; Time Factors
Chemical Substances	Antibodies, Monoclonal ; Biomarkers ; CALCA protein, human ; Protein Precursors ; Calcitonin Gene-Related Peptide (83652-28-2) ; Calcitonin (9007-12-9)
Language	English
Publishing date	2011
Publishing country	Germany
Document type	Comparative Study ; Journal Article ; Validation Studies
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
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Article ; Online: The effect of azithromycin on sputum inflammatory markers in bronchiectasis.

Terpstra, L C / Altenburg, J / Doodeman, H J / Piñeros, Y S Sabogal / Lutter, R / Heijerman, H G M / Boersma, W G

BMC pulmonary medicine

2023 Volume 23, Issue 1, Page(s) 151

Abstract: Background: Long term macrolide treatment has been found beneficial in bronchiectasis (BE) -pathogical bronchial dilatation- possibly due to a combined anti-bacterial and immunomodulatory effect. The exact mechanism of inflammatory response is unknown. ... ...

Abstract	Background: Long term macrolide treatment has been found beneficial in bronchiectasis (BE) -pathogical bronchial dilatation- possibly due to a combined anti-bacterial and immunomodulatory effect. The exact mechanism of inflammatory response is unknown. Here, we investigated the effect of maintenance macrolide treatment on the inflammatory response in BE. In addition, we assessed the inflammatory profile in BE in relation to disease severity. Methods: During the BAT randomized controlled trial (investigating the effect of 1 year of azithromycin (AZM) in 83 BE patients), data on BE severity, lung function and sputum microbiology was collected. For the current study, a wide range of inflammatory markers were analysed in 3- monthly sputum samples in all participants. Results: At baseline, marked neutrophilic but also eosinophilic inflammation was present in both groups, which remained stable throughout the study and was not affected by AZM treatment. Significant upregulation of pro-inflammatory markers correlated with FEV Conclusion: One year of AZM treatment did not result in attenuation of the inflammatory response in BE. Increasing disease severity and the presence of an exacerbation were reflected by upregulation of pro-inflammatory markers.
MeSH term(s)	Humans ; Azithromycin/therapeutic use ; Tumor Necrosis Factor-alpha ; Sputum/microbiology ; Bronchiectasis/microbiology ; Anti-Bacterial Agents/therapeutic use ; Macrolides ; Bronchi ; Inflammation ; Interleukin-1
Chemical Substances	Azithromycin (83905-01-5) ; Tumor Necrosis Factor-alpha ; Anti-Bacterial Agents ; Macrolides ; Interleukin-1
Language	English
Publishing date	2023-04-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-023-02444-1
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Article ; Online: Caloric restriction reduces proteinuria in male rats with established nephropathy.

Sijbesma, J W A / van Waarde, A / Klooster, A / Kion, I / Slart, R H J A / Lammertsma, A A / Giacobbo, B Lima / Boersma, H H / Dierckx, R A J O / van Goor, H / Bakker, S J L

Physiological reports

2024 Volume 12, Issue 5, Page(s) e15942

Abstract: Reducing proteinuria is a crucial approach in preventing kidney function loss. Previous preclinical studies indicated that caloric restriction (CR) imposed at a young age protects against age-related proteinuria. However, these studies have not explored ... ...

Abstract	Reducing proteinuria is a crucial approach in preventing kidney function loss. Previous preclinical studies indicated that caloric restriction (CR) imposed at a young age protects against age-related proteinuria. However, these studies have not explored CR in established renal disease. Therefore, this study aimed to investigate the impact of CR on established proteinuria. Rats, aged 12 ± 2 weeks, were administered 2.1 mg/kg of Adriamycin. Six weeks after injection, protein excretion was measured, and a [
MeSH term(s)	Male ; Animals ; Rats ; Caloric Restriction ; Kidney Diseases ; Proteinuria ; Blood Pressure ; Ammonia
Chemical Substances	Ammonia (7664-41-7)
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.15942
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Article ; Online: Validation of the YEARS algorithm and Wells' score with the age-adjusted cut-off to exclude pulmonary embolism in COVID-19 patients.

Speksnijder, Esther M / Hessels, Lisa M / Muusses, Linda / Büller, Harry R / Boersma, Wim G / Simsek, Suat

Thrombosis research

2022 Volume 219, Page(s) 109–111

MeSH term(s)	Algorithms ; COVID-19/complications ; Fibrin Fibrinogen Degradation Products ; Humans ; Predictive Value of Tests ; Pulmonary Embolism/complications ; Pulmonary Embolism/diagnosis
Chemical Substances	Fibrin Fibrinogen Degradation Products
Language	English
Publishing date	2022-09-15
Publishing country	United States
Document type	Letter
ZDB-ID	121852-9
ISSN	1879-2472 ; 0049-3848
ISSN (online)	1879-2472
ISSN	0049-3848
DOI	10.1016/j.thromres.2022.09.011
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Article ; Online: Long-term glucocorticoids in relation to the metabolic syndrome and cardiovascular disease: A systematic review and meta-analysis.

Kuckuck, Susanne / Lengton, Robin / Boon, Mariëtte R / Boersma, Eric / Penninx, Brenda W J H / Kavousi, Maryam / van Rossum, Elisabeth F C

Journal of internal medicine

2023 Volume 295, Issue 1, Page(s) 2–19

Abstract: The striking link of Cushing's syndrome with the metabolic syndrome (MetS) and cardiovascular disease (CVD) suggests that long-term exposure to extremely high cortisol levels catalyzes cardiometabolic deterioration. However, it remained unclear whether ... ...

Abstract	The striking link of Cushing's syndrome with the metabolic syndrome (MetS) and cardiovascular disease (CVD) suggests that long-term exposure to extremely high cortisol levels catalyzes cardiometabolic deterioration. However, it remained unclear whether the findings from the extreme glucocorticoid overabundance observed in Cushing's syndrome could be translated into more subtle variations in long-term glucocorticoid levels among the general population, for example, due to chronic stress. Here, we performed a systematic review (PROSPERO: CRD42023425541) of evidence regarding the role of subtle variations in long-term biological stress, measured as levels of scalp hair cortisol (HairF) and cortisone (HairE), in the context of MetS and CVD in adults. We also performed a meta-analysis on the cross-sectional difference in HairF levels between individuals with versus without CVD. Seven studies were included regarding MetS, sixteen regarding CVD, and one regarding both. Most articles indicated a strong, consistent cross-sectional association of higher HairF and HairE levels with CVD, which was confirmed by our meta-analysis for HairF (eight studies, SMD = 0.48, 95% confidence intervals [CIs]: 0.16-0.79, p = 0.0095). Moreover, these relationships appear largely independent of standard risk factors. Age seems relevant as the effect seems stronger in younger individuals. Results regarding the associations of HairF and HairE with MetS were inconsistent. Altogether, long-term biological stress, measured as HairF and HairE, is associated with the presence of CVD, and less consistently with MetS. Prospective studies need to evaluate the directionality of this relationship and determine whether HairF and HairE can be used in addition to standard risk factors in predicting future cardiometabolic deterioration.
MeSH term(s)	Adult ; Humans ; Glucocorticoids ; Hydrocortisone ; Metabolic Syndrome/metabolism ; Prospective Studies ; Cushing Syndrome ; Cardiovascular Diseases/etiology ; Cross-Sectional Studies
Chemical Substances	Glucocorticoids ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2023-11-05
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	96274-0
ISSN	1365-2796 ; 0954-6820
ISSN (online)	1365-2796
ISSN	0954-6820
DOI	10.1111/joim.13739
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Article ; Online: Exploring the impacts of social media and crowdsourcing on disaster resilience.

Clark, Nathan / Boersma, Kees / Bonati, Sara / Fonio, Chiara / Gehlhar, Simon / Habig, Therese / Larruina, Robert / Lüke, Richard / Morelli, Stefano / Nielsen, Anne Bach / Opromolla, Antonio / Pazzi, Veronica / Raju, Emmanuel

Open research Europe

2024 Volume 1, Page(s) 60

Abstract: Social media and crowdsourcing (SMCS) are increasingly proving useful for addressing the effects of natural and human-made hazards. SMCS allow different stakeholders to share crucial information during disaster management processes and to strengthen ... ...

Abstract	Social media and crowdsourcing (SMCS) are increasingly proving useful for addressing the effects of natural and human-made hazards. SMCS allow different stakeholders to share crucial information during disaster management processes and to strengthen community resilience through engagement and collaboration. To harvest these opportunities there is a need for better knowledge on SMCS for diverse disaster scenarios. These challenges are being addressed within the LINKS Horizon 2020 project. The project aims at strengthening societal resilience by producing advanced learning on the use of SMCS in disasters. This is done through an in-depth study across three knowledge domains (disaster risk perception and vulnerability, disaster management processes, SMCS technologies), the establishment of an interactive framework, and an online platform in which a community of relevant stakeholders can learn and share knowledge and experiences. This paper provides an overview of the project objectives and approaches and a summary of the initial results.
Language	English
Publishing date	2024-01-05
Publishing country	Belgium
Document type	Journal Article
ISSN	2732-5121
ISSN (online)	2732-5121
DOI	10.12688/openreseurope.13721.3
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Article ; Online: B cells: The many facets of B cells in allergic diseases.

Satitsuksanoa, Pattraporn / Iwasaki, Sayuri / Boersma, Jolien / Imam, Manal Bel / Schneider, Stephan R / Chang, Iris / van de Veen, Willem / Akdis, Mübeccel

The Journal of allergy and clinical immunology

2023 Volume 152, Issue 3, Page(s) 567–581

Abstract: B cells play a key role in our immune system through their ability to produce antibodies, suppress a proinflammatory state, and contribute to central immune tolerance. We aim to provide an in-depth knowledge of the molecular biology of B cells, including ...

Abstract	B cells play a key role in our immune system through their ability to produce antibodies, suppress a proinflammatory state, and contribute to central immune tolerance. We aim to provide an in-depth knowledge of the molecular biology of B cells, including their origin, developmental process, types and subsets, and functions. In allergic diseases, B cells are well known to induce and maintain immune tolerance through the production of suppressor cytokines such as IL-10. Similarly, B cells protect against viral infections such as severe acute respiratory syndrome coronavirus 2 that caused the recent coronavirus disease 2019 pandemic. Considering the unique and multifaceted functions of B cells, we hereby provide a comprehensive overview of the current knowledge of B-cell biology and its clinical applications in allergic diseases, organ transplantation, and cancer.
MeSH term(s)	Humans ; Allergens ; COVID-19 ; Hypersensitivity ; Cytokines ; Immune Tolerance ; B-Lymphocytes, Regulatory ; Desensitization, Immunologic
Chemical Substances	Allergens ; Cytokines
Language	English
Publishing date	2023-05-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2023.05.011
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Article ; Online: Inter-reviewer reliability of human literature reviewing and implications for the introduction of machine-assisted systematic reviews: a mixed-methods review.

Hanegraaf, Piet / Wondimu, Abrham / Mosselman, Jacob Jan / de Jong, Rutger / Abogunrin, Seye / Queiros, Luisa / Lane, Marie / Postma, Maarten J / Boersma, Cornelis / van der Schans, Jurjen

BMJ open

2024 Volume 14, Issue 3, Page(s) e076912

Abstract: Objectives: Our main objective is to assess the inter-reviewer reliability (IRR) reported in published systematic literature reviews (SLRs). Our secondary objective is to determine the expected IRR by authors of SLRs for both human and machine-assisted ... ...

Abstract	Objectives: Our main objective is to assess the inter-reviewer reliability (IRR) reported in published systematic literature reviews (SLRs). Our secondary objective is to determine the expected IRR by authors of SLRs for both human and machine-assisted reviews. Methods: We performed a review of SLRs of randomised controlled trials using the PubMed and Embase databases. Data were extracted on IRR by means of Cohen's kappa score of abstract/title screening, full-text screening and data extraction in combination with review team size, items screened and the quality of the review was assessed with the A MeaSurement Tool to Assess systematic Reviews 2. In addition, we performed a survey of authors of SLRs on their expectations of machine learning automation and human performed IRR in SLRs. Results: After removal of duplicates, 836 articles were screened for abstract, and 413 were screened full text. In total, 45 eligible articles were included. The average Cohen's kappa score reported was 0.82 (SD=0.11, n=12) for abstract screening, 0.77 (SD=0.18, n=14) for full-text screening, 0.86 (SD=0.07, n=15) for the whole screening process and 0.88 (SD=0.08, n=16) for data extraction. No association was observed between the IRR reported and review team size, items screened and quality of the SLR. The survey (n=37) showed overlapping expected Cohen's kappa values ranging between approximately 0.6-0.9 for either human or machine learning-assisted SLRs. No trend was observed between reviewer experience and expected IRR. Authors expect a higher-than-average IRR for machine learning-assisted SLR compared with human based SLR in both screening and data extraction. Conclusion: Currently, it is not common to report on IRR in the scientific literature for either human and machine learning-assisted SLRs. This mixed-methods review gives first guidance on the human IRR benchmark, which could be used as a minimal threshold for IRR in machine learning-assisted SLRs. Prospero registration number: CRD42023386706.
MeSH term(s)	Humans ; Reproducibility of Results ; Publications ; PubMed
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-076912
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Article ; Online: Prognostic value of temporal patterns of left atrial reservoir strain in patients with heart failure with reduced ejection fraction.

Abou Kamar, S / Aga, Y S / de Bakker, M / van den Berg, V J / Strachinaru, M / Bowen, D / Frowijn, R / Akkerhuis, K M / Brugts, J J / Manintveld, O / Umans, V / Geleijnse, M / de Boer, R A / Boersma, E / Kardys, I / van Dalen, B M

Clinical research in cardiology : official journal of the German Cardiac Society

2023

Abstract: Background: We investigated whether repeatedly measured left atrial reservoir strain (LASr) in heart failure with reduced ejection fraction (HFrEF) patients provides incremental prognostic value over a single baseline LASr value, and whether temporal ... ...

Abstract	Background: We investigated whether repeatedly measured left atrial reservoir strain (LASr) in heart failure with reduced ejection fraction (HFrEF) patients provides incremental prognostic value over a single baseline LASr value, and whether temporal patterns of LASr provide incremental prognostic value over temporal patterns of other echocardiographic markers and NT-proBNP. Methods: In this prospective observational study, 153 patients underwent 6-monthly echocardiography, during a median follow-up of 2.5 years. Speckle tracking echocardiography was used to measure LASr. Hazard ratios (HRs) were calculated for LASr from Cox models (baseline) and joint models (repeated measurements). The primary endpoint (PEP) comprised HF hospitalization, left ventricular assist device, heart transplantation, and cardiovascular death. Results: Mean age was 58 ± 11 years, 76% were men, 82% were in NYHA class I/II, mean LASr was 20.9% ± 11.3%, and mean LVEF was 29% ± 10%. PEP was reached by 50 patients. Baseline and repeated measurements of LASr (HR per SD change (95% CI) 0.20 (0.10-0.41) and (0.13 (0.10-0.29), respectively) were both significantly associated with the PEP, independent of both baseline and repeated measurements of other echo-parameters and NT-proBNP. Although LASr was persistently lower over time in patients with PEP, temporal trajectories did not diverge in patients with versus without the PEP as the PEP approached. Conclusion: LASr was associated with adverse events in HFrEF patients, independent of baseline and repeated other echo-parameters and NT-proBNP. Temporal trajectories of LASr showed decreased but stable values in patients with the PEP, and do not provide incremental prognostic value for clinical practice compared to single measurements of LASr.
Language	English
Publishing date	2023-06-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2213295-8
ISSN	1861-0692 ; 1861-0684
ISSN (online)	1861-0692
ISSN	1861-0684
DOI	10.1007/s00392-023-02244-x
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Article ; Online: Efficacy of pulmonary artery pressure monitoring in patients with chronic heart failure: a meta-analysis of three randomized controlled trials.

Clephas, Pascal R D / Radhoe, Sumant P / Boersma, Eric / Gregson, John / Jhund, Pardeep S / Abraham, William T / McMurray, John J V / de Boer, Rudolf A / Brugts, Jasper J

European heart journal

2023 Volume 44, Issue 37, Page(s) 3658–3668

Abstract: Aims: Adjustment of treatment based on remote monitoring of pulmonary artery (PA) pressure may reduce the risk of hospital admission for heart failure (HF). We have conducted a meta-analysis of large randomized trials investigating this question.: ... ...

Abstract	Aims: Adjustment of treatment based on remote monitoring of pulmonary artery (PA) pressure may reduce the risk of hospital admission for heart failure (HF). We have conducted a meta-analysis of large randomized trials investigating this question. Methods and results: A systematic literature search was performed for randomized clinical trials with PA pressure monitoring devices in patients with HF. The primary outcome of interest was the total number of HF hospitalizations. Other outcomes assessed were urgent visits leading to treatment with intravenous diuretics, all-cause mortality, and composites. Treatment effects are expressed as hazard ratios, and pooled effect estimates were obtained applying random effects meta-analyses. Three eligible randomized clinical trials were identified that included 1898 outpatients in New York Heart Association functional classes II-IV, either hospitalized for HF in the prior 12 months or with elevated plasma NT-proBNP concentrations. The mean follow-up was 14.7 months, 67.8% of the patients were men, and 65.8% had an ejection fraction ≤40%. Compared to patients in the control group, the hazard ratio (95% confidence interval) for total HF hospitalizations in those randomized to PA pressure monitoring was 0.70 (0.58-0.86) (P = .0005). The corresponding hazard ratio for the composite of total HF hospitalizations, urgent visits and all-cause mortality was 0.75 (0.61-0.91; P = .0037) and for all-cause mortality 0.92 (0.73-1.16). Subgroup analyses, including ejection fraction phenotype, revealed no evidence of heterogeneity in the treatment effect. Conclusion: The use of remote PA pressure monitoring to guide treatment of patients with HF reduces episodes of worsening HF and subsequent hospitalizations.
MeSH term(s)	Male ; Humans ; Female ; Pulmonary Artery ; Randomized Controlled Trials as Topic ; Heart Failure ; Hospitalization ; Chronic Disease ; Stroke Volume
Language	English
Publishing date	2023-07-18
Publishing country	England
Document type	Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehad346
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