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Article ; Online: Thumb sign: acute epiglottitis.

Takata, Mina / Fujikawa, Tatsuya / Goto, Rieko

BMJ case reports

2016 Volume 2016

MeSH term(s)	Acute Disease ; Aged ; Diagnosis, Differential ; Epiglottis/diagnostic imaging ; Epiglottitis/diagnostic imaging ; Humans ; Laryngitis/diagnosis ; Male ; Pharyngitis/diagnosis
Language	English
Publishing date	2016-05-31
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2016-214742
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Article ; Online: Choroidal Thickness is Increased following Restraint Stress in Rats.

Maeda, Yuki / Takata, Masashi / Gomi, Fumi

Current eye research

2023 Volume 48, Issue 5, Page(s) 506–511

Abstract: ... old male F334/Jcl rats were subjected to 30 min of restraint stress, and choroidal thickness was ...

Abstract	Purpose: Central serous chorioretinopathy is a stress-induced disease and often shows pachychoroid; however, the relationship between stress and choroid remains unlear. The purpose of this study was to investigate, using optical coherence tomography, whether the choroid thickens when rats are subjected to restraint stress. Methods: Eight-week-old male F334/Jcl rats were subjected to 30 min of restraint stress, and choroidal thickness was measured before and after stress loading using optical coherence tomography. In addition, salivary corticosterone levels were measured before and after stress loading. Results: Choroidal thickness was significantly increased from 30.1 ± 6.4 µm to 39.7 ± 9.2 µm just after stress loading ( Conclusions: Choroidal thickness increased when rats were subjected to restraint stress, supporting the hypothesis that stress is one of the causes of pachychoroid spectrum disease, as exemplified by central serous chorioretinopathy.
MeSH term(s)	Male ; Animals ; Rats ; Central Serous Chorioretinopathy/diagnosis ; Central Serous Chorioretinopathy/etiology ; Corticosterone ; Retrospective Studies ; Choroid ; Tomography, Optical Coherence ; Fluorescein Angiography
Chemical Substances	Corticosterone (W980KJ009P)
Language	English
Publishing date	2023-01-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	82079-9
ISSN	1460-2202 ; 0271-3683
ISSN (online)	1460-2202
ISSN	0271-3683
DOI	10.1080/02713683.2023.2171067
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Zs.A 1775: Show issues

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Article ; Online: tDCS-induced modulation of GABA concentration and dopamine release in the human brain: A combination study of magnetic resonance spectroscopy and positron emission tomography.

Bunai, Tomoyasu / Hirosawa, Tetsu / Kikuchi, Mitsuru / Fukai, Mina / Yokokura, Masamichi / Ito, Shigeru / Takata, Yohei / Terada, Tatsuhiro / Ouchi, Yasuomi

Brain stimulation

2020 Volume 14, Issue 1, Page(s) 154–160

Abstract: ... double-blind, crossover design. Seventeen healthy male subjects underwent active and sham tDCS (13 min ... twice at an interval of 20 min) with the anode placed at the left DLPFC and the cathode at the right ...

Abstract	Background: Transcranial direct current stimulation (tDCS) to the dorsolateral prefrontal cortex (DLPFC) hypothetically modulates cognitive functions by facilitating or inhibiting neuronal activities chiefly in the cerebral cortex. The effect of tDCS in the deeper brain region, the basal ganglia-cortical circuit, remains unknown. Objective: To investigate the interaction between γ-aminobutyric acid (GABA) concentrations and dopamine release following tDCS. Method: This study used a randomized, placebo-controlled, double-blind, crossover design. Seventeen healthy male subjects underwent active and sham tDCS (13 min twice at an interval of 20 min) with the anode placed at the left DLPFC and the cathode at the right DLPFC, followed by examinations with [ Results: MRS data analyses showed elevations in GABA in the left striatum along with moderate reductions in the right striatum and the left DLPFC after active tDCS. PET data analyses showed that reductions in [ Conclusion: The present results suggest that tDCS to the DLPFC modulates dopamine-GABA functions in the basal ganglia-cortical circuit.
MeSH term(s)	Brain/diagnostic imaging ; Dopamine ; Double-Blind Method ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Positron-Emission Tomography ; Prefrontal Cortex/diagnostic imaging ; Transcranial Direct Current Stimulation ; gamma-Aminobutyric Acid
Chemical Substances	gamma-Aminobutyric Acid (56-12-2) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2020-12-28
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2394410-9
ISSN	1876-4754 ; 1935-861X
ISSN (online)	1876-4754
ISSN	1935-861X
DOI	10.1016/j.brs.2020.12.010
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Zs.A 6740: Show issues

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Article ; Online: Pulse rate variability and health-related quality of life assessment with the Short Form-8 Japanese version in the general Japanese population.

Saito, Isao / Maruyama, Koutatsu / Yamauchi, Kanako / Funakoshi, Yayoi / Kato, Tadahiro / Kawamura, Ryoichi / Takata, Yasunori / Osawa, Haruhiko

Scientific reports

2024 Volume 14, Issue 1, Page(s) 4157

Abstract: ... Japanese men and women aged 30-79 years. PRV was assessed at rest using 5-min recordings of pulse waves ...

Abstract	We aimed to investigate the association between pulse rate variability (PRV) and health-related quality of life (HRQOL) in the general population. A cross-sectional study was conducted with 5908 Japanese men and women aged 30-79 years. PRV was assessed at rest using 5-min recordings of pulse waves with a photoplethysmographic signal from a fingertip sensor, and the time and frequency domains of PRV were determined. HRQOL was assessed with the Short Form-8 (SF-8) Japanese version, and poor HRQOL was defined as an SF-8 sub-scale score < 50. A test for nonlinear trends was performed with the generalized additive model with a smoothing spline adjusted for confounders. The lowest multivariable-adjusted odds ratios for poor physical component score were found in those who had second or third quartile levels of standard deviation of normal-to-normal intervals (SDNN) and root mean square of successive difference (RMSSD), and high-frequency (HF) power and trended slightly upward in the higher levels. PRV-derived parameters were nonlinearly associated with poor physical component scores. In conclusion, reduced PRV-derived SDNN, RMSSD and HF power were associated with poor HRQOL in the domain of physical function. Higher levels of these parameters did not necessarily translate into better HRQOL.
MeSH term(s)	Male ; Humans ; Female ; Heart Rate ; Quality of Life ; Cross-Sectional Studies ; Japan ; Bradycardia
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54748-9
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Article ; Online: The association between masticatory ability and lower Timed Up & Go Test performance among community-dwelling Japanese aging men and women: The Toon Health Study.

Miyazaki, Saori / Maruyama, Koutatsu / Tomooka, Kiyohide / Nishioka, Shinji / Miyoshi, Noriko / Kawamura, Ryoichi / Takata, Yasunori / Osawa, Haruhiko / Tanigawa, Takeshi / Saito, Isao

Osteoporosis and sarcopenia

2023 Volume 9, Issue 3, Page(s) 94–98

Abstract: ... tasteless and odorless gum for 5 min, calculated stimulated salivary flow rate (g/min) during all chews ...

Abstract	Objectives: Few studies examined the association between deterioration of masticatory ability assessed by objective marker and physical function. Therefore, we examined the association between salivary flow rate which is one of the objective and surrogate marker of masticatory ability and lower Timed Up & Go (TUG) performance which is one of major measurement of physical function among aging Japanese. Methods: This cross-sectional study enrolled 464 Japanese aged 60-84 years old. Participants chewed tasteless and odorless gum for 5 min, calculated stimulated salivary flow rate (g/min) during all chews. The 3 m TUG was conducted, and 75th percentile value (6.8 s for men and 7.0 s for women) or higher was defined as lower TUG performance. Logistic regression analysis was used to examine the association between stimulated salivary flow rate and lower TUG performance. Results: We found that the stimulated salivary flow rate tended to be negatively associated with the TUG time. We also observed significant negative association between stimulated salivary flow rate and lower TUG performance; the multivariable-adjusted OR (95% confidence interval, CIs) of lower TUG performance for the highest quartile of stimulated salivary flow rate compared with the lowest quartile was 0.34 (0.16-0.69, P for trend = 0.02). Further adjusting for BMI, the association was attenuated but remaind significant; the OR (95% CIs) in highest quartile was 0.37 (0.18-0.76, P for trend = 0.04). Conclusions: Higher stimulated salivary flow, which means well masticatory ability, was inversely associated with lower TUG performance in the aging Japanese population.
Language	English
Publishing date	2023-08-22
Publishing country	Netherlands
Document type	Journal Article
ISSN	2405-5263
ISSN (online)	2405-5263
DOI	10.1016/j.afos.2023.08.001
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Article: Temporal expression profiles of microRNAs associated with acute phase of brain ischemia in gerbil hippocampus.

Hamada, Yasuhiro / Takata, Tadayuki / Iwama, Hisakazu / Kawakita, Rie / Nonaka, Wakako / Deguchi, Kazushi / Kobara, Hideki / Morishita, Asahiro / Miyamoto, Osamu / Nakamura, Takehiro / Itano, Toshifumi / Masaki, Tsutomu

Heliyon

2024 Volume 10, Issue 7, Page(s) e28875

Abstract: ... miRNA expression profiles at 5, 9, 18, 36, and 72 h after 5-min whole brain ischemia in gerbils ...

Abstract	Neuroprotective therapeutic potential for restoring dysregulated microRNA (miRNA) expression has previously been demonstrated in a gerbil cerebral infarction model. However, since temporal changes in miRNA expression profiles following stroke onset are unknown, miRNAs proving to be useful therapeutic targets have yet to be identified. We evaluated cognitive function, hippocampal neuronal cell death, and microarray-based miRNA expression profiles at 5, 9, 18, 36, and 72 h after 5-min whole brain ischemia in gerbils. A decline in cognitive function occurred in parallel with increased neuronal cell death 36-72 h after ischemia. The Jonckheere-Terpstra test was used to analyze miRNA expression trends 5-72 h after ischemia. The expression levels of 63 miRNAs were significantly upregulated, whereas 32 miRNAs were significantly downregulated, monotonically. Of the 32 monotonically downregulated miRNAs, 18 showed the largest decrease in expression 5-9 h after ischemia. A subset of these dysregulated miRNAs (miR-378a-5p, miR-204-5p, miR-34c-5p, miR-211-5p, miR-34b-3p, and miR-199b-3p) could be associated with brain ischemia and neuropsychiatric disorders.
Language	English
Publishing date	2024-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28875
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Article ; Online: Age-Related Decline in Physical Activity Level in the Healthy Older Japanese Population.

Ishikawa-Takata, Kazuko / Nakae, Satoshi / Sasaki, Satoshi / Katsukawa, Fuminori / Tanaka, Shigeho

Journal of nutritional science and vitaminology

2021 Volume 67, Issue 5, Page(s) 330–338

Abstract: ... who habitually exercised, and those over 75 y old taking more than 40 min a day of moderate to vigorous physical ...

Abstract	The Dietary Reference Intakes 2020 divided the older population into those aged 65-74 y and those over 75 y old. However, physical activity level in each age group was not specified. This study examined age-related differences in physical activity level among healthy Japanese older people, and the effect of lifestyles on these differences. In total, 70 people (22 men, 48 women) aged 65-85 y old participated in this study. Total energy expenditure was measured using the doubly labeled water method, and basal metabolic rate using expired gas concentration and volume. The Physical Activity Scale for the Elderly and a triaxial accelerometer were used to assess physical activities. Physical activity level was significantly higher among 65-74 y old (median 1.86) than those over 75 y old (1.76). However, the Physical Activity Scale for the Elderly did not show any significant differences between the age groups. The duration of physical activity with 3.0-5.9 metabolic equivalents was longer for both locomotive and household activities among 65-74 y old than those over 75 y old. Younger participants walked a median of 6,364 steps a day, compared with 4,419 steps for older people. The 65-74 y old participants involved in paid work or who habitually exercised, and those over 75 y old taking more than 40 min a day of moderate to vigorous physical activity, and walking more than the median level for their sex and age group had significantly higher physical activity levels.
MeSH term(s)	Aged ; Energy Metabolism ; Exercise ; Female ; Health Status ; Humans ; Japan ; Male ; Walking
Language	English
Publishing date	2021-10-31
Publishing country	Japan
Document type	Journal Article
ZDB-ID	191366-9
ISSN	1881-7742 ; 0301-4800
ISSN (online)	1881-7742
ISSN	0301-4800
DOI	10.3177/jnsv.67.330
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Zs.B 596: Show issues

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Article ; Online: Correlation of 4-meter gait speed with clinical indicators of chronic obstructive pulmonary disease.

Nakano, Takako / Kimura, Shinichi / Yamashita, Takafumi / Yoshimi, Michihiro / Tao, Yoshiaki / Takata, Shohei

Respiratory investigation

2021 Volume 59, Issue 4, Page(s) 505–512

Abstract: ... strong relationships between 4mGS performance, the 6-min walk test (R = 0.70; p < 0.0001), and ...

Abstract	Background: Measuring daily physical activity and exercise capacity is recommended in the routine care of patients with chronic obstructive pulmonary disease (COPD). The 4-m gait speed (4mGS) is simple and effective in stratifying patients according to exercise performance, dyspnea, health status, and prognosis. We assessed the reliability of the 4mGS as a clinical marker by examining its association with established clinical indicators among hospitalized patients with COPD. Methods: This retrospective study included 78 patients hospitalized with COPD (mean age: 76.3 ± 0.9 years; males, n = 69) between January 2016 and June 2018 who were assessed using the 4mGS and divided into slow (<0.8 m/s) and normal (≥0.8 m/s) 4mGS groups. Clinical characteristics were compared, including death during the observation period, time to first exacerbation, and long-term oxygen therapy requirement. Results: There were strong relationships between 4mGS performance, the 6-min walk test (R = 0.70; p < 0.0001), and the modified Medical Research Council dyspnea scale (R = 0.68; p < 0.0001) among the 78 patients. The slow 4mGS group had a higher frequency of death during the observation period (p = 0.0095) and a greater requirement for long-term oxygen therapy (p = 0.0063). The 4mGS correlated with inspiratory capacity (IC) and IC/total lung capacity ratios, which are respiratory failure indicators. Conclusions: The 4mGS is a simple and easy method of assessing the physical condition as well as estimating the prognosis of patients with COPD, and may serve as a useful marker in home medical treatment or clinical settings.
MeSH term(s)	Dyspnea/etiology ; Exercise Tolerance ; Humans ; Infant ; Male ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/therapy ; Reproducibility of Results ; Retrospective Studies ; Walk Test ; Walking Speed
Language	English
Publishing date	2021-04-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2660821-2
ISSN	2212-5353 ; 2212-5345
ISSN (online)	2212-5353
ISSN	2212-5345
DOI	10.1016/j.resinv.2021.03.008
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Article: [The Effectiveness of Two Anesthesia Machines in the Water Generation of the Anesthesia Circuit during the Prolonged Low Flow Desflurane Anesthesia].

Obata, Ryoji / Hori, Etsuyo / Takata, Koutaro / Obata, Yukako

Masui. The Japanese journal of anesthesiology

2018 Volume 65, Issue 7, Page(s) 750–755

Abstract: ... with FGF 11 - min- low flow desflurane anesthesia for more than 6 hours. The water situation in an anesthe ... circuit of the anesthesia machines inside during FGF 11 - min-I prolonged low flow desflurane anesthesia. ...

Abstract	Background: Water is generated by a reaction of carbon dioxide and a carbon dioxide absorbent We evaluated the effectiveness of the anesthesia machines about the water generation which occurs to an anes- thetic circuit during the prolonged low flow anesthesia. Methods: Fifteen patients were divided into three groups; group HHS (n=5) in which a hot heater system was equipped inside anesthesia machine, group WCD (n=5) in which a water catchment device was connected with anesthesia machine, and control group N(n=5)in which normal anesthesia machine was used without special device, and studies were performed with FGF 11 - min- low flow desflurane anesthesia for more than 6 hours. The water situation in an anesthe- sia circuit was observed during the operation and was compared after the operation between these groups. Results: In an anesthesia circuit of the anesthesia machines inside there was no water in group HHS and WCD, but more water in group N. In an anesthesia circuit of the anesthesia machines outside there was little water in group WCD, but more water in group HHS and N. Conclusions: Two anesthesia machines, group HHS and WCD, were effective about reduction of water generation in an anesthesia circuit of the anesthesia machines inside during FGF 11 - min-I prolonged low flow desflurane anesthesia.
MeSH term(s)	Aged ; Aged, 80 and over ; Anesthesiology/instrumentation ; Carbon Dioxide ; Desflurane/administration & dosage ; Humans ; Middle Aged ; Water
Chemical Substances	Water (059QF0KO0R) ; Carbon Dioxide (142M471B3J) ; Desflurane (CRS35BZ94Q)
Language	Japanese
Publishing date	2018-10-25
Publishing country	Japan
Document type	Journal Article
ZDB-ID	391878-6
ISSN	0021-4892
ISSN	0021-4892
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Article ; Online: Clinical Impact of Two-Week Placement of a Subcutaneous Suction Drain in Preventing Incisional Surgical Site Infection in Open Gastrointestinal Surgery with Class 4 Dirty Wound: A Retrospective Study.

Sawada, Genta / Kim, Ho Min / Ichikawa, Yoshitoshi / Hayashi, Rie / Takata, Akihiro / Murakami, Masahiro / Fukunaga, Hiroki / Morita, Shunji

Surgical infections

2022 Volume 23, Issue 8, Page(s) 722–728

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Digestive System Surgical Procedures/adverse effects ; Drainage/adverse effects ; Humans ; Retrospective Studies ; Risk Factors ; Steroids ; Suction ; Surgical Wound Infection/epidemiology
Chemical Substances	Steroids
Language	English
Publishing date	2022-09-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1440120-4
ISSN	1557-8674 ; 1096-2964
ISSN (online)	1557-8674
ISSN	1096-2964
DOI	10.1089/sur.2022.175
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