Article ; Online: Comparison of the 24-h efficacy and safety of fixed combination carteolol/latanoprost and timolol/latanoprost in patients with primary open-angle glaucoma and ocular hypertension: a prospective crossover study.
Japanese journal of ophthalmology
2021 Volume 65, Issue 5, Page(s) 598–607
Abstract: Purpose: To evaluate the 24-h efficacy and safety of fixed combination carteolol/latanoprost (LCFC ... over after a 2-month treatment period. The 24-h curves of intraocular pressure (IOP), pulse rate, and ... between the groups.: Conclusion: The 24-h IOP curve of patients in the LCFC group was similar ...
| Abstract | Purpose: To evaluate the 24-h efficacy and safety of fixed combination carteolol/latanoprost (LCFC) and timolol/latanoprost (LTFC) in patients with primary open-angle glaucoma and ocular hypertension. Study design: Prospective, randomized, crossover study METHODS: Twenty-two patients pretreated with a prostaglandin analog at baseline were randomly assigned at a 1:1 ratio to either LCFC or LTFC treatment. The patients received the assigned study drug in both eyes daily in the evening (20:00). Each treatment group crossed over after a 2-month treatment period. The 24-h curves of intraocular pressure (IOP), pulse rate, and blood pressure were evaluated. Safety was also assessed. Results: The changes in mean daytime IOP from baseline at the end of the 2-month treatment period in the LCFC and LTFC groups were - 0.93 and - 1.15 mmHg, respectively. The changes in peak IOP in the 2 groups were - 0.91 and - 0.68 mmHg, respectively. The nighttime pulse rate in the LCFC group increased; that in the LTFC group was lower at all time points. The changes in pulse rate from baseline at 22:00, 2:00, 4:00, and 6:00 differed statistically between the 2 groups. No differences in changes from baseline in systolic and diastolic blood pressures were found between the groups. Conclusion: The 24-h IOP curve of patients in the LCFC group was similar to that of the LTFC group, but on the basis of the pulse rate findings, the effect of LCFC on the cardiovascular system over 24 h was less than that of LTFC. |
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| MeSH term(s) | Antihypertensive Agents/adverse effects ; Carteolol ; Cross-Over Studies ; Drug Combinations ; Glaucoma, Open-Angle/diagnosis ; Glaucoma, Open-Angle/drug therapy ; Humans ; Intraocular Pressure ; Latanoprost ; Ocular Hypertension/diagnosis ; Ocular Hypertension/drug therapy ; Prospective Studies ; Prostaglandins F, Synthetic ; Timolol ; Treatment Outcome |
| Chemical Substances | Antihypertensive Agents ; Drug Combinations ; Prostaglandins F, Synthetic ; Latanoprost (6Z5B6HVF6O) ; Timolol (817W3C6175) ; Carteolol (8NF31401XG) |
| Language | English |
| Publishing date | 2021-07-19 |
| Publishing country | Japan |
| Document type | Journal Article ; Randomized Controlled Trial |
| ZDB-ID | 82032-5 |
| ISSN | 1613-2246 ; 0021-5155 |
| ISSN (online) | 1613-2246 |
| ISSN | 0021-5155 |
| DOI | 10.1007/s10384-021-00856-2 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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