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  1. Article: Future directions of noninvasive prediction of esophageal variceal bleeding: No worry about the present computed tomography inefficiency.

    Zhang, Yu-Hang / Hu, Bing

    World journal of gastrointestinal endoscopy

    2024  Volume 16, Issue 3, Page(s) 108–111

    Abstract: In this editorial, we comment on the minireview by Martino A, published in the recent issue ... ...

    Abstract In this editorial, we comment on the minireview by Martino A, published in the recent issue of
    Language English
    Publishing date 2024-03-31
    Publishing country United States
    Document type Editorial
    ZDB-ID 2573698-X
    ISSN 1948-5190
    ISSN 1948-5190
    DOI 10.4253/wjge.v16.i3.108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Synthesis, Antimicrobial Evaluation, and Interaction of Emodin Alkyl Azoles with DNA and HSA.

    Zhou, Yu-Hang / Wang, Ying / Zhang, Hui-Zhen

    Medicinal chemistry (Shariqah (United Arab Emirates))

    2024  

    Abstract: Objective: This study aimed to overcome the growing antibiotic resistance. Moreover, the new series of emodin alkyl azoles were synthesized.: Method: The novel emodin alkyl azoles were synthesized using commercial emodin and azoles by alkylation. The ...

    Abstract Objective: This study aimed to overcome the growing antibiotic resistance. Moreover, the new series of emodin alkyl azoles were synthesized.
    Method: The novel emodin alkyl azoles were synthesized using commercial emodin and azoles by alkylation. The NMR and HRMS spectra were employed to confirm the structures of novel prepared compounds. The in vitro antibacterial and antifungal activities of the prepared emodin compounds were studied by the 96-well plate method. The binding behavior between emodin 4-nitro imidazole compound 3c and S. aureus DNA was researched using an ultraviolet-visible spectrophotometer. Furthermore, fluorescence spectrometry was used to explore the interaction with human serum albumin (HSA).
    Results: The in vitro antimicrobial results displayed that compound 3c gave relatively strong activities with MIC values of 4-16 µg/mL. Notably, this compound exhibited 2-fold more potent activity against S. aureus (MIC = 4 µg/mL) and E. coli (MIC = 8 µg/mL) strains than clinical drug Chloromycin (MIC = 8 and 16 µg/mL). The UV-vis absorption spectroscopy showed that 4-nitro imidazole emodin 3c could form the 3c-DNA complex by intercalating into S. aureus DNA, inhibiting antimicrobial activities. The simulation results displayed that the emodin 3c and DNA complex were formed by hydrogen bonds. The spectral experiment demonstrated that compound 3c could be transported by human serum albumin (HSA) via hydrogen bonds. The molecular simulation found that the hydroxyl group and the nitroimidazole ring of the emodin compound showed an important role in transportation behavior.
    Conclusion: This work may supply useful directions for the exploration of novel antimicrobial agents.
    Language English
    Publishing date 2024-02-13
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1875-6638
    ISSN (online) 1875-6638
    DOI 10.2174/0115734064283049240124115544
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Identifying allergic-rhinitis-associated genes with random-walk-based method in PPI network.

    Li, Lin / Huang, FeiMing / Zhang, Yu-Hang / Cai, Yu-Dong

    Computers in biology and medicine

    2024  Volume 175, Page(s) 108495

    Abstract: Allergic rhinitis is a common allergic disease with a complex pathogenesis and many unresolved issues. Studies have shown that the incidence of allergic rhinitis is closely related to genetic factors, and research on the related genes could help further ... ...

    Abstract Allergic rhinitis is a common allergic disease with a complex pathogenesis and many unresolved issues. Studies have shown that the incidence of allergic rhinitis is closely related to genetic factors, and research on the related genes could help further understand its pathogenesis and develop new treatment methods. In this study, 446 allergic rhinitis-related genes were obtained on the basis of the DisGeNET database. The protein-protein interaction network was searched using the random-walk-with-restart algorithm with these 446 genes as seed nodes to assess the linkages between other genes and allergic rhinitis. Then, this result was further examined by three screening tests, including permutation, interaction, and enrichment tests, which aimed to pick up genes that have strong and special associations with allergic rhinitis. 52 novel genes were finally obtained. The functional enrichment test confirmed their relationships to the biological processes and pathways related to allergic rhinitis. Furthermore, some genes were extensively analyzed to uncover their special or latent associations to allergic rhinitis, including IRAK2 and MAPK, which are involved in the pathogenesis of allergic rhinitis and the inhibition of allergic inflammation via the p38-MAPK pathway, respectively. The new found genes may help the following investigations for understanding the underlying molecular mechanisms of allergic rhinitis and developing effective treatments.
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2024.108495
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    Zs.A 653: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Retraction notice to "Comparison between diagnostic performance of intestinal Fusobacterium nucleatum, Bacteroides fragilis and Escherichia coli in 5-fluorouracil resistance to colorectal cancer: A meta-analysis"[Cancer letters 32 (2022) 100536].

    Wang, Wen-Yu / Zhou, Hang / Wang, Zhi / Zhang, Yu-Hang

    Cancer treatment and research communications

    2022  Volume 33, Page(s) 100651

    Language English
    Publishing date 2022-10-25
    Publishing country England
    Document type Journal Article ; Retraction of Publication
    ISSN 2468-2942
    ISSN (online) 2468-2942
    DOI 10.1016/j.ctarc.2022.100651
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  5. Article ; Online: RETRACTED: Comparison between diagnostic performance of intestinal Fusobacterium nucleatum, Bacteroides fragilis and Escherichia coli in 5-fluorouracil resistance to colorectal cancer: A meta‑analysis.

    Wang, Wen-Yu / Zhou, Hang / Wang, Zhi / Zhang, Yu-Hang

    publication RETRACTED

    Cancer treatment and research communications

    2022  Volume 32, Page(s) 100536

    MeSH term(s) Bacteroides fragilis ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/drug therapy ; Escherichia coli ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use ; Fusobacterium nucleatum ; Humans
    Chemical Substances Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2022-02-22
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review ; Research Support, Non-U.S. Gov't ; Retracted Publication
    ISSN 2468-2942
    ISSN (online) 2468-2942
    DOI 10.1016/j.ctarc.2022.100536
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  6. Article ; Online: Surface profile measurement and parameter analysis of silicon wafers in the upright state.

    Yang, Ying / Han, Sen / Zhang, Ling-Hua / Shen, Yu-Hang / Xu, Chun-Feng

    Applied optics

    2024  Volume 63, Issue 10, Page(s) 2587–2593

    Abstract: A novel approach, to the best of our knowledge, is presented for assessing silicon wafer surface profiles using an interferometer and vertically rotatable wafer holder. This approach significantly enhances precision and reduces costs, and outperforms ... ...

    Abstract A novel approach, to the best of our knowledge, is presented for assessing silicon wafer surface profiles using an interferometer and vertically rotatable wafer holder. This approach significantly enhances precision and reduces costs, and outperforms traditional techniques in measurement consistency and accuracy. It effectively reduces sample distortion and positional shifts owing to the removal and reinstallation of the wafers. Using this method, a global backsurface-referenced ideal range of 0.385 µm, warp of 0.193 µm, and other parameters were obtained, demonstrating its practicality in efficiently capturing key surface profile metrics for silicon wafers. This innovation promises substantial improvements in high-volume wafer surface profile testing, overcoming prevalent technological challenges in this industry.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.515440
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Targeting epigenetic and post-translational modifications regulating pyroptosis for the treatment of inflammatory diseases.

    Ri-Wen / Yang, Yu-Hang / Zhang, Tie-Ning / Liu, Chun-Feng / Yang, Ni

    Pharmacological research

    2024  Volume 203, Page(s) 107182

    Abstract: Inflammatory diseases, including infectious diseases, diabetes-related diseases, arthritis-related diseases, neurological diseases, digestive diseases, and tumor, continue to threaten human health and impose a significant financial burden despite ... ...

    Abstract Inflammatory diseases, including infectious diseases, diabetes-related diseases, arthritis-related diseases, neurological diseases, digestive diseases, and tumor, continue to threaten human health and impose a significant financial burden despite advancements in clinical treatment. Pyroptosis, a pro-inflammatory programmed cell death pathway, plays an important role in the regulation of inflammation. Moderate pyroptosis contributes to the activation of native immunity, whereas excessive pyroptosis is associated with the occurrence and progression of inflammation. Pyroptosis is complicated and tightly controlled by various factors. Accumulating evidence has confirmed that epigenetic modifications and post-translational modifications (PTMs) play vital roles in the regulation of pyroptosis. Epigenetic modifications, which include DNA methylation and histone modifications (such as methylation and acetylation), and post-translational modifications (such as ubiquitination, phosphorylation, and acetylation) precisely manipulate gene expression and protein functions at the transcriptional and post-translational levels, respectively. In this review, we summarize the major pathways of pyroptosis and focus on the regulatory roles and mechanisms of epigenetic and post-translational modifications of pyroptotic components. We also illustrate these within pyroptosis-associated inflammatory diseases. In addition, we discuss the effects of novel therapeutic strategies targeting epigenetic and post-translational modifications on pyroptosis, and provide prospective insight into the regulation of pyroptosis for the treatment of inflammatory diseases.
    MeSH term(s) Humans ; Pyroptosis/drug effects ; Protein Processing, Post-Translational ; Epigenesis, Genetic ; Animals ; Inflammation/genetics ; Inflammation/metabolism ; Anti-Inflammatory Agents/therapeutic use ; Anti-Inflammatory Agents/pharmacology
    Chemical Substances Anti-Inflammatory Agents
    Language English
    Publishing date 2024-04-12
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2024.107182
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 721: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Gut Microbiome Metabolism Drives the Resolution of Patients With Coronavirus Disease 2019.

    Zhang, Yu-Hang / Wang, Wen-Yu / Cui, Yi-Min

    Gastroenterology

    2021  Volume 163, Issue 1, Page(s) 336–337

    MeSH term(s) COVID-19 ; Gastrointestinal Microbiome ; Humans
    Language English
    Publishing date 2021-12-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2021.12.261
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    Ui V Zs.44: Show issues Location:
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    Zs.MO 572: Show issues

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  9. Article ; Online: Species of the

    Qiao, Yu-Hang / Zhang, Chen-Ning / Li, Min / Li, Huan / Mao, Yun-Fei / Chen, Feng-Mao

    Journal of fungi (Basel, Switzerland)

    2023  Volume 9, Issue 4

    Abstract: European hornbeam ( ...

    Abstract European hornbeam (
    Language English
    Publishing date 2023-04-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof9040489
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  10. Article ; Online: Massive hemothorax secondary to internal jugular vein central venous catheter placement in a patient undergoing spinal surgery complicated by chest trauma: a case report.

    Gong, Tao-Wu / Zhu, Yu-Hang / Zhao, Peng-Cheng / Zhang, Fan

    Journal of cardiothoracic surgery

    2023  Volume 18, Issue 1, Page(s) 104

    Abstract: Background: Placement of a central venous catheter (CVC) is a common procedure for spinal surgery and is relatively safe under ultrasound guidance.: Case presentation: We report the case of a 56-year-old female who underwent ultrasound-guided ... ...

    Abstract Background: Placement of a central venous catheter (CVC) is a common procedure for spinal surgery and is relatively safe under ultrasound guidance.
    Case presentation: We report the case of a 56-year-old female who underwent ultrasound-guided placement of an internal jugular vein CVC for fluid replacement during spinal surgery for thoracic vertebral burst compression fracture and multiple rib fractures as a result of a high-altitude fall injury. Hemothorax developed intraoperatively. During a thoracotomy, the tip of the CVC was found within the chest cavity. The presence of chest trauma may impact on clinician's appreciation of the potential complications of internal jugular vein CVC placement.
    Conclusion: The present case demonstrates the need for clinical awareness of the potential complications of CVC placement in patients with chest trauma and the need for adequate training in this technique.
    MeSH term(s) Female ; Humans ; Middle Aged ; Central Venous Catheters/adverse effects ; Hemothorax/etiology ; Hemothorax/surgery ; Jugular Veins ; Catheterization, Central Venous/adverse effects ; Catheterization, Central Venous/methods ; Ultrasonography
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2227224-0
    ISSN 1749-8090 ; 1749-8090
    ISSN (online) 1749-8090
    ISSN 1749-8090
    DOI 10.1186/s13019-023-02194-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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