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Article ; Online: Secretory leukocyte protease inhibitor protects against severe urinary tract infection in mice.

Rosen, Anne L / Lint, Michael A / Voelker, Dayne H / Gilbert, Nicole M / Tomera, Christopher P / Santiago-Borges, Jesús / Wallace, Meghan A / Hannan, Thomas J / Burnham, Carey-Ann D / Hultgren, Scott J / Kau, Andrew L

mBio

2024 Volume 15, Issue 2, Page(s) e0255423

Abstract: Millions suffer from urinary tract infections (UTIs) worldwide every year with women accounting for the majority of cases. ... ...

Abstract	Millions suffer from urinary tract infections (UTIs) worldwide every year with women accounting for the majority of cases. Uropathogenic
MeSH term(s)	Adolescent ; Adult ; Animals ; Female ; Humans ; Mice ; Middle Aged ; Young Adult ; Anti-Infective Agents ; Cystitis ; Escherichia coli Infections/microbiology ; Secretory Leukocyte Peptidase Inhibitor/genetics ; Urinary Tract Infections/microbiology ; Uropathogenic Escherichia coli/genetics
Chemical Substances	Anti-Infective Agents ; Secretory Leukocyte Peptidase Inhibitor ; Slpi protein, mouse
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.02554-23
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Secretory Leukocyte Protease Inhibitor Protects Against Severe Urinary Tract Infection in Mice.

bioRxiv : the preprint server for biology

2023

Abstract: Millions suffer from urinary tract infections (UTIs) worldwide every year with women accounting for the majority of cases. ... ...

Abstract	Millions suffer from urinary tract infections (UTIs) worldwide every year with women accounting for the majority of cases. Uropathogenic
Language	English
Publishing date	2023-10-13
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.10.10.561753
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Article ; Online: Probing entanglement in a 2D hard-core Bose-Hubbard lattice.

Karamlou, Amir H / Rosen, Ilan T / Muschinske, Sarah E / Barrett, Cora N / Di Paolo, Agustin / Ding, Leon / Harrington, Patrick M / Hays, Max / Das, Rabindra / Kim, David K / Niedzielski, Bethany M / Schuldt, Meghan / Serniak, Kyle / Schwartz, Mollie E / Yoder, Jonilyn L / Gustavsson, Simon / Yanay, Yariv / Grover, Jeffrey A / Oliver, William D

Nature

2024 Volume 629, Issue 8012, Page(s) 561–566

Abstract: Entanglement and its propagation are central to understanding many physical properties of quantum ... ...

Abstract	Entanglement and its propagation are central to understanding many physical properties of quantum systems
MeSH term(s)	Quantum Theory ; Entropy ; Superconductivity
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-024-07325-z
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Article ; Online: It Pays to Be Bumpy: Drag Reducing Armor in the Pacific Spiny Lumpsucker, Eumicrotremus orbis.

Hoover, R C / Hawkins, Olivia H / Rosen, Jack / Wilson, Conrad D / Crawford, Callie H / Holst, Meghan M / Huie, Jonathan M / Summers, Adam P / Donatelli, Cassandra M / Cohen, Karly E

Integrative and comparative biology

2023 Volume 63, Issue 3, Page(s) 796–807

Abstract: Armor is a multipurpose set of structures that has evolved independently at least 30 times in fishes. In addition to providing protection, armor can manipulate flow, increase camouflage, and be sexually dimorphic. There are potential tradeoffs in armor ... ...

Abstract	Armor is a multipurpose set of structures that has evolved independently at least 30 times in fishes. In addition to providing protection, armor can manipulate flow, increase camouflage, and be sexually dimorphic. There are potential tradeoffs in armor function: increased impact resistance may come at the cost of maneuvering ability; and ornate armor may offer visual or protective advantages, but could incur excess drag. Pacific spiny lumpsuckers (Eumicrotremus orbis) are covered in rows of odontic, cone-shaped armor whorls, protecting the fish from wave driven impacts and the threat of predation. We are interested in measuring the effects of lumpsucker armor on the hydrodynamic forces on the fish. Bigger lumpsuckers have larger and more complex armor, which may incur a greater hydrodynamic cost. In addition to their protective armor, lumpsuckers have evolved a ventral adhesive disc, allowing them to remain stationary in their environment. We hypothesize a tradeoff between the armor and adhesion: little fish prioritize suction, while big fish prioritize protection. Using micro-CT, we compared armor volume to disc area over lumpsucker development and built 3D models to measure changes in drag over ontogeny. We found that drag and drag coefficients decrease with greater armor coverage and vary consistently with orientation. Adhesive disc area is isometric but safety factor increases with size, allowing larger fish to remain attached in higher flows than smaller fish.
MeSH term(s)	Animals ; Fishes ; Perciformes ; Hydrodynamics ; Predatory Behavior
Language	English
Publishing date	2023-06-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2159110-6
ISSN	1557-7023 ; 1540-7063
ISSN (online)	1557-7023
ISSN	1540-7063
DOI	10.1093/icb/icad076
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Article ; Online: Bone mineral density and the risk of incident dementia: A meta-analysis.

Lary, Christine W / Ghatan, Samuel / Gerety, Meghan / Hinton, Alexandra / Nagarajan, Archana / Rosen, Clifford / Ross, Ryan D / Bennett, David A / DeStefano, Anita L / Ikram, Mohammad A / Rivadeneira, Fernando / Kiel, Douglas P / Seshadri, Sudha / Beiser, Alexa

Journal of the American Geriatrics Society

2023 Volume 72, Issue 1, Page(s) 194–200

Abstract: Background: It is not known whether bone mineral density (BMD) measured at baseline or as the rate of decline prior to baseline (prior bone loss) is a stronger predictor of incident dementia or Alzheimer's disease (AD).: Methods: We performed a meta- ... ...

Abstract	Background: It is not known whether bone mineral density (BMD) measured at baseline or as the rate of decline prior to baseline (prior bone loss) is a stronger predictor of incident dementia or Alzheimer's disease (AD). Methods: We performed a meta-analysis of three longitudinal studies, the Framingham Heart Study (FHS), the Rotterdam Study (RS), and the Rush Memory and Aging Project (MAP), modeling the time to diagnosis of dementia as a function of BMD measures accounting for covariates. We included individuals with one or two BMD assessments, aged ≥60 years, and free of dementia at baseline with follow-up available. BMD was measured at the hip femoral neck using dual-energy X-ray absorptiometry (DXA), or at the heel calcaneus using quantitative ultrasound to calculate estimated BMD (eBMD). BMD at study baseline ("baseline BMD") and annualized percentage change in BMD prior to baseline ("prior bone loss") were included as continuous measures. The primary outcome was incident dementia diagnosis within 10 years of baseline, and incident AD was a secondary outcome. Baseline covariates included age, sex, body mass index, ApoE4 genotype, and education. Results: The combined sample size across all three studies was 4431 with 606 incident dementia diagnoses, 498 of which were AD. A meta-analysis of baseline BMD across three studies showed higher BMD to have a significant protective association with incident dementia with a hazard ratio of 0.47 (95% CI: 0.23-0.96; p = 0.038) per increase in g/cm Conclusions: Baseline BMD but not prior bone loss was associated with incident dementia in a meta-analysis across three studies.
MeSH term(s)	Humans ; Bone Density ; Absorptiometry, Photon ; Longitudinal Studies ; Bone Diseases, Metabolic ; Alzheimer Disease
Language	English
Publishing date	2023-11-07
Publishing country	United States
Document type	Meta-Analysis ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/jgs.18638
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Article ; Online: Thyroid hormone receptor mutations in cancer and resistance to thyroid hormone: perspective and prognosis.

Rosen, Meghan D / Privalsky, Martin L

Journal of thyroid research

2011 Volume 2011, Page(s) 361304

Abstract: Thyroid hormone, operating through its receptors, plays crucial roles in the control of normal human physiology and development; deviations from the norm can give rise to disease. Clinical endocrinologists often must confront and correct the consequences ...

Abstract	Thyroid hormone, operating through its receptors, plays crucial roles in the control of normal human physiology and development; deviations from the norm can give rise to disease. Clinical endocrinologists often must confront and correct the consequences of inappropriately high or low thyroid hormone synthesis. Although more rare, disruptions in thyroid hormone endocrinology due to aberrations in the receptor also have severe medical consequences. This review will focus on the afflictions that are caused by, or are closely associated with, mutated thyroid hormone receptors. These include Resistance to Thyroid Hormone Syndrome, erythroleukemia, hepatocellular carcinoma, renal clear cell carcinoma, and thyroid cancer. We will describe current views on the molecular bases of these diseases, and what distinguishes the neoplastic from the non-neoplastic. We will also touch on studies that implicate alterations in receptor expression, and thyroid hormone levels, in certain oncogenic processes.
Language	English
Publishing date	2011-06-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2549014-X
ISSN	2042-0072 ; 2042-0072
ISSN (online)	2042-0072
ISSN	2042-0072
DOI	10.4061/2011/361304
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Article ; Online: Thyroid hormone receptor mutations found in renal clear cell carcinomas alter corepressor release and reveal helix 12 as key determinant of corepressor specificity.

Rosen, Meghan D / Privalsky, Martin L

Molecular endocrinology (Baltimore, Md.)

2009 Volume 23, Issue 8, Page(s) 1183–1192

Abstract: Thyroid hormone receptors (TRs) regulate multiple normal physiological and developmental pathways, whereas mutations in TRs can result in endocrine and neoplastic disease. A particularly high rate of TR mutations has been found in human renal clear cell ... ...

Abstract	Thyroid hormone receptors (TRs) regulate multiple normal physiological and developmental pathways, whereas mutations in TRs can result in endocrine and neoplastic disease. A particularly high rate of TR mutations has been found in human renal clear cell carcinomas (RCCCs). We report here that the majority of these RCCC TR mutants tested are defective for transcriptional activation and behave as dominant-negative inhibitors of wild-type receptor function. Although several of the dominant-negative RCCC TR mutants are impaired for hormone binding, all fail to release from corepressors appropriately in response to T(3), a trait that closely correlates with their defective transcriptional properties. Notably, many of these mutants exhibit additional changes in their specificity for different corepressor splice forms that may further contribute to the disease phenotype. Mapping of the relevant mutations reveals that the C-terminal receptor helix 12 is not simply a hormone-operated switch that either permits or prevents all corepressor binding, but is instead a selective gatekeeper that actively discriminates between different forms of corepressor even in the absence of T(3).
MeSH term(s)	Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Cell Line, Tumor ; Cloning, Molecular ; Gene Expression Regulation, Neoplastic ; Genes, Dominant ; Hormones/metabolism ; Humans ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Mutation ; Phenotype ; Protein Binding ; Protein Structure, Tertiary ; Receptors, Thyroid Hormone/genetics ; Repressor Proteins/metabolism ; Transcriptional Activation
Chemical Substances	Hormones ; Receptors, Thyroid Hormone ; Repressor Proteins
Language	English
Publishing date	2009-04-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	639167-9
ISSN	1944-9917 ; 0888-8809
ISSN (online)	1944-9917
ISSN	0888-8809
DOI	10.1210/me.2009-0126
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Zs.A 2261: Show issues

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Article ; Online: Thyroid Hormone Receptor Mutations in Cancer and Resistance to Thyroid Hormone

Martin L. Privalsky / Meghan D. Rosen

Journal of Thyroid Research, Vol

Perspective and Prognosis

2011 Volume 2011

Keywords	Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2011-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Probing entanglement across the energy spectrum of a hard-core Bose-Hubbard lattice

Karamlou, Amir H. / Rosen, Ilan T. / Muschinske, Sarah E. / Barrett, Cora N. / Di Paolo, Agustin / Ding, Leon / Harrington, Patrick M. / Hays, Max / Das, Rabindra / Kim, David K. / Niedzielski, Bethany M. / Schuldt, Meghan / Serniak, Kyle / Schwartz, Mollie E. / Yoder, Jonilyn L. / Gustavsson, Simon / Yanay, Yariv / Grover, Jeffrey A. / Oliver, William D.

2023

Abstract: Entanglement and its propagation are central to understanding a multitude of physical properties of quantum systems. Notably, within closed quantum many-body systems, entanglement is believed to yield emergent thermodynamic behavior, yet a universal ... ...

Abstract	Entanglement and its propagation are central to understanding a multitude of physical properties of quantum systems. Notably, within closed quantum many-body systems, entanglement is believed to yield emergent thermodynamic behavior, yet a universal understanding remains challenging due to the non-integrability and computational intractability of most large-scale quantum systems. Quantum hardware platforms provide a means to study the formation and scaling of entanglement in interacting many-body systems. Here, we use a controllable $4 \times 4$ array of superconducting qubits to emulate a two-dimensional hard-core Bose-Hubbard lattice. We generate superposition states by simultaneously driving all lattice sites and extract correlation lengths and entanglement entropy across its many-body energy spectrum. We observe volume-law entanglement scaling for states at the center of the spectrum and a crossover to the onset of area-law scaling near its edges.
Keywords	Quantum Physics
Subject code	612
Publishing date	2023-06-04
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Systematic Review of Interventions to Increase Awareness of Ultraviolet Radiation-Induced Harm and Protective Behaviors in Post-Secondary School Adults.

Asai, Yuka / Armstrong, Dawn / McPhie, Meghan L / Xue, Chao / Rosen, Cheryl F

Journal of cutaneous medicine and surgery

2021 Volume 25, Issue 4, Page(s) 424–436

Abstract: College and university students are a group known for excessive sun exposure and indoor tanning. Health education campaigns for avoidance of ultraviolet (UV) radiation have been relatively unsuccessful in this population. This systematic review examines ... ...

Abstract	College and university students are a group known for excessive sun exposure and indoor tanning. Health education campaigns for avoidance of ultraviolet (UV) radiation have been relatively unsuccessful in this population. This systematic review examines interventions aimed at post-secondary school young adults on college and university campuses for skin cancer awareness, photoprotection, and change in UV-exposure-related behavior. Fifty-nine studies were identified for inclusion according to predetermined criteria. Study heterogeneity was high; methods of intervention were individual or group-based, and were mostly visually delivered and/or passive learning. Most interventions occurred at a single time point. Intervention success was assessed by evaluating subject behavior, intention, attitudes, knowledge, and emotion. Multicomponent interventions, generally consisting of UV photography and a passively delivered educational component, may be more effective than a single component alone. Overall, study quality was poor. Sample size of the majority of studies was <150 subjects. Most studies used self-report of behavior and had a short follow-up time. Generalizability of findings may be impacted as women, particularly white/Caucasian women, were overrepresented in the studies identified by this systematic review. For this specific target population, themes arising from the review include the importance of self-relevance and message framing. Self-affirmation was identified as a potential challenge in designing interventions for this target group, which can lead to defensiveness and a negative reaction to the health message. The findings of this systematic review may inform future research in this field, as well as guide planning of effective interventions in this target population.
MeSH term(s)	Female ; Health Behavior ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Schools ; Skin Neoplasms/prevention & control ; Sunburn/prevention & control ; Ultraviolet Rays/adverse effects ; Young Adult
Language	English
Publishing date	2021-02-10
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	1361720-5
ISSN	1615-7109 ; 1203-4754
ISSN (online)	1615-7109
ISSN	1203-4754
DOI	10.1177/1203475420988863
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Zs.A 4987: Show issues

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