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  1. Article ; Online: Low correlation between serum thyroglobulin and

    Thai, Janice N / De Marchena, Ingrid Rymer / Nehru, Vijeyaluxmy Motilal / Landau, Elliot / Demissie, Seleshi / Josemon, Raina / Peti, Steven / Brenner, Arnold I

    Clinical imaging

    2022  Volume 87, Page(s) 1–4

    Abstract: Purpose: To evaluate postoperative serum thyroglobulin (Tg) as a reliable tumor marker in low-risk differentiated thyroid cancer (DTC).: Methods: Two hundred and three patients met the selection criteria of >18 years old; who had undergone total or ... ...

    Abstract Purpose: To evaluate postoperative serum thyroglobulin (Tg) as a reliable tumor marker in low-risk differentiated thyroid cancer (DTC).
    Methods: Two hundred and three patients met the selection criteria of >18 years old; who had undergone total or near total thyroidectomy; had a postoperative Tg, and had undergone
    Results: One hundred ten patients (54.1%) had discordant results (p < 0.05) with positive PA-WBS and Tg <1 ng/ml, while 93 patients (45.9%) had concordant results. For concordant results, 88 patients had positive PA-WBS and Tg >1 ng/ml, and 5 patients had negative PA-WBS and Tg <1 ng/ml. There was no patient with Tg >1 ng/ml and negative PA-WBS. There were 74 patients with high TSH (>30 mU/l) on abstention (thyroxine withdrawal protocol). Twenty-four (32.5%) had discordant results (p < 0.001) and 50 (67.5%) had concordant results.
    Conclusion: There is low correlation between postoperative Tg and PA-WBS. The sole use of Tg as a serum biomarker for postoperative disease status may not be reliable.
    MeSH term(s) Adenocarcinoma ; Humans ; Iodine Radioisotopes/therapeutic use ; Radionuclide Imaging ; Thyroglobulin/blood ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/surgery ; Thyrotropin ; Thyroxine ; Whole Body Imaging
    Chemical Substances Iodine Radioisotopes ; Iodine-131 ; Thyrotropin (9002-71-5) ; Thyroglobulin (9010-34-8) ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2022-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1028123-x
    ISSN 1873-4499 ; 0899-7071
    ISSN (online) 1873-4499
    ISSN 0899-7071
    DOI 10.1016/j.clinimag.2022.04.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Thyrotoxicosis Mimicking ST Elevation Myocardial Infarction.

    Rymer De Marchena, Ingrid / Gutman, Anna / Zaidan, Julie / Yacoub, Harout / Hoyek, Wissam

    Cureus

    2017  Volume 9, Issue 6, Page(s) e1323

    Abstract: Hyperthyroidism is well known to be associated with cardiac disease. Delay in making the diagnosis and occurrence of complications are common and are associated with a worse outcome. A 54-year-old male, non-smoker, with no past medical history and no ... ...

    Abstract Hyperthyroidism is well known to be associated with cardiac disease. Delay in making the diagnosis and occurrence of complications are common and are associated with a worse outcome. A 54-year-old male, non-smoker, with no past medical history and no significant family history presented to our hospital with severe left sided chest pain, "crushing" in nature. Electrocardiogram showed ST-segment elevations in the inferior leads. Troponin I level was 0.32 ng/mL (normal range 0-0.05 ng/mL) on presentation. The patient underwent an emergent coronary angiography which showed no evidence of occlusive coronary artery disease. The patient's symptoms and signs prompted a high suspicion of thyrotoxicosis which was subsequently confirmed by a low thyroid stimulating hormone and high free thyroxine levels. The patient was given Methimazole and atenolol and his symptoms resolved. Awareness of coronary vasospasm due to thyrotoxicosis should be raised in patients presenting with typical angina pectoris with subsequent normal coronary angiographic results. History and physical examination may suggest underlying hyperthyroidism, but the absence of typical findings does not rule out the diagnosis.
    Language English
    Publishing date 2017-06-07
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.1323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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