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Book ; Online ; E-Book: Diagnosis and management of craniopharyngiomas

Lania, Andrea / Spada, Anna / Lasio, Giovanni

key current topics

2016

Author's details	Andrea Lania, Anna Spada, Giovanni Lasio editors
Keywords	Craniopharyngioma / diagnosis ; Craniopharyngioma / therapy
Language	English
Size	1 Online-Ressource (viii, 153 Seiten), Illustrationen, Diagramme
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019444949
ISBN	978-3-319-22297-4 ; 9783319222967 ; 3-319-22297-X ; 3319222961
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Real-world sex differences in type 2 diabetes patients treated with GLP-1 receptor agonists.

Piccini, Sara / Favacchio, Giuseppe / Morenghi, Emanuela / Mazziotti, Gherardo / A Lania, Andrea G / Mirani, Marco

Diabetes research and clinical practice

2024 , Page(s) 111689

Abstract: Aims: To evaluate the determinants of cardiovascular (CV) protection in men and women treated with glucagon-like peptide-1 receptor agonists (GLP1-RA).: Methods: Retrospective cohort study of 550 patients (43% women), with and without established CV ... ...

Abstract	Aims: To evaluate the determinants of cardiovascular (CV) protection in men and women treated with glucagon-like peptide-1 receptor agonists (GLP1-RA). Methods: Retrospective cohort study of 550 patients (43% women), with and without established CV disease, followed at a single center after the first prescription of a GLP1-RA. We analyzed the determinants of major adverse cardiovascular events (MACE) in men and women. Results: The rate of MACE was similar between sexes. In primary prevention, among men, older age (HR 1.13, 95 % C.I. 1.05-1.22; P = 0.001) and GLP-1 RA withdrawal by time (HR 2.77, 95 % C.I. 1.15-6.68; P = 0.023) increased the HR for MACE. Among women, significant predictors of MACE were diabetes duration (HR 1.05, C.I. 1.01-1.10; P = 0.020), GLP-1 withdrawal by time (HR 2.84, 95 % C.I. 1.13-7.10; P = 0.026) and BMI at GLP-1 RA withdrawal (HR 1.08, 95 % C.I. 1.01-1.15; P = 0.026). For individuals with prior CV disease, the HR for MACE was solely impacted by GLP-1 withdrawal over time in males (HR 2.18, 95 % C.I. 1.10-4.30; P = 0.025) and by older age at GLP-1 RA initiation (HR 1.17, 95 % C.I. 1.03-1.33; P = 0.015) in females. Conclusions: Although MACE rates were similar, the factors contributing to MACE differed by sex.
Language	English
Publishing date	2024-04-30
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632523-3
ISSN	1872-8227 ; 0168-8227
ISSN (online)	1872-8227
ISSN	0168-8227
DOI	10.1016/j.diabres.2024.111689
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Article ; Online: Skeletal disorders associated with the growth hormone-insulin-like growth factor 1 axis.

Mazziotti, Gherardo / Lania, Andrea G / Canalis, Ernesto

Nature reviews. Endocrinology

2022 Volume 18, Issue 6, Page(s) 353–365

Abstract: Growth hormone (GH) and insulin-like growth factor 1 (IGF1) are important regulators of bone remodelling and metabolism and have an essential role in the achievement and maintenance of bone mass throughout life. Evidence from animal models and human ... ...

Abstract	Growth hormone (GH) and insulin-like growth factor 1 (IGF1) are important regulators of bone remodelling and metabolism and have an essential role in the achievement and maintenance of bone mass throughout life. Evidence from animal models and human diseases shows that both GH deficiency (GHD) and excess are associated with changes in bone remodelling and cause profound alterations in bone microstructure. The consequence is an increased risk of fractures in individuals with GHD or acromegaly, a condition of GH excess. In addition, functional perturbations of the GH-IGF1 axis, encountered in individuals with anorexia nervosa and during ageing, result in skeletal fragility and osteoporosis. The effect of interventions used to treat GHD and acromegaly on the skeleton is variable and dependent on the duration of the disease, the pre-existing skeletal state, coexistent hormone alterations (such as those occurring in hypogonadism) and length of therapy. This variability could also reflect the irreversibility of the skeletal structural defect occurring during alterations of the GH-IGF1 axis. Moreover, the effects of the treatment of GHD and acromegaly on locally produced IGF1 and IGF binding proteins are uncertain and in need of further study. This Review highlights the pathophysiological, clinical and therapeutic aspects of skeletal fragility associated with perturbations in the GH-IGF1 axis.
MeSH term(s)	Acromegaly/drug therapy ; Animals ; Dwarfism, Pituitary ; Growth Hormone ; Human Growth Hormone/metabolism ; Humans ; Insulin-Like Growth Factor I
Chemical Substances	Human Growth Hormone (12629-01-5) ; Insulin-Like Growth Factor I (67763-96-6) ; Growth Hormone (9002-72-6)
Language	English
Publishing date	2022-03-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2489381-X
ISSN	1759-5037 ; 1759-5029
ISSN (online)	1759-5037
ISSN	1759-5029
DOI	10.1038/s41574-022-00649-8
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Zs.A 6336: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 93: Show issues

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Article: Editorial: Functional hypothalamic amenorrhea seen from different perspectives.

Garzia, Emanuele / Marconi, Anna Maria / Lania, Andrea / Miozzo, Monica Rosa / Vegni, Elena / Priori, Alberto

Frontiers in endocrinology

2023 Volume 14, Page(s) 1167668

MeSH term(s)	Female ; Humans ; Amenorrhea/etiology ; Polycystic Ovary Syndrome ; Hypogonadism
Language	English
Publishing date	2023-04-06
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1167668
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Article ; Online: Looking at the spine in controlled Acromegaly.

Birtolo, Maria Francesca / Antonini, Simone / Lania, Andrea G / Mazziotti, Gherardo

Endocrine

2022 Volume 79, Issue 2, Page(s) 283–286

Abstract: Skeletal fragility with high risk of vertebral fractures (VFs) is an emerging complication of growth hormone (GH) hypersecretion. VFs often coexist with spine arthropathy and both clinical conditions negatively impact on quality of life of acromegalic ... ...

Abstract	Skeletal fragility with high risk of vertebral fractures (VFs) is an emerging complication of growth hormone (GH) hypersecretion. VFs often coexist with spine arthropathy and both clinical conditions negatively impact on quality of life of acromegalic subjects. Management of spine osteopathy and arthropathy in acromegaly could be challenging since both complications can persist or even progress after biochemical control of disease. This article analyzes the latest evidence about possible pathophysiological links between VFs and spine arthropathy in active and controlled acromegaly, as well as the diagnostic and therapeutic aspects concerning the holistic management of acromegalic osteo-arthropathy.
MeSH term(s)	Humans ; Acromegaly/therapy ; Acromegaly/drug therapy ; Quality of Life ; Bone Density/physiology ; Spinal Fractures/complications ; Spinal Fractures/diagnostic imaging ; Human Growth Hormone/therapeutic use
Chemical Substances	Human Growth Hormone (12629-01-5)
Language	English
Publishing date	2022-12-27
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1194484-5
ISSN	1559-0100 ; 1355-008X ; 0969-711X
ISSN (online)	1559-0100
ISSN	1355-008X ; 0969-711X
DOI	10.1007/s12020-022-03258-7
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Article ; Online: Prediction of adrenal insufficiency after pituitary surgery: a retrospective study using beckman access cortisol assay.

Birtolo, Maria Francesca / Giannini, Emma / Antonini, Simone / Lavezzi, Elisabetta / Lasio, Giovanni / Da Rin, Giorgio / Mazziotti, Gherardo / Lania, Andrea G

Pituitary

2024 Volume 27, Issue 2, Page(s) 160–168

Abstract: Purpose: Identifying patients requiring glucocorticoid replacement therapy after pituitary surgery is challenging as the tests commonly used for the diagnosis of secondary adrenal insufficiency (SAI) are not recommended in the immediate postoperative ... ...

Abstract	Purpose: Identifying patients requiring glucocorticoid replacement therapy after pituitary surgery is challenging as the tests commonly used for the diagnosis of secondary adrenal insufficiency (SAI) are not recommended in the immediate postoperative period. There are controversial data on the role of postoperative days' morning cortisol, with no specific data for each cortisol assay. The aim of this study is to investigate the reliability of 8.00 a.m. cortisol of the first and second postoperative days in predicting SAI. Methods: Data of patients underwent pituitary surgery in Humanitas Research Hospital in Italy, from March 2017 to August 2022, were retrospectively analyzed. Definitive diagnosis of SAI was made through ACTH test 1 µg six weeks after surgery. Cortisol was measured through Beckman Access Cortisol and the diagnosis of SAI was made if cortisol peak was below 14.8 µg/dL (408 nmol/L) at 30 or 60 min after stimulus. Results: Of the sixty-four patients enrolled, seven developed SAI. The ROC curves demonstrated that both first- and second-day postoperative 8.00 a.m. cortisol predict SAI (AUC 0.94 and 0.95, respectively). The optimal thresholds were 15.6 µg/dL (430.3 nmol/L; accuracy 89%) for the first day and 11.5 µg/dL (317.2 nmol/L, accuracy 81%) for the second day. Patients who developed SAI had larger tumors (p = 0.004) and lower fT4 (p = 0.038) before surgery. Conclusions: Clinicians might rely on the first- and second- postoperative days 8.00 a.m. cortisol to identify patients to discharge with glucocorticoid replacement therapy waiting for the confirmation of SAI through the ACTH test.
MeSH term(s)	Humans ; Hydrocortisone ; Retrospective Studies ; Glucocorticoids/therapeutic use ; Reproducibility of Results ; Hypothalamo-Hypophyseal System ; Pituitary-Adrenal System ; Adrenal Insufficiency/diagnosis ; Pituitary Diseases ; Adrenocorticotropic Hormone
Chemical Substances	Hydrocortisone (WI4X0X7BPJ) ; Glucocorticoids ; Adrenocorticotropic Hormone (9002-60-2)
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1385151-2
ISSN	1573-7403 ; 1386-341X
ISSN (online)	1573-7403
ISSN	1386-341X
DOI	10.1007/s11102-023-01368-7
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Article ; Online: Impact of Thyroid Autoimmunity on Assisted Reproductive Technology Outcomes and Ovarian Reserve Markers: An Updated Systematic Review and Meta-Analysis.

Busnelli, Andrea / Beltratti, Carola / Cirillo, Federico / Bulfoni, Alessandro / Lania, Andrea / Levi-Setti, Paolo Emanuele

Thyroid : official journal of the American Thyroid Association

2022 Volume 32, Issue 9, Page(s) 1010–1028

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Abortion, Spontaneous/epidemiology ; Anti-Mullerian Hormone ; Autoimmunity ; Biomarkers ; Female ; Follicle Stimulating Hormone ; Humans ; Live Birth/epidemiology ; Ovarian Reserve ; Pregnancy ; Pregnancy Rate ; Prospective Studies ; Reproducibility of Results ; Reproductive Techniques, Assisted ; Thyroid Gland/physiopathology
Chemical Substances	Biomarkers ; Anti-Mullerian Hormone (80497-65-0) ; Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2022-08-29
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	1086044-7
ISSN	1557-9077 ; 1050-7256
ISSN (online)	1557-9077
ISSN	1050-7256
DOI	10.1089/thy.2021.0656
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Zs.MO 106: Show issues

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Article: ACTH Stimulation Test for the Diagnosis of Secondary Adrenal Insufficiency: Light and Shadow.

Birtolo, Maria Francesca / Antonini, Simone / Saladino, Andrea / Zampetti, Benedetta / Lavezzi, Elisabetta / Chiodini, Iacopo / Mazziotti, Gherardo / Lania, Andrea G A / Cozzi, Renato

Biomedicines

2023 Volume 11, Issue 3

Abstract: Secondary Adrenal Insufficiency (SAI) is a condition characterized by inappropriately low ACTH secretion due to a disease or injury to the hypothalamus or the pituitary. The evaluation when suspected is often challenging for the non-specific symptoms, ... ...

Abstract	Secondary Adrenal Insufficiency (SAI) is a condition characterized by inappropriately low ACTH secretion due to a disease or injury to the hypothalamus or the pituitary. The evaluation when suspected is often challenging for the non-specific symptoms, the rarity of the disease, and the pitfalls associated with laboratory tests. A prompt and correct diagnosis of SAI is essential because although an adequate hormonal replacement therapy could be lifesaving, inappropriate life-long therapy with steroids can be harmful. The gold standard test for assessing the hypothalamus-pituitary-adrenal axis (HPA) is the insulin tolerance test (ITT), but due to safety issues is not widely used. Conversely, the ACTH stimulation test is a safer and well-tolerated tool for SAI diagnosis. However, data about its diagnostic accuracy show great variability due to both technical and interpretative aspects, such as dose, route of administration, the timing of the test, and assay used for cortisol measurements. Consequently, the clinical background of the patient and the pretest probability of HPA axis impairment become of paramount importance. We aimed to summarize the recent literature evidence in the conduction and interpretation of the ACTH stimulation test for the diagnosis of SAI to provide updated insights on its correct use in clinical practice.
Language	English
Publishing date	2023-03-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11030904
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Article ; Online: Letter to the Editor: "Delayed Denosumab Injections and Bone Mineral Density Response: En Electronic Health Record-Based Study".

Mazziotti, Gherardo / Betella, Nazarena / Lania, Andrea G

The Journal of clinical endocrinology and metabolism

2020 Volume 105, Issue 10

MeSH term(s)	Bone Density ; Bone Density Conservation Agents ; Denosumab ; Electronic Health Records ; Female ; Humans ; Osteoporosis, Postmenopausal
Chemical Substances	Bone Density Conservation Agents ; Denosumab (4EQZ6YO2HI)
Language	English
Publishing date	2020-06-17
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgaa384
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Article ; Online: Osteosarcopenia in autoimmune cholestatic liver diseases: Causes, management, and challenges.

Pugliese, Nicola / Arcari, Ivan / Aghemo, Alessio / Lania, Andrea G / Lleo, Ana / Mazziotti, Gherardo

World journal of gastroenterology

2022 Volume 28, Issue 14, Page(s) 1430–1443

Abstract: Primary biliary cholangitis and primary sclerosing cholangitis (PSC) are the most common cholestatic liver diseases (CLD) in adults and are both characterized by an immune pathogenesis. While primary biliary cholangitis is a model autoimmune disease, ... ...

Abstract	Primary biliary cholangitis and primary sclerosing cholangitis (PSC) are the most common cholestatic liver diseases (CLD) in adults and are both characterized by an immune pathogenesis. While primary biliary cholangitis is a model autoimmune disease, with over 90% of patients presenting very specific autoantibodies against mitochondrial antigens, PSC is considered an immune mediated disease. Osteoporosis is the most common bone disease in CLD, resulting in frequent fractures and leading to significant morbidity. Further, sarcopenia is emerging as a frequent complication of chronic liver diseases with a significant prognostic impact and severe implications on the quality of life of patients. The mechanisms underlying osteoporosis and sarcopenia in CLD are still largely unknown and the association between these clinical conditions remains to be dissected. Although timely diagnosis, prevention, and management of osteosarcopenia are crucial to limit the consequences, there are no specific guidelines for management of osteoporosis and sarcopenia in patients with CLD. International guidelines recommend screening for bone disease at the time of diagnosis of CLD. However, the optimal monitoring strategies and treatments have not been defined yet and vary among centers. We herein aim to comprehensively outline the pathogenic mechanisms and clinical implications of osteosarcopenia in CLD, and to summarize expert recommendations for appropriate diagnostic and therapeutic approaches.
MeSH term(s)	Adult ; Autoimmune Diseases/complications ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/therapy ; Cholangitis, Sclerosing/complications ; Cholestasis/complications ; Cholestasis/diagnosis ; Humans ; Liver Cirrhosis, Biliary/complications ; Liver Cirrhosis, Biliary/diagnosis ; Liver Cirrhosis, Biliary/therapy ; Liver Diseases/complications ; Liver Diseases/diagnosis ; Liver Diseases/therapy ; Osteoporosis/diagnosis ; Osteoporosis/epidemiology ; Osteoporosis/etiology ; Quality of Life ; Sarcopenia/diagnosis ; Sarcopenia/etiology ; Sarcopenia/therapy
Language	English
Publishing date	2022-05-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v28.i14.1430
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