Result 1 - 10 of total 144
1961
| Author's details | [Regie: Wang Jiayi] |
|---|---|
| Language | Chinese |
| Size | 2 VCDs, 99 Min |
| Publishing place | China |
| Document type | Book |
| Note | Audiosprache: Chinesisch |
| Database | Former special subject collection: coastal and deep sea fishing |
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Sustainability, Vol 15, Iss 1784, p
2023 Volume 1784
Abstract: Foreign investment in renewable energy generation projects is a critical part of the Belt and Road Initiative. Under the background of the market economy, the electric energy will participate in power market competition among the countries along the line, ...
| Abstract | Foreign investment in renewable energy generation projects is a critical part of the Belt and Road Initiative. Under the background of the market economy, the electric energy will participate in power market competition among the countries along the line, and the sales revenue will be settled in the local currency. The exchange rate of the countries along the Belt and Road fluctuates frequently and widely, thereby posing significant risks to the investment income of the projects. To address this problem, this paper proposes the concept of Ek as the effective exchange rate expressed by the on-grid price, investment cost per kilowatt electricity generation equipment, and annual operating cost rate of unit power generation capacity. Moreover, this paper presents a model of power generation cost, income, and earning expressed by the real exchange rate. The flexibility formula of the fluctuation of power generation cost, income, profit, and internal rate of return relative(IRR) to Ek is derived, and the effect of exchange rate level and fluctuation on projects is analyzed. With the wind power projects invested by China in Pakistan taken as an example, the trend during the entire life cycle is calculated. The changes in net profit rate, IRR, and levelized cost of energy (LCOE) are calculated under Chinese currency appreciation of 10%, 20%, and 35% and 5% and 10% reduction of investment cost per unit. As the Chinese currency appreciates and the project IRR declines significantly, LCOE decreases slightly, but this decrease is not sufficient to compensate for the losses caused by the decline in IRR. The following effective measures are proposed to deal with the exchange rate fluctuation of foreign renewable energy generation projects: building energy Internet, reducing project cost, and using Chinese currency as the settlement currency. In this paper, a solution is provided for investments in renewable energy projects in regions where exchange rates fluctuate greatly. |
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| Keywords | RE investment ; Chinese currency appreciation ; effective exchange rate ; net profit rate ; internal rate of return ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350 |
| Subject code | 332 |
| Language | English |
| Publishing date | 2023-01-01T00:00:00Z |
| Publisher | MDPI AG |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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2023 Volume 898, Page(s) 148118
Abstract: FRS2 has demonstrated oncogenic roles in various malignancies, including liposarcoma and giant cell tumor of bone. However, its role in osteosarcoma remains less understood, and the upstream regulatory molecules influencing FRS2 remain unclear. This ... ...
| Abstract | FRS2 has demonstrated oncogenic roles in various malignancies, including liposarcoma and giant cell tumor of bone. However, its role in osteosarcoma remains less understood, and the upstream regulatory molecules influencing FRS2 remain unclear. This study aims to explore the clinical implications and biological function of FRS2 in osteosarcoma, and the potential regulatory microRNAs (miRNAs) governing its expression. Our study indicated significant upregulation of FRS2 in osteosarcoma cells and tissues by Western blotting and immunohistochemical staining. Elevated FRS2 expression correlated positively with increased angiogenesis and poor prognosis, possibly serving as an independent prognostic indicator for osteosarcoma patients. Functional assays revealed that attenuating FRS2 in osteosarcoma cells could mitigate proliferation, migration, and angiogenesis of vascular endothelial cells. Further investigations revealed that miR-429 and miR-206 directly targeted FRS2, exerting a negative regulation on its expression. Furthermore, FRS2 played a role in repressing osteosarcoma advancement influenced by miR-429 or miR-206. In summary, FRS2, influenced by miR-429 and miR-206, emerges as a promising therapeutic candidate for antiangiogenic osteosarcoma treatments. |
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| MeSH term(s) | Humans ; Endothelial Cells/metabolism ; Angiogenesis ; Cell Line, Tumor ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Osteosarcoma/metabolism ; Bone Neoplasms/metabolism ; Cell Proliferation/genetics ; Cell Movement/genetics ; Gene Expression Regulation, Neoplastic ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Adaptor Proteins, Signal Transducing/genetics |
| Chemical Substances | MicroRNAs ; FRS2 protein, human ; Membrane Proteins ; Adaptor Proteins, Signal Transducing ; MIRN206 microRNA, human ; MIRN429 microRNA, human |
| Language | English |
| Publishing date | 2023-12-28 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 391792-7 |
| ISSN | 1879-0038 ; 0378-1119 |
| ISSN (online) | 1879-0038 |
| ISSN | 0378-1119 |
| DOI | 10.1016/j.gene.2023.148118 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1357: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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Remote Sensing, Vol 14, Iss 14, p
2022 Volume 3261
Abstract: The summer upwelling around the Zhoushan Islands is well-known. The previous concise review of (mostly) observational studies reveals that the present knowledge of the Zhoushan upwelling is unsatisfactory and has focused on seasonal variations. In this ... ...
| Abstract | The summer upwelling around the Zhoushan Islands is well-known. The previous concise review of (mostly) observational studies reveals that the present knowledge of the Zhoushan upwelling is unsatisfactory and has focused on seasonal variations. In this study, a sea surface temperature (SST) gradient-based upwelling detection algorithm was used. The Level 3 daily and hourly SST data from the geostationary satellite Himawari-8 were used to explore statistical features, seasonal variations, and short-term variations of the Zhoushan upwelling. Despite the duration period being like in previous studies, there is a new finding that the location of the upwelling center has a significant monthly migration. The statistical results show that the potential upwelling spots are clustered in the location with large topographic gradients and can be divided into four aggregation areas: between Gouqi Island and Lvhua Island, off Shengsi Island, around the Zhongjieshan Islands, and off the Taohua-Liuheng Islands. The core area of the Zhoushan upwelling is located at 122°E–123°E, 29.5°N–31.15°N with an irregular ellipse extending from southwest to northeast. The continuous cloud-free satellite images display that the lifecycle of the short-term variations was about 24 h and included two stages: intensification and decay. Meanwhile, the surface upwelling center has onshore–offshore movement under the advective transport of local tidal currents. A preliminary discussion suggests that the quasi-24 h periodic variations may be caused by the competing effect between tidal mixing and the stratification in the water column. |
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| Keywords | surface upwelling ; Zhoushan Islands ; Himawari-8 ; SST ; Science ; Q |
| Subject code | 551 |
| Language | English |
| Publishing date | 2022-07-01T00:00:00Z |
| Publisher | MDPI AG |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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2024
Abstract: Prenatal lethality associated with mouse knockout of Mettl16, a recently identified RNA N6-methyladenosine ( ... ...
| Abstract | Prenatal lethality associated with mouse knockout of Mettl16, a recently identified RNA N6-methyladenosine (m |
|---|---|
| Language | English |
| Publishing date | 2024-04-11 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 586044-1 |
| ISSN | 1460-2075 ; 0261-4189 |
| ISSN (online) | 1460-2075 |
| ISSN | 0261-4189 |
| DOI | 10.1038/s44318-024-00082-9 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1808: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.MG 100: Show issues |
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2023 Volume 13, Issue 11, Page(s) e2303623
Abstract: PD-1/PD-L1 blockade immunotherapy has gained approval for the treatment of a diverse range of tumors; however, its efficacy is constrained by the insufficient infiltration of T lymphocytes into the tumor microenvironment, resulting in suboptimal patient ... ...
| Abstract | PD-1/PD-L1 blockade immunotherapy has gained approval for the treatment of a diverse range of tumors; however, its efficacy is constrained by the insufficient infiltration of T lymphocytes into the tumor microenvironment, resulting in suboptimal patient responses. Here, a pioneering immunotherapy ferritin nanodrug delivery system denoted as ITFn-Pt(IV) is introduced. This system orchestrates a synergistic fusion of PD-L1 blockade, chemotherapy, and T-cell activation, aiming to augment the efficacy of tumor immunotherapy. Leveraging genetic engineering approach and temperature-regulated channel-based drug loading techniques, the architecture of this intelligent responsive system is refined. It is adept at facilitating the precise release of T-cell activating peptide Tα1 in the tumor milieu, leading to an elevation in T-cell proliferation and activation. The integration of PD-L1 nanobody KN035 ensures targeted engagement with tumor cells and mediates the intracellular delivery of the encapsulated Pt(IV) drugs, culminating in immunogenic cell death and the subsequent dendritic cell maturation. Employing esophageal squamous cell carcinoma (ESCC) as tumor model, the potent antitumor efficacy of ITFn-Pt(IV) is elucidated, underscored by augmented T-cell infiltration devoid of systemic adverse effects. These findings accentuate the potential of ITFn-Pt(IV) for ESCC treatment and its applicability to other malignancies resistant to established PD-1/PD-L1 blockade therapies. |
|---|---|
| MeSH term(s) | Animals ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/immunology ; Humans ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/immunology ; B7-H1 Antigen/metabolism ; Mice ; Esophageal Squamous Cell Carcinoma/drug therapy ; Esophageal Squamous Cell Carcinoma/immunology ; Esophageal Squamous Cell Carcinoma/pathology ; Esophageal Squamous Cell Carcinoma/therapy ; Cell Line, Tumor ; Lymphocyte Activation/drug effects ; Ferritins/chemistry ; Tumor Microenvironment/drug effects ; Immunotherapy/methods ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Nanoparticles/chemistry ; Drug Delivery Systems/methods |
| Chemical Substances | B7-H1 Antigen ; Ferritins (9007-73-2) ; Antineoplastic Agents |
| Language | English |
| Publishing date | 2023-12-31 |
| Publishing country | Germany |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2649576-4 |
| ISSN | 2192-2659 ; 2192-2640 |
| ISSN (online) | 2192-2659 |
| ISSN | 2192-2640 |
| DOI | 10.1002/adhm.202303623 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 6966: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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Remote Sensing. 2022 July 06, v. 14, no. 14
2022
Abstract: The summer upwelling around the Zhoushan Islands is well-known. The previous concise review of (mostly) observational studies reveals that the present knowledge of the Zhoushan upwelling is unsatisfactory and has focused on seasonal variations. In this ... ...
| Abstract | The summer upwelling around the Zhoushan Islands is well-known. The previous concise review of (mostly) observational studies reveals that the present knowledge of the Zhoushan upwelling is unsatisfactory and has focused on seasonal variations. In this study, a sea surface temperature (SST) gradient-based upwelling detection algorithm was used. The Level 3 daily and hourly SST data from the geostationary satellite Himawari-8 were used to explore statistical features, seasonal variations, and short-term variations of the Zhoushan upwelling. Despite the duration period being like in previous studies, there is a new finding that the location of the upwelling center has a significant monthly migration. The statistical results show that the potential upwelling spots are clustered in the location with large topographic gradients and can be divided into four aggregation areas: between Gouqi Island and Lvhua Island, off Shengsi Island, around the Zhongjieshan Islands, and off the Taohua-Liuheng Islands. The core area of the Zhoushan upwelling is located at 122°E–123°E, 29.5°N–31.15°N with an irregular ellipse extending from southwest to northeast. The continuous cloud-free satellite images display that the lifecycle of the short-term variations was about 24 h and included two stages: intensification and decay. Meanwhile, the surface upwelling center has onshore–offshore movement under the advective transport of local tidal currents. A preliminary discussion suggests that the quasi-24 h periodic variations may be caused by the competing effect between tidal mixing and the stratification in the water column. |
|---|---|
| Keywords | algorithms ; satellites ; summer ; surface water temperature ; topography ; East China Sea |
| Language | English |
| Dates of publication | 2022-0706 |
| Publishing place | Multidisciplinary Digital Publishing Institute |
| Document type | Article |
| ZDB-ID | 2513863-7 |
| ISSN | 2072-4292 |
| ISSN | 2072-4292 |
| DOI | 10.3390/rs14143261 |
| Database | NAL-Catalogue (AGRICOLA) |
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Advanced materials (Deerfield Beach, Fla.)
2023 Volume 36, Issue 7, Page(s) e2310033
Abstract: Single-atom nanozymes (SANzymes) emerge as promising alternatives to conventional enzymes. However, chemical instability limits their application. Here, a systematic synthesis of highly active and stable SANzymes is presented by leveraging noble metal- ... ...
| Abstract | Single-atom nanozymes (SANzymes) emerge as promising alternatives to conventional enzymes. However, chemical instability limits their application. Here, a systematic synthesis of highly active and stable SANzymes is presented by leveraging noble metal-porphyrins. Four noble metal-porphyrins are successfully synthesized to mimic the active site of natural peroxidases through atomic metal-N coordination anchored to the porphyrin center. These noble metal-porphyrins are integrated into a stable and biocompatible Zr-based metal-organic framework (MxP, x denoting Ir, Ru, Pt, and Pd). Among these, MIrP demonstrates superior peroxidase-like activity (685.61 U mg |
|---|---|
| MeSH term(s) | Humans ; Epstein-Barr Virus Infections ; Nasopharyngeal Carcinoma ; Herpesvirus 4, Human ; Engineering ; Catalysis ; Metals ; Nasopharyngeal Neoplasms |
| Chemical Substances | Metals |
| Language | English |
| Publishing date | 2023-12-07 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 1474949-X |
| ISSN | 1521-4095 ; 0935-9648 |
| ISSN (online) | 1521-4095 |
| ISSN | 0935-9648 |
| DOI | 10.1002/adma.202310033 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2023 Volume 14, Issue 6, Page(s) 349
Abstract: Infertility is a worldwide reproductive health problem and there are still many unknown etiologies of infertility. In recent years, increasing evidence emerged and confirmed that epigenetic regulation played a leading role in reproduction. However, the ... ...
| Abstract | Infertility is a worldwide reproductive health problem and there are still many unknown etiologies of infertility. In recent years, increasing evidence emerged and confirmed that epigenetic regulation played a leading role in reproduction. However, the function of m |
|---|---|
| MeSH term(s) | Pregnancy ; Humans ; Female ; Mice ; Animals ; Progesterone ; Infertility, Female/genetics ; Infertility, Female/metabolism ; Methylation ; Epigenesis, Genetic ; Receptors, Progesterone/metabolism ; Uterus/metabolism ; Endometrium/metabolism ; Estrogens/metabolism ; Fertility/genetics ; Methyltransferases/genetics ; Methyltransferases/metabolism |
| Chemical Substances | Progesterone (4G7DS2Q64Y) ; Receptors, Progesterone ; Estrogens ; METTL3 protein, human (EC 2.1.1.62) ; Methyltransferases (EC 2.1.1.-) ; Mettl3 protein, mouse (EC 2.1.1.-) |
| Language | English |
| Publishing date | 2023-06-03 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2541626-1 |
| ISSN | 2041-4889 ; 2041-4889 |
| ISSN (online) | 2041-4889 |
| ISSN | 2041-4889 |
| DOI | 10.1038/s41419-023-05866-1 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Frontiers in Marine Science, Vol
2022 Volume 9
Abstract: Temporal variation of summer hypoxia, along a repeated hydrographic section from the Changjiang River mouth to Cheju Island, is investigated using cruise data during 1997–2014. The climatological mean of dissolved oxygen (DO) presents a “dual-core ... ...
| Abstract | Temporal variation of summer hypoxia, along a repeated hydrographic section from the Changjiang River mouth to Cheju Island, is investigated using cruise data during 1997–2014. The climatological mean of dissolved oxygen (DO) presents a “dual-core structure” below the oxycline, associated with two hypoxic centers near the river mouth and offshore of the Changjiang Bank, respectively. The DO value is highly variable from year to year, with dramatic interannual variation but an insignificant linear trend during 1997–2014. Composite analysis indicates that the interannual variation of DO and associated hypoxia events are strongly affected by the El Niño–Southern Oscillation (ENSO) cycle. In the El Niño decaying summer, large river discharge and relatively strong stratification, combined with calm climatic and hydrographic conditions, enhance DO depletion off the Changjiang Estuary. It is likely that El Niño is not a prerequisite for hypoxia occurrences. However, El Niño did enhance bottom hypoxia probability off the Changjiang Estuary during 1997–2014. |
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| Keywords | Hypoxia ; Changjiang Estuary ; East China Sea ; repeated hydrographic section ; ENSO ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5 |
| Subject code | 550 |
| Language | English |
| Publishing date | 2022-06-01T00:00:00Z |
| Publisher | Frontiers Media S.A. |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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