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  1. Article: Analysis of Experimental Results Regarding the Selection of Spring Elements in the Front Suspension of a Four-Axle Truck.

    Stańco, Mariusz / Kowalczyk, Marcin

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 4

    Abstract: Most special vehicles on public roads and off-road are equipped with various suspension systems. The suspensions used in trucks are designed to absorb the energy that results from overcoming uneven ground. These suspensions are divided into dependent and ...

    Abstract Most special vehicles on public roads and off-road are equipped with various suspension systems. The suspensions used in trucks are designed to absorb the energy that results from overcoming uneven ground. These suspensions are divided into dependent and independent ones. Knowledge of the loads that occur while driving a vehicle, mainly off-road, is critical from the point of view of the adhesion and fatigue life of the suspension system. In the case of four-axle cars with 2 + 2 axles, in which the first two axles are equipped with a dependent suspension based on leaf springs, only one axle may carry the load. This paper attempts to analyze the results of experimental tests carried out on a vehicle in the conditions of roads with an unstable surface such as dirt roads, gravel roads, and roadless tracks. An analysis of fatigue life estimation is presented using equivalent stress values. It was also determined how the use of front axles load equalizing elements in the tested car influences their fatigue life.
    Language English
    Publishing date 2022-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15041539
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  2. Article: Kalanchoe

    Stefanowicz-Hajduk, Justyna / Hering, Anna / Kowalczyk, Mariusz / Hałasa, Rafał / Gucwa, Magdalena / Ochocka, J Renata

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 12

    Abstract: ... ...

    Abstract Kalanchoe
    Language English
    Publishing date 2023-06-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12122268
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  3. Article ; Online: Anti-inflammatory and antioxidant actions of extracts from Rheum rhaponticum and Rheum rhabarbarum in human blood plasma and cells in vitro.

    Liudvytska, Oleksandra / Bandyszewska, Magdalena / Skirecki, Tomasz / Krzyżanowska-Kowalczyk, Justyna / Kowalczyk, Mariusz / Kolodziejczyk-Czepas, Joanna

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 165, Page(s) 115111

    Abstract: Rheum rhaponticum L. (rhapontic rhubarb) and Rheum rhabarbarum L. (garden rhubarb) are edible and medicinal rhubarb species used for many centuries in traditional medicine. This work is focused on the biological activity of extracts from petioles and ... ...

    Abstract Rheum rhaponticum L. (rhapontic rhubarb) and Rheum rhabarbarum L. (garden rhubarb) are edible and medicinal rhubarb species used for many centuries in traditional medicine. This work is focused on the biological activity of extracts from petioles and roots of R. rhaponticum and R. rhabarbarum as well as rhapontigenin and rhaponticin, typical stilbenes present in these rhubarbs, in a context of their effects on blood physiology and cardiovascular health. Anti-inflammatory properties of the examined substances were evaluated in human peripheral blood mononuclear cells (PBMCs) and THP1-ASC-GFP inflammasome reporter cells. Due to the coexistence of inflammation and oxidative stress in cardiovascular diseases, the study design included also antioxidant assays. This part of the work involved the assessment of the protective efficiency of the examined substances against the peroxynitrite-triggered damage to human blood plasma components, including fibrinogen, a protein of critical importance for blood clotting and maintaining the haemostatic balance. Pre-incubation of PBMCs with the examined substances (1-50 μg/mL) considerably decreased the synthesis of prostaglandin E
    MeSH term(s) Humans ; Antioxidants/pharmacology ; Rheum/chemistry ; Leukocytes, Mononuclear ; Anti-Inflammatory Agents/pharmacology ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Plasma ; Fibrinogen
    Chemical Substances Antioxidants ; Anti-Inflammatory Agents ; Plant Extracts ; Fibrinogen (9001-32-5)
    Language English
    Publishing date 2023-07-06
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.115111
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  4. Article: Saponin Fractions from

    Kikowska, Małgorzata / Piotrowska-Kempisty, Hanna / Kucińska, Małgorzata / Murias, Marek / Budzianowski, Jaromir / Budzianowska, Anna / Kaczmarek, Mariusz / Kowalczyk, Mariusz / Stochmal, Anna / Thiem, Barbara

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 13

    Abstract: 1) The cytotoxicity and antioxidant activity of different fractions as well as the pro-apoptotic activity of saponin fractions ... ...

    Abstract (1) The cytotoxicity and antioxidant activity of different fractions as well as the pro-apoptotic activity of saponin fractions from
    Language English
    Publishing date 2023-06-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12132485
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  5. Article ; Online: Pioneering Metabolomic Studies on

    Abramczyk, Barbara / Pecio, Łukasz / Kozachok, Solomiia / Kowalczyk, Mariusz / Marzec-Grządziel, Anna / Król, Ewa / Gałązka, Anna / Oleszek, Wiesław

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 3

    Abstract: Fungi from the ... ...

    Abstract Fungi from the genus
    MeSH term(s) Trees ; Fruit ; Poland ; Ascomycota/chemistry ; Plants ; Saccharomycetales
    Language English
    Publishing date 2023-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28031175
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    Zs.MO 81: Show issues

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  6. Article: Development, validation, and application of capillary zone electrophoresis method for determination of pyrimidine glucosides in seeds of Vicia faba L. var. minor

    Kowalczyk, Mariusz / Krzyżanowska‐Kowalczyk, Justyna / Stochmal, Anna

    Phytochemical analysis. 2021 May, v. 32, no. 3

    2021  

    Abstract: INTRODUCTION: Consumption of fava beans seeds can be harmful to both humans and animals due to the presence of pyrimidine glucosides: vicine and convicine. Therefore, seeds, feed supplements, and protein extracts derived from fava beans should be ... ...

    Abstract INTRODUCTION: Consumption of fava beans seeds can be harmful to both humans and animals due to the presence of pyrimidine glucosides: vicine and convicine. Therefore, seeds, feed supplements, and protein extracts derived from fava beans should be monitored for the contents of pyrimidine derivatives. OBJECTIVES: The main objective of this work was the development and validation of an inexpensive, uncomplicated, quick, and robust method for the quantitation of vicine and convicine in seeds of fava beans. METHODOLOGY: Plant material was extracted using a dual‐phase extraction system to remove lipophilic contaminants and deactivate residual enzymes. Pyrimidine glucosides together with the internal standard: 5‐bromouridine were separated using capillary zone electrophoresis (CZE) on an uncoated fused‐silica capillary with alkaline, tetraborate‐based electrolyte. Linearity, limits of detection and quantitation, precision, accuracy, recovery, and robustness of the method were investigated. The method was applied for quantitation of pyrimidine glucosides in seeds. RESULTS: Validation results suggest that the method is suitable for quantitation of pyrimidine glucosides, although it may not be sensitive enough for low‐concentrated samples. Application of the method showed that seeds of the investigated variety of fava beans contain both vicine at 10–15 mg/g of dry weight and convicine at 3–5 mg/g of dry weight. CONCLUSION: Developed and validated CZE‐ultraviolet (UV) method is suitable for analysis of pyrimidine glucosides in seeds of Vicia faba L. var. minor. It can be used as an inexpensive, greener alternative to more advanced methods while providing equally reliable and accurate results.
    Keywords Vicia faba ; capillary zone electrophoresis ; electrolytes ; glucosides ; lipophilicity ; phytochemicals
    Language English
    Dates of publication 2021-05
    Size p. 375-381.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note NAL-AP-2-clean ; JOURNAL ARTICLE
    ZDB-ID 1073576-8
    ISSN 1099-1565 ; 0958-0344
    ISSN (online) 1099-1565
    ISSN 0958-0344
    DOI 10.1002/pca.2984
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 4608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: From 2,5-Diformyl-1,4-dihydropyrrolo[3,2-

    Kowalczyk, Paweł / Tasior, Mariusz / Ozaki, Shuhei / Kamada, Kenji / Gryko, Daniel T

    Organic letters

    2022  Volume 24, Issue 13, Page(s) 2551–2555

    Abstract: An original approach has been developed for the insertion of formyl substituents at positions 2 and 5 of 1,4-dihydropyrrolo[3,2- ...

    Abstract An original approach has been developed for the insertion of formyl substituents at positions 2 and 5 of 1,4-dihydropyrrolo[3,2-
    Language English
    Publishing date 2022-03-28
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c00718
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  8. Article ; Online: Development, validation, and application of capillary zone electrophoresis method for determination of pyrimidine glucosides in seeds of Vicia faba L. var. minor.

    Kowalczyk, Mariusz / Krzyżanowska-Kowalczyk, Justyna / Stochmal, Anna

    Phytochemical analysis : PCA

    2020  Volume 32, Issue 3, Page(s) 375–381

    Abstract: Introduction: Consumption of fava beans seeds can be harmful to both humans and animals due to the presence of pyrimidine glucosides: vicine and convicine. Therefore, seeds, feed supplements, and protein extracts derived from fava beans should be ... ...

    Abstract Introduction: Consumption of fava beans seeds can be harmful to both humans and animals due to the presence of pyrimidine glucosides: vicine and convicine. Therefore, seeds, feed supplements, and protein extracts derived from fava beans should be monitored for the contents of pyrimidine derivatives.
    Objectives: The main objective of this work was the development and validation of an inexpensive, uncomplicated, quick, and robust method for the quantitation of vicine and convicine in seeds of fava beans.
    Methodology: Plant material was extracted using a dual-phase extraction system to remove lipophilic contaminants and deactivate residual enzymes. Pyrimidine glucosides together with the internal standard: 5-bromouridine were separated using capillary zone electrophoresis (CZE) on an uncoated fused-silica capillary with alkaline, tetraborate-based electrolyte. Linearity, limits of detection and quantitation, precision, accuracy, recovery, and robustness of the method were investigated. The method was applied for quantitation of pyrimidine glucosides in seeds.
    Results: Validation results suggest that the method is suitable for quantitation of pyrimidine glucosides, although it may not be sensitive enough for low-concentrated samples. Application of the method showed that seeds of the investigated variety of fava beans contain both vicine at 10-15 mg/g of dry weight and convicine at 3-5 mg/g of dry weight.
    Conclusion: Developed and validated CZE-ultraviolet (UV) method is suitable for analysis of pyrimidine glucosides in seeds of Vicia faba L. var. minor. It can be used as an inexpensive, greener alternative to more advanced methods while providing equally reliable and accurate results.
    MeSH term(s) Animals ; Electrophoresis, Capillary ; Glucosides ; Seeds ; Vicia faba
    Chemical Substances Glucosides
    Language English
    Publishing date 2020-09-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1073576-8
    ISSN 1099-1565 ; 0958-0344
    ISSN (online) 1099-1565
    ISSN 0958-0344
    DOI 10.1002/pca.2984
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  9. Article ; Online: Molecular Oxygen Levels and Percentages of DNA Damage in TPN Patients.

    Dąbrowska, Karolina / Zaczek, Zuzanna / Panczyk, Mariusz / Osowska, Sylwia / Kowalczyk, Paweł / Kramkowski, Karol / Sobocki, Jacek

    Nutrients

    2023  Volume 15, Issue 9

    Abstract: Total parenteral nutrition (TPN) is a life-saving therapy for patients with intestinal failure, but it carries the risk of complications, including an increase in liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) after ... ...

    Abstract Total parenteral nutrition (TPN) is a life-saving therapy for patients with intestinal failure, but it carries the risk of complications, including an increase in liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) after long-term use. Patients receiving chronic TPN are also exposed to metabolic stress from both the underlying disease and parenteral nutrition. The aim of this study was to compare the concentration of liver transaminases AST and ALT in relation to the rate of oxygen consumption in platelet mitochondria in patients receiving long-term TPN with the degree of oxidative stress induced by lipid emulsions, and to explain their role in cellular energy metabolism and changes in the liver based on the percentage of genomic DNA damage. The study group consisted of 86 TPN patients, while the control group consisted of 86 healthy volunteers who were fed only orally. The results of the study showed that the percentage of molecular oxygen depended on the type of lipid emulsion supplied. Analyzing time on TPN as a factor, we observed a decrease in percentage genomic DNA damage and an increase in percentage molecular oxygen in cells. It remains unclear whether TPN has a direct effect on genomic DNA damage and the level of molecular oxygen in cells during the course of treatment. In conclusion, this study provides important insights into the potential effects of TPN on liver enzymes and cellular metabolism. Further research is needed to better understand the underlying mechanisms and to develop strategies to minimize the risk of complications associated with TPN.
    MeSH term(s) Humans ; Parenteral Nutrition, Total ; Parenteral Nutrition/adverse effects ; DNA Damage ; Oxygen ; Lipids
    Chemical Substances Oxygen (S88TT14065) ; Lipids
    Language English
    Publishing date 2023-05-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15092206
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  10. Article ; Online: Rheum rhaponticum

    Liudvytska, Oleksandra / Ponczek, Michał B / Ciesielski, Oskar / Krzyżanowska-Kowalczyk, Justyna / Kowalczyk, Mariusz / Balcerczyk, Aneta / Kolodziejczyk-Czepas, Joanna

    Nutrients

    2023  Volume 15, Issue 4

    Abstract: Background: Inflammation, endothelial dysfunction, and alterations in blood physiology are key factors contributing to atherosclerosis and other cardiovascular disorders. Hence, modulation of endothelial function and reducing its pro-inflammatory and ... ...

    Abstract Background: Inflammation, endothelial dysfunction, and alterations in blood physiology are key factors contributing to atherosclerosis and other cardiovascular disorders. Hence, modulation of endothelial function and reducing its pro-inflammatory and pro-thrombotic activity is considered one of the most important cardioprotective strategies. This study aimed to evaluate the anti-inflammatory potential of rhubarb extracts isolated from petioles and underground organs of
    Methods: Analysis of the anti-inflammatory effects of the indicated rhubarb-derived substances involved different aspects of the endothelial cells' (HUVECs) response: release of the inflammatory mediators; cyclooxygenase (COX-2) and 5-lipoxygenase (5-LOX) expression as well as the recruitment of leukocytes to the activated HUVECs. The ability of the rhubarb-derived extracts to inhibit COX-2 and 5-LOX activities was examined as well. The study was supplemented with the in silico analysis of major components of the analyzed extracts' interactions with COX-2 and 5-LOX.
    Results: The obtained results indicated that the examined plant extracts and stilbenes possess anti-inflammatory properties and influence the inflammatory response of endothelial cells. Biochemical and in silico tests revealed significant inhibition of COX-2, with special importance of rhaponticin, as a compound abundant in both plant species. In addition to the reduction in COX-2 gene expression and enzyme activity, a decrease in the cytokine level and leukocyte influx was observed. Biochemical tests and computational analyses indicate that some components of rhubarb extracts may act as COX-2 inhibitors, with marginal inhibitory effect on 5-LOX.
    MeSH term(s) Anti-Inflammatory Agents ; Cyclooxygenase 2 ; Endothelial Cells/drug effects ; Plant Extracts/pharmacology ; Rheum/chemistry ; Humans ; Human Umbilical Vein Endothelial Cells
    Chemical Substances Anti-Inflammatory Agents ; Cyclooxygenase 2 (EC 1.14.99.1) ; Plant Extracts ; rhapontin (K691M2Z08V)
    Language English
    Publishing date 2023-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15040949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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